Discounting the Future: on Climate Change, Ambiguity Aversion and Epstein-Zin Preferences [electronic journal].
Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism
DOI: 10.1039/D4SC05499G, Edge Article
A highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.
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Sequence-dependent Conformational Transitions of Disordered Proteins During Condensation
DOI: 10.1039/D4SC05004E, Edge Article
Intrinsically disordered proteins (IDPs) can form biomolecular condensates through phase separation. It is recognized that the conformation of IDPs in the dense and dilute phases, as well as at the...
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Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA
DOI: 10.1039/D4LC00628C, Paper
Using nanofluidics to probe protein mobility on DNA reveals how DNA base methylation impacts protein–DNA interactions.
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Researchers uncover new role of mutant RAS proteins in some of the deadliest cancers
A new study led by NCI researchers shows that mutant RAS proteins help release a nuclear protein from a complex transported from the nucleus to the cytoplasm, kicking off a series of events that lead to the breakdown of a tumor suppressor protein.
CoO/Co-graphene quantum dots as an oxidative mimetic nanozyme for the colorimetric detection of L-cysteine
DOI: 10.1039/D4AY00086B, Paper
The preparation of CoO/Co-graphene quantum dots nanozymes with high oxidase-like activity.
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A lateral flow strip for on-site detection of homocysteine based on a truncated aptamer
DOI: 10.1039/D4AY00274A, Paper
A lateral flow strip based on a truncated aptamer for on-site detection of homocysteine in human serum.
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A novel fluorescent probe with a large Stokes shift for colorimetric and selective detection of cysteine in water, milk, cucumber, pear and tomato
DOI: 10.1039/D3AY02322B, Paper
A novel fluorescent probe for colorimetric and selective detection of cysteine was efficiently constructed through a simple and mild reaction conditions. Probe 2 displays a linear response to Cys concentrations (0–30 μM), low detection limit (0.89 μM), large Stoke shift (125 nm).
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Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment
DOI: 10.1039/D3AY02075D, Paper
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
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Anti-aggregation colorimetric sensing of cysteine using silver nanoparticles in the presence of Pb2+
DOI: 10.1039/D4AY00351A, Paper
In this study, an unmodified AgNPs was synthesized to prepare AgNPs-Pb2+ as a probe for colorimetric sensing of cysteine. We developed a AgNPs colorimetric method for the determination of cysteine in urine, utilizing the anti-aggregation principle.
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Quantifying platinum binding on protein-functionalized magnetic microparticles using single particle-ICP-TOF-MS
DOI: 10.1039/D4AY00268G, Paper
This work describes an analytical procedure, single particle-inductively coupled plasma-time-of-flight-mass spectrometry (SP-ICP-TOF-MS), that was developed to determine the platinum binding efficiency of protein-coated magnetic microparticles.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders
DOI: 10.1039/D4MD00594E, Research Article
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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633: Thomas Steiner on AI in Chrome and the Web
Thomas Steiner from Project Fugu talks with us about AI in Chrome, the small large language model in use, how features like this are rolled out, the ethics and concerns around sending and sharing data, on device vs web APIs, and ideas for use cases and ways to explore AI on the web.
Morning runs, protein-packed breakfast, and a rest day
Paddy varieties with protein, zinc content get thumbs up in Odisha’s tribal pocket
Paddy varieties have high protein (10.1%) and moderately high level of zinc (20 ppm) content
Effective patchiness from critical points of a coarse-grained protein model with explicit shape and charge anisotropy
DOI: 10.1039/D4SM00867G, Paper
Critical points of an anisotropic, coarse-grained protein model are used to detemine an “effective patchiness” by comparison to the Kern–Frenkel patchy model.
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Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures
DOI: 10.1039/D4SM00907J, Paper
Exploiting the ability of a solid-binding elastin-like peptide to micellize, we mineralize monodisperse silica nanoparticles whose positive surface charge enables one-step electrostatic assembly of various mono- and bi-material superstructures.
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The history of approximation theory [electronic resource] : from Euler to Bernstein / Karl-Georg Steffens
Pd-catalyzed S-glycosylation of cysteine-containing peptides at room temperature
DOI: 10.1039/D4QO01389A, Research Article
This study reports the synthesis of thioglycopeptides via a Pd-catalyzed coupling of cysteine-containing peptides with iodoglycals. A variety of cysteine-containing peptides and other thiol nucleophiles including thiosugars and thiophenols were used.
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Advanced introduction to behavioral law and economics [electronic resource] / Cass R. Sunstein.
An energy-efficient tellurium electrode enabled by a Cs2TeI6 perovskite structure for durable aqueous Zn–Te batteries
DOI: 10.1039/D4EE02916J, Paper
CsI in 2 M ZnSO4 aqueous electrolyte facilitates the formation of Cs2TeI6 perovskite phase for Te electrode, effectively suppressing Te4+ hydrolysis and sustaining fast redox kinetics in multi-electron transfer Zn–Te aqueous batteries.
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Microencapsulation of broccoli sulforaphane using whey and pea protein: in vitro dynamic gastrointestinal digestion and intestinal absorption by Caco-2-HT29-MTX-E12 cells
DOI: 10.1039/D4FO03446E, Paper
Sulforaphane-rich extract was prepared from broccoli. The extract was encapsulated with whey and pea protein isolates by freeze-drying. The products were characterised and assessed for in vitro bioaccessibility and bioavailability.
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Enhancement of the flavor and functional characteristics of cod protein isolate using an enzyme–microbe system
DOI: 10.1039/D4FO02272F, Paper
Cod protein isolate was first debittered using Streptomyces canus aminopeptidase (ScAPase) and then deodorized through probiotic fermentation, showing the most substantial. These products showed the most substantial proliferation effect on probiotics.
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Correction: A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice
DOI: 10.1039/D4FO90102A, Correction
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Impact of pH on the fabrication of egg white reinforced soy protein composite microgels for gastrointestinal delivery purposes
DOI: 10.1039/D4FO03997A, Paper
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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Protein-bound AGEs derived from methylglyoxal induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism
DOI: 10.1039/D4FO00364K, Paper
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1
DOI: 10.1039/D4FO02479F, Paper
Aronia melanocarpa (AM) was shown to promote the lifespan and health-span of C. elegans via the PMK-1 pathway, highlighting the potential of AM as a dietary supplement for delaying aging.
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Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice
DOI: 10.1039/D4FO03355H, Paper
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
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Techno-functional, antioxidant, and amino acid characterization of hydrolyzed bioactive peptides from coconut (Cocos nucifera L.) meal protein
DOI: 10.1039/D4FO02741H, Paper
In this study, the techno-functional characteristics and nutritional value of coconut meal protein (CMP) and the obtained polypeptides by alcalase (H-Alc), trypsin (H-Try), pancreatin (H-Pan), and pepsin (H-pep) were investigated.
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Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein
DOI: 10.1039/D4FO03582H, Paper
We developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.
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Alleviating effect of whey protein supplementation on oxidative stress in hypothyroidism
DOI: 10.1039/D4FO03186E, Paper
Supplementation with whey protein is effective for treating hypothyroidism-associated oxidative stress by enhancing the antioxidant system, reducing lipid peroxidation and maintaining cellular ionic balance.
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Broadening the substrate range of serine palmitoyltransferase by protein engineering and applications to 3-keto-dihydrosphingosine analogs
DOI: 10.1039/D4CY01019A, Paper
Introducing an additional mutation at position 73 dramatically increases the substrate range, allowing access to a wide variety of sphingolipid analogs.
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Self-adjuvanted L-arginine-modified dextran-based nanogels for sustained local antigenic protein delivery to antigen-presenting cells and enhanced cellular and humoral immune responses
DOI: 10.1039/D3BM01150J, Paper
Antigens are delivered in self-adjuvanted arginine-modified dextran-based nanogels to the dendritic cells in promoting antigen specific cellular immunity.
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Correction: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis
DOI: 10.1039/D4BM90029D, Correction
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Correction: A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer
DOI: 10.1039/D4BM90022G, Correction
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Towards a better understanding of the effect of protein conditioning layers on microbial adhesion: A focused investigation on Fibronectin and Bovine Serum Albumin layers on SiO2 surfaces
DOI: 10.1039/D4BM00099D, Paper
The interaction of foreign implants with its surrounding environment is significantly influenced by the adsorption of proteins on the biomaterial surfaces, playing role in the microbial adhesion. Therefore, understanding protein...
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Protein-hydrogel crystal expands and contracts
Synthorx raises $63 million to make synthetic proteins from an expanded genetic code
Chemists synthesize and screen massive library of nonnatural proteins
How an opossum protein may lead to a broad-spectrum snakebite treatment
San Jose State’s Claire Komives is testing an antivenom inspired by opossum biochemistry against various snake species to prevent deaths in the developing world
Study reveals structure of protein that transports body odor precursor
Follow-up studies could lead to inhibitors that block uptake, thus stopping body odor production
New variant of Parkinson’s protein goes against the grain
Short α-synuclein peptide affects uptake of dopamine rather than forming typical clumps in the brain
One-pot, cell-free method makes glycoproteins
Ambar Protein Industries Ltd - Board Meeting Intimation for Intimation Board Meeting To Be Held On 14Th August 2019
Bodies of 2 Meitei men found, search on for 6 missing
Operations are underway to trace three women and three children, who have been reported missing since the violence erupted in Jiribam on Monday, IGP (operations) IK Muivah said.
Kukis, Meiteis hold separate protests across Manipur
The Kuki-Zo Council called for a 13-hour shutdown in Manipur's hill areas on Tuesday, demanding an investigation into the death of 11 people in a clash with security forces in Jiribam. The shutdown, which began at 5 am, saw schools, markets, and public transport remain closed. Various Kuki-Zo organizations, including the Kuki Students' Organisation, the Zomi Students' Federation, and the Hmar Students' Association, demanded a probe into the incident, accusing the Central Reserve Police Force of "treacherous murder." The Hmar Village Volunteers, who were identified by the Kuki-Zo groups as the victims, condemned the incident and called for intervention from the Ministry of Home Affairs.