Substituted phenylcarbamoyl alkylamino arenes; substituted phenylthiocarbamyl alkylamino arenes; substituted phenylcarbamoyl alkylamino heteroarenes; substituted phenylthiocarbamyl alkylamino heteroarenes; N-substituted aryl, N'-substituted aryl urea compounds; N-substituted aryl, N'-substituted heteroaryl urea compounds; N-substituted aryl, N'-substituted aryl thiourea compounds and N-substituted aryl, N'-substituted heteroaryl thiourea compounds are provided and may find use as androgen receptor modulators. The compounds may find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn'H2n'+1OH, Cn'H2n'+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn'″H2n″+1OH, Cn″H2n″+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n' is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n'+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.

There is provided a method for producing an aqueous acrylamide solution by reacting a composition including acrylonitrile with water to produce acrylamide, in which the composition including acrylonitrile includes 3 to 15 mg of propionitrile per 1 kg of the total weight of the composition including acrylonitrile. According to the present invention, a production method with which it is possible to suppress acrylamide polymerization without lowering quality and thereby obtain a stable aqueous acrylamide solution can be provided.

The esterfication of hypophosphorous acid is followed by reaction with another molecule of alcohol under the action of a nickel catalyst to provide a green method for the preparation of H-phosphonate diesters. This method avoids the need for any stoichiometric chlorine unlike those based on phosphorous trichloride.

A method and apparatus for using an ad hoc peer-to-peer distributed message bus is provided. The method may include determining, by a local bus node, using a first power level communication protocol, that a remote bus node is available, obtaining, by the local bus node, connection information from the remote bus node using a second power level communication protocol, wherein the connection information comprises connection information for one or more remote endpoints associated with the remote bus node, and generating one or more local virtual endpoints, wherein each of the one or more local virtual endpoints corresponds to each of the one or more remote endpoints, and wherein the remote endpoint is described with reference to a well-known name, unique to the remote endpoint.

Internet streaming from broadcast radio or television stations is described wherein triggers for dynamic content from internal or external systems cause an encoder system to generate command messages, and to optionally synchronize those command messages with any delays associated with the triggering events. Command messages are delivered through a streaming media distribution system to client media players which obtain or present the dynamic content, in association with any desired configuration changes to the appearance of the media player or the method or manner in which the dynamic content is presented.

A method begins by a router receiving data for storage and interpreting the data to determine whether the data is to be forwarded or error encoded. The method continues with the router obtaining a routing table when the data is to be error encoded. Next, the method continues with the router selecting a routing option from the plurality of routing options and determining error coding dispersal storage function parameters based on the routing option. Next, the method continues with the router encoding the data based on the error coding dispersal storage function parameters to produce a plurality of sets of encoded data slices. Next, the method continues with the router outputting at least some of the encoded data slices of a set of the plurality of sets of encoded data slices to an entry point of the routing option.

A system, method, and computer-readable medium are disclosed for realizing server management functionalities in the absence of a routable Internet Protocol (IP) network address of a remote access controller (RAC). A first device, which is operatively coupled to a link-local network, generates a Multicast Domain Name System (mDNS) IP multicast query message, which it then sends to a second device on the link-local network. In response, the second device, which comprises a RAC, returns its link-local IP address to the first device.

Methods and systems for remotely provisioning applications from the cloud in secure environments with robust license control failover options using a hierarchical server topology. Cloud-based servers provide applications and licenses to an organization's local servers, which in turn serve applications and licenses to end user devices. By synchronizing information including license and application provision information among the local and cloud-based servers, an organization's local servers can continue to serve applications and licenses when one or more of the organization's local servers fail.

A risk aware domain name service (DNS), which includes modulating a time to live (TTL) value associated with the DNS based at least in part on one or more DNS-related metrics associated with a DNS server providing DNS resolution is disclosed. A zone file that indicates a particular TTL value may be generated based at least in part on the one or more DNS-related metrics and provided to the DNS server.

According to one embodiment, a method comprises evaluating messages between nodes of a distributed computing environment. Based on timing relationships of the messages, probability of causal links between pairs of messages determined. Based on the determined probability, at least one causal path comprising a plurality of causal links is inferred. Further, an overall probability that the inferred causal path is accurate is determined. In certain embodiments, the overall probability is output for the corresponding causal path to provide an indication of the confidence of the accuracy of such inferred causal path.

An example method to monitor media exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer. The example method also involves determining if the client computer is known. If the client computer is not known, a response is sent from the first internet domain to the client computer, the response to instruct the client computer to send a second request to a second internet domain, the second request to be indicative of access to the media at the client computer. If the client computer is known, an impression of the media is logged.

A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

A calendar display apparatus includes a reference signal generator, a calendar data generator, and rotational display members. The reference signal generator generates a reference signal every period of 24 hours. The calendar data generator generates year, month, date, and day data upon reception of the reference signal. The rotational display members are driven by signals from the calendar data generator so as to display a year, a month, a date, and a day. A scale corresponding to the rotational display member for displaying years is constituted by multiple circular scales. Scale marks representing years are sequentially and continuously formed on the multiple circular scales from its inner circumference to outer circumferences.

A method for depositing a wear-resistant decorative coating on a substrate, comprising a first stage of vacuum deposition on the surface of the substrate of a layer of at least one metal of the group titanium, zirconium, hafnium, vanadium, niobium, tantalum, chromium, molybedenum, tungsten and aluminium, to which is added at least one element of the group carbon, nitrogen, oxygen, boron, silicon, fluorine, chlorine, sulfur and phosphorus; a second stage including activation of the first layer by ionic bombardment under vacuum conditions and simultaneous deposition of a second fine layer of a metal or metal alloy; and a third stage involving galvanic deposition of a third layer of a decorative metal coating over the second layer.

The case (1) of the watch carries, along its periphery (5), hooking members in the form of rings (6a, 6a', 6b, 6b', 6c, 6c'), these rings being disposed radially relative to the center (7) of the dial (2) and hence of the watch. A chain (8) is fixed by loops (9, 10) at its ends to two (6c, 6c') of these rings and passes through the other rings (6a, 6a', 6b, 6b'), passing several of times around the wearer's wrist. After the loops (9, 10) have been detached from their respective rings, the chain (8) can be passed in a different manner around the case, so that the watch can be hung around the neck. In order to make this change, the chain is equipped with a flat link (13) which can pass through radial slots provided in the periphery of the rings.

A wind direction indicating and time display unit is provided for use at the tee areas of a golf course. The unit wind direction indicating device is mounted on an upper surface of a support structure and extends upwardly therefrom. The wind direction indicating device includes a support pole, a sleeve mounted for rotation on the pole at the top thereof, a wind direction indicating element, such as a flag, secured to the sleeve and movable in response to changes in wind direction, and a pole support fitting. Secured to the upper surface of the support structure. A time display device, such as a clock, is secured in a laterally facing wall surface of the support structure.

Accessory for a laptop computer with LCD display which is connected to the laptop serial communications port and optically transmits data to a portable information device, such as a wristwatch designed to receive data as sequential pulses of light. The accessory includes a microcomputer with an RC timebase which is calibrated each time it is used by a special internal program, so that the input baud rate to the accessory matches the communications baud rate of the data received from the laptop. The internal program also permits selection of an output baud rate for the optically transmitted data.

A radio paging selective receiver determines that a received message is unread based on the time difference between the message reception time and the current time being larger that some predetermined value of time, and the paging selective receiver provides an indication of the unread message by displaying the reception time of the unread message in a second fashion which is visibly different from a first fashion normally used to display the current time.

An LCD is integrated with the cover glass of a wrist watch radio paging receiver which indicates the time data with a dial plate and hands, and a message is displayed on the cover glass by controlling this LCD. In this message display, the parts of the characters indicating the message are made transparent and the remaining parts intercept light. In this manner, message display is made possible by the difference in light transmissivity.

An object of the present invention is to provide a method for producing a display device by which a substrate is thinned efficiently. Onto one original substrate having an area for a plurality of display devices, the other original substrate is bonded via a sealing resin layer, the pair of bonded original substrates is divided and separated into a plurality of pairs of substrates of a size of each individual display device, and thereafter a substrate thinning process of thinning the substrates is performed in a state where the substrates are held by substrate holding means.

A mechanism for determining whether the sun is visible at a diurnal solar event and for mechanically triggering actions based upon the sun being visible during the diurnal solar event is disclosed. The mechanisms of the invention can perform these operations without intervention or supervision for long periods of time. Certain embodiments have been applied to provide a diurnal solar event trigger based upon sidereal noon for a clock providing accurate timing for 10,000 years without intervention or supervision.

A network is described for providing estimates of the current time. The network includes multiple computer systems each configured to provide an estimate of the current time in response to a received request. The computer systems are logically arranged to form a hierarchical structure, wherein the hierarchical structure includes multiple levels ranked with respect to one another. Each of the computer systems is assigned one of multiple levels of trust, and occupies one of the levels of the hierarchical structure dependent upon the assigned level of trust. The level of trust assigned to a given computer system is dependent upon a timekeeping dependability of the given computer system. The assigned level of trust may also be dependent upon a timekeeping security of the given computer system, where the timekeeping security is dependent upon a tamper resistance of the time clock of the given computer system. Methods for delegating a level of trust to a new computer system (i.e., a computer system not part of the network) and for adding a new computer system to the network are also described.

A wristwatch, which comprises an atomic oscillator comprising a system for detecting the beat frequencies obtained by the Raman effect.

Various systems and methods are described for configuring a data storage system. In one embodiment, a plurality of actual capacities of a plurality of storage devices of the data storage system are identified and divided into a plurality of capacity slices. The plurality of capacity slices are combined into a plurality of chunks of capacity slices, each having a combination of characteristics of the underlying physical storage devices. The chunks of capacity slices are then mapped to a plurality of logical storage devices. A group of the plurality of logical storage devices is then organized into a redundant array of logical storage devices.

A controller receives a request to perform a release space operation. A determination is made that a new discard scan has to be performed on a cache, in response to the received request to perform the release space operation. A determination is made as to how many task control blocks are to be allocated to the perform the new discard scan, based on how many task control blocks have already been allocated for performing one or more discard scans that are already in progress.

Systems, methods, and other embodiments associated with a distributed cache coherency protocol are described. According to one embodiment, a method includes receiving a request from a requester for access to one or more memory blocks in a block storage device that is shared by at least two physical computing machines and determining if a caching right to any of the one or more memory blocks has been granted to a different requester. If the caching right has not been granted to the different requester, access is granted to the one or more memory blocks to the requester.

A dispersed storage (DS) unit for use within a dispersed storage network is capable of self-configuring using registry information provided to the DS unit. The registry information includes a slice name assignment indicating a range of slice names corresponding to a plurality of potential data slices of potential data objects to be stored in the DS unit. Based on the registry information, the DS unit allocates a portion of physical memory to store the potential data slices.

A prefetch optimizer tool for an information handling system (IHS) may improve effective memory access time by controlling both hardware prefetch operations and software prefetch operations. The prefetch optimizer tool selectively disables prefetch instructions in an instruction sequence of interest within an application. The tool measures execution times of the instruction sequence of interest when different prefetch instructions are disabled. The tool may hold hardware prefetch depth constant while cycling through disabling different prefetch instructions and taking corresponding execution time measurements. Alternatively, for each disabled prefetch instruction in the instruction sequence of interest, the tool may cycle through different hardware prefetch depths and take corresponding execution time measurements at each hardware prefetch depth. The tool selects a combination of hardware prefetch depth and prefetch instruction disablement that may improve the execution time in comparison with a baseline execution time.

A method and system for dynamic distributed data caching is presented. The system includes one or more peer members and a master member. The master member and the one or more peer members form cache community for data storage. The master member is operable to select one of the one or more peer members to become a new master member. The master member is operable to update a peer list for the cache community by removing itself from the peer list. The master member is operable to send a nominate master message and an updated peer list to a peer member selected by the master member to become the new master member.

A process is provided for recovering aliphatic monocarboxylic acids having from 4 to 11 carbon atoms from the distillation residue obtained in the oxidation of the corresponding aldehyde by means of oxygen or oxygen-containing gas mixtures in the presence of alkali metal carboxylates or alkaline earth metal carboxylates to form the corresponding monocarboxylic acid and subsequent distillation, characterized in that the distillation residue is reacted with an aqueous acid in a tube reactor and the two-phase mixture flowing out from the tube reactor is introduced into a settling vessel in which the organic phase which separates out has a pH of 4.5 or less.

The invention discloses a deep-ultraviolet chemically-amplified positive photoresist. The deep-ultraviolet chemically-amplified positive photoresist according to one embodiment of the invention includes a cyclopentenyl pimaric acid, a divinyl ether, a photoacid generator and an organic solvent. The deep-ultraviolet chemically-amplified positive photoresist according to the invention has a good sensitivity and a good transparency.

The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.

An ammonium hydroxyfluoroalkanesulfinate is obtained by using an organic base while sulfinating a bromofluoroalcohol with a sulfinating agent. An ammonium hydroxyfluoroalkanesulfonate is obtained by oxidizing the ammonium hydroxyfluoroalkanesulfinate. An onium fluoroalkanesulfonate is obtained by converting the ammonium hydroxyfluoroalkanesulfonate into an onium salt through esterification. This onium fluoroalkanesulfonate is useful as a photoacid generator in chemically amplified resists and the like.

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.

The polycyclic organic compounds which are substantially transparent for an electromagnetic radiation in the visible spectral range, an anisotropic optical film comprising at least one polycyclic organic compound and a method of producing thereof are disclosed. The polycyclic organic compounds have a general formula (I) wherein A and B are acid groups, n is the number of phenyl rings in the range from 3 to 10; m is 0, 1, 2 or 3; l is 1, 2, or 3, p is 1, 2, 3, 4, 5 or 6, C is a counterion from a list comprising H+, NH+4, Na+, K+, Li+, Cs+, Ca2+, Mg2+, Sr2+, La3+, Zn2+, Zr4+, Ce3+, Y3+, Yb3+, Gd3+, and any combination thereof; k is the number of counterions necessary for compensation of the negative electric charge equal to (−p).

Various embodiments of the present invention generally disclose systems and processes for the conversion of a feed stream comprising at least one C8 aromatic into a product stream comprising isophthalic acid and purified terephthalic acid (IPA/TA).

An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method.

The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.

Provided herein are methods, compounds, and compositions for reducing expression of PTP1B mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate metabolic disease, for example, diabetes, or a symptom thereof.

A pharmaceutical composition comprising lectins is anti-tumorigenic and anti-viral, bacterial or protozoan. The composition, termed BiOmune is also useful for imaging, diagnosis and therapy of cancer.

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

An α-amylase from Bacillus subtilis (AmyE) produces significant amounts of glucose from various carbohydrate substrates, including vegetable starch, maltoheptaose, and maltotriose. Among other things, this advantageous property allows AmyE or variants thereof to be used in a saccharification reaction having a reduced or eliminated requirement for glucoamylase. The reduction or elimination of the glucoamylase requirement significantly improves the efficiency of the production of ethanol or high fructose corn syrup, for example.

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N4, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula where R1 is H, R3, R4, 2'-deoxyribosyl, R4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R5 and R6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

The present invention relates to oligomer compounds (oligomers) for the treatment and prevention of acute myeloid leukemia, which target GLI2 mRNA in a cell, leading to reduced expression of GLI2.

A composition comprising an SL0101 [kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.

A coating agent containing a hydroxyalkyl cellulose in which a content of hydroxyalkoxy groups within the hydroxyalkyl cellulose is within a range of 40 to 50% by mass, preferably a coating agent containing a hydroxyalkyl cellulose in which the content of hydroxyalkoxy groups is within a range of 40 to 50% by mass and also a viscosity of 2% aqueous solution at 20° C. is within a range of 3.0 to 5.9 mPa·s; and a solid preparation coated with the coating agent.

The present invention provides for an electronic device having cryptographic computation means arranged to generate cryptographic data within the device for enhancing security of communications therewith, the device including an onboard power supplying means arranged to provide for the driving of the said cryptographic computational means, and so as to provide a device by way of a manufacturing phase and a post manufacturing phase arranged for distribution and/or marketing of the device, and wherein the step of generating the cryptographic data occurs during the post manufacturing phase.