On Sept. 3, U.S. President Barack Obama and China's President, Xi Jinping, formally agreed to participation in the negotiated 2015 United Nations Climate Change Conference (COP 21) Paris Agreement, a global agreement on the reduction of climate change.
 

Papua New Guinea recently became the first country to formally submit the final version of its national climate action plan (called a “Nationally Determined Contribution,” or NDC) under the Paris Agreement. The small Pacific nation’s plan to transition to 100 percent renewable energy by 2030 is no longer just an “intended” nationally determined contribution (INDC) — it is now the country’s official climate plan.

Less than two weeks after 175 nations signed the pivotal Paris Agreement on climate change, a question lingers: What happens now?

The G20 meeting in Hangzhou, China, this September brings together leaders of the world’s largest economies for the first such gathering since the 2015 Paris Agreement on climate. G20 Leaders Summits traditionally focus on economic growth and financial stability, but since more than 190 countries collectively agreed to greatly enhance mitigation of the causes and impacts of climate change, the need to tackle a changing climate and foster clean energy has become a clear economic and business reality.

The United States and China on Sept. 3 formally joined the Paris Agreement in a ceremony in Hangzhou, China, ahead of the G20 Summit. President Obama and President Xi both deposited their country’s official instrument with United Nations Secretary, General Ban-Ki Moon.

TROOP D NEWS RELEASE May 9, 2020 **UPDATE** Driver and Passenger Killed in Head-On Crash in Calcasieu Parish Sulphur, LA. - The deceased passenger is identified as 38-year-old Michael C. Vidrine of Eunice, LA. Original Release - On May 8, 2020, at approximately 4:15 p.m., Troopers from Louisiana State Police Troop D responded to a two-vehicle, fatal crash on LA Hwy 27 on top of...

Spitting on people is illegal and violates France’s emergency measures to curb the COVID-19 pandemic.

This publication provides estimates of purchasing power parities (PPPs) and real expenditures for 22 economies in Asia and the Pacific. These are summary regional results from the 2017 cycle of the International Comparison Program (ICP).

There could be a planetary threshold beyond which the earth will keep warming even if we stop pumping out more fossil fuels - the so-called 'Hothouse Earth' scenario

From a bunch of radishes to a sleeping cat, Parisian Agnes Goyet has turned to her life indoors for inspiration as France's coronavirus lockdown frees her up to pursue her hobby - art.

Christiana Figueres and Tom Rivett-Carnac led the 2015 Paris climate negotiations. They tell us why they’re hopeful for the future, and explain how fighting climate change is “the most exciting experiment in history”

Ground-breaking aviation technology is on display at this week's Paris Airshow. Jim Drury went to take a look.

ABSTRACT

Many HIV prevention strategies are currently under consideration where it is highly informative to know the study participants’ times of infection. These can be estimated using viral sequence data sampled early in infection. However, there are several scenarios that, if not addressed, can skew timing estimates. These include multiple transmitted/founder (TF) viruses, APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like)-mediated mutational enrichment, and recombination. Here, we suggest a pipeline to identify these problems and resolve the biases that they introduce. We then compare two modeling strategies to obtain timing estimates from sequence data. The first, Poisson Fitter (PF), is based on a Poisson model of random accumulation of mutations relative to the TF virus (or viruses) that established the infection. The second uses a coalescence-based phylogenetic strategy as implemented in BEAST. The comparison is based on timing predictions using plasma viral RNA (cDNA) sequence data from 28 simian-human immunodeficiency virus (SHIV)-infected animals for which the exact day of infection is known. In this particular setting, based on nucleotide sequences from samples obtained in early infection, the Poisson method yielded more accurate, more precise, and unbiased estimates for the time of infection than did the explored implementations of BEAST.

IMPORTANCE The inference of the time of infection is a critical parameter in testing the efficacy of clinical interventions in protecting against HIV-1 infection. For example, in clinical trials evaluating the efficacy of passively delivered antibodies (Abs) for preventing infections, accurate time of infection data are essential for discerning levels of the Abs required to confer protection, given the natural Ab decay rate in the human body. In such trials, genetic sequences from early in the infection are regularly sampled from study participants, generally prior to immune selection, when the viral population is still expanding and genetic diversity is low. In this particular setting of early viral growth, the Poisson method is superior to the alternative approach based on coalescent methods. This approach can also be applied in human vaccine trials, where accurate estimates of infection times help ascertain if vaccine-elicited immune protection wanes over time.

BACKGROUND Pregnant patients from rural counties of Western North Carolina face additional barriers when accessing comprehensive perinatal substance use disorders care at Project CARA as compared to patients local to the program in Buncombe County. We hypothesized regional patients would be less engaged in care.

METHOD Using a retrospective cohort design, univariate analyses (², t-test; P < .05) compared patients' characteristics, engagement in care, and delivery outcomes. Engagement in care, the primary outcome, was operationalized as: attendance at expected, program-specific prenatal and postpartum visits, utilization of in-house counseling, community-based and/or inpatient substance use disorders treatment, and maternal urine drug screen at delivery negative for illicit substances.

RESULTS Regional patients (n = 324) were more likely than Buncombe County patients (n = 284) to have opioid [209 (64.5%) versus 162 (57.0%)] or amphetamine/methamphetamine use disorders (25 [7.7%] versus 13 [4.6%]), but less likely to have cannabis use (19 [5.9%] versus 38 [13.4%]; P = .009) and concurrent psychiatric disorders (214 [66.0%] versus 220 [77.5%]; P = .002). Engagement at postpartum visits was the significantly different outcome between patients (110/221 [49.8%] versus 146/226 [64.6%]; P = .002).

LIMITATIONS Outcomes were available for 66.8% of regional and 79.6% of Buncombe County patients of one program in one predominately white, non-Hispanic region of the state.

CONCLUSION Contrary to our hypothesis, regional and Buncombe County women engaged in prenatal care equally. However, a more formal transition into the postpartum period is needed, especially for regional women. A "hub-and-spokes" model that extends delivery of perinatal substance use disorders care into rural communities may be more effective for engagement retention.

The kidneys play an important role in many processes, including urine formation, water conservation, acid-base equilibrium, and elimination of waste. The anatomic and functional development of the kidney has different maturation time points in humans versus animals, with critical differences between species in maturation before and after birth. Absorption, distribution, metabolism, and excretion (ADME) of drugs vary depending on age and maturation, which will lead to differences in toxicity and efficacy. When neonate/juvenile laboratory animal studies are designed, a thorough knowledge of the differences in kidney development between newborns/children and laboratory animals is essential. The human and laboratory animal data must be combined to obtain a more complete picture of the development in the kidneys around the neonatal period and the complexity of ADME in newborns and children. This review examines the ontogeny and cross-species differences in ADME processes in the developing kidney in preterm and term laboratory animals and children. It provides an overview of insights into ADME functionality in the kidney by identifying what is currently known and which gaps still exist. Currently important renal function properties such as glomerular filtration rate, renal blood flow, and ability to concentrate are generally well known, while detailed knowledge about transporter and metabolism maturation is growing but is still lacking. Preclinical data in those properties is limited to rodents and generally covers only the expression levels of transporter or enzyme-encoding genes. More knowledge on a functional level is needed to predict the kinetics and toxicity in neonate/juvenile toxicity and efficacy studies.

¹⁸F-prostate-specific membrane antigen (PSMA)-1007 is excreted mainly through the liver. We benchmarked the performance of ¹⁸F-PSMA-1007 against 3 renally excreted PSMA tracers. Methods: Among 668 patients, we selected 27 in whom PET/CT results obtained with ⁶⁸Ga-PSMA-11, ¹⁸F-DCFPyL (2-(3-(1-carboxy-5-[(6-[¹⁸F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid), or ¹⁸F-JK-PSMA-7 (JK, Juelich-Koeln) were interpreted as equivocal or negative or as oligometastatic disease (PET-1). Within 3 wk, a second PET scan with ¹⁸F-PSMA-1007 was performed (PET-2). The confidence in the interpretation of PSMA-positive locoregional findings was scored on a 5-point scale, first in routine diagnostics (reader 1) and then by an independent second evaluation (reader 2). Discordant PSMA-positive skeletal findings were examined by contrast-enhanced MRI. Results: For both readers, ¹⁸F-PSMA-1007 facilitated the interpretability of 27 locoregional lesions. In PET-2, the clinical readout led to a significantly lower number of equivocal locoregional lesions (P = 0.024), and reader 2 reported a significantly higher rate of suspected lesions that were falsely interpreted as probably benign in PET-1 (P = 0.023). Exclusively in PET-2, we observed a total of 15 PSMA-positive spots in the bone marrow of 6 patients (22%). None of the 15 discordant spots had a morphologic correlate on the corresponding CT scan or on the subsequent MRI scan. Thus, ¹⁸F-PSMA-1007 exhibits a significantly higher rate of unspecific medullary spots (P = 0.0006). Conclusion: ¹⁸F-PSMA-1007 may increase confidence in interpreting small locoregional lesions adjacent to the urinary tract but may decrease the interpretability of skeletal lesions.

The RESTORE-IMI 1 phase 3 trial demonstrated the efficacy and safety of imipenem-cilastatin (IMI) combined with relebactam (REL) for treating imipenem-nonsusceptible infections. The objective of this analysis was to compare the outcomes among patients meeting eligibility requirements based on central laboratory susceptibility versus local laboratory susceptibility. Patients with serious infections caused by imipenem-nonsusceptible, colistin-susceptible, and imipenem-REL-susceptible pathogens were randomized 2:1 to IMI-REL plus placebo or colistin plus IMI for 5 to 21 days. The primary endpoint was a favorable overall response. Key endpoints included the clinical response and all-cause mortality. We compared outcomes between the primary microbiological modified intent-to-treat (mMITT) population, where eligibility was based on central laboratory susceptibility testing, and the supplemental mMITT (SmMITT) population, where eligibility was based on local, site-level testing. The SmMITT (n = 41) and MITT (n = 31) populations had similar baseline characteristics, including sex, age, illness severity, and renal function. In both analysis populations, favorable overall response rates in the IMI-REL treatment group were >70%. Favorable clinical response rates at day 28 were 71.4% for IMI-REL and 40.0% for colistin plus IMI in the mMITT population, whereas they were 75.0% for IMI-REL and 53.8% for colistin plus IMI in the SmMITT population. Day 28 all-cause mortality rates were 9.5% for IMI-REL and 30.0% for colistin plus IMI in the mMITT population, whereas they were 10.7% for IMI-REL and 23.1% for colistin plus IMI in the SmMITT population. The outcomes in the SmMITT population were generally consistent with those in the mMITT population, suggesting that outcomes may be applicable to the real-world use of IMI-REL for treating infections caused by imipenem-nonsusceptible Gram-negative pathogens. (This study has been registered at ClinicalTrials.gov under identifier NCT02452047.)

In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequence type 12 (ST12) was associated with bla_CMY-2 in both populations. In contrast, the widespread resistant IncF plasmids were not linked to a single epidemic plasmid.

Preimplantation genetic testing (PGT) is a reproductive technology that, in the course of in vitro fertilization (IVF), allows prospective parents to select their future offspring based on genetic characteristics. PGT could be seen as an exercise of reproductive liberty, thus potentially raising significant socioethical and legal controversy. In this review, we examine—from a comparative perspective—variations in policy approaches to the regulation of PGT. We draw on a sample of 19 countries (Australia, Austria, Belgium, Brazil, Canada, China, France, Germany, India, Israel, Italy, Japan, Mexico, Netherlands, Singapore, South Korea, Switzerland, United Kingdom, and the United States) to provide a global landscape of the spectrum of policy and legislative approaches (e.g., restrictive to permissive, public vs. private models). We also explore central socioethical and policy issues and contentious applications, including permissibility criteria (e.g., medical necessity), nonmedical sex selection, and reproductive tourism. Finally, we further outline genetic counseling requirements across policy approaches.

BACKGROUND AND PURPOSE:

Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences.

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

BACKGROUND AND PURPOSE:

Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.

Paris Games Week 2020 organizer SELL announced it has cancelled this years event due to concerns over the ongoing coronavirus (COVID-19) pandemic. The event was set to run from October 23 to 27. 

Read the message from SELL below:

Dear players,

It is with great emotion that we have made the difficult decision to cancel Paris Games Week, initially scheduled from 23rd to 27th October and which would have marked our 10th anniversary.

The current context and the necessary anticipation of both the technical and logistical complexities of an event such as Paris Games Week have led us to cancel this edition.

This year should have been special, with a line-up full of new releases, and an anniversary edition which we were thrilled to celebrate with you.

We are going to work with all the industry players to enable us all to live our passion. We are already preparing next year’s edition and are looking forward to seeing you again.

Our Very Best Regards,

The Paris Games Week Team

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443416/paris-games-week-2020-cancelled-due-to-coronavirus-pandemic/

Waters lap perilously close to audience as grand capes and latex trench coats are modelled

How to make the fashion industry engage with the climate crisis? Flood the venue, and submerge the front row.

Arriving at the Balenciaga show in Paris on Sunday morning, the audience found themselves entering at the periphery of what looked like a sports stadium, with banks of flip-up plastic seats around a central oval. In pitch blackness, it was hard to tell exactly, but attendants were on hand with torches, and strict instructions not to proceed beyond the third row.

New Zealand's Greg Henderson won the 201.5-km first stage of Paris-Nice between St Arnoult-en-Yvelines and Contres on Monday.

Paris will hold a men's fashion week in virtual format from July 9 to July 13 for the Men Spring/Summer collections 2021, organisers said on Wednesday.

Riots erupted on the outskirts of Paris for a second night as young people fought with police and unleashed fireworks amid growing unrest over the impact of lockdown restrictions.

The French are facing social disparities in the face of the coronavirus pandemic. With long bread lines and tensions with police, the Paris suburbs are faring poorly under the lockdown.

The Downton Abbey creator's calling cards litter this series finale which, for all its frantic plot developments, can't help feeling worn out

High-concept drama is just waiting to be binged

Disney is shutting down its theme parks in Florida and Paris for just over a fortnight in addition to its iconic facility in Los Angeles over coronavirus fears.

The brand has revealed that it intends to "take control of its pace"

Crystal Palace chairman Steve Parish has described his reasons for backing the Premier League's 'Project Restart', including wanting to "crown Liverpool champions."

Crystal Palace chairman Steve Parish has warned the bottom six clubs opposing the resumption of the Premier League in neutral grounds that they are not taking the financial threat to the league seriously enough.

Patrice Evra undoubtedly holds a special place the hearts of Manchester United fans.

Today, the U.S. District Court for the Eastern District of Louisiana in New Orleans entered the revised settlement agreement reached between the United States and Terrebonne Parish as an order of the court.

"Over the last two days, I’ve had the opportunity to work alongside Ambassador Rivkin, and with my French counterparts – and our fellow G-6 ministers – in discussing the shared concerns, goals, and priorities that bind our nations to one another, and to our allies across Europe," said Attorney General Holder.

The Department of Justice today filed a lawsuit against St. Bernard Parish, La., alleging that the parish violated the Fair Housing Act by engaging in a multi-year campaign to limit rental housing opportunities for African-Americans in the parish.

A Delaware company pleaded guilty today in federal court in the Eastern District of Louisiana to negligently discharging oil into the bayous of Jefferson Parish, Louisiana, the Department of Justice announced.

Cedyco Corporation, headquartered in Houston, was sentenced today in federal court in the Eastern District of Louisiana.

The Justice Department announced today that it has moved to intervene in a class action lawsuit regarding conditions of confinement at the Orleans Parish Prison (OPP), a pre-trial and correctional facility in New Orleans. The litigation seeks to address conditions that violate the U.S. Constitution and Title VI of the Civil Rights Act of 1964. The department seeks remedies to correct inadequate medical, mental health care and suicide prevention practices; failures to protect prisoners from physical and sexual violence; deficiencies in environmental health and safety; and inadequate language access services for Latino prisoners with limited English proficiency (LEP).

The Justice Department announced today that it has reached a proposed consent decree with class plaintiffs and Orleans Parish Prison (OPP) Sheriff Marlin Gusman following a comprehensive investigation and extensive settlement negotiations regarding unlawful conditions at the prison. The consent decree outlines remedial measures to address the allegations in the complaints filed by class plaintiffs and by the United States in Jones v. Gusman, including deficiencies in prisoner safety from physical and sexual assaults, medical and mental health care, suicide prevention, environmental and life safety and limited English proficiency (LEP) services for Spanish-speaking prisoners.

An indictment against former Jefferson Parish, La., Sheriff’s Deputy Mark Hebert, 48, was announced today by Roy L. Austin Jr., Deputy Assistant Attorney General for the Civil Rights Division; Dana J. Boente, Acting U.S. Attorney for the Eastern District of Louisiana; Michael J. Anderson, Special Agent in Charge of the FBI New Orleans Field Office; and Sheriff Newell Normand from the Jefferson Parish Sheriff’s Office.

The Justice Department announced today that St. Bernard Parish, La., has agreed to a settlement valued at more than $2.5 million to resolve separate lawsuits by the United States and private plaintiffs alleging that the parish sought to restrict rental housing to African Americans in the aftermath of Hurricane Katrina.

The U.S. District Court for the Eastern District of Louisiana has mandated systemic reform of unconstitutional conditions at the Orleans Parish Prison (OPP), by entering the proposed consent judgment executed by the United States, class plaintiffs, and Sheriff Marlin Gusman in Jones v. Gusman. The agreement was filed with the court by the parties on Dec. 11, 2012.

The Justice Department announced today that it has entered into a comprehensive agreement with the Parish of St. Tammany, La., and the St. Tammany Parish Sheriff to correct conditions of confinement at the St. Tammany Parish Jail and to ensure that improvements made since the Department’s investigation will be maintained.

Former Jefferson Parish Sheriff’s Deputy Mark Hebert, 48, pled guilty today to one civil rights violation, five bank fraud violations and one aggravated identity theft violation, announced Acting Assistant Attorney General Jocelyn Samuels for the Civil Rights Division, U.S. Attorney Kenneth A. Polite Jr. for the Eastern District of Louisiana, Special Agent in Charge Michael J. Anderson of the FBI New Orleans Field Office and Sheriff Newell Normand from the Jefferson Parish Sheriff’s Office.

The Departments of Justice and Education announced today that they have reached a comprehensive agreement with the Jefferson Parish Public School System in Louisiana (JPPSS) to ensure that all students can enroll in school regardless of their own national origin or immigration status, or that of their parents or guardians. The agreement also resolves complaints regarding JPPSS’ policies and practices for communicating with parents who have limited English proficiency (LEP) and JPPSS’ response to alleged harassment of Latino students based on their national origin

Dec 4, 2019

The authors explain why the Trump administration's reiteration of its intent to finalize U.S. withdrawal from the Paris Agreement is a tragic mistake that will weaken us as a nation.