The invention relates to embedding data symbols of a data signal into a luminance output of an illumination device. The device includes a controller configured for receiving a first base pattern and a second base pattern within a frame period, and generating a shifted second pattern by phase shifting the second base pattern within the frame period with respect to the first base pattern in response to the data signal such that the data symbols are embedded in the luminance output of the device. The device also includes a first light source configured to generate a first luminance output in response to the first base pattern and a second light source configured to generate a second luminance output in response to the shifted second pattern. The first and second luminance outputs have different output spectra and the luminance output of the illumination device comprises both the first and second luminance outputs. With this approach, the short-time average light output of the illumination device remains constant, decreasing the visible flicker and allowing the use of lower switching frequencies relative to the prior art approaches.

Disclosed is a transmitter optical module which includes a first package generating an optical signal; a second package bonded with the first package by using chip-to-chip bonding, having a silicon optical circuit platform structure, and amplifying the optical signal; and an optical waveguide forming a transmission path of the optical signal from the first package to the second package.

An optical receiver circuit is disclosed in which a number of electrical signals are processed to extract data encoded therein. The electrical signals may be compared during the process to selectively remove one or more waveforms from one or more corresponding electrical signals. Various data signals, each including one or more waveforms, may then be processed to extract the encoded data. The optical receiver circuit reduces, or eliminates, electrical offsets which may be present in one or more of the electrical signals to reduce corresponding errors in the encoded data signals.

It is an object of the present invention to provide a sintered cBN compact having excellent wear resistance and fracture resistance even in machining centrifugally cast iron having a property of being difficult to machine, and to provide a sintered cBN compact tool. A sintered cBN compact of the present invention contains 20% by volume or more and 65% by volume or less of cBN and, as a binder, 34% by volume or more and less than 80% by volume of Al2O3, at least one selected from the group consisting of nitrides, carbides, carbonitrides, borides, and boronitrides of Zr and solid solutions thereof (hereinafter, referred to as “X”), and ZrO2, the total amount of X and ZrO2 being 1.0% by volume or more and 6.0% by volume or less, the volume ratio of ZrO2 to Al2O3, ZrO2/Al2O3, being 0.010 or more and less than 0.100, in which the ratio Itetragonal ZrO2(101)/IαAl2O3(110) is 0.1 or more and 3 or less, where Itetragonal ZrO2(101) is the intensity of the (101) plane of tetragonal ZrO2 and IαAl2O3(110) is the intensity of the (110) plane of αAl2O3 among X-ray diffraction peaks of the sintered cBN compact.

The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device.

Method and apparatus for performing a discrete glucose testing and bolus dosage determination including a glucose meter with bolus calculation function are provided.

An apparatus for storing and dispensing a test strip includes a container configured to store a stack of test strips. The container maintains appropriate environmental conditions, such as humidity, for storing the test strips. An engaging member is disposed in the container and is adapted to contact one test strip of the stack of test strips. An actuator actuates the engaging member to dispense the one test strip from the container. Since one test strip is dispensed at a time, the remaining test strips are not handled by the user. Accordingly, the unused test strips remain free of contaminants such as naturally occurring oils on the user's hand.

The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

A laminated body composed of a holding member and an inner cylinder is arranged between a heat generation element, which is electrically energized to generate heat, and a case which covers the heat generation element, and the inner cylinder has an upstream side end portion extended to a more upstream side than an upstream side end face of said heat generation element and an upstream side end face of said holding member to form an extension portion, which is formed with a protruding portion protruding to an inner side in a diametrical direction. A flow of an exhaust gas, which flows backwards after colliding with the heat generation element, will be obstructed by said protruding portion. As a result, the backflow exhaust gas stops flowing into a gap between the case and the inner cylinder.

A steam cooled chemical reactor (1) comprising a vertical vessel (2), a plate heat exchanger embedded in a catalytic bed, to cool the catalytic bed by evaporation of a cooling water flow, wherein a water inlet and a steam outlet are located underneath the heat exchanger, and the plates and related piping are arranged so that the path of the cooling flow comprises a first ascending path from bottom to top of the catalytic bed, and a second descending path from top to the bottom of catalytic bed, and wherein internal evaporation channels of the plates provide the second descending or the first ascending path, and water upcomers or respectively steam downcomers provide the other of said first and second path.

The present invention extends to a disinfection cap for disinfecting a male luer end of an infusion therapy device. The disinfection cap can include an internal reservoir containing an antimicrobial or saline solution which is sealed with a flexible septum to prevent the solution from evaporating. The septum can include one or more slits or pierceable seams that allow a male luer end of an infusion therapy device to be inserted through the septum and into the solution. While the male luer is inserted through the septum, the solution contacts both the inner and outer surfaces of the male luer. Because the septum reduces evaporation of the solution and prevents the solution from leaking out of the cap, the solution remains in contact with the male luer for a longer duration then when typical disinfection caps are used thereby increasing the effectiveness of the disinfectant.

A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

Microfluidic devices of the present disclosure relate to quick and inexpensive microfluidic manipulation/handling. A number of channels may be supplied with fluid ingredient(s). In some embodiments, a number of protrusions as well as a sealing material may be disposed adjacent to the channels. When the channels are supplied with fluid ingredient(s), the channels may be partitioned into a number of separate cavities that are fluidly isolated from one another. For instance, a sealing material may be compressed so as to deform into the channels, obstructing fluid flow. In some embodiments, the channels supply fluid ingredients to a number of pre-formed cavities. Once the cavities are supplied with fluid ingredient, channels connecting the cavities may be sealed off; that is, the cavities may be subject to fluid isolation. When appropriate, contents within reaction chambers may be subject to further processing (e.g., thermal cycling, various analyses).

A micro device includes a substrate and a structure configured to bind to an object or a material, or not to bind to an object or material. The structure has a roughness based on a roughness of the object or material. For example, a microarray includes a substrate and a well positioned in the substrate and configured to bind to a type of bead. The well has a roughness based on a roughness of the type of bead to which the well is configured to bind. The roughness of the well is controlled by controlling a position and number of striations in the side of the well. In another example, a moveable component of a micro device may have a roughness different from a roughness of an adjacent component, to reduce the likelihood of the moveable component sticking to the adjacent component.

The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

The present invention provides methods and apparatus for efficiently providing accurate temperature control of a microtiter cold plate and precise alignment of the microtiter cold plate with a microtiter plate.

Provided is a masking system of masks for use with multiwell plates such as microtiter plates to facilitate sample dispensing and assay accuracy, especially when dispensing more than one solution into the wells. One or more masks, adapted in size to fit snugly over a multiwell plate and the mask formed with openings each aligned with a subset of one or more wells of the plate beneath, aids the user in sample and/or reagent administration. Advantageously, the masks contain registration aids so that proper orientation with respect to the plate below is achieved; the registration aid may be a cut corner, registration peg or mark, or visual marking or stamping.

An apparatus for sampling and storing biological fluids from a human or animal subject is provided. In one embodiment of the present disclosure, the apparatus includes a main body, lancet carrier or hub, lancet, lancet trigger, capillary tube, and sample compartments for collecting and storing dried blood and other bodily fluids. The lancet hub supports a lancet and provides for moving the lancet longitudinally between a first retracted position and a second extended position. The device includes a capillary tube having an internal diameter sized to draw and retain fluid from a contacted source using capillary action. The main body of the apparatus further includes a sample compartment for holding sampling and storage materials. In at least one embodiment of the present disclosure, the sample compartment can be accessed by lifting sample compartment lid. Also included is a new “fan” or “daisy” shaped collection material format for use in collecting and preserving samples.

A sensing device including an inlet port for receiving a fluid, a measurement chamber for sensing the fluid, a fluid channel coupling the inlet port and the measurement chamber for transporting the fluid from the inlet port to the measurement chamber, and a fluid stop unit for stopping and controllably releasing the flow of fluid between the inlet port and the measurement chamber.

The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.

The present invention generally relates to a sample receiving device for releasably storing a substance. The sample receiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance within the reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasable attachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnel into the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that upon cutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into the sample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.

The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.

A device for capturing a three-dimensional object is presented, which allows, on one hand, a sufficiently large number of projected pixels and a high image quality of the projected pixels, and which has, on the other hand, a compact size and low assembly costs.

The invention refers to a device for recording biometric data, such as lines of finger or hand. A rest is provided on the device for the hand and finger, respectively, as well as an illuminating unit. According to the invention an illuminating unit and/or rest is provided that can traverse and be positioned.

A 3D image sensor includes a depth pixel that includes; a photo detector generating photo-charge, first and second floating diffusion regions, a first transfer transistor transferring photo-charge to the first floating diffusion region during a first transfer period in response to a first transfer gate signal, a second transfer transistor transferring photo-charge to the second floating diffusion region during a second transfer period in response to a second transfer gate signal, and an overflow transistor that discharges surplus photo-charge in response to a drive gate signal. Control logic unit controlling operation of the depth pixel includes a first logic element providing the first transfer gate signal, a second logic element providing the second transfer gate signal, and another logic element providing the drive gate signal to the overflow transistor when the first transfer period overlaps, at least in part, the second transfer period.

An approach for IR-based metrology for detecting stress and/or defects around TSVs of semiconductor devices is provided. Specifically, in a typical embodiment, a beam of IR light will be emitted from an IR light source through the material around the TSV. Once the beam of IR light has passed through the material around the TSV, the beam will be analyzed using one or more algorithms to determine information about TSV stress and/or defects such as imbedded cracking, etc. In one embodiment, the beam of IR light may be split into a first portion and a second portion. The first portion will be passed through the material around the TSV while the second portion is routed around the TSV. After the first portion has passed through the material around the TSV, the two portions may then be recombined, and the resulting beam may be analyzed as indicated above.

A portable, tabletop fluid sampling device simplifies spectral analysis to produce an accurate but inexpensive chromatic fingerprint for fluid samples. In one embodiment, the sampling device uses an array of variable wavelength LED emitters and photodiode detectors to measure Rayleigh scattering of electromagnetic energy from the fluid sample contained in a cuvette. Either the fluid itself, or particles suspended in the fluid can then be identified by performing spectral pattern matching to compare results of a spectral scan against a library of known spectra. A wide range of applications include substance identification, security screening, authentication, quality control, and medical diagnostics.

A defect inspection device has: an illumination optical system which irradiates a predetermined region of an inspection target with illumination light; a detection optical system which has a detector provided with a plurality of pixels by which scattered light from the predetermined region of the inspection target due to illumination light from the illumination optical system can be detected; and a signal processing portion which is provided with a correction portion which corrects pixel displacement caused by change in a direction perpendicular to a surface of the inspection target with respect to a detection signal based on the scattered light detected by the detector of the detection optical system, and a defect determination portion which determines a defect on the surface of the inspection target based on the detection signal corrected by the correction portion.

A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.

Spectroscopy apparatuses oriented to the critical angle of the sample are described that detecting the spectral characteristics of a sample wherein the apparatus consists of an electromagnetic radiation source adapted to excite a sample with electromagnetic radiation introduced to the sample at a location at an angle of incidence at or near a critical angle of the sample; a transmitting crystal in communication with the electromagnetic radiation source and the sample, the transmitting crystal having a high refractive index adapted to reflect the electromagnetic radiation internally; a reflector adapted to introduce the electromagnetic radiation to the sample at or near an angle of incidence near the critical angle between the transmitting crystal and sample; and a detector for detecting the electromagnetic radiation from the sample. Also, provided herein are methods, systems, and kits incorporating the peri-critical reflection spectroscopy apparatus.

A method of optically determining the presence of volcanic ash within a cloud comprises emitting a circularly polarized illuminating beam within a cloud and analyzing backscatter light to identify the presence of volcanic ash within the cloud. The method further includes determining the degree to which the cloud has altered the polarization state of the emitted beam. The index of refraction of the backscatter light and the opacity of the backscatter light are also analyzed.

An estimation device is configured to estimate a feature value of a specific component contained in a sample and includes: a spectral estimation parameter storage module; a calibration parameter storage module; a multiband image acquirer; an optical spectrum operator configured to compute an optical spectrum from a multiband image using a spectral estimation parameter; and a calibration processor configured to compute the feature value from the optical spectrum using a calibration parameter.

An apparatus for securing a diagnostic tool proximate to and in front of a display device between the corners thereof. A harness is adapted to releasably hold the diagnostic tool, a restraining bracket extends from the harness, and there is at least one elastic cord having a first end, an intermediate portion and a second end. The cord is threaded through the restraining bracket and is sized so as to impart elastic tension to the corners of the display device while concomitantly protecting the front surface from pressure due to the position of the harness and diagnostic tool.

A system for imposing and analyzing surface acoustic waves in a substrate to determine characteristics of the substrate is disclosed. Optical elements and arrangements for imposing and analyzing surface acoustic waves in a substrate are also disclosed. NSOM's, gratings, and nanolight elements may be used to impose surface acoustic waves in a substrate and may also be used to measure transient changes in the substrate due to the passage of surface acoustic waves therethrough.

A dispersion managed interferometric fiber optic gyroscope comprising: a coupler coupled to the broadband light source via a first input fiber; an IOC comprising: a beamsplitter that directs the input signal to a first output and a second output; a combiner configured to combine a first return signal from the first output and a second return signal from the second output into a combined return signal; an integrated optical circuit input coupled to the coupler via a second input fiber; a fiber optic gyroscope sensing coil coupled to a first pigtail fiber and second pigtail fiber, the sensing coil comprising sensing fibers, wherein at least one dispersion slope of at least one of the first input fiber, second input fiber, first pigtail fiber, second pigtail fiber, and the sensing fibers is selected such that the signals at the IOC input has a second order coherence substantially equal to two.

Techniques and devices for measuring polarization crosstalk in birefringence optical media including polarization maintaining fiber.

An integrated swept wavelength tunable optical source uses a narrowband filtered broadband signal with an optical amplifier and self-tracking filter. This source comprises a micro optical bench, a source for generating broadband light, a tunable Fabry Perot filter, installed on the bench, for spectrally filtering the broadband light from the broadband source to generate a narrowband tunable signal, an amplifier, installed on the bench, for amplifying the tunable signal. The self-tracking arrangement is used where a single tunable filter both generates the narrowband signal and spectrally filters the amplified signal. In some examples, two-stage amplification is provided. The use of a single bench implementation yields a low cost high performance system. For example, polarization control between components is no longer necessary.

[Problem to be Solved] To improve the measurement accuracy of an interference measurement device which utilizes interference of light. [Means for Solution] An interference measurement device includes a light source 10 for emitting supercontinuum light (SC light), an optical fiber coupler 11 for splitting the SC light into measurement light and reference light, a dispersion compensation element 12, a drive unit 13 for moving the dispersion compensation element 12, and light-receiving means 14 for measuring an interference waveform produced as a result of interference between the measurement light and the reference light. A measurement object 15 to be measured is an Si substrate having a thickness of 800 μm. The dispersion compensation element 12 is an Si substrate having a thickness of 780 μm. Namely, the dispersion compensation element 12 is formed of the same material as that of the measurement object 15 and is 20 μm thinner than the measurement object 15. The interference caused by reflection on the back surface of the measurement object 15 and reflection on the back surface of the dispersion compensation element 12 has a narrow peak width because wavelength dispersion is cancelled almost completely. Thus, the accuracy in measuring the peak position improves. As a result, the accuracy in measuring temperature, etc., improves.

An optical system for occupancy sensing according to the invention includes a plurality of optical line sensors, each consisting of a linear array of light sensing elements; and an optical light integrating device that integrates light from rays with incidence angles subject to geometric constraints to be sensed by a light sensing element.

Ellipsometry systems and ellipsometry data collection methods with improved stabilities are disclosed. In accordance with the present disclosure, multiple predetermined, discrete analyzer angles are utilized to collect ellipsometry data for a single measurement, and data regression is performed based on the ellipsometry data collected at these predetermined, discrete analyzer angles. Utilizing multiple discrete analyzer angles for a single measurement improves the stability of the ellipsometry system.

A projection exposure tool for microlithography for imaging mask structures of an image-providing substrate onto a substrate to be structured includes a measuring apparatus configured to determine a relative position of measurement structures disposed on a surface of one of the substrates in relation to one another in at least one lateral direction with respect to the substrate surface and to thereby simultaneously measure a number of measurement structures disposed laterally offset in relation to one another.

An optical electrical field enhancing device includes: a transparent substrate having a structure of fine protrusions and recesses on the surface thereof; and a metal structure layer of fine protrusions and recesses formed on the surface of the structure of fine protrusions and recesses. The metal structure layer of fine protrusions and recesses has a structure of fine protrusions and recesses, in which the distances among adjacent protrusions are less than the distances among corresponding adjacent protrusions of the structure of fine protrusions and recesses of the transparent substrate.

A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide two- to five-dimensional fluorescence images of samples, including two or three spatial dimensions, a spectral dimension (for fluorescence emission), and a temporal dimension (on a scale of less than approximately one second). Two-dimensional (spatial) images with a complete wavelength spectrum are generated from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The line scans may be formed using one or more of curved mirrors and lenses. The multiple beams may be formed using one of a grating, an array of lenses, and a beam splitter.

Within machine vision, object movement is often estimated by applying image evaluation techniques to visible light images, utilizing techniques such as perspective and parallax. However, the precision of such techniques may be limited due to visual distortions in the images, such as glare and shadows. Instead, lidar data may be available (e.g., for object avoidance in automated navigation), and may serve as a high-precision data source for such determinations. Respective lidar points of a lidar point cloud may be mapped to voxels of a three-dimensional voxel space, and voxel clusters may be identified as objects. The movement of the lidar points may be classified over time, and the respective objects may be classified as moving or stationary based on the classification of the lidar points associated with the object. This classification may yield precise results, because voxels in three-dimensional voxel space present clearly differentiable statuses when evaluated over time.

A reflection type optical sensor that detect a surface condition of a moving body and that is used for an image generation apparatus which forms images on a recording media includes a light-emitting device which has a plurality of light emitter systems including at least two light-emitting members and a light-emitting optical system having a plurality of light-emitting lenses corresponding to a plurality of the light emitter systems and guiding light emitted from the light emitter systems to the moving body and a light-receiving device which has a light receiver system including at least two light-receiving members and a light-receiving optical system having light-receiving lenses corresponding to the at least two light-receiving members and guiding light reflected by the moving body to the light receiver system. The image generation apparatus has further a surface condition judging device in addition to the reflection type optical sensor.

There is disclosed a polarization-modulating element for modulating a polarization state of incident light into a predetermined polarization state, the polarization-modulating element being made of an optical material with optical activity and having a circumferentially varying thickness profile.

An adaptive optics scanning system using a beam projection module with four or more axes of motion that can project and control the position and angle of a beam of light to or from an adaptive optics element. The adaptive optics scanning system is compact in size, overcoming the challenges of a traditional lens and mirror based pupil relay design. The adaptive optics scanning system has little to no dispersion, chromatic aberration, and off-axis aberration for improved optical performance. The system and methods for calibrating and optimizing the system are described. A modular adaptive optics unit that scans and interfaces an adaptive optics element is described.

A binding device includes binding rod portions, coupling portions for coupling a plurality of the binding rod portions, and an axis portion serving as a center upon opening/closing of binding rods. The coupling portions have lower portions to which the axis portion is provided at a position close to base portions of the binding rods so that a leaf bound at the binding rod portions can be flipped along the binding rods and flipped through 360 degrees and leaves can make contact with each other with the axis portion sandwiched therebetween. The axis portion includes a shaft portion and receiving portions for the shaft portion. The receiving portions are provided to the coupling portions the shaft portion is disposed therein.

A binding device includes a plurality of binding rings, a holding member which enables the binding rings to be disposed with a spacing therebetween, an operating member having a surface to which base portions of the binding rings are secured such that the binding rings are disposed with a spacing therebetween, the operating member including a pair of operating pieces movable in the holding member in a longitudinal direction of the holding member, and an opening-closing member which causes the binding rings to be changed in an opening direction. The opening-closing member includes an elastic member. The elastic member is provided in the operating member such that a distance between the operating pieces in an opening-closing direction of the binding rings is maintained at a distance enabling the pair of the operating pieces to be moved and is arranged to move the pair of the operating pieces defining the operating member relative to each other in respective opposite directions and so as to elastically urge the pair of the operating pieces in a direction allowing the binding rings to be held in an opened state.

A scrapbooking page alignment device for temporarily aligning at least two adjacent scrapbook pages having retention receivers extending from their respective spine edges, the device comprising (i) a base; and (ii) two or more spaced retention posts extending from said base; where said retention posts are dimensioned to temporarily receive the retention receivers of the two adjacent scrapbook pages.