An important component of every country's COVID-19 response is fast and efficient testing -- to identify and isolate cases, as well as for early detection of local hotspots. For many countries, producing a sufficient number of tests has been a serious limiting factor in their efforts to control COVID-19 infections. Group testing is a well-established mathematical tool, which can provide a serious and rapid improvement to this situation. In this note, we compare several well-established group testing schemes in the context of qPCR testing for COVID-19. We include example calculations, where we indicate which testing architectures yield the greatest efficiency gains in various settings. We find that for identification of individuals with COVID-19, array testing is usually the best choice, while for estimation of COVID-19 prevalence rates in the total population, Gibbs-Gower testing usually provides the most accurate estimates given a fixed and relatively small number of tests. This note is intended as a helpful handbook for labs implementing group testing methods.

Reinhard Heckel, Nihar B. Shah, Kannan Ramchandran, Martin J. Wainwright.

Source: The Annals of Statistics, Volume 47, Number 6, 3099--3126.

Abstract:
We consider sequential or active ranking of a set of $n$ items based on noisy pairwise comparisons. Items are ranked according to the probability that a given item beats a randomly chosen item, and ranking refers to partitioning the items into sets of prespecified sizes according to their scores. This notion of ranking includes as special cases the identification of the top-$k$ items and the total ordering of the items. We first analyze a sequential ranking algorithm that counts the number of comparisons won, and uses these counts to decide whether to stop, or to compare another pair of items, chosen based on confidence intervals specified by the data collected up to that point. We prove that this algorithm succeeds in recovering the ranking using a number of comparisons that is optimal up to logarithmic factors. This guarantee does depend on whether or not the underlying pairwise probability matrix, satisfies a particular structural property, unlike a significant body of past work on pairwise ranking based on parametric models such as the Thurstone or Bradley–Terry–Luce models. It has been a long-standing open question as to whether or not imposing these parametric assumptions allows for improved ranking algorithms. For stochastic comparison models, in which the pairwise probabilities are bounded away from zero, our second contribution is to resolve this issue by proving a lower bound for parametric models. This shows, perhaps surprisingly, that these popular parametric modeling choices offer at most logarithmic gains for stochastic comparisons.

Zhonghua Liu, Ian Barnett, Xihong Lin.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 433--451.

Abstract:
Principal component analysis (PCA) is a popular method for dimension reduction in unsupervised multivariate analysis. However, existing ad hoc uses of PCA in both multivariate regression (multiple outcomes) and multiple regression (multiple predictors) lack theoretical justification. The differences in the statistical properties of PCAs in these two regression settings are not well understood. In this paper we provide theoretical results on the power of PCA in genetic association testings in both multiple phenotype and SNP-set settings. The multiple phenotype setting refers to the case when one is interested in studying the association between a single SNP and multiple phenotypes as outcomes. The SNP-set setting refers to the case when one is interested in studying the association between multiple SNPs in a SNP set and a single phenotype as the outcome. We demonstrate analytically that the properties of the PC-based analysis in these two regression settings are substantially different. We show that the lower order PCs, that is, PCs with large eigenvalues, are generally preferred and lead to a higher power in the SNP-set setting, while the higher-order PCs, that is, PCs with small eigenvalues, are generally preferred in the multiple phenotype setting. We also investigate the power of three other popular statistical methods, the Wald test, the variance component test and the minimum $p$-value test, in both multiple phenotype and SNP-set settings. We use theoretical power, simulation studies, and two real data analyses to validate our findings.

KH Britten
Dec 1, 1992; 12:4745-4765
Articles

Interview with Ms Christine Lagarde, President of the European Central Bank, and Le Parisien, conducted by Mr Matthieu Pelloli and published on 9 April 2020.

Denver Newsroom, May 8, 2020 / 02:59 am (CNA).- On Sunday, March 15, Nebraskans in the Diocese of Lincoln still had a choice of whether or not they wanted to attend Mass and risk possible exposure to coronavirus.

By the next day, they didn’t. Public Masses in the diocese were canceled, as they soon were throughout the country due to the pandemic.

Now that curves of infection are “flattening” and hospitals have had a chance to ramp up their capacity and supplies, many dioceses, including Lincoln, are slowly reopening Masses to the public. What exactly that will look like varies a lot depending on each parish's unique spaces and limitations. 

Archbishop George Lucas, currently serving as acting bishop of Lincoln, has followed guidelines from Governor Pete Ricketts in issuing some general guidance for re-starting public Masses. Ultimately, however, he left the decision to reopen up to each individual parish.

One place that has been offering public Masses as of Monday, May 4, is St. Wenceslaus parish in Wahoo, Nebraska, a town of 4,500 people located in the Diocese of Lincoln.

Fr. Joseph Faulkner, the pastor of St. Wenceslaus in Wahoo, said he decided to reopen public Masses at his parish after meeting virtually with the other priests in his area. The Masses, of course, will look quite different than normal - with limited capacity, social distancing, and precautions like no holy water, no hymnals, and no sign of peace.

And in many ways, Faulkner said he is encouraging his parishioners to act like it’s the weekend of March 14-15 again.

“From the get-go, we're telling people - you need to make a decision. I even put in my message (to parishioners), think back to - it's March 14th and you're trying to make a decision. Whatever decision you made then is probably still the right decision. If you need to be extra careful for yourself, for your family, for your parents, for your coworkers, for your patients you see in the nursing home, stay away,” he said.

Parishes in the cities of Lincoln and Omaha decided to wait to reopen, Faulkner said. Lincoln has a re-opening date of May 11 for non-essential businesses, and the size of Omaha parishes made re-opening at this point very difficult. Although Wahoo sees a lot of traffic from Lincoln and Omaha and other surrounding towns, Faulkner said he thought he could use appropriate precautions to make reopening safe at his parish.

“St. Wenceslaus specifically is lucky. We've got a nice big basement, so that gets you another 30%-40% seating room. We've got three priests, which is really lucky. So from five weekend Masses, we're going up to eight, so we can do more to spread our people out.”

Faulkner said he has even offered to other parishes with just one priest that he can send someone to help them out if they are offering extra Masses for social distancing and are feeling burned out.

For attendance and seating, Faulkner said he is blocking off every other pew and is going to stagger families in order to maintain six feet of distance. Instead of having people call or sign up online, Faulkner said he is hoping that the extra Mass times, the use of the basement space, as well as the people who choose to stay home, will be enough to maintain an appropriately staggered congregation.

Faulkner said he has been grateful to have public weekday Masses before the weekend to work out some of the kinks of the new restrictions. For example, he’s still working on his communion line protocol, he said. He tried a method using the side aisles and then the center aisle at his first Mass on May 4th, and “it was horrible. So I'm going to fix that tomorrow.”

Masks during communion have also been tricky.

“It's really hard to say Mass with a mask on, and then I have to make my Communion, I have to receive,” Faulkner said. The priests were donated some N95 masks, which Faulkner tried to use on Monday, but the straps made it hard to quickly receive communion and readjust the mask without touching his face or his glasses, he said, so he’s hoping to find a different kind of mask by the weekend.

From his parishioners, Faulkner said he has seen a variety of attitudes toward the closing, and now re-opening, of public Masses.

“There's really three camps,” he said. “There's the, yes, amen, be safe, meditate-on-the-saints-who-didn't-have-the-Eucharist-for-years group.”

“Then there's definitely the middle group, which is like, I don't want to take any risks, but I want the first available ‘okay’ to go to Mass,” he said.

“And then there's the, ‘I'm 85. If I die because I went to Mass, thank God’ crowd. Literally the people who are most cavalier are the older ones,” Faulkner said.

A bishop’s perspective: Oklahoma

Archbishop Paul Coakley, the bishop of Oklahoma City, told CNA that Catholic parishes throughout the state will start celebrating public Masses again on May 18th, with their first public weekend Masses on May 23-24, the Feast of the Ascension.

In a May 7 letter to Oklahoma Catholics posted on the archdiocese’s website, Coakley recognized that while the past two months without Mass have been a painful time for many, God never abandoned his people.

“The gift of the Holy Spirit assures us of God's continued presence in our lives. No matter the circumstance, he is with us. Perhaps the greatest sacrifice for the lay faithful these past few months has been fasting from Christ’s body, blood, soul and divinity given to us in his real presence in the Eucharist. We pray that in this time of Eucharistic fasting, God has graced you with a profound hunger for this communion with Jesus and the members of his Body, the Church,” he stated.
 
The timing of reopening public Masses was chosen just before the feasts of the Ascension and Pentecost “to remind us of God’s faithfulness and to prepare to celebrate the birth of our beloved Church on Pentecost,” he added.

The decision was reached through consultations with Bishop David Konderla of Tulsa, priest councils in the state, and medical experts, “including a prominent infectious disease specialist,” Coakley said.

“It won't be business as usual,” he said.  “We will be celebrating public Mass and people will be able to come and they will be able to receive Holy communion, but the churches won't be full. In fact, we're limiting it to 33% of the occupancy capacity,” he noted.

“We've been very cautious watching the numbers and putting in place pretty strict guidelines to ensure that we were able to maintain social distances and practice the appropriate kind of hygiene,” he added.

A five page document released by the state’s Catholic dioceses details the exact guidelines, such as including 6-foot social distancing between pews, the recommendation that all attendees wear masks, and the recommendation that priests have plenty of hand sanitizer readily available throughout the church.

Coakley said the document offers guidelines for pastors while still giving them the flexibility to implement the recommendations and requirements in the way that works best for their unique parishes.

“If the church fills beyond capacity, we’re asking them to consider using other space in the parish, perhaps the parish hall, to be able to put overflow crowds and continuing to social distance properly, parking lots, things of that sort,” he said. “We're going to have to rely upon the creativity of our pastors and they have been demonstrating a great deal of creativity up to now, so I'm sure they'll continue to do so.”

Coakley said he is asking priests to also continue offering livestream Masses for people who will choose not to come to the public Masses at this time. He noted in his May 7 message that the dispensation from the Sunday obligation still stands for all Oklahoma Catholics at this time.

“We are dealing with an invisible threat to people’s lives, a virus that our brightest doctors and scientists are still figuring out. The ever-present temptation in our American culture is to want solutions immediately and to act quickly, because we want what we want, and we want it now. As a Church, we must proceed more deliberatively,” he said.

Coakley told CNA that while he understands Catholics’ fear, anger and frustration during these past two months of suspended Masses, he also encouraged them to think of their time away as a way of serving others.

“We’re really living through a health crisis, a time of severe challenges, and it's impacting us in so many ways economically, and in terms of social isolation, loneliness, the liturgy also. But I think we need to think beyond individual rights and consider also our responsibilities toward one another, especially the responsibility to love and serve one another, to be mindful of one another's needs.”

Wichita, Kansas

On May 3, Bishop Carl Kemme of the Diocese of Wichita announced plans to reopen public Masses starting on Wednesday, May 6, following recommendations of the county’s local public health authorities.

Phase one of the guidelines will last until May 20, and they stipulate that parishes may hold Masses at no more than 33% capacity. Churches will use only one entrance, so that the number of people coming may be properly counted and seated, and six foot spacing should be clearly marked so that people can maintain social distance.

Mass attendees are encouraged to wear masks, and priests are required to wear them while distributing communion. Parishes are also encouraged to keep hand sanitizer available at entrances, and parishioners are “strongly encouraged” to receive communion in the hand.

Fr. Clay Kimbro is the parochial vicar at St. Anne’s parish in Wichita. Kimbro said he and the other priests of the diocese have been having weekly virtual talks with the bishop about when to re-open Masses and what that might look like, and so priests were able to give feedback as to what guidelines they thought would work well.

At St. Anne’s, which has 1,200 families, Kimbro and his leadership team have been meeting and working on logistical things, like roping off every other pew so that Mass attendees can maintain proper distancing.

He said he has also had extra meetings with his ushers, who on the weekends will “seat everyone so that they can make sure that the distance is maintained. That's a lot more responsibility than our ushers are normally given.”

Kimbro said the parish is not having parishioners sign up for Masses online. Instead, if more people show up than the allowed 33%, the overflow congregation will be directed to the school’s auditorium, where a second priest - either Kimbro or his pastor - will celebrate a concurrent Mass, also with social distancing protocols in place.

“We were a little leery of (adding Mass times), because when you add Mass times, it's hard to take them back,” Kimbro said. “Also, it's hard to turn people away. They come to the door at 10 a.m. for Mass, and we say, ‘Come back at 1:00 p.m.’ Well, it's a lot easier to say, ‘Go over to the auditorium.’”

Kimbro said the parish is working on decorating the auditorium to make it an appropriate place to have Mass, and they are also putting down tape lines to direct traffic and to mark distances.

“There's a lot of work in planning, and it can be a little overwhelming, but we're overall just really excited to see people again,” he said.

St. Anne’s parishioners have been “all over the map” in terms of their eagerness to return to Mass at this time, Kimbro said. Some have been signing up to read at Mass, or to usher or distribute communion, because they miss Mass so much and they want to be involved.

Others are a bit more anxious, Kimbro said, and he has encouraged those people to attend weekday Masses, where there are likely to be fewer people.

He also added that the Sunday obligation continues to be dispensed for everyone, as Bishop Kemme made clear in his May 3 announcement.

“I do want to emphasize that the current pandemic is far from over. Medical experts tell us that this health crisis remains a very serious threat to the lives of many people,” Kemme stated.

“Because of this, I want to urge all those in the high risk population and others who so choose to continue to use the general dispensation I am giving from the obligation to attend the Sunday celebration of the Mass, which continues indefinitely during this crisis. Please do not put yourself or others at risk by attending the Masses once they resume. This is my urgent appeal to all in our Catholic Community: use extraordinary caution and good judgment in determining if you should attend Mass. No mortal sin is committed if you decide that you and your family should not attend.”

Kimbro said that he is looking forward to having parishioners come back to Mass, even though it might not be the triumphant return that some may have envisioned just yet, with everyone packing in the pews like normal.

“I think everybody was hoping it would kind of be like this post-9/11 experience, where churches are packed and everybody recognizes that need (for God), but we're tempering that, and it's kind of like everything in this virus, right? Our expectations versus our reality - having to live in the reality of the moment and what we're given and just go with that,” he said. 

“But then I looked at the Gospel for this Sunday that we're back, and the first line is: ‘Do not let your hearts be troubled.’ So that's perfect.”

CNA Staff, May 8, 2020 / 04:15 pm (CNA).- As parishes and dioceses across the country deal with a drop in collections and the prospects of layoffs amid the pandemic, many parishes have managed to avail themselves of government loans designed to cover eight weeks of payroll expenses.

CBS News reported Friday that an estimated 12,000-13,000 of the 17,000 Catholic parishes in the U.S. had applied for Paycheck Protection Program (PPP) payroll loans from the Small Business Administration (SBA), and 9,000 so far had received them.

Guidance from the SBA on eligibility for the loans states that “no otherwise eligible organization will be disqualified from receiving a loan because of the religious nature, religious identity, or religious speech of the organization.”

Religious organizations are eligible for the loans as long as they meet the requirements of Section 501(c)(3) nonprofit and employ 500 or fewer people, the SBA said.

“The PPP isn't about the federal government assisting houses of worship or churches,” Pat Markey, the executive director of the Diocesan Fiscal Management Conference, told CBS News.

“PPP is about keeping people on payrolls, and a large segment of our society [in] the not for profit world...are churches and houses of worship. And they have people on payrolls too. So, if what this is about is keeping people on payrolls, then we all should have availability to do that.”

The Diocesan Fiscal Management Conference did not reply by press time to CNA’s request for additional comment.

Congress passed the Coronavirus Aid, Relief, and Economic Security (CARES) Act March 27 to help relieve the economy during the coronavirus pandemic.

The CARES Act initially authorized some $350 billion in loans to small businesses, intended to allow them to continue to pay their employees. The loans were given on a first come, first serve basis.

The second round of funding, with some $310 billion in additional funds available, began April 27.

The loans were capped at $10 million, were open to businesses with fewer than 500 employees per location, and were intended to cover two months of payroll costs.

The federal government promised to forgive the loans if a business used at least 75% of the funds to maintain its payroll at “pre-pandemic levels” for eight weeks after the loan is disbursed, the New York Times reports.

The remaining money could be used only to pay for certain expenses, such as a mortgage, rent, and utilities, according to the Times.

A survey of Protestant pastors by LifeWay Research found that about 40% had applied for PPP loans with more than half of them reporting being approved.

NPR reports that synagogues have also applied for government funding, though in a smaller proportion— of nearly 4,000 synagogues in the United States, about 250 were approved for PPP loans in the first round of lending, according to surveys by the Jewish Federations of North America and the Union of Orthodox Jewish Congregations of America.

The PPP has been subject to some criticism since its launch, including from those who say business owners with criminal records have been excluded from the program thus far.

In addition, several large companies, such as Ruth’s Chris Steakhouse, have received multi-million dollar loans through the program. Some of these large companies, such as Shake Shack, have since returned their loans.

Two New York dioceses— Rochester and Buffalo— are suing the Small Business Administration for access to PPP funds, after they were denied loans because of their bankruptcy status.

An SBA rule stipulated that the funds would not go to bankruptcy debtors. Both the dioceses of Rochester and Buffalo have filed for bankruptcy in the past several months, after being named in hundreds of clergy sex abuse lawsuits filed under New York Child Victims Protection Act.

 

CNA Staff, Apr 30, 2020 / 05:00 am (CNA).- The bishops of England and Wales have urged parishes to help domestic abuse victims after a surge in requests for aid during the coronavirus crisis. 

Since the lockdown began in the U.K. March 23 there has been a 49% increase in calls and online pleas for assistance related to domestic abuse, the bishops said in a statement April 29. 

Bishop John Sherrington, chairman of the bishops’ domestic abuse group, said: “Catholic parishes can play an important role in fighting the scourge of domestic abuse, especially during the COVID-19 pandemic where we are seeing some shocking statistics from leading domestic abuse organisations.”

Guidance provided by the bishops’ domestic abuse group encourages pastors to raise the issue of domestic violence during livestreamed Masses and in homilies published on parish websites. 

The group also asks parishes to establish local domestic abuse support groups. Teams of volunteers should keep in regular contact with vulnerable parishioners, and collect and deliver donations to those living in refuges and other safe locations, the group advises.

It adds that team leaders ought to be “in a non-vulnerable COVID-19 category, and not living with any vulnerable people.” They should also have been checked by the Disclosure and Barring Service, which informs employers about applicants’ criminal records.

“Every local situation will differ and so our new guidance is designed to be used as an introduction to start a local project,” Bishop Sherrington said. “I hope that Catholics and parishes will be inspired to take this up in their local area.”

“Violence of this kind should never be tolerated or justified. It is an offence against the dignity of the human person.”
 

Denver Newsroom, May 8, 2020 / 02:59 am (CNA).- On Sunday, March 15, Nebraskans in the Diocese of Lincoln still had a choice of whether or not they wanted to attend Mass and risk possible exposure to coronavirus.

By the next day, they didn’t. Public Masses in the diocese were canceled, as they soon were throughout the country due to the pandemic.

Now that curves of infection are “flattening” and hospitals have had a chance to ramp up their capacity and supplies, many dioceses, including Lincoln, are slowly reopening Masses to the public. What exactly that will look like varies a lot depending on each parish's unique spaces and limitations. 

Archbishop George Lucas, currently serving as acting bishop of Lincoln, has followed guidelines from Governor Pete Ricketts in issuing some general guidance for re-starting public Masses. Ultimately, however, he left the decision to reopen up to each individual parish.

One place that has been offering public Masses as of Monday, May 4, is St. Wenceslaus parish in Wahoo, Nebraska, a town of 4,500 people located in the Diocese of Lincoln.

Fr. Joseph Faulkner, the pastor of St. Wenceslaus in Wahoo, said he decided to reopen public Masses at his parish after meeting virtually with the other priests in his area. The Masses, of course, will look quite different than normal - with limited capacity, social distancing, and precautions like no holy water, no hymnals, and no sign of peace.

And in many ways, Faulkner said he is encouraging his parishioners to act like it’s the weekend of March 14-15 again.

“From the get-go, we're telling people - you need to make a decision. I even put in my message (to parishioners), think back to - it's March 14th and you're trying to make a decision. Whatever decision you made then is probably still the right decision. If you need to be extra careful for yourself, for your family, for your parents, for your coworkers, for your patients you see in the nursing home, stay away,” he said.

Parishes in the cities of Lincoln and Omaha decided to wait to reopen, Faulkner said. Lincoln has a re-opening date of May 11 for non-essential businesses, and the size of Omaha parishes made re-opening at this point very difficult. Although Wahoo sees a lot of traffic from Lincoln and Omaha and other surrounding towns, Faulkner said he thought he could use appropriate precautions to make reopening safe at his parish.

“St. Wenceslaus specifically is lucky. We've got a nice big basement, so that gets you another 30%-40% seating room. We've got three priests, which is really lucky. So from five weekend Masses, we're going up to eight, so we can do more to spread our people out.”

Faulkner said he has even offered to other parishes with just one priest that he can send someone to help them out if they are offering extra Masses for social distancing and are feeling burned out.

For attendance and seating, Faulkner said he is blocking off every other pew and is going to stagger families in order to maintain six feet of distance. Instead of having people call or sign up online, Faulkner said he is hoping that the extra Mass times, the use of the basement space, as well as the people who choose to stay home, will be enough to maintain an appropriately staggered congregation.

Faulkner said he has been grateful to have public weekday Masses before the weekend to work out some of the kinks of the new restrictions. For example, he’s still working on his communion line protocol, he said. He tried a method using the side aisles and then the center aisle at his first Mass on May 4th, and “it was horrible. So I'm going to fix that tomorrow.”

Masks during communion have also been tricky.

“It's really hard to say Mass with a mask on, and then I have to make my Communion, I have to receive,” Faulkner said. The priests were donated some N95 masks, which Faulkner tried to use on Monday, but the straps made it hard to quickly receive communion and readjust the mask without touching his face or his glasses, he said, so he’s hoping to find a different kind of mask by the weekend.

From his parishioners, Faulkner said he has seen a variety of attitudes toward the closing, and now re-opening, of public Masses.

“There's really three camps,” he said. “There's the, yes, amen, be safe, meditate-on-the-saints-who-didn't-have-the-Eucharist-for-years group.”

“Then there's definitely the middle group, which is like, I don't want to take any risks, but I want the first available ‘okay’ to go to Mass,” he said.

“And then there's the, ‘I'm 85. If I die because I went to Mass, thank God’ crowd. Literally the people who are most cavalier are the older ones,” Faulkner said.

A bishop’s perspective: Oklahoma

Archbishop Paul Coakley, the bishop of Oklahoma City, told CNA that Catholic parishes throughout the state will start celebrating public Masses again on May 18th, with their first public weekend Masses on May 23-24, the Feast of the Ascension.

In a May 7 letter to Oklahoma Catholics posted on the archdiocese’s website, Coakley recognized that while the past two months without Mass have been a painful time for many, God never abandoned his people.

“The gift of the Holy Spirit assures us of God's continued presence in our lives. No matter the circumstance, he is with us. Perhaps the greatest sacrifice for the lay faithful these past few months has been fasting from Christ’s body, blood, soul and divinity given to us in his real presence in the Eucharist. We pray that in this time of Eucharistic fasting, God has graced you with a profound hunger for this communion with Jesus and the members of his Body, the Church,” he stated.
 
The timing of reopening public Masses was chosen just before the feasts of the Ascension and Pentecost “to remind us of God’s faithfulness and to prepare to celebrate the birth of our beloved Church on Pentecost,” he added.

The decision was reached through consultations with Bishop David Konderla of Tulsa, priest councils in the state, and medical experts, “including a prominent infectious disease specialist,” Coakley said.

“It won't be business as usual,” he said.  “We will be celebrating public Mass and people will be able to come and they will be able to receive Holy communion, but the churches won't be full. In fact, we're limiting it to 33% of the occupancy capacity,” he noted.

“We've been very cautious watching the numbers and putting in place pretty strict guidelines to ensure that we were able to maintain social distances and practice the appropriate kind of hygiene,” he added.

A five page document released by the state’s Catholic dioceses details the exact guidelines, such as including 6-foot social distancing between pews, the recommendation that all attendees wear masks, and the recommendation that priests have plenty of hand sanitizer readily available throughout the church.

Coakley said the document offers guidelines for pastors while still giving them the flexibility to implement the recommendations and requirements in the way that works best for their unique parishes.

“If the church fills beyond capacity, we’re asking them to consider using other space in the parish, perhaps the parish hall, to be able to put overflow crowds and continuing to social distance properly, parking lots, things of that sort,” he said. “We're going to have to rely upon the creativity of our pastors and they have been demonstrating a great deal of creativity up to now, so I'm sure they'll continue to do so.”

Coakley said he is asking priests to also continue offering livestream Masses for people who will choose not to come to the public Masses at this time. He noted in his May 7 message that the dispensation from the Sunday obligation still stands for all Oklahoma Catholics at this time.

“We are dealing with an invisible threat to people’s lives, a virus that our brightest doctors and scientists are still figuring out. The ever-present temptation in our American culture is to want solutions immediately and to act quickly, because we want what we want, and we want it now. As a Church, we must proceed more deliberatively,” he said.

Coakley told CNA that while he understands Catholics’ fear, anger and frustration during these past two months of suspended Masses, he also encouraged them to think of their time away as a way of serving others.

“We’re really living through a health crisis, a time of severe challenges, and it's impacting us in so many ways economically, and in terms of social isolation, loneliness, the liturgy also. But I think we need to think beyond individual rights and consider also our responsibilities toward one another, especially the responsibility to love and serve one another, to be mindful of one another's needs.”

Wichita, Kansas

On May 3, Bishop Carl Kemme of the Diocese of Wichita announced plans to reopen public Masses starting on Wednesday, May 6, following recommendations of the county’s local public health authorities.

Phase one of the guidelines will last until May 20, and they stipulate that parishes may hold Masses at no more than 33% capacity. Churches will use only one entrance, so that the number of people coming may be properly counted and seated, and six foot spacing should be clearly marked so that people can maintain social distance.

Mass attendees are encouraged to wear masks, and priests are required to wear them while distributing communion. Parishes are also encouraged to keep hand sanitizer available at entrances, and parishioners are “strongly encouraged” to receive communion in the hand.

Fr. Clay Kimbro is the parochial vicar at St. Anne’s parish in Wichita. Kimbro said he and the other priests of the diocese have been having weekly virtual talks with the bishop about when to re-open Masses and what that might look like, and so priests were able to give feedback as to what guidelines they thought would work well.

At St. Anne’s, which has 1,200 families, Kimbro and his leadership team have been meeting and working on logistical things, like roping off every other pew so that Mass attendees can maintain proper distancing.

He said he has also had extra meetings with his ushers, who on the weekends will “seat everyone so that they can make sure that the distance is maintained. That's a lot more responsibility than our ushers are normally given.”

Kimbro said the parish is not having parishioners sign up for Masses online. Instead, if more people show up than the allowed 33%, the overflow congregation will be directed to the school’s auditorium, where a second priest - either Kimbro or his pastor - will celebrate a concurrent Mass, also with social distancing protocols in place.

“We were a little leery of (adding Mass times), because when you add Mass times, it's hard to take them back,” Kimbro said. “Also, it's hard to turn people away. They come to the door at 10 a.m. for Mass, and we say, ‘Come back at 1:00 p.m.’ Well, it's a lot easier to say, ‘Go over to the auditorium.’”

Kimbro said the parish is working on decorating the auditorium to make it an appropriate place to have Mass, and they are also putting down tape lines to direct traffic and to mark distances.

“There's a lot of work in planning, and it can be a little overwhelming, but we're overall just really excited to see people again,” he said.

St. Anne’s parishioners have been “all over the map” in terms of their eagerness to return to Mass at this time, Kimbro said. Some have been signing up to read at Mass, or to usher or distribute communion, because they miss Mass so much and they want to be involved.

Others are a bit more anxious, Kimbro said, and he has encouraged those people to attend weekday Masses, where there are likely to be fewer people.

He also added that the Sunday obligation continues to be dispensed for everyone, as Bishop Kemme made clear in his May 3 announcement.

“I do want to emphasize that the current pandemic is far from over. Medical experts tell us that this health crisis remains a very serious threat to the lives of many people,” Kemme stated.

“Because of this, I want to urge all those in the high risk population and others who so choose to continue to use the general dispensation I am giving from the obligation to attend the Sunday celebration of the Mass, which continues indefinitely during this crisis. Please do not put yourself or others at risk by attending the Masses once they resume. This is my urgent appeal to all in our Catholic Community: use extraordinary caution and good judgment in determining if you should attend Mass. No mortal sin is committed if you decide that you and your family should not attend.”

Kimbro said that he is looking forward to having parishioners come back to Mass, even though it might not be the triumphant return that some may have envisioned just yet, with everyone packing in the pews like normal.

“I think everybody was hoping it would kind of be like this post-9/11 experience, where churches are packed and everybody recognizes that need (for God), but we're tempering that, and it's kind of like everything in this virus, right? Our expectations versus our reality - having to live in the reality of the moment and what we're given and just go with that,” he said. 

“But then I looked at the Gospel for this Sunday that we're back, and the first line is: ‘Do not let your hearts be troubled.’ So that's perfect.”

CNA Staff, May 8, 2020 / 04:15 pm (CNA).- As parishes and dioceses across the country deal with a drop in collections and the prospects of layoffs amid the pandemic, many parishes have managed to avail themselves of government loans designed to cover eight weeks of payroll expenses.

CBS News reported Friday that an estimated 12,000-13,000 of the 17,000 Catholic parishes in the U.S. had applied for Paycheck Protection Program (PPP) payroll loans from the Small Business Administration (SBA), and 9,000 so far had received them.

Guidance from the SBA on eligibility for the loans states that “no otherwise eligible organization will be disqualified from receiving a loan because of the religious nature, religious identity, or religious speech of the organization.”

Religious organizations are eligible for the loans as long as they meet the requirements of Section 501(c)(3) nonprofit and employ 500 or fewer people, the SBA said.

“The PPP isn't about the federal government assisting houses of worship or churches,” Pat Markey, the executive director of the Diocesan Fiscal Management Conference, told CBS News.

“PPP is about keeping people on payrolls, and a large segment of our society [in] the not for profit world...are churches and houses of worship. And they have people on payrolls too. So, if what this is about is keeping people on payrolls, then we all should have availability to do that.”

The Diocesan Fiscal Management Conference did not reply by press time to CNA’s request for additional comment.

Congress passed the Coronavirus Aid, Relief, and Economic Security (CARES) Act March 27 to help relieve the economy during the coronavirus pandemic.

The CARES Act initially authorized some $350 billion in loans to small businesses, intended to allow them to continue to pay their employees. The loans were given on a first come, first serve basis.

The second round of funding, with some $310 billion in additional funds available, began April 27.

The loans were capped at $10 million, were open to businesses with fewer than 500 employees per location, and were intended to cover two months of payroll costs.

The federal government promised to forgive the loans if a business used at least 75% of the funds to maintain its payroll at “pre-pandemic levels” for eight weeks after the loan is disbursed, the New York Times reports.

The remaining money could be used only to pay for certain expenses, such as a mortgage, rent, and utilities, according to the Times.

A survey of Protestant pastors by LifeWay Research found that about 40% had applied for PPP loans with more than half of them reporting being approved.

NPR reports that synagogues have also applied for government funding, though in a smaller proportion— of nearly 4,000 synagogues in the United States, about 250 were approved for PPP loans in the first round of lending, according to surveys by the Jewish Federations of North America and the Union of Orthodox Jewish Congregations of America.

The PPP has been subject to some criticism since its launch, including from those who say business owners with criminal records have been excluded from the program thus far.

In addition, several large companies, such as Ruth’s Chris Steakhouse, have received multi-million dollar loans through the program. Some of these large companies, such as Shake Shack, have since returned their loans.

Two New York dioceses— Rochester and Buffalo— are suing the Small Business Administration for access to PPP funds, after they were denied loans because of their bankruptcy status.

An SBA rule stipulated that the funds would not go to bankruptcy debtors. Both the dioceses of Rochester and Buffalo have filed for bankruptcy in the past several months, after being named in hundreds of clergy sex abuse lawsuits filed under New York Child Victims Protection Act.

 

We travel to France to find out how the 2011 Homeless World Cup helped to change lives.

Registries have been established in a number of countries to monitor the health of patients with cystic fibrosis. Few international comparisons have been made between registries. International data registry comparisons may be useful for informing best practice and benchmarking.

Registry comparisons are feasible but are limited by factors such as nonstandardization of data collection. Lung function was lower in Australian children with cystic fibrosis compared with their US counterparts after adjusting for the benefits of diagnosis after newborn screening. (Read the full article)

Although it has been shown that cystic fibrosis newborn screening is beneficial, the strategies vary widely, and there has been uncertainty about the costs and consequences of different algorithms and whether screening methods/decisions should be based on assumed cost differences.

This study contributes by offering a comparison of both costs, assessed comprehensively, and the consequences associated with the 2 most popular screening methodologies, immunoreactive trypsinogen/immunoreactive trypsinogen and immunoreactive trypsinogen/DNA, by using a decision-tree framework allowing variation in the model parameters. (Read the full article)

As a result of safety and environmental concerns about mercury, aneroid sphygmomanometers have replaced mercury-filled devices for blood pressure measurements. Despite this change, few studies have compared the 2 devices.

Little clinical variation exists between blood pressure measurements obtained from an aneroid or mercury device, suggesting that either device could be used in a research or clinical setting. (Read the full article)

Some studies demonstrate that adolescents have different perinatal risks and outcomes than nonadolescents. Few studies have explored the maternity experiences or practices of adolescents that may underlie these differences, or compared these with nonadolescents by using a nationally representative sample.

Adolescents and young adults were more likely to experience physical abuse, late prenatal care initiation, poor prenatal health behaviors, lower breastfeeding initiation and duration rates, postpartum depression, and lower folic acid supplementation than adult women. (Read the full article)

Evaluation of neonatal surgical outcomes is necessary to guide improvements in the quality of care. Meaningful comparisons must adjust for factors that alter outcomes independent of the surgical procedures.

Herein is described a method that permits risk adjustment for the broad range of noncardiac neonatal surgery, regardless of gestational age, to permit useful comparisons for quality improvement. (Read the full article)

Although several studies have demonstrated increased morbidity and mortality with pH1N1 in children, others have found its clinical course to be similar to seasonal influenza. Moreover, most studies were conducted at single centers, thus raising concerns about generalizability of findings.

This analysis provides national-level active hospital-based surveillance data comparing pH1N1 with 5 previous years of seasonal influenza A and demonstrates differences in risk factors and clinical presentation but not in ICU admission or mortality. (Read the full article)

Mortality of very low birth weight infants varies widely between regions and countries; however, the variation in morbidities after adjusting for confounders has not been adequately studied.

Composite outcome of mortality or short-term morbidity for very low birth weight infants was lower in Japan than in Canada. However, marked variations in mortality and individual morbidity exist, revealing areas for improvement in each country. (Read the full article)

The false-positive rate of newborn screening for classic congenital adrenal hyperplasia (CAH) remains high and has not been significantly improved by adjusting 17α-hydroxyprogesterone cutoff values for birth weight and/or gestational age. In response, 4 states have initiated second-tier steroid profile screening.

Under second-tier screening, the false-positive rate remains high, and classic CAH cases missed by screening (false-negatives) occur more frequently than reported. Physicians are cautioned that a negative screen does not necessarily rule out CAH. (Read the full article)

In adolescents with eating disorders, percent expected body weight (EBW) is used for diagnosis and to make clinical decisions. The assumption is that the weight-for-stature (WFS) and BMI methods of determining EBW are equivalent, but that may not be true.

This study demonstrates that EBW_WFS is ~3.5% higher than EBW_BMI. Differences are most pronounced at extremes of height. Compared with the EBW_WFS method, sensitivity of EBW_BMI to detect those <75% EBW is low. (Read the full article)

Rapid cranial MRI is a radiation-free method to assess children with possible ventricular shunt malfunction. However, the test performance of rapid cranial MRI has never been compared with that of cranial CT, the current reference standard.

The accuracy of rapid cranial MRI was not inferior to that of CT for diagnosing ventricular shunt malfunction. Rapid cranial MRI is an important radiation-sparing diagnostic alternative for children presenting emergently with possible ventricular shunt malfunction. (Read the full article)

Quality improvement (QI) studies generally do not account for concurrent trends of improvement and it is difficult to distinguish the impact of a multihospital collaborative QI project without a contemporary control group.

A multihospital collaborative QI model led to greater declines in hypothermia and invasive ventilation rates in the delivery room compared with an individual NICU QI model and NICUs that did not participate in formal QI activities. (Read the full article)

IP-10 is a novel immunologic marker for tuberculosis (TB) infection. It has been suggested that IP-10 may perform better in children compared with the QuantiFERON test, but only a few studies have investigated IP-10 for diagnosing active TB in children.

This study is the first to investigate IP-10 and QuantiFERON for diagnosing TB in children by using consensus classifications. Both IP-10 and QuantiFERON exhibited poor performance in children from a high-burden setting, and performance was especially compromised in young children. (Read the full article)

Migraine headaches are a common presenting complaint in emergency departments. Abortive treatment in this setting is not well studied, leading to considerable variation in treatment. The relationship between acute medications and emergency department revisits has not been studied.

Eighty-five percent of children with migraine are successfully discharged from the emergency department; only 1 in 18 children require a return visit. Prochlorperazine is associated with less revisits than metoclopramide, and diphenhydramine use is associated with increased risk of return visits. (Read the full article)

Medical home transformation is led by practice-level assessment, but much of the evidence supporting the medical home derives from individual-level assessment based on parental perception. The association between these 2 levels of assessment is unknown.

Among Boston-area community health centers, there was no association between the individual- and practice-level assessments of the medical home. This highlights the need for studies supporting the child health benefits of medical home practice transformation. (Read the full article)

Pediatric patients suffer higher mortality due to the shortage of transplantable organs. Factors influencing families’ donation decisions are similar for pediatric and adult patients. However, the general perception that families of pediatric patients are less willing to donate persists.

Communication emerged as a critical factor of family authorization, reinforcing its importance in the organ donation process. Patient age (ie, adult versus pediatric) was not predictive of family authorization. (Read the full article)

Carbapenems are currently the preferred agents for the treatment of serious Acinetobacter infections. However, whether cefepime/cefpirome can be used to treat Acinetobacter bloodstream infection (BSI) if it is active against the causative pathogens is not clear. This study aimed to compare the efficacy of cefepime/cefpirome and carbapenem monotherapy in patients with Acinetobacter BSI. The population included 360 patients with monomicrobial Acinetobacter BSI receiving appropriate antimicrobial therapy admitted to four medical centres in Taiwan in 2012–2017. The predictors of 30-day mortality were determined by Cox regression analysis. The overall 30-day mortality rate in the appropriate antibiotic treatment group was 25.0% (90/360 patients), respectively. The crude 30-day mortality rates for cefepime/cefpirome and carbapenem therapy were 11.5% (7/61 patients) and 26.3% (21/80 patients), respectively. The patients receiving cefepime/cefpirome/carbapenem therapy were infected by Acinetobacter nosocomialis (51.8%), A. baumannii (18.4%) and A. pittii (12.1%). After adjusting for age, Sequential Organ Failure Assessment (SOFA) score, invasive procedures, and underlying diseases, cefepime/cefpirome therapy was not independently associated with a higher or lower 30-day mortality compared to the carbapenem therapy. SOFA score (hazard ratio [HR], 1.324; 95% confidence interval [CI], 1.137–1.543; P < 0.001) and neutropenia (HR, 7.060; 95% CI, 1.607–31.019; P = 0.010) were independent risk factors for 30-day mortality of patients receiving cefepime/cefpirome or carbapenem monotherapy. The incidence density of 30-day mortality for cefepime/cefpirome versus carbapenem therapy was 0.40% versus 1.04%. The therapeutic response of cefepime/cefpirome therapy was comparable to that of carbapenems among patients with Acinetobacter BSI receiving appropriate antimicrobial therapy.

Background: Intensive care unit (ICU) patients may experience ceftriaxone underexposure but clinical outcomes data are lacking. The objective of this study was to determine the impact of ceftriaxone dosing on clinical outcomes amongst ICU patients without central nervous system (CNS) infection.

Methods: A retrospective study of ICU patients receiving intravenous, empiric ceftriaxone for non-CNS infections was conducted. Patients ≥18 years of age who received ≤2 grams of ceftriaxone daily for ≥72 hours were included and categorized as receiving ceftriaxone 1 gram or 2 grams daily. The primary, composite outcome was treatment failure: inpatient mortality and/or antibiotic escalation due to clinical worsening. Propensity score matching was performed based on the probability of receiving ceftriaxone 2 grams daily. Multivariable logistic regression determined the association between ceftriaxone dose and treatment failure in a propensity-matched cohort.

Results: A total of 212 patients were included in the propensity-matched cohort. The most common diagnoses (83.0%) were pneumonia and urinary tract infection. Treatment failure occurred in 17.0% and 5.7% of patients receiving 1 gram and 2 grams daily, respectively (p=0.0156). Overall inpatient mortality was 8.5%. Ceftriaxone 2 gram dosing was associated with a reduced likelihood of treatment failure (adjusted odds ratio=0.190; 95% confidence interval: 0.059 – 0.607). Other independent predictors of treatment failure included sequential organ failure assessment score (aOR 1.440, 95% CI 1.254 – 1.653) and creatinine clearance at 72 hours from ceftriaxone initiation (aOR 0.980, 95% CI (0.971 – 0.999).

Conclusions: Ceftriaxone 2 grams daily when used as appropriate antimicrobial coverage may be appropriate for ICU patients with lower mortality risk.

Aspergillus niger, the third species responsible for invasive aspergillosis has been considered as a homogeneous species until DNA-based identification uncovered many cryptic species. These species have been recently reclassified into the Aspergillus section Nigri. However little is yet known among the section Nigri about the species distribution and the antifungal susceptibility pattern of each cryptic species. A total of 112 clinical isolates collected from 5 teaching hospitals in France and phenotypically identified as A. niger were analyzed. Identification to the species level was carried out by nucleotide sequence analysis. The Minimum Inhibitory Concentrations (MICs) of itraconazole, voriconazole, posaconazole, isavuconazole and amphotericin B were determined by both the EUCAST and gradient concentration strips methods. Aspergillus tubingensis (n=51, 45.5%) and A. welwitschiae (n=50, 44.6%) were the most common species while A. niger accounted for only 6.3% (n=7). The MICs of azoles drugs were higher for A. tubingensis than for A. welwitschiae. The MIC of amphotericin B was 2 mg/L or less for all isolates. Importantly, MICs determined by EUCAST showed no correlation with those determined by gradient concentration strips methods, these latter being lower than the former (Spearman's rank correlation tests ranging - depending on the antifungal agent - from 0.01 to 0.25; p>0.4). In conclusion, A. niger should be considered as a minority species in the section Nigri. The differences in MICs between species for different azoles underline the importance of accurate identification. Significant divergences in the determination of MIC between EUCAST and gradient concentration strips methods require further investigation.

Two Erling Braut Haaland strikes have given Dortmund an advantage to take to Paris, although Neymar's away goal could prove crucial.

Several countries that consistently outperform the U.S. on the Program for International Student Assessment also have more equitable education systems, but American schools are making progress on that front.

In this episode of the Getting Smart Podcast, Tom sits down with Daniel to learn more about his life as an international educator, the American School of Paris, Daniel's goals and challenges in international education, and what he thinks all American educators should know about international educat

Across the 34 countries in the Organization for Economic Cooperation and Development, education gives a strong return on investment for students in the workplace—unless you are a teacher.

Governor Markell has ordered the American and Delaware flags at state buildings and facilities lowered as a mark of respect for the victims of the terrorist attacks in Paris on November 13.

MG Hector is the new kid on the block, but how does it match with Tata's Harrier and the reigning king of the compact SUV space the Hyundai Creta? We drive all three of these SUVs to decipher which of these you should sink your hard earned money into and have a happily ever after […]

Born in Ait Lahcene, near the Kabylie capital of Tizi Ouzou, then part of French Algeria, he studied to be a geologist, but his life took a turn in 1973 when he was called up as a last-minute replacement on the radio to sing the Berber lullaby 'A Vava Inouva.'

French President Emmanuel Macron promised to rebuild within five years but work so far has been slow. Delays were caused by toxic lead released by the fire, winter storms and then by the COVID-19 epidemic which closed the site in March.

The downfall of Nissan Motor Co chairman Carlos Ghosn reverberated for a second day as politicians and executives scrambled to fill the vacuum at the top of the world’s largest car alliance amid new reports about his alleged financial improprieties.

Agile and astute, Simon Nogueira wanders over the rooftops of Paris.

Paris Region has kept its fDi European Region of the Future title, while Dublin Region holds on to second place and North Rhine-Westphalia is in third. 

On the premise that the nations of the world are not doing enough to meet the goals of the 2015 Paris Climate Agreement, Governor Jerry Brown, New York City’s former Mayor Michael Bloomberg and other dignitaries convened a high-profile international gathering in San Francisco September 12-14 to inspire more ambitious action and showcase successful efforts.

Papua New Guinea recently became the first country to formally submit the final version of its national climate action plan (called a “Nationally Determined Contribution,” or NDC) under the Paris Agreement. The small Pacific nation’s plan to transition to 100 percent renewable energy by 2030 is no longer just an “intended” nationally determined contribution (INDC) — it is now the country’s official climate plan.

Less than two weeks after 175 nations signed the pivotal Paris Agreement on climate change, a question lingers: What happens now?

The G20 meeting in Hangzhou, China, this September brings together leaders of the world’s largest economies for the first such gathering since the 2015 Paris Agreement on climate. G20 Leaders Summits traditionally focus on economic growth and financial stability, but since more than 190 countries collectively agreed to greatly enhance mitigation of the causes and impacts of climate change, the need to tackle a changing climate and foster clean energy has become a clear economic and business reality.

The United States and China on Sept. 3 formally joined the Paris Agreement in a ceremony in Hangzhou, China, ahead of the G20 Summit. President Obama and President Xi both deposited their country’s official instrument with United Nations Secretary, General Ban-Ki Moon.