A new course offered to nursing students at the University of Calgary is shining a light on the impacts of colonization on the health experiences of Indigenous peoples.

Some Ukrainians living in Calgary say they're even more worried for their friends and family back home in light of Donald Trump's election win.

The Calgary-based team beat Hamilton Forge FC in a 2-1 nail-biter at home on Saturday, in front of a sold-out crowd of over 7,000 fans at Spruce Meadows.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

Eyare died of injuries she sustained while moving between back of house spaces, Wilder Institute director of animal care, health and welfare, Colleen Baird said Tuesday.

55,000 Licenses Purchased to Train Next Generation of Engineers and Designers

A group of students called Tailgate Ambassadors, supported by Penn State Sustainability, the Office of Physical Plant, and Pepsi, are working reduce the amount of waste generated on game days. This partnership is incentivizing fans to learn about game-day recycling — and offering prizes to those who do.

An educator's experience teaching math is important, but performance on math-content-certification tests is the best predictor of how well a teacher's students will perform in early algebra, finds a new study by the Regional Educational Laboratory Central at Marzano Research.

An overview of the biggest business developments in SA and beyond.

A group of Bulgarian teenagers and leaders took part in this year’s TeenStreet Europe for the first time and experienced God in new ways.

This year at the sports and English camp in Bulgaria, the team noticed the fruit of building on relationships over time.

The newly identified ‘Chonkus’ strain of cyanobacteria, discovered in Italy's volcanic waters, may be a natural ally in carbon sequestration. With its CO₂-absorbing properties and ability to thrive in extreme environments, Chonkus shows promise in industrial carbon storage and bio-manufacturing, potentially lowering costs while contributing to climate action.

LG Display, a subsidiary of the South Korea-based conglomerate focused on display technology, unveiled a new stretchable display that can expand by 50 percent of its original size. The company introduced the new stretchable display panel last week at LG Science Park in Seoul during a meeting of more than 100 South Korean industry, academia, and research stakeholders.

The cast also included Rani Mukerji, Manoj Bajpayee, Amitabh Bachchan, Hema Malini and Boman Irani.

D'MONDE is an exclusive members-only club that offers opulence through its various offerings.

Together with prior deals, Delaware now expects to recover a quarter-billion dollars to combat opioid crisis Attorney General Kathy Jennings today announced that she has finalized settlement agreements with CVS and Walgreens, bringing the national amount from investigations and litigation against the pharmaceutical industry for its role in the opioid crisis to more than $50 billion. Delaware’s […]

Delaware to receive nearly $70 million to fight the opioid crisis Delaware Attorney General Kathy Jennings today announced the final approval of $17.3 billion in opioid agreements with drug makers Teva and Allergan and pharmacies CVS and Walgreens. Following successful state sign-on and subdivision sign-on periods, the defendants have committed to the deal and will start releasing funds […]

                Attorney General Kathy Jennings joined a group of 15 state attorneys general calling on Target to support inclusivity and to reject anti-LGBTQ+ hate, intimidation and discrimination.                The letter, sent to national retail chain Target during Pride Month, comes in response to Target’s recent decision to remove certain Pride-related merchandise from its stores and […]

NEW CASTLE (Feb. 21, 2022) – A Dover primary care office is expanding behavioral health services for LGBTQ individuals thanks to federal grant funding. A Peaceful Place Integrated Care is using the grant to support the addition of a certified drug and alcohol counselor, a licensed clinical social worker, and a peer navigator to help […]

Read the in depth Review of LG GX 65-inch 4K OLED TV TV. Know detailed info about LG GX 65-inch 4K OLED TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of LG Tone Free FN7 Audio Video. Know detailed info about LG Tone Free FN7 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of LG CX 48-inch 4K OLED TV TV. Know detailed info about LG CX 48-inch 4K OLED TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of LG C1 55-inch 4K OLED TV TV. Know detailed info about LG C1 55-inch 4K OLED TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of LG ToneFree FP9 Audio Video. Know detailed info about LG ToneFree FP9 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of LG C2 42-inches 4K OLED evo TV (OLED42C2PSA) TV. Know detailed info about LG C2 42-inches 4K OLED evo TV (OLED42C2PSA) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

LG has unveiled a stretchable display that can expand up to 50 percent.

LG's 55-inch B3 OLED TV normally retails for $1,199. As of Nov. 12, it's on sale for $798 as part of Walmart's early Black Friday sale.

Even post-spooky season, GFN Thursday has some treats for GeForce NOW members: a new batch of 17 games joining the cloud in November. Catch the five games available to stream this week, including Dragon Age: The Veilguard, the highly anticipated next installment in BioWare’s beloved fantasy role-playing game series. Players who purchased the GeForce NOW Read Article

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Former French MP Meyer Habib describes his worries about France's future as antisemitism soars across Europe and violence becomes normalized.

[Huawei] Istanbul, Türkiye -- The Net5.5G Pioneer Award ceremony was successfully held at the Net5.5G Intelligent IP Network Summit themed "Accelerating Net5.5G, Striding to Intelligence" during the 10th Global Ultra-Broadband Forum (UBBF 2024), co-hosted by the UN Broadband Commission, World Broadband Association (WBBA), and Huawei.

Georgia’s ruling party has put LGBTQI+ people firmly in the firing line ahead of next month’s election. On 17 September, parliament gave final approval to a highly discriminatory law that empowers the authorities to censor books and films with LGBTQI+ content, stop discussion of LGBTQI+ issues in schools, ban people from flying rainbow flags and […]

Title: Study: Acupuncture Helps Fibromyalgia
Category: Health News
Created: 8/25/2005 12:00:00 AM
Last Editorial Review: 8/25/2005 12:00:00 AM

Title: Health Tip: Living With Fibromyalgia
Category: Health News
Created: 8/30/2012 8:05:00 AM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: For Muslim Pilgrimage, Climate Change Poses Health Risks
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

In this study, the nonclinical pharmacokinetics of OLX702A-075-16, an RNA interference therapeutic currently in development, were investigated. OLX702A-075-16 is a novel N-acetylgalactosamine conjugated asymmetric small-interfering RNA (GalNAc-asiRNA) used for the treatment of an undisclosed liver disease. Its unique 16/21-mer asymmetric structure reduces nonspecific off-target effects without compromising efficacy. We investigated the plasma concentration, tissue distribution, metabolism, and renal excretion of OLX702A-075-16 following a subcutaneous administration in mice and rats. For bioanalysis, high-performance liquid chromatography with fluorescence detection was used. The results showed rapid clearance from plasma (0.5 to 1.5 hours of half-life) and predominant distribution to the liver and/or kidney. Less than 1% of the liver concentration of OLX702A-075-16 was detected in the other tissues. Metabolite profiling using liquid chromatography coupled with high-resolution mass spectrometry revealed that the intact duplex OLX702A-075-16 was the major compound in plasma. The GalNAc moiety was predominantly metabolized from the sense strand in the liver, with the unconjugated sense strand of OLX702A-075-16 accounting for more than 95% of the total exposure in the rat liver. Meanwhile, the antisense strand was metabolized by the sequential loss of nucleotides from the 3'-terminus by exonuclease, with the rat liver samples yielding the most diverse truncated forms of metabolites. Urinary excretion over 96 hours was less than 1% of the administered dose in rats. High plasma protein binding of OLX702A-075-16 likely inhibited its clearance through renal filtration.

People with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pain, which significantly affects their quality of life and life expectancy. Current treatment strategies for SCD-associated pain primarily rely on opioid analgesics, which have limited efficacy and cause serious adverse effects. Cannabis has emerged as a potential alternative, yet its efficacy remains uncertain. In this study, we investigated the antinociceptive effects of ⁹-tetrahydrocannabinol (THC), cannabis’ intoxicating constituent, in male HbSS mice, which express >99% human sickle hemoglobin, and male HbAA mice, which express normal human hemoglobin A, as a control. Acute THC administration (0.1–3 mg/kg^–1, i.p.) dose-dependently reduced mechanical and cold hypersensitivity in human sickle hemoglobin (HbSS) but not human normal hemoglobin A (HbAA) mice. In the tail-flick assay, THC (1 and 3 mg/kg^–1, i.p.) produced substantial antinociceptive effects in HbSS mice. By contrast, THC (1 mg/kg^–1, i.p.) did not alter anxiety-like behavior (elevated plus maze) or long-term memory (24-hour novel object recognition). Subchronic THC treatment (1 and 3 mg/kg^–1, i.p.) provided sustained relief of mechanical hypersensitivity but led to tolerance in cold hypersensitivity in HbSS mice. Together, the findings identify THC as a possible therapeutic option for the management of chronic pain in SCD. Further research is warranted to elucidate its mechanism of action and possible interaction with other cannabis constituents.

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and α/β-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action and without intoxication. We review evidence on plant-derived cannabinoids for pain, with an emphasis on CBD and its multiple molecular targets expressed in pain pathways. We also discuss the function of eCB signaling in regulating pain responses and the therapeutic promises of inhibitors targeting ABHD6, a 2-arachidonoylglycerol (2-AG)-hydrolyzing enzyme. Finally, we discuss how the novel cannabinoid biosensor GRAB_eCB2.0 may be leveraged to enable the discovery of targets modulated by cannabinoids at a circuit-specific level.

Low-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door. Behavioral measures included (1) crosses between compartments (vertical activity over the obstruction) and (2) movement counts quantified as photobeam breaks summed across compartments (horizontal activity). Each drug was tested alone and as a pretreatment to IP acid. A charcoal-meal test and whole-body-plethysmography assessment of breathing in 5% CO₂ were also used to assess gastrointestinal (GI) inhibition and respiratory depression, respectively. IP acid produced a concentration-dependent depression in crosses and movement that was optimally alleviated by intermediate- to low-efficacy phenylmorphans with sufficient efficacy to produce analgesia with minimal locomotor disruption. Follow-up studies with two low-efficacy phenylmorphans (JL-2-39 and DC-1-76.1) indicated that both drugs produced naltrexone-reversible antinociception with a rapid onset and a duration of ~1 h. Potency of both drugs increased when behavior was depressed by a lower IP-acid concentration, and neither drug alleviated behavioral depression by a non-pain stimulus (IP lithium chloride). Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression. Results support further consideration of selective, low-efficacy MOR agonists as candidate analgesics.

Kelley ruins Warcraft by including Conker. Chris mortgages his Xbox. Josh's cat won't let him control his Xbox. And Microsoft has announced their new Candy Crush themed Windows 12.

The post RPG Cast – Episode 615: “The New Dialga Looks Like My Brother’s Broken Vacuum Cleaner” appeared first on RPGamer.

Call of Duty: Black Ops 6 has remained in first place on the Australian charts, according to IGEA for the week ending November 3, 2024.

There were three new releases in the top 10 this week with Dragon Age: The Veilguard debuting in second place, Horizon Zero Dawn Remastered in fourth place, and Life Is Strange: Double Exposure in ninth place.

Hogwarts Legacy is up one spot to third place, EA Sports FC 25 remained in fifth place, and Super Mario Party Jamboree dropped from second to sixth place.

Red Dead Redemption is in seventh place, NBA 2K25 is in eight place, and Battlefield 2042 rounds out the top 10.

Here are the top 10 best-selling titles in Australia for the week:

1. Call of Duty: Black Ops 6
2. Dragon Age: The Veilguard - NEW
3. Hogwarts Legacy
4. Horizon Zero Dawn Remastered - NEW
5. EA Sports FC 25 
6. Super Mario Party Jamboree
7. Red Dead Redemption
8. NBA 2K25
9. Life Is Strange: Double Exposure - NEW
10. Battlefield 2042

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463028/dragon-age-the-veilguard-debuts-in-2nd-on-the-australian-charts/

Call of Duty: Black Ops 6 has remained in first place on the New Zealand charts, according to IGEA for the week ending November 3, 2024.

There were two new releases in the top 10 this week with Dragon Age: The Veilguard debuting in second place and Horizon Zero Dawn Remastered in fourth place.

Hogwarts Legacy is down one spot to third place, Grand Theft Auto V is up three spots to fifth place, and NBA 2K25 climbed from ninth to sixth place.

Red Dead Redemption is in seventh place, Borderlands 3 is in eight place, Battlefield 2042 is in ninth place, and EA Sports FC 25 rounds out the top 10.

Here are the top 10 best-selling titles in New Zealand for the week:

1. Call of Duty: Black Ops 6
2. Dragon Age: The Veilguard - NEW
3. Hogwarts Legacy
4. Horizon Zero Dawn Remastered - NEW
5. Grand Theft Auto V
6. NBA 2K25
7. Red Dead Redemption
8. Borderlands 3
9. Battlefield 2042
10. EA Sports FC 25 

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463029/dragon-age-the-veilguard-debuts-in-2nd-on-the-new-zealand-charts/

Some extremely fresh vintage workwear that I bought for entirely practical reasons aside, I’m not exactly a fashion person. I have nobody to impress most days but my cat, and the only item of clothing she appears to have an opinion on is my Oodie, which is very comfortable for both of us and also smells like a chicken shop, which I imagine is more pleasant for her than me.

This aside, I found myself taking a whole bunch of Dragon Age: The Veilguard screenshots as I played just to capture the RPG’s various outfits. They are ridiculous. Incredibly intricate and detailed, as well as being obscenely impractical for the most part. I do not like any of them in the sense I would wear them, but I like all of them in the sense that they display artists allowed to run free like caffeinated weasels and indulge their every whim.

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There’s plenty that you could justifiably expect from a Bioware RPG: chats with mates, opportunities to get those mates horribly killed, surviving mates turning to the side then walking offscreen. But I don’t think anyone expected Dragon Age: The Veilguard to be, at least on a purely technical level, one of the smoothest-performing, settings-rich AAA PC releases of the year so far.

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BioWare currently has no plans for Dragon Age: The Veilguard expansions, according to reports. Instead the studio will support the fantasy RPG with smaller updates and otherwise turn their full attention towards Mass Effect 5.

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