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Nanomaterials and methods for cancer therapy: 2D materials, biomolecules, and molecular dynamics simulations

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01667J, Review Article
Welela M. Kedir, Lunna Li, Yaw Sing Tan, Natasa Bajalovic, Desmond K. Loke
Nanomaterials made from 2D semiconductors and biomolecules are reviewed. Cell-nanoparticle interactions are examined in recent simulations. These nanomaterials and MD simulations reveal novel mechanisms and enable cancer drug delivery and targeting.
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Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01995D, Review Article
Jipeng Yao, Zhencun Cui, Feifei Zhang, Haidong Li, Longlong Tian
Localized cancer therapy such as radiotherapy, phototherapy, and chemotherapy are precise cancer treatment strategy, aiming to minimize systemic side effect. However, cancer metastasis remains the primary cause of cancer patients’...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lactobionic acid modified cobalt coordination polymer-coated peroxymonosulfate nanoparticles generate sulfate/hydroxy dual-radicals for targeted cancer therapy

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01777C, Paper
Jiahui Li, Jiaxuan Li, Zelong Chen, Yichen Wan, Yi Wang, Zhichao Pei, Yuxin Pei
LCP NPs were prepared by forming a coordination polymer on peroxymonosulfate through the coordination between imidazole-2-carboxaldehyde and Co2+, then modified with lactobionic acid to improve the efficacy of sulfate/hydroxy dual-radical therapy.
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Development of a Xanthene-Based NIR Fluorescent Probe for Accurate and Sensitive Detection of γ-Glutamyl Transpeptidase in Cancer Diagnosis and Treatment

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01841A, Paper
Chia-Kai Lai, KUPPAN MAGESH, Sivan Velmathi, Shu-Pao Wu
γ-Glutamyl transpeptidase (GGT) regulates glutathione (GSH), essential for cell functions and linked to cancer. High GGT levels in tumors make it a valuable cancer biomarker. Current GGT detection methods often...
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Quantum DFT analysis and molecular docking investigation of various potential breast cancer drugs

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01803F, Paper
Ashraf Ayub, Ankit Raj Tyagi, Sunil Kumar Srivastava, Pranveer Singh
Breast cancer is the most often diagnosed and deadliest type of cancer in the world. These days, the world is facing the threat of breast cancer. It is essential to...
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Cuproptosis in cancer therapy: mechanisms, therapeutic application and future prospects

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01877J, Review Article
Jiawei Hu, Junfei Zhu, Tao Chen, Yudie Zhao, Qingwen Xu, Yan Wang
Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways.
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Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01798F, Paper
Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang, Rong Tian
Malignant tumors pose substantial treatment challenges due to their heterogeneity, metastatic potential, and therapeutic resistance, underscoring the urgent need for more effective treatment options.
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Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01656D, Paper
Li Xu, Hongwen Liu, Yi Kong, Lingyun Li, Jia Li, Kang Li, Shuzhi Liang, Bolin Chen
Using activatable NIR fluorescent/PA bimodal probes, we successfully monitored real-time biothiol changes during ferroptosis in NSCLC cells and tumors, revealing enhanced ferroptosis with the combined use of erastin and cisplatin.
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Alterations of the chemical profile of cholesterol in cancer tissue as traced with ToF-SIMS

Analyst, 2024, 149,5344-5352
DOI: 10.1039/D4AN01050G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Auraya Manaprasertsak, Julhash U. Kazi, Catharina Hagerling, Kenneth J. Pienta, Per Malmberg, Emma U. Hammarlund
This study uses Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) to analyze cholesterol alterations in cancer tissue, revealing changes in fragmentation and isotopes that suggest potential diagnostic vulnerabilities.
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An improved cancer diagnosis algorithm for protein mass spectrometry based on PCA and a one-dimensional neural network combining ResNet and SENet

Analyst, 2024, Advance Article
DOI: 10.1039/D4AN00784K, Paper
Liang Ma, Wenqing Gao, Xiangyang Hu, Dongdong Zhou, Chenlu Wang, Jiancheng Yu, Keqi Tang
An improved cancer diagnosis algorithm for protein mass spectrometry based on PCA and 1D neural network combining ResNet and SENet is proposed and successfully applied to the diagnosis of ovarian cancer with high accuracy and strong fitting ability.
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Advancing nanotechnology for neoantigen-based cancer theranostics

Chem. Soc. Rev., 2024, 53,3224-3252
DOI: 10.1039/D3CS00162H, Tutorial Review
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jianhua Zou, Yu Zhang, Yuanbo Pan, Zhengwei Mao, Xiaoyuan Chen
Developing nanotechnology for neoantigen-based precision therapy, including photodynamic therapy, photothermal therapy, radiotherapy, chemo/chemodynamic therapy, immunotherapy, and other therapies.
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SERS in 3D cell models: a powerful tool in cancer research

Chem. Soc. Rev., 2024, Advance Article
DOI: 10.1039/D3CS01049J, Review Article
Open Access
Lara Troncoso-Afonso, Gail A. Vinnacombe-Willson, Clara García-Astrain, Luis M. Liz-Márzan
3D cancer models recapitulate the tumor microenvironment and serve as a platform to study cancer cell behavior, drug discovery and early diagnosis, which can be monitored chemically with subcellular resolution in real time, via SERS.
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Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(II)-N^N scaffold in breast cancer cells

Chem. Commun., 2024, 60,13376-13379
DOI: 10.1039/D4CC04276J, Communication
Lavanya Thilak Babu, Nilmadhab Roy, Tiasha Dasgupta, Sreejani Ghosh, Ramasamy Tamizhselvi, Priyankar Paira
This article portrays the construction of biotinylated-MWCNTs for SMVT-guided delivery of a potent Ru(II)-scaffold into MCF7 cells.
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Structural optimization of icaritin for advanced cancer: novel carbamates via oral administration

New J. Chem., 2024, Advance Article
DOI: 10.1039/D3NJ05723B, Paper
Fengxiao Li, Weiping Wang, Jiaqi Fan, Yixiu Zhai, Jiaming Zhang, Tianhong Zhang, Qikun Jiang
Carbamates of icaritin (3N-Me and 3N-Et) are synthesized first to overcome the challenge of the phase II metabolism of ICT. 3N-Me has potential as a novel advanced cancer treatment agent via oral administration in the future.
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Synthesis, anticancer activity and molecular simulation of N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thioureas containing pyrimidine ring

New J. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4NJ00209A, Paper
Vu Ngoc Toan, Nguyen Dinh Thanh, Do Son Hai, Nguyen Minh Tri
A series of thioureas 7a-k containing pyrimidine and D-glucose moiety have been synthesized through the reaction between substituted 2-aminopyrimidines 3a-k and tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate 6. The yields achieved were 55‒77%. The...
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A zwitterionic salt–cocrystal: in vitro insights from niraparib tosylate, an anti-cancer drug

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D4CE00114A, Paper
Ramesh Reddy Mudda, Ramesh Devarapalli, Arijit Das, Pulla Reddy Lakkireddy, C. Malla Reddy, Ramanaiah Chennuru
Schematic representation showing nomenclature of different cocrystals.
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Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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National Pharmaceutical Pricing Authority directs firms to cut prices of three anti-cancer drugs

Govt. had earlier scrapped customs duty on Trastuzumab, Osimertinib and Durvalumab and also reduced GST rates on them




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As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors




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What is breast density and how is it associated with cancer? Explained

Breast density matters because of two main reasons: it may make it harder to detect signs of cancer on a mammogram, and it is linked with an increased risk of breast cancer




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Glioblastoma: why immunotherapy may offer hope for brain cancer patients

Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively




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Development of Polymeric Aptamer Probes for In Vivo Continuous Precision Cancer Targeting

Mater. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QM00731J, Research Article
Silin Huang, Yu-Ting He, Xiao-Jing Zhang, Xueqiang Wang, Qiang Guo
Aptamers, despite their specific targeting capabilities and widespread applications in various research domains, face a significant hurdle in biomedical research area due to their rapid degradation by nucleases. To address...
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Gene-modification is the Next Frontier in Fighting Against Cancer

A single dose of infusion therapy can eradicate leukemia and destroy kilograms of cancer cells. Bruce Levine tells WIRED Health 2018 how he and his team are developing therapies to tackle cancer. Read more here: http://wired.uk/JxvIdt ABOUT WIRED HEALTH 2018 Hundreds of healthcare, pharmaceutical and technology influencers and leaders met at the sixth annual WIRED Health event at The Crick Institute, London on March 13. Discover some of the fascinating insights from the speakers here: http://wired.uk/O6xMxJ ABOUT WIRED EVENTS WIRED events shine a spotlight on the innovators, inventors and entrepreneurs who are changing our world for the better. Explore this channel for videos showing on-stage talks, behind-the-scenes action, exclusive interviews and performances from our roster of events. Join us as we uncover the most relevant, up-and-coming trends and meet the people building the future. ABOUT WIRED WIRED brings you the future as it happens - the people, the trends, the big ideas that will change our lives. An award-winning printed monthly and online publication. WIRED is an agenda-setting magazine offering brain food on a wide range of topics, from science, technology and business to pop-culture and politics. CONNECT WITH WIRED Web: http://po.st/WiredVideo Twitter: http://po.st/TwitterWired Facebook: http://po.st/FacebookWired Google+: http://po.st/GoogleWired Instagram: http://po.st/InstagramWired Magazine: http://po.st/MagazineWired Newsletter: http://po.st/NewslettersWired




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Correction: Enhancing the chemotherapeutic efficacy of platinum prodrug nanoparticles and inhibiting cancer metastasis by targeting iron homeostasis

Nanoscale Horiz., 2024, 9,2067-2068
DOI: 10.1039/D4NH90069C, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fang Ding, Lingpu Zhang, Hao Chen, Haiqin Song, Shiguo Chen, Haihua Xiao
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Researchers develop new genetic model to decode breast cancer




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Scientists to probe if grape juice chemical can prevent bowel cancer




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New antibody could be promising cancer treatment: Study




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Google developing nanoparticles to detect cancer




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Cancer cell fingerprints in blood may speed up diagnosis




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Australian researchers discover new treatment for prostrate cancer




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Bespoke cancer vaccines hold promise

They are designed to make a patient’s immune system attack tumours




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Diabetes drug may raise bladder cancer risk: study

Compared with no thiazolidinedione use, pioglitazone associated with an overall 63 p.c. increased risk




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Compound in turmeric may treat colon cancer: study

Researchers from Saint Louis University in the United States have said that curcumin, an active ingredient in the spice, holds promise in treating such cancers.




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Novel drug compound inhibits skin cancer in mice, finds study




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‘Cervical cancer can possibly be eliminated’

India lagging behind in implementing cervical cancer vaccines in its national immunisation programmes, says Dr. R. Sankaranarayanan, Special Advisor on cancer control




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Blood cancer day: More people urged to sign-up as stem cell donors, given the shortage 

Thousands of patients are in dire need of matching stem cell donors to undergo life-saving transplants




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Don’t trivialise cancer with a stunt

By faking her death to cervical cancer, Poonam Pandey has done a disservice to cancer awareness



  • From the Viewsroom

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IBM’s Supercomputer helps doctors to fight cancer

Watson Supercomputer gets hidden insights from 15 million pages of medical content, including more than 200 medical textbooks. The computer combines Artificial Intelligence and analytical software to perform as a question answering machine.




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Gennova Biopharmaceuticals launches a paediatric pack of pegaspargase, to treat rare blood cancer

The drug, marketed as Hamsyl – Junior will now be available in a 1500 IU pack, and is priced at ₹Rs 20,970, a company official told businessline




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US’ Memorial Sloan Kettering Cancer Centre builds on India-connect at multiple levels 

“In addition to patient care, MSK has been running successful  educational programmes” - Dr Mrinal Gounder, Sarcoma oncologist, and Early drug development specialist at MSK




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Alcohol and Cancer Risk

A fact sheet that summarizes the evidence linking alcohol consumption to the risk of various cancers. Includes information about factors that affect the risk of alcohol-associated cancers, such as a person’s genes and tobacco use.




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Primary Bone Cancer

A fact sheet about the diagnosis and treatment of cancers that develop in the bones.




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Secondhand Smoke and Cancer

A fact sheet that summarizes the studies on the health effects of exposure to environmental (secondhand) tobacco smoke.




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Electromagnetic Fields and Cancer

A fact sheet about research on electric and magnetic fields and studies examining their potential connection with cancer.




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Cell Phones and Cancer Risk

A fact sheet that outlines the available evidence regarding use of cellular/mobile telephones and cancer risk.




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Hormone Therapy for Prostate Cancer

A fact sheet that describes hormone therapy and its role in treating prostate cancer. Includes information about the different types of hormone therapy, how they are used, and possible side effects.




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Genetic Testing for Inherited Cancer Susceptibility Syndromes

A fact sheet about genetic testing for inherited cancer risk, including who should consider testing, how to understand test results, and who has access to a person’s test results. Also contains information about at-home, or direct-to-consumer, genetic tests.




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Targeted Cancer Therapies

A fact sheet that describes targeted cancer therapies, which are drugs that interfere with specific molecules involved in cancer cell growth and survival.




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Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chem. Soc. Rev., 2024, Advance Article
DOI: 10.1039/D4CS00404C, Review Article
Xiaodan Jia, Yue Wang, Yue Qiao, Xiue Jiang, Jinghong Li
This review provides a comprehensive summary of the dysregulation of redox metabolism in cancer cells and the advantages and the latest advances in nanomaterial-assisted redox metabolic regulation therapy.
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