Impaired baroreflex sensitivity (BRS) predicts cardiovascular mortality and is prevalent in long-term diabetes. We determined spontaneous BRS in patients with recent-onset diabetes and its temporal sequence over 5 years by recording beat-to-beat blood pressure and R-R intervals over 10 min. Four time domain and four frequency domain BRS indices were computed in participants from the German Diabetes Study baseline cohort with recent-onset type 1/type 2 diabetes (n = 206/381) and age-matched glucose-tolerant control subjects (control 1/control 2: n = 65/83) and subsets of consecutive participants with type 1/type 2 diabetes who reached the 5-year follow-up (n = 84/137). Insulin sensitivity (M-value) was determined using a hyperinsulinemic-euglycemic clamp. After appropriate adjustment, three frequency domain BRS indices were reduced in type 2 diabetes compared with control 2 and were positively associated with the M-value and inversely associated with fasting glucose and HbA_1c (P < 0.05), whereas BRS was preserved in type 1 diabetes. After 5 years, a decrease in one and four BRS indices was observed in patients with type 1 and type 2 diabetes, respectively (P < 0.05), which was explained by the physiologic age-dependent decline. Unlike patients with well-controlled recent-onset type 1 diabetes, those with type 2 diabetes show early baroreflex dysfunction, likely due to insulin resistance and hyperglycemia, albeit without progression over 5 years.

Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa isolates recovered from cystic fibrosis (CF) patients is further enhanced by the occurrence of hypermutator strains, a hallmark of chronic infections in CF patients. However, the within-patient genetic diversity of P. aeruginosa populations related to antibiotic resistance remains unexplored. Here, we show the evolution of the mutational resistome profile of a P. aeruginosa hypermutator lineage by performing longitudinal and transversal analyses of isolates collected from a CF patient throughout 20 years of chronic infection. Our results show the accumulation of thousands of mutations, with an overall evolutionary history characterized by purifying selection. However, mutations in antibiotic resistance genes appear to have been positively selected, driven by antibiotic treatment. Antibiotic resistance increased as infection progressed toward the establishment of a population constituted by genotypically diversified coexisting sublineages, all of which converged to multidrug resistance. These sublineages emerged by parallel evolution through distinct evolutionary pathways, which affected genes of the same functional categories. Interestingly, ampC and ftsI, encoding the β-lactamase and penicillin-binding protein 3, respectively, were found to be among the most frequently mutated genes. In fact, both genes were targeted by multiple independent mutational events, which led to a wide diversity of coexisting alleles underlying β-lactam resistance. Our findings indicate that hypermutators, apart from boosting antibiotic resistance evolution by simultaneously targeting several genes, favor the emergence of adaptive innovative alleles by clustering beneficial/compensatory mutations in the same gene, hence expanding P. aeruginosa strategies for persistence.

In patients with renal impairment (n = 22 of 39), the median serum concentrations of linezolid, PNU-142300, and PNU-142586 were 1.6-, 3.3-, 2.8-fold higher, respectively, than in patients without renal impairment. Metabolite concentrations in paired samples were poorly correlated with linezolid concentrations (r² = 0.26 for PNU-142300 and 0.06 for PNU-142586). Linezolid and its metabolites share potential toxicophores that deserve characterization to mitigate higher myelosuppression risk in patients with renal impairment.

Mismatch repair (MMR)–deficient tumors exhibit proteome-wide protein instability and aggregation.

BACKGROUND AND PURPOSE:

Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences.

MATERIALS AND METHODS:

This was a retrospective study performed in 16 patients with Menière disease who underwent 3T MR imaging 4 hours after gadolinium injection using two 3D-FLAIR sequences with a constant flip angle at 140° for the first and a heavily-T2 variable flip angle for the second. The signal intensity ratio was measured using the ROI method. We graded endolymphatic hydrops and evaluated the cochlear blood-labyrinth barrier impairment.

RESULTS:

Both for symptomatic and asymptomatic ears, the median signal intensity ratio was significantly higher with the constant flip angle than with the heavily-T2 variable flip angle (7.16 versus 1.54 and 7.00 versus 1.45, P < .001). Cochlear blood-labyrinth barrier impairment was observed in 4/18 symptomatic ears with the heavily-T2 variable flip angle versus 8/19 with constant flip angle sequences. With heavily-T2 variable flip angle sequences, endolymphatic hydrops was observed in 7–10/19 symptomatic ears versus 12/19 ears with constant flip angle sequences. We found a significant association between the clinical symptomatology and the presence of endolymphatic hydrops with constant flip angle but not with heavily-T2 variable flip angle sequences. Interreader agreement was always perfect with constant flip angle sequences while it was fair-to-moderate with heavily-T2 variable flip angle sequences.

CONCLUSIONS:

3D-FLAIR constant flip angle sequences provide a higher signal intensity ratio and are superior to heavily-T2 variable flip angle sequences in reliably evaluating the cochlear blood-labyrinth barrier impairment and the endolymphatic space.

1. Location: - Lotus Villa & Shophouse located in Ciputra Township, Vo Chi Cong street, Tay Ho District, Hanoi, Vietnam. It's close to Nhat Tan bridge. It takes 15 minutes to Airport/ 20 munites to Centre of Hanoi. - It's close to Hong River & West Lake so that the Environment he...

Hotel for sale The hotel is near Noi Bai Airport, only 800 meters away to International Terminal. It contains 11 rooms for guest and 1 room for family host spread over 5 storeys. Price is 9.2 billion VND included all furniture and system set up for the hotel.Please contact for v...

Studio for rent (www.mkhome.vn) at 159/9 Bach Dang Street, Ward 2, Tan Binh District, cool and airy, full of light, good ventilation. The house is taken care of and kept clean. Quiet space, suitable for IT staff, foreign Ng teachers, flight attendants, pilots, long-term business ...

Nice Studio for rent (www.mkhome.vn) at 159/9 Bach Dang Street, Ward 2, Tan Binh District - Cool and airy, full of light, good ventilation. -The house is taken care of and kept clean. - Quiet neighbour, suitable for IT staff, foreign teachers, flight attendants, pilots, long-ter...

The room is beautiful, clean and convenience. On top of that, it nears to the airport. We have free wifi, amenities, modern furniture, elevator, TV. We also have a kitchen shared with everyone. In the kitchen, we have modern equipment for cooking. We have laundry, clothes drier,....

Studio for rent (www.mkhome.vn) at 159/9 Bach Dang Street, Ward 2, Tan Binh District; cool, full of light, good ventilation. The house is taken care of and kept clean. Quiet space, suitable for IT staff, foreign teachers, flight attendants, pilots, long-term business travellers i...

Studio at 159/9 Bach Dang, Ward 2, Tan Binh district, cool, full of light, good ventilation. The house is taken care of and kept clean. Quiet space, suitable for IT staff, foreign teachers, flight attendants, pilots, long-term business travellers in Saigon, students, ... Price: E...

- 3 minutes from the airport by motorbike - The house is well-maintained and clean - Quiet space, suitable for IT staff, foreign teachers, flight attendants, pilots, long-term business travellers in SG, students, ... - Price: Equal to 1/3 of the hotel. - Long term monthly rental...

Hà Đô Airport Building là dự án văn phòng tiếp nối sự thành công của nhiều dự án bất động sản của Tập đoàn Hà Đô. Dự án nằm trong khu vực đắc địa của sân bay Tân Sơn Nhất, sẽ chính thức đưa vào khai thác tháng 10/2016.

Self-made millionaire David Bach says not buying a home is the single biggest mistake millennials (who were born between 1980 and 2000) are making.

You are preparing your home for sale? Don’t forget to make some small repairs since they can make a big difference both in terms of interest levels and offer prices for the home.

A self-powered device that generates electricity from the wind can also absorb and break down harmful nitric oxide and nitrogen dioxide from the air

The US Navy is researching how to use lasers to form plasma into 2D or 3D infrared images of aeroplanes that can distract heat-seeking missiles

It delivers almost all the functionality Apple promised, with a steep Apple-like price tag to match.

The revolution will be on a website for a midcentury modern bungalow.

The road to haircut hell is paved with good questions. Questions like: Is the coronavirus pandemic the Flowbee’s time to shine?

The Queen gave a 75th anniversary VE Day speech Friday night that doubled as a rallying cry against coronavirus. “Never give up, never despair, that was the message of VE Day,” she told the British people.

Second World War heroes would “recognize and admire,” the sacrifices the British were making today in the fight against coronavirus, the Queen added. It was her second major coronavirus-themed speech to the nation.

“It may seem hard that we cannot mark this special anniversary as we would wish. Instead we remember from our homes and our doorsteps. But our streets are not empty,” the Queen said, “They are filled with the love and the care that we have for each other.”

Read more at The Daily Beast.

Rafael Nadal revealed this week he was doubtful there will be further tennis in 2020.

Watford chairman Scott Duxbury has questioned whether the Premier League should return amid the coronavirus pandemic.

In our atmosphere, strange dense patches of charged air sometimes bounce radio waves around and disrupt radar – and now they have been spotted on Mars

Whether for maintenance or augmentation, robots that can use tools on themselves are more independent and capable

New Zealand’s competition watchdog has cited areas of overlap from a Fairfax-APN merger.

It could be a matter of time before a Chinese airline tries to buy a strategic stake in Qantas.

These are the vent dragons made and sold by artist David Lee Pancake. The dragons are available in a variety of dragony colors, cost $200 apiece, and are made to be hung on the wall, NOT cover an actual air vent. "But--" Hey, if you want to be hot all summer because the A/C isn't blowing in the living room, that's up to you.

Vent Dragons comes with a little remote control to light up the eyes of the two little monsters and surprise your guests and friends. The lights are powered by 3 AA batteries and should burn for 150 hours before you need to replace them. To replace the batteries unscrew the grate and lift off, the batteries are in a small pack inside. The lighted eyes have 8 different settings from fast blinking to continually glowing and there is a timer to turn them off in 6 hours. Enjoy! Size: 12x7 inches. Do NOT install in an actual heating/AC vent.

Gosh, just think how much you could save on home heating and cooling costs if you had ACTUAL fire and ice breathing dragons living in your air vents. I mean granted they'd have to be trained, but I have seen all those movies. Keep going for a few more shots of some of the different colors.

This is a terrifying elevator cam gif from Korea of an elevator that begins ascending before a man enters, tripping him and almost creating a classic horror movie death scene in real life. Thankfully he was able to escape. And this is exactly why I don't take elevators -- or escalators. "So you're a stair guy?" Please *jiggling belly* jetpack or grappling gun only. Thanks to PK, who agrees they always say use the stairs in case of emergency, and what's 2020 if not a nonstop emergency? Besides, how do you social distance in an elevator? I mean if somebody farts everyone smells it.

कोरोना संक्रमण के कारण पूरे देश में लॉकडाउन लगा हुआ है और यह कब खत्म होगा इसका अंदाजा लगाया जाना मुश्किल है। ऐसे में आप भी हर महीने मोबाइल नंबर रिचार्ज करा कर परेशान हो गए हैं, तो यह खबर आपके लिए है।

भारत की दिग्गज टेलीकॉम कंपनी एयरटेल ने अपने ग्राहकों को फायदा पहुंचाने के लिए तीन नए प्री-पेड प्लान लॉन्च किए हैं। इन तीनों प्लान की कीमत 99 रुपये, 129 रुपये और 199 रुपये है।

Things go off the rail before we get to the meat of the show. But we pull it together to discuss what we've been playing, too many Compile Heart games, and a potential dungeon crawling disaster.

People who attended religious services at least once a week were significantly less likely to die from 'deaths of despair,' including deaths related to suicide, drug overdose, and alcohol poisoning, according to new research.

To campaigners’ dismay, the UK’s biggest hubs, Heathrow and Gatwick, are pushing on with plans to increase capacity

Christine Taylor has lived her entire life in the shadow of London’s Heathrow airport, her childhood bedroom affording a view of one of its two runways. She grew up in Sipson, a village that can trace its history back more than 1,000 years, but now sits immediately north of Britain’s busiest airline hub.

Now living a mile to the east in Harlington, Taylor, 62, is experiencing a rare moment of quiet, thanks to the dramatic reduction in air traffic caused by the coronavirus pandemic.

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Staff of the magazine that kicked off the French New Wave say its new elite owners pose a threat to editorial independence

The mass resignation of the staff of Cahiers du Cinéma, the film journal that launched the French New Wave, has reignited debate in France about the possibility of critical independence in a society whose major stakeholders frequently operate in several spheres.

On Thursday, the 15 staff writers and editors announced their resignation, saying they believed its new owners posed a threat to the magazine’s cherished independence.

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Comfort, however, can be an issue

Noida Police Commissioner has written to national carrier Air India, requesting the airline to ensure that pilots and crew involved in repatriation flights should stay back in Delhi.

New Delhi, May 09 (ANI): An Air India flight carrying 129 passengers from Dhaka, Bangladesh has landed at Delhi airport. The stranded Indian nationals are being brought back to the country through government’s initiative, ‘Vande Bharat Mission’.

Around 250 Indian students and tourists were seen queuing with their luggage at the airport as they prepared for the journey home.

High salt intake seems to impair the immune cells in humans that fight bacteria because of a side effect of the hormones that help get rid of salt

Laser pointer attacks on aircraft have become increasingly rare over the years in Saskatchewan, as figures from Transport Canada show.

Gary Neville took to Twitter to answer questions around Paul Pogba and Bruno Fernandes, and Manchester United's future transfer policy.

From pure, racing-style gaming chairs to rockers and recliners, we've got the bet gaming chairs to fit your seating needs.

The British government has told airlines it will introduce a 14-day quarantine period for most people arriving from abroad to try to avoid a second peak of the coronavirus pandemic, an association representing the airlines said on Saturday.

Shelling of Tripoli's Mitiga airport early on Saturday, part of an intensified barrage of artillery fire on the capital in recent days, hit fuel tanks and damaged passenger planes, the Transport Ministry said in a statement.

We've picked some of the best projects recently completed in our project log forum.

BRITONS flocked outside to celebrate the 75th anniversary of VE Day yesterday, which caused major backlash online, especially against the BBC.

The unified anti-Trump effort has already spent millions on attacking the Trump administration's handling of the virus, or praising former Vice President Joe Biden on the issue.