Do not deny the possibility of losing the job, or being furloughed briefly.

The inbox was flooded with questions after the first Ask Ray video feature was published, and this week – unlike his maiden voyage – Ray has come up with actual answers to questions from Paulick Report readers (all without the assistance of Google…well, mostly). Several questions were related to the starting gate, including the new 20-stall […]

The post Ask Ray: Starting Gate Questions And Camel Races? appeared first on Horse Racing News | Paulick Report.

Rangers in Grand Canyon National Park are investigating the possible abduction of a woman from a residential area within the park. https://www.nps.gov/grca/learn/news/news-2009-07-16-abduction.htm

https://www.nps.gov/grca/learn/news/grand-canyon-national-park-will-offer-free-shuttle-service-between-the-gateway-community-of-tusayan-and-the-grand-canyon-visitor-center-again-this-year.htm

Progress on a multi-use Greenway trail linking Grand Canyon National Park with the gateway town of Tusayan continues. The eight mile trail passes through both Grand Canyon National Park and Kaibab National https://www.nps.gov/grca/learn/news/progress-on-multi-use-trail-connecting-grand-canyon-national-park-with-gateway-town-of-tusayan-continues.htm

https://www.nps.gov/grca/learn/news/2011-10-03_nr-fatality.htm

At approximately 12:30 am on December 12, the Grand Canyon Regional Communications Center received a call alerting rangers to an overdue individual at Grand Canyon National Park. https://www.nps.gov/grca/learn/news/possible-suicide-twin-overlooks.htm

Land use and climate change are two key factors with the potential to affect stream conditions and fish habitat. Since the 1950s, Washington and Oregon have required forest practices designed to mitigate the effects of timber harvest on streams and fish.

Principal findings of the National Fire and Fire Surrogate (FFS) study are presented in an annotated bibliography and summarized in tabular form by site, discipline (ecosystem component), treatment type, and major theme. Composed of 12 sites, the FFS is a comprehensive multidisciplinary experiment designed to evaluate the costs and ecological consequences of alternative fuel reduction treatments in seasonally dry forests of the United States. The FFS has a common experimental design across the 12-site network, with each site a fully replicated experiment that compares four treatments: prescribed fi re, mechanical treatments, mechanical + prescribed fire, and an unmanipulated control. We measured treatment cost and variables within several components of the ecosystem, including vegetation, the fuel bed, soils, bark beetles, tree diseases, and wildlife in the same 10-ha experimental units. This design allowed us to assemble a fairly comprehensive picture of ecosystem response to treatment at the site scale, and to compare treatment response across a wide variety of conditions.

A man has been arrested on suspicion of murder

A driver of a car collided with a bridge barrier and two lorries

Officers found the body of a woman in her 40s on Friday morning

One of the most frustrating aspects of running a website is having to troubleshoot an error when you don’t know why it’s happening. Some issues, such as the 502 bad gateway error, have many potential causes. This means you may need to try multiple solutions before you land on the right one. In this post […]

The post How to Fix the 502 Bad Gateway Error in WordPress appeared first on Elegant Themes Blog.

Operational-scale experiments that evaluate the consequences of fire and mechanical "surrogates" for natural disturbance events are essential to better understand strategies for reducing the incidence and severity of wildfire. The national Fire and Fire Surrogate (FFS) study was initiated in 1999 to establish an integrated network of long-term studies designed to evaluate the consequences of using fire and fire surrogate treatments for fuel reduction and forest restoration. Beginning in September2005, four regional workshops were conducted with selected clients to identify effective and efficient means of communicating FFS study findings to users. We used participatory evaluation to design the workshops, collect responses to focused questions and impressions, and summarize the results. We asked four overarching questions: (1) Who needs fuel reduction information? (2) What information do they need? (3) Why do they need it? (4) How can it best be delivered to them? Participants identified key users of FFS science and technology, specific pieces of information that users most desired, and how this information might be applied to resolve fuel reduction and restoration issues. They offered recommendations for improving overall science delivery and specific ideas for improving delivery of FFS study results and information. User groups identified by workshop participants and recommendations for science delivery are then combined in a matrix to form the foundation of a strategic plan for conducting science delivery of FFS study results and information. These potential users, their information needs, and preferred science delivery processes likely have wide applicability to other fire science research.

The Fire and Fire Surrogate (FFS) project is a large long-term metastudy established to assess the effectiveness and ecological impacts of burning and fire "surrogates" such as cuttings and mechanical fuel treatments that are used instead of fire, or in combination with fire, to restore dry forests. One of the 13 national FFS sites is the Northeastern Cascades site at Mission Creek on the Okanogan- Wenatchee National Forest. The study area includes 12 forested stands that encompass a representative range of dry forest conditions in the northeastern Cascade Range. We describe site histories and environmental settings, experimental design, field methods, and quantify the pretreatment composition and structure of vegetation, fuels, soils and soil biota, entomology and pathology, birds, and small mammals that occurred during the 2000 and 2001 field seasons. We also describe the implementation of thinning treatments completed during 2003 and spring burning treatments done during 2004 and 2006.

The first phase of the multi million pound development in Durham city is under way and is expected to take 18 months to complete

Garden lovers are welcoming new contactless delivery service from Southdene Nursery in Low Fell

Gateshead Rugby Football Club members swap Bank Holiday festival plans for a 554-mile fund-raising 'journey' to London and back

We kick things off talking about the Jewish holiday of Yom Kippur. We then discuss David D Rainman's recent request...

The post METAL INJECTION LIVECAST #536 - Sinema with Chase from GATECREEPER appeared first on Metal Injection.

ON INLANDER.COM COVER: While Washington state forges alliances, Idaho battles coronavirus its own way.…

The preparation of phosphorescent metalloporphyrin labelling reagents and their use for preparation of phosphorescent conjugates with biomolecules. The labelling reagents obtainable are water soluble monofunctional derivatives of Pt- and Pd-coproporphyrins, where the term “monofunctional” refers to the number of reactive groups in the porphyrin moiety.

A mechanism for generating gate-level activity data for use in clock gating efficiency analysis of an integrated circuit (IC) design is provided. Generating the gate-level activity data includes generating a signal behaviour description for inter-register signals, generating a gate-level netlist for the IC design, generating gate-level stimuli based at least partly on the generated signal behaviour description, and performing gate-level simulation using the generated gate-level stimuli to generate gate-level activity data for the IC design. In one embodiment, generating the signal behaviour description includes performing Register Transfer Level (RTL) simulation of the IC design, and generating the gate-level netlist includes performing RTL synthesis. The RTL simulation and RTL synthesis are performed on RTL data for the IC design.

The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.

Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile. Formulations comprising the conjugates are also provided, as are methods of using the conjugates and kits comprising the conjugates.

The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.

A polymer composition for solar cell and flexible electronics devices, where the polymer is a p-type conducting polymer. The p-type polymer comprises a benzothiadiazole acceptor and indeno-fluorene donor. Further, a solar cell and flexible electronic device article may be made from the polymer.

A method for providing a biological logic gate comprising the following steps: subjecting a bistable autoregulatory gene network (GRN) to a noisy background; identifying adjustable parameters of the GRN; using logical stochastic resonance to determine values of the GRN parameters which result in the GRN performing different logic gate functions; and setting the parameter values of the GRN such that the GRN performs a first logic gate function.

Methods for creating and using space-time surrogate models of subsurface regions, such as subsurface regions containing at least one hydrocarbon formation. The created surrogate models are explicit models that may be created from implicit models, such as computationally intensive full-physics models. The space-time surrogate models are parametric with respect to preselected variables, such as space, state, and/or design variables, while also indicating responsiveness of the preselected variables with respect to time. In some embodiments, the space-time surrogate model may be parametric with respect to preselected variables as well as to time. Methods for updating and evolving models of subsurface regions are also disclosed.

The embodiments relate to modeling resistance in a multi-fin multi-gate field effect transistor (MUGFET). In these embodiments, a design for a multi-fin MUGFET comprises a gate structure with a horizontal portion traversing multiple semiconductor fins and comprising a plurality of first resistive elements connected in series, with vertical portions adjacent to opposing sides of the semiconductor fins and comprising second resistive elements connected in parallel by the horizontal portion, and with contact(s) comprising third resistive element(s). The total gate resistance is determined based on resistance contributions from the first resistive elements, the second resistive elements and the third resistive element(s), particularly, where each resistive contribution is based on a resistance value of the resistive element, a first fraction of current from the semiconductor fins entering the resistive element and a second fraction of the current from the semiconductor fins exiting the resistive element.

An apparatus, system and method are introduced for preserving privacy of data in a dataset in a database with a number n of entries. In one embodiment, the apparatus includes memory including computer program code configured to, with a processor, cause the apparatus to form a random matrix of dimension m by n, wherein m is less than n, operate on the dataset with the random matrix to produce a compressed dataset, form a pseudoinverse of the random matrix, and operate on the dataset with the pseudoinverse of the random matrix to produce a decompressed dataset.

Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.

The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk1, Alk2, and W are as defined and described herein.

Length adjustment can be performed in a simple manner and without impairment of the insulating effect in an insulation cassette for the heat insulation of elongated elements. A multilayer insulation includes flat reflection elements (21, 22). Each layer of the insulation has at least two of the flat reflection elements (21, 22), which overlap at least partly at their ends (24) facing each other.

To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6. [A-(B)n]x—C (I)

This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.

A low profile, wrappable spacer and method for maintaining a pair of elongate members in fixed, spaced relation to one another is provided. The wrappable spacer includes a flexible elongate body having oppositely facing inner and outer faces extending along laterally spaced, lengthwise extending edges between opposite ends. The inner face has an adhesive surface. At least one member extends between the edges transversely to the lengthwise extending edges. The member extends outwardly from the adhesive surface, wherein the adhesive surface is configured for adhesion to at least one of the member, the elongate members or the outer face.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

An application gateway enables controlled communication between application components within a browser based environment while maintaining a level of isolation of the individual application components. A dispatching API wrapper and a listening API wrapper are registered for each of a plurality of application components. The registered API wrappers are used to send and receive communications from the associated application components. For example, a first application component can dispatch an action to a second application component via the first application component's dispatching API wrapper. The second application component can receive the action via the second application component's listening API wrapper. As another example, a first application component can dispatch an event that broadcasts a state to other application components via the first application component's dispatching API wrapper. A listening API wrapper of at least one other application component receives the state and may perform other functions dependent on the state.

Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

A shift register and driving method thereof, a gate driving apparatus and a display apparatus, the shift register comprises a pulling-up unit(21), a precharging and resetting unit(22), an output signal terminal at present stage(OUTPUT), a pulling-down unit(23), an input terminal connected to an output signal terminal of a shift register at previous stage(OUTF), an input terminal connected to an output signal terminal of a shift register at next stage(OUTL), and a scan control signal input terminal(INPUT), wherein: the precharging and resetting unit(22) precharges a gate of a first thin film transistor(T1) included in the pulling-up unit(21) and resets its potential; the pulling-down unit(23) pulls down a potential at the gate of the first thin film transistor(T1) and the output signal at present stage after the precharging and resetting unit(22) resets the potential at the gate of the first thin film transistor(T1), so that the pulling-up unit(21) is turned off and the output signal at present stage is at a low level. The present shift register realizes a bidirectional gate driving scan from up to down or from down to up by a conversion control for high-low levels of input signals.

A shift register, comprising a plurality of shift register sub-units connected in cascade, each of the plurality of shift register sub-units comprising first to third TFTs, an eleventh TFT, a first capacitor and a first reset control module for controlling the second TFT to be turned on or off. Besides the shift register sub-unit at a first stage, for each of the shift register sub-units at other stages, the second TFT gate control terminal thereof is connected to the third TFT gate control terminal of the shift register sub-unit at a previous stage. Accordingly, a gate driving circuit comprising the shift register and a display comprising the gate driving circuit are provided. Compared with the prior art, reliability of the shift register is highly improved and area occupied by the shift register is smaller.

A shift register of a gate driving circuit includes a pull-up unit for pulling up a first output signal and a first gate signal to a high voltage level according to a driving voltage and a high-frequency clock signal, a start-up unit for transmitting a second gate signal, an energy-store unit for providing the driving voltage to the pull-up unit according to the second gate signal, a first discharging unit for pulling down the driving voltage to a first voltage level according to a first control signal, a first leakage-preventing unit for turning off the first discharging unit when the first gate signal reaches the high voltage level, a first pull-down unit for respectively pulling down the first output and first gate signals to the first and a second voltage levels according to the first control signal, and a first control unit for generating the first control signal.

A reset circuit for Gate Driver on Array, an array substrate and a display is used for increasing reliability and long-term stability of a GOA circuit and thus improving performance of the GOA circuit. The GOA reset circuit includes a first electronic switch circuit (301) connected to an input terminal of a GOA unit of the Gate Driver on Array (INPUT); and a second electronic switch circuit connected to an output terminal of the GOA unit (OUTPUT), wherein the first electronic switch circuit (301) is connected to a low level signal terminal and is switched on to connect the low level signal terminal to a reset terminal of the GOA unit (RESET) when the input terminal of the GOA unit (INPUT) is at a high level; and the second electronic switch circuit (302) is connected to a high level signal terminal and is switched on to connect the high level signal terminal to the reset terminal of the GOA unit (RESET) when the output terminal of the GOA unit (OUTPUT) is at a high level.

An n-bit counter is formed from cascading counter sub-modules. The counter includes combinatorial control logic coupled to a lower order counter sub-module. The control logic is arranged to clock gate at least one higher order counter sub-module dependent on a logical combination of outputs of the lower order counter sub-module and where the control logic uses pipelining to store at least one previous control logic output for use in determining a later control logic output.

The present invention divides a wire supplying a scan start signal to a gate driver into two wires, so as to avoid overlapping a clock signal line. In this way the clock signal is not delayed by interference, and a gate driving margin may continue uninterrupted, thereby uniformly outputting a gate-on voltage. In particular, if the clock signal line is connected to all stages in the gate driver and the clock signal line overlaps the scan start signal line, unsightly horizontal bands appear on the image and the parallel gate lines generate a very large parasitic capacitance. In contrast, the gate drivers in the present disclosure comprise clock signal lines which do not overlap the scan start signal lines. As benefits, interference resulting in horizontal banding is minimized and the power consumption may be reduced by about 10%.

A display apparatus and a method for generating gate signal thereof are provided. The display apparatus includes a timing controller and a display panel. The timing controller is used for providing a plurality of timing signals. The display panel includes a pixel array and a gate drive circuit. The pixel array has a plurality of pixels. The gate drive circuit is electrically connected to the timing controller and the pixel array and including a plurality of shift register circuits. The shift register circuit includes a first shift register and a second shift register. The first shift register is configured for generating a corresponding primary gate signal. The second shift register is configured for generating a corresponding secondary gate signal. The timing controller adjusts overlapping relations of the timing signals according to a frame rate of the display apparatus.

There is disclosed a gate driver, a driving circuit, and a liquid crystal display (LCD), wherein the gate driver comprises input terminals for inputting a CPV signal, an OE signal, and an STV signal, and output terminals for outputting a CKV signal and a CKVB signal, and a processing circuit is connected between the input terminals and the output terminals for processing the CPV signal, the OE signal, and the STV signal such that a preset time interval is present between the falling edge of the CKV signal and the rising edge of the CKVB signal during one period of the CKV signal, or a preset time interval is present between the rising edge of the CKV signal and the falling edge of the CKVB signal during one period of the CKVB signal.

When forming sophisticated semiconductor-based gate electrode structures of transistors, the pre-doping of one type of gate electrode structure may be accomplished after the actual patterning of the electrode material by using an appropriate mask or fill material for covering the active regions and using a lithography mask. In this manner, a high degree of flexibility is provided with respect to selecting an appropriate patterning regime, while at the same time a uniform and superior cross-sectional shape for any type of gate electrode structure is obtained.

The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

Nonconjugated conductive polymers absorb radioactive iodine, therefore are useful for protection against nuclear radiation. These polymers have at least one double bond per repeat unit. The ratio of the number of double bonds to the total number of bonds along the polymer chain is less than half. Examples of nonconjugated conductive polymers include: cis-1,4-polyisoprene (natural rubber), trans-1,4-polyisoprene (gutta percha), polybutadiene, polydimethyl butadiene, poly(b-pinene), styrene butadiene rubber (SBR), polyalloocimene, polynorbornene and many others. Through interaction with iodine atoms the double bonds in the nonconjugated polymers transform into radical cations leading to a dark color. The iodine atoms remain (immobile) bound to the polymer chain through the charge-transfer interaction, these polymers are very inexpensive and can be easily processed into any shape, structure and size. Therefore, these are useful for protection against nuclear radiation including radioactive iodine. These polymers when used as a thick cover can provide safe storage of nuclear waste materials including spent fuel rods.