This week, Xcel Energy announced plans to retire its last two coal plants in the Upper Midwest a decade earlier than scheduled. The acceleration of the coal closures is part of the company’s clean energy transition that includes expanding wind and solar, using natural gas and operating its Monticello nuclear plant until at least 2040.

This week, Xcel Energy announced plans to retire its last two coal plants in the Upper Midwest a decade earlier than scheduled. The acceleration of the coal closures is part of the company’s clean energy transition that includes expanding wind and solar, using natural gas and operating its Monticello nuclear plant until at least 2040.

This week, Xcel Energy announced plans to retire its last two coal plants in the Upper Midwest a decade earlier than scheduled. The acceleration of the coal closures is part of the company’s clean energy transition that includes expanding wind and solar, using natural gas and operating its Monticello nuclear plant until at least 2040.

Overtime pay, a barometer of strength in corporate activity, also fell at a record pace in March, data showed.

Kitchen Talks is a social project that aims to connect different groups in Israeli society.

A luxurious estate in Boulder's Knollwood neighborhood is on the market for $7.5 million.

ADBI, CCAF, and the JBSEEL are offering an 8-week Online Course on Fintech & Regulatory Innovation and related scholarships for select policy makers from Asian Development Bank developing member countries.

Title: Genetic Changes May Dictate Course of Acute Myeloid Leukemia
Category: Health News
Created: 5/1/2008 2:00:00 AM
Last Editorial Review: 5/1/2008 12:00:00 AM

A time course experiment is a widely used design in the study of cellular processes such as differentiation or response to stimuli. In this paper, we propose time course regulatory analysis (TimeReg) as a method for the analysis of gene regulatory networks based on paired gene expression and chromatin accessibility data from a time course. TimeReg can be used to prioritize regulatory elements, to extract core regulatory modules at each time point, to identify key regulators driving changes of the cellular state, and to causally connect the modules across different time points. We applied the method to analyze paired chromatin accessibility and gene expression data from a retinoic acid (RA)–induced mouse embryonic stem cells (mESCs) differentiation experiment. The analysis identified 57,048 novel regulatory elements regulating cerebellar development, synapse assembly, and hindbrain morphogenesis, which substantially extended our knowledge of cis-regulatory elements during differentiation. Using single-cell RNA-seq data, we showed that the core regulatory modules can reflect the properties of different subpopulations of cells. Finally, the driver regulators are shown to be important in clarifying the relations between modules across adjacent time points. As a second example, our method on Ascl1-induced direct reprogramming from fibroblast to neuron time course data identified Id1/2 as driver regulators of early stage of reprogramming.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

Mammographic breast density is a strong risk factor for breast cancer. We comprehensively investigated the associations of body mass index (BMI) change from ages 10, 18, and 30 to age at mammogram with mammographic breast density in postmenopausal women. We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women. At the time of mammogram, the mean age was 57.9 years. Compared with women who had a BMI gain of 0.1–5 kg/m² from age 10, women who had a BMI gain of 5.1–10 kg/m² had a 24.4% decrease [95% confidence interval (CI), 6.0%–39.2%] in volumetric percent density; women who had a BMI gain of 10.1–15 kg/m² had a 46.1% decrease (95% CI, 33.0%–56.7%) in volumetric percent density; and women who had a BMI gain of >15 kg/m² had a 56.5% decrease (95% CI, 46.0%–65.0%) in volumetric percent density. Similar, but slightly attenuated associations were observed for BMI gain from ages 18 and 30 to age at mammogram and volumetric percent density. BMI gain over the life course was positively associated with nondense volume, but not dense volume. We observed strong associations between BMI change over the life course and mammographic breast density. The inverse associations between early-life adiposity change and volumetric percent density suggest that childhood adiposity may confer long-term protection against postmenopausal breast cancer via its effect of mammographic breast density.

The star of M*A*S*H, The Long Goodbye – and more recently, Friends – talks about drugs, his fiery marriage to Barbra Streisand and getting his best reviews from Groucho Marx and Muhammad Ali

The best review ever received by Elliott Gould – renowned actor and star of M*A*S*H and The Long Goodbye; not to mention, Ross and Monica’s dad on Friends – was from Groucho Marx. The two of them had become close in the comedian’s latter years – so close, Gould says, “he used to let me shave him”. One day Marx asked Gould to change a lightbulb in his bedroom. Gould took off his shoes, stood on the bed and replaced the broken bulb. Marx told him: “That was the best acting I’ve ever seen you do.”

Gould, now 81, has been telling the story for decades – but it is clear even in our pixelated video call that it still delights him. “Isn’t that great?” he says, his distinctive nasal, New York baritone now deepened with age. As we speak he is sitting at a computer at a friend’s house in Los Angeles, relaxed in a blue hoodie, with a seemingly bottomless mug of coffee before him. In isolation on either side of the Atlantic, neither of us has anywhere to be. And after more than half a century in Hollywood, in which he went from leading man to exile and, eventually, fixture – Gould could fill days, not just hours, with his stories. Even without his eight-year marriage to Barbra Streisand.

The basic coaching course will be attended by 32 senior men and 23 senior women core probables on May 11 and 15 respectively.

Enemies of the U.S. Army are now deliberately hiding targets behind mountain ridges, under bridges, in rocky crevices and other locations intended to elude state-of-the art GPS-guided artillery round attacks -- complicating U.S. efforts to pinpoint and destroy targets

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Follow our live coronavirus updates here Coronavirus: the symptoms

Captain Tom Moore and Michael Ball are on course to score a number one single for their cover of You'll Never Walk Alone.

A mile-wide asteroid is on course to pass the Earth on Wednesday at a distance 16 times further than the moon.

For years I have been warning that hatred kills. Like it did in Orlando last Sunday. Or like it did in Britain last Thursday. When the gentle, decent Labour MP Jo Cox was shot and stabbed to death by a another cowardly bigot. And I've also warned that the same poison was spreading in Canada. Where [...]

Prime Minister Justin Trudeau says it's a fundamental principle of life in Canada that no one should have to go to work if they don't feel safe doing so.

While many parts of our economy remain shuttered and other sports continue to wait for the go ahead to resume play, courses in all 10 provinces will soon be open for business.

From headlining the Super Bowl to reading up on Plato...

The French government is pushing for the rest of Europe's top football leagues to follow Ligue 1's example and end the 2019-20 season, according to reports in France.

Un comité est formé pour repenser le modèle des compétitions de course.

The world's third-largest cruise ship operator cast doubt on its ability to stay afloat as a company for much longer, even as one of its biggest rivals said it is taking its first tentative steps toward reopening after COVID-19.

Veteran character actor Peter Gerety has a meaty role in Richard Jury's "Working Man" even as the movie shifts from quiet dignity into melodrama.

The Justice Department announced today that it has reached a settlement with Louisiana Tech University and the Board of Supervisors for the University of Louisiana System to remedy alleged violations of the Americans with Disabilities Act (ADA).

It was just confirmed that I'll be teaching in Temple University's RA/QA MS program this spring. Specifically, I'll be teaching the ad-promo course.

If you or anyone you know is interested, please reach out to me for information. The course will be taught out of the Fort Washington campus, but online enrollment is permitted.

Here's the complete schedule of classes for the spring.

Merchants rejoice they finally reopen businesses and greet customers, with social distancing

On May 8, the Center for the United States and Europe at Brookings (CUSE) hosted R. Nicholas Burns, former under secretary of state for political affairs, for the fourth annual Sakıp Sabancı Lecture. Ambassador Burns focused his address on the future of U.S.-Turkish relations. In March, Ambassador Burns retired as the under secretary of state…

Celebrities buying plots of land to block developments is the new new. Last year people opposed to the third runway at Heathrow Airport bought up a plot in the middle of the runway in an attempt to thwart it. Now opponents to

Unemployed workers are gaining free access to 3,800 courses created by elite universities and companies such as Amazon to learn skills and gain professional certificates for new job opportunities.

Blackstone chief investment strategist Joseph Zidle predicts the Federal Reserve won't ease as much as Wall Street wants.

The provision contained in section 136 of the CGST Act, 2017 also states that a statement made and signed by a person on appearance in response to any summons issued under section 70 during the course of any inquiry or proceedings under this Act shall be relevant for the purpose of proving in any pr

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British medical journal’s editorial says the Brazilian president’s disregard for lockdown measures is damaging

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The biggest threat to Brazil’s ability to successfully combat the spread of the coronavirus and tackle the unfolding public health crisis is the country’s president, Jair Bolsonaro, according to the British medical journal The Lancet.

In an editorial, The Lancet said his disregard for and flouting of lockdown measures was sowing confusion across Brazil, which reported a record number of Covid-19 deaths on Friday, and is fast emerging as one of the world’s coronavirus hot spots.

At the Automattic Grand Meetup, 2019, @zeldman shares a tale from his childhood.
#standup #comedy #zeldman #WordPress #Automattic

The post Crash Course in Judaism appeared first on Zeldman on Web & Interaction Design.

Winter is finally here, and the wait for Game Of Thrones (GoT) has been long enough to test everyone’s patience. To commemorate the launch of the final season, Star World organised an eventful, five-course Westerosi meal fit for the ruler of Seven Kingdoms earlier this week. With expectations riding high, we ventured into what looked like an inspiration from the red wedding — the dining arena.

As we sat down to ravish the interesting spread created by a culinary team at The A Club helmed by chef Amit Bharadwaj, five iconic scenes from the show were screened. Chef Bharadwaj explained how each dish was conceptualised. For the first course, we tasted sumac chicken tostada, which is soft melted grilled chicken on a tortilla chip with a lace of tangy-spicy red sauce pressed on mayonnaise with fenugreek used as garnishing. It was unanimously one of the better dishes, but who can have just three portions? This one was actually inspired by the red wedding when — spoiler alert — Walder Frey kills the Stark family.

Seared tuna with curry leaf, lemon ice

For the second course, the chef drew inspiration from the scene when the Night King slays Daenerys’ dragon Viserion and turns him into the undead. As envisioned by the scene, the chef laid the next dish and called it seared tuna with curry leaf and lemon ice. While the seared tuna was to indicate the dragon, he used lemon ice to mirror the spear of the Night King. The pan-seared tuna not only looked appetising but was also rich in flavour. The minty feel of the lemon ice on the thin slices of fish left us wanting more.

The third course, eggs in a pyre of root vegetables, looked interesting but didn’t match our palate’s expectations. Interestingly, the dish came served with two different sauces that were shaped like eggs in a basket made of vermicelli along with olives placed on the heap of veggies. As for the main course, the chef tried his own variation on spaghetti and meatballs. Of course, it initially reminded us of Frey’s pie, but the taste didn’t seem any different. The chef got the inspiration from the skull-crushing The Mountain vs Oberyn Martell scene. Called snake spaghetti with mountain goat polpette, this dish was just about average.

And as a fitting finale, gold-crusted coconut panna cotta, heart of dark chocolate olive dust and Verbena glass, was the perfect finish to this meal. Chefs tend to increase the coconut flavour in panna cotta, but this version was well-balanced, with melting chocolate (although not dark) inside and a sprinkle of gold not only making it visually appealing but also delightful to eat.

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The dinner was a one-off event at A Club, Lower Parel.

Jagadamb refers to the ancestral deity Tulja Bhavani whose shrine sits in the mid-size city of Tuljapur in Osmanabad district. But, in present-day Maharashtra, the term Jagadamb rises above the geographical address. It is an embodiment of the feisty street-fighting youth, belonging to the Marathas or other backward castes, who owe their allegiance to a goddess who was also the motivation for Maharashtra's most-revered Chhatrapati Shivaji. Flashed on hooded T-shirts and pullovers, 'Jagadamb' has emerged topmost among the potent watchwords currently dominating popular discourse. Online sales and offline retail purchases across the state speak for the all-seasons connect of Jagadamb, which has takers irrespective of commemorative days and morcha schedules.

Abhijit Tarphe, a Dadar-based calligraphy artist, creates tees that occupy the fun space between political discourse, street lingo and social commentary. Pic/Ashish Raje

Apparel carrying longer mantras of Maratha loyalty — Ek Maratha Lakh Maratha, Hoy Maratha and Amhi Shivrayanche Sainik — have enjoyed cyclical demand, corresponding with the calendar of the 58 silent marches held last year. As the anecdote goes, Maratha T-shirts are in a "politically dormant" state at the moment. But fiery speaker (at the Maratha Kranti Morcha) and advocate from Aurangabad, Swati Nakhate Patil, feels T-shirts are effective communication tools. "What better reminder of the time when we took to the streets for reservations and equal terms? The identifiable catch lines recap our journey so far." T-shirt messages, she thinks, help in creating a family of volunteers. She'd know considering she is head of the Akka Foundation which has initiated a reform movement against socials ills like dowry and superstition among the Marathas. The foundation's signature T-shirt, wears a generic slogan – Sarvansathi Sarva Kahi – which indicates a wider fight for everyone's rights.

Swati Nakhate Patil, seen here with volunteers wearing their signature tee with the slogan, Sarvansathi Sarva Kahi. She heads the Akka Foundation which is fighting against socials ills. She has been one of the main speakers at the Maratha Kranti Morcha over the last one year

"The Marāthās" is a collective term referring to an Indo Aryan group of Hindus, Marathi-speaking castes of warriors and peasants who created an empire, covering a major part of India. They are not alone in the fight for rights. Another rights movement that's currently finding a reflection on T-shirts through creative slogans, photographs and graphic designs concerns the Lingayat community. They are seeking legal recognition as a religion distinct from Hinduism. Inspired by the success of their counterparts in Karnataka, the Lingayats in Maharashtra (some of whom have thronged Mantralaya too) are pressing for their religious minority status on T-shirts, which sing paeans to 12th century social reformer, philosopher and statesman Basaveshwara.

The Killa brand of tees focuses on Maratha pride associated with Chhatrapati Shivaji, and his various forts

He rejected temple worship by replacing it with direct worship of Shiva in the form of the Ishtalinga necklace, the image of the linga set in a silver casket, to be worn at all times close to the heart. Little wonder that both, Basaveshwara and the Shiv linga prominently feature on the T-shirts. As a professor of history and a keen observer of progressive movement slogans, Satara-based Amrut Salunkhe points out an interesting contradiction in the Lingayat factions. Not all sub-sects recognise Basava as the founder, but they don't seem to mind the T-shirt — available in Kannada and Marathi typography — carrying the phrase, Jai Vishwaguru Dharmsansthapak Basaveshwar! "The dissident factions have not yet come up with a counter icon. At this point, two different T-shirt creatives wouldn't have helped in lobbying for the larger Lingayat brotherhood," Salunkhe feels.

Theme T-shirts honouring the men of letters in the Marathi cultural world have been in currency for two decades; a recent manifestation was seen during a death anniversary of late Namdeo Dhasal whose fans wore the poet-ideologue's world view on a memorial T-shirt. The Bharatiya brand made use of faces of popular litterateurs like PL Deshpande and Narayan Surve, just as it made good use of the Marathi Abhiman Geet, and distributed T-shirts on Ashadi Ekadashi, Holi and Ganesh Chaturthi. They fashioned kid-centric lyrical sequence tees on monsoon joys too. Bharatiya has now extended its T-shirt ideation to Hindi and is soon to come up with Tamil messages. Their fare was earlier vended at literary summits, before it grew popular online, somewhat in the provincial cosmos where the Killa T-shirts thrived. Designed by Malvan-based artist and JJ School of Applied Art alumnus Arun Amberkar, Killa garments focus on the fortresses built by Chhatrapati Shivaji. The iconic rajmudra (official signature) T-shirt has been a hit for over a decade. Amberkar calls the line "lovingly crafted, wearable and usable slivers of history."

Dadar-based calligraphy artist Abhijit Tarphe feels customised tees are a fun zone for current affairs to find a rightful space. His T-shirts displayed apt word play (Sonu, tuza mazhyavar bharvasa nay ka?) when RJ Mallishka had attacked the BMC. He captures the Mumbai commuter spirit in the line, Mili to BEST, Nahi Toh Next.
Tarphe also has a range of occasion-based T-shirts like the tricolour-filled Independence Day special or Gokulashtami's Aya Makhan Chor creative. It is another story that T-shirts for Gokulashtami and Holi usually are gifted by political party leaders, chiefly Shiv Sena Shakha Pramukhs.

Jai Bhim T-shirts as a community-building tool have worked well over the years, not just for the April 14 Babasaheb Ambedkar Jayanti or the December 6 Mahaparinirvan Din. The apparel also comes in handy for Buddha Jayanti and during any political rally Dalit groups organise. This year, a Goregaon-based youth association, designed a special T-shirt declaring Mazhi Chaityabhoomi, Swacchabhoomi (My clean Chaityabhoomi). It served two political purposes; an affirmation of the Swacch Bharat mantra, challenging the stereotypical notion of Dalits arriving from rural Maharashtra who converge at Dadar's Shivaji Park Chaityabhoomi and litter.

T-shirt messaging extends to a range of causes — Separate Vidarbha; Who Killed Judge Loya?; Make (Women Safe) in India; Rape Roko; India Against Corruption; Donate Eyes; Pinkathon run against breast cancer. It has also been used to add cohesion to groups (I am with Anna Hazare; Desh Me Narendra/ Pradesh Me Devendra) or merely declare strength (Dr B R Ambedkar: King Number 1) or sport a vibe (Dude Please, Thane is not Bombay!/ Delhi is about Mera Baap Kaun Hai, Mumbai is about Who I am). T-shirts can help start a conversation, from the polite to the political.

Sumedha Raikar-Mhatre is a culture columnist in search of the sub-text. You can reach her at sumedha.raikar@gmail.com

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Ayushmann Khurrana has enrolled himself for an online course on Indian history. The actor-singer considers learning a life-long process. "I'm a seeker of knowledge," he says. Being a history buff, he decided to make the most of the current time on hand.

"We have a fascinating history; it's rich and diverse. I want to learn more about our past. The session will be an enriching and fulfilling experience," he adds. It will also come in handy if Khurrana is roped in for a historical in the future.

Recently, Ayushmann, accompanied by Virat Kohli, Kriti Sanon and Sara Ali Khan joined hands for a new initiative called 'Mat Kar Forward'. Sharing the same on Instagram, Ayushmann wrote, "No one thought they'd catch it, no one thought it would become a pandemic. But we can change this and the change begins with you. #MatKarForward @indiatiktok"

 

 

 

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A post shared by Ayushmann Khurrana (@ayushmannk) onMay 4, 2020 at 1:25am PDT

The initiative urges people to not share any unverified message, picture or video, on any social networking sites.

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While sports stars across the globe are trying their hands at doing things they never got to do thanks to the Coronavirus lockdown, Bulgarian tennis star Grigor Dimitrov has revealed he will be taking up a course at the Harvard Business School soon.

In a column for the ATP Tour website, Grigor wrote: "I'm starting a course at Harvard Business School in a few weeks. It's something I've always wanted to do. I loved being in school, but haven't had the chance to experience it to the extent that I would have wanted to. Now I have the time to do something new and different."

Grigor, who is currently in California, USA, during quarantine, added: "I decided to stay on the west coast of the US once it was announced that Indian Wells was cancelled. Tennis players are creatures of habit, so I still make sure to structure my day. Go to bed on time, wake up early, be productive in the morning. I'm a crazy fanatic when it comes to laundry and have been doing that twice a day."

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

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