av Traveling to Asia? Here’s Why You Should Try Dragon Tiger By www.upgradetravelbetter.com Published On :: Sat, 22 Jul 2023 07:36:51 +0000 Key Takeaways Description Dragon Tiger’s Popularity Dragon Tiger is a popular game in Asian casinos due to its simplicity and speed. Cultural Experience Playing Dragon Tiger offers travelers a unique cultural experience and a chance to engage with locals. Online Play Dragon Tiger can be played online, allowing travelers to enjoy the game regardless of […] The post Traveling to Asia? Here’s Why You Should Try Dragon Tiger first appeared on UPGRADE: TRAVEL BETTER. Full Article Travel
av Traveling to India: A Deep Dive into the World of Andar Bahar By www.upgradetravelbetter.com Published On :: Sat, 29 Jul 2023 00:17:03 +0000 Introduction India is a place full of diverse cultures and traditions that offers many fascinating experiences for curious travelers. One such experience that provides a unique glimpse into Indian culture is the classic card game Andar Bahar. With its simple yet engaging gameplay, Andar Bahar has been a beloved pastime across India for generations. For […] The post Traveling to India: A Deep Dive into the World of Andar Bahar first appeared on UPGRADE: TRAVEL BETTER. Full Article Travel
av News24 | Heat attack: 2024 is world's hottest year, and likely to leave South Africans sweating this summer By www.news24.com Published On :: Wednesday Nov 13 2024 04:45:18 The World Meteorological Organisation (WMO) has raised the alarm over climate change, reporting 2024 is the world's hottest year yet. Full Article
av News24 | Do you have any complaints or feedback about News24's content? Here's how to get in touch By www.news24.com Published On :: Tuesday Oct 08 2024 20:38:59 Any complaints, queries or suggestions about content on News24 may be sent to our public editor George Claassen. Full Article
av Why We Made a Home Air Purifier Part of Our Travel Lifestyle By vagabondish.com Published On :: Sat, 01 Aug 2020 18:05:40 +0000 A minimal design, compact size, and true HEPA filter make Sharp's FPK50UW Air Purifier an affordable clean-home solution for travelers. The post Why We Made a Home Air Purifier Part of Our Travel Lifestyle appeared first on Vagabondish. Full Article Modern Vagabond Review Air Purifier
av How We Travel with a Cat in Our Tiny 17' Casita Travel Trailer By vagabondish.com Published On :: Wed, 09 Dec 2020 16:08:22 +0000 Traveling with dogs is easy; cats not so much. Here's everything we've learned about traveling with cats in a travel trailer or RV. The post How We Travel with a Cat in Our Tiny 17′ Casita Travel Trailer appeared first on Vagabondish. Full Article Features RV Travel
av Travel Trailer Accessories You Absolutely Need (Read This BEFORE Your First Trip) By vagabondish.com Published On :: Fri, 11 Dec 2020 15:57:34 +0000 Iif you're a new owner or just bought your first travel trailer, these are the must-have travel trailer accessories that may not have occurred to you. The post Travel Trailer Accessories You Absolutely Need (Read This BEFORE Your First Trip) appeared first on Vagabondish. Full Article RV Travel travel trailer
av Woah! Woman waves at a stranger's cat — and much to her surprise, it waves back (video) By boingboing.net Published On :: Tue, 01 Oct 2024 17:51:38 +0000 While on a walk, a woman saw a tuxedo cat in a window and greeted it with a wave. But she never imagined the cat would return the greeting, lifting its paw to say "hey." "How many aura points did I gain when I waved to a cat and it waved back," says the caption of her TikTok video, accompanied by footage of the surreal exchange. — Read the rest The post Woah! Woman waves at a stranger's cat — and much to her surprise, it waves back (video) appeared first on Boing Boing. Full Article Post animals cats cute Delightful Creatures
av The new TOXIC AVENGER comic book is great By boingboing.net Published On :: Tue, 01 Oct 2024 18:18:00 +0000 It's been just over a year since director Macon Blair premiered his new reboot of The Toxic Avenger at Fantastic Fest in Austin, Texas. The new film stars Peter Dinklage as the eponymous hideously deformed creature of superhuman size and strength, along with Elijah Wood, Kevin Bacon, and more—but has unfortunately struggled to find support for a wider distribution, according to The Hollywood Reporter. — Read the rest The post The new TOXIC AVENGER comic book is great appeared first on Boing Boing. Full Article Post Comic Books hideously deformed creatures of superhuman size and strength matt bors mr gotcha peter dinklage toxic avenger troma
av Obama Saves on Gas By communicationtransformation.blogspot.com Published On :: Tue, 07 Apr 2009 04:28:00 +0000 On March 26, President Obama took questions in East Room of the White House, but there was a twist. The East Room is usually the scene of press conferences where the President submits to questioning from the White House press corps. But in this case, President Obama took questions directly from an internet audience as 67,000 viewers watched a live stream of the event.There are many interesting implications: the bypass of the media filter; the virtual town halll; the modern fireside chat; the 21st century version of participatory democracy.But on a very basic level the event contains a significant lesson for corporate America.An Associated Press article cited in the dailycamera blog quotes presidential spokesperson Robert Gibbs:"It's not a whole lot different than were we in California doing the meeting," Gibbs said. "It's just we'll have people hooked up from a lot of different places all over the country, but he'll be able to do all that from the East Room.""It's a way for the president to do what he enjoys doing out on the road, but saves on gas,"IVT's client NEC, a leading provider of IT network integrated solutions, documented annual savings of $250,000 replacing road shows with webcasts.How much can the White House save by using webcasting to bring the American people to the East Room of the White House rather than traveling around the country to take questions in local town halls?Has any politcal town hall been held in a venue that could hold 67,000 people? Full Article
av From Savings to Student Loans: The Financial Realities of Single Female Home Buyers By www.nar.realtor Published On :: Tue, 20 Aug 2024 13:30:10 +0000 Financial Realities for Single Female Home Buyers Examining the different ways single female home buyers approach buying a home and the challenges they face. By: Amethyst Marroquin Demographic Groups, Working With Buyers, Student Loan Debt Full Article
av Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country By conservativefiringline.com Published On :: Wed, 13 Nov 2024 01:15:35 +0000 The following article, Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country, was first published on Conservative Firing Line. I really wish that everyone would just calm down. Emotions always run high immediately after an election, but what we are witnessing this time around is truly frightening. We live at a time when people feel free to express their deepest, darkest emotions on social media, and right now “freak out video” after “freak out … Continue reading Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country ... Full Article Opinion Politics country Harris leave liberals Trump voters
av Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik By www.adventurouskate.com Published On :: Wed, 04 Sep 2024 15:28:31 +0000 Cavtat, Croatia, might be the biggest surprise of your trip! This peaceful seaside town in the far south of Croatia is so close to Dubrovnik, and yet a world away. If you want to visit Dubrovnik but would rather stay somewhere with a quiet, more relaxing atmosphere — oh, and cheaper, too! — Cavtat (pronounced […] The post Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik appeared first on Adventurous Kate. Full Article Beaches Croatia
av Favorite Finds from the Winter Fancy Food Show 2017 By www.everintransit.com Published On :: Fri, 10 Feb 2017 02:49:09 +0000 Last week I went up to San Francisco for the Winter Fancy Food Show. This annual trade show draws more than 1,400 food companies from 30 countries who come to SF to show off their newest food products to the retail and hospitality vendors and food media. Last year, I spent a lot of time at the […] The article Favorite Finds from the Winter Fancy Food Show 2017 originated at EverInTransit.com Full Article Food + Drink events San Francisco Bay Area
av 3 Easy Steps to Save Money for Travel By www.everintransit.com Published On :: Thu, 30 May 2019 21:45:27 +0000 Finding ways to save money is much easier than you think, because you’re probably spending money you don’t have to spend. The article 3 Easy Steps to Save Money for Travel originated at EverInTransit.com Full Article Points + Miles Travel Tips credit card points food saving money
av EIT Elsewhere | Sharing the World’s Weirdest Plants on Fodor’s Travel By www.everintransit.com Published On :: Fri, 13 Mar 2020 04:49:55 +0000 The quirky folks at Fodor’s let me share some of the world’s weirdest plants, fungi, and microorganisms to inspire your #plantnerd bucket list (I’ve seen 5 out of 10 of these weirdos out in the wild!) 10 Plants From Around the World That Will Upset and Delight | Fodor’s Travel The article EIT Elsewhere | Sharing the World’s Weirdest Plants on Fodor’s Travel originated at EverInTransit.com Full Article California Responsible Travel United States eco EIT Elsewhere
av BOOM: Trump’s Lawyers SAVAGE Letitia James… Threaten PRISON If She Plays More Of Her Games By clashdaily.com Published On :: Fri, 08 Nov 2024 11:05:28 +0000 If anyone could accuse Trump of being on 'defense' during his witch-hunt trials, he's going on full offense now. The post BOOM: Trump’s Lawyers SAVAGE Letitia James… Threaten PRISON If She Plays More Of Her Games appeared first on Clash Daily. Full Article Videos
av Democrats Have Another Problem to Worry About as Man Who Helped Trump Win Has Eyes on Blue State By www.westernjournal.com Published On :: Tue, 12 Nov 2024 00:06:25 +0000 Conservative activist Scott Presler, whose organization Early Vote Action helped swing Pennsylvania to the right in the general election, announced Monday he will be working to do the same in […] The post Democrats Have Another Problem to Worry About as Man Who Helped Trump Win Has Eyes on Blue State appeared first on The Western Journal. Full Article News 2024 election New Jersey Pennsylvania Republicans Voting
av CNN Host Reportedly Leaving Network After Short-Lived Stay: His Career Change Is Completely Absurd By www.westernjournal.com Published On :: Tue, 12 Nov 2024 14:42:13 +0000 Three years ago, Chris Wallace walked away from Fox News over concerns that those at the “Fair and Balanced” network were beginning to, as he put it, “question the truth.” […] The post CNN Host Reportedly Leaving Network After Short-Lived Stay: His Career Change Is Completely Absurd appeared first on The Western Journal. Full Article Commentary Chris Wallace CNN Establishment media Fox News Social media
av Sport | It's been a long walk to Bafana for Sage Stephens: 'To have your first call up at 33 is special' By www.news24.com Published On :: Tuesday Nov 12 2024 05:00:32 With some of its infrastructure decaying and no premier division club using it, the somewhat abandoned Dobsonville Stadium offered the perfect setting for Sage Stephens to take his first steps as a Bafana Bafana player at the ripe age of 33. Full Article
av Sport | Key dying minutes of Tests: Boks have been demons, England disasters By www.news24.com Published On :: Tuesday Nov 12 2024 10:06:14 In his latest Rucking with Rob newsletter, Rob Houwing argues that for England to have any hopes of beating the Springboks, they'll have to be on the ball in the final stages. Full Article
av Sport | Khanyiso Tshwaku | Markram's T20 run drought no laughing matter as leadership crown weighs heavy By www.news24.com Published On :: Tuesday Nov 12 2024 12:33:48 As captain, Aiden Markram is allowed a long rope from a wonky form perspective, but how long can that rope be as the run river continues to shrivel, asks Khanyiso Tshwaku. Full Article
av The West, a New Haven for the ‘Muslim Brotherhood’s Planetary Nebula’? By cynthiafarahat.com Published On :: Thu, 01 Dec 2022 13:59:01 +0000 By SADF – Nov. 30, 2022 Online conversation on The West, a New Haven for the ‘Muslim Brotherhood’s Planetary Nebula’? On November the 29th at 16H.00 (CET), SADF promoted an online conversation in the web platform StreamYard titled ‘The West, a New Haven for the ‘Muslim Brotherhood’s Planetary Nebula’?’ The conversation included the Member of the European Parliament (EPP, […] Full Article Featured Articles
av Commentary: Secret Service Agents Placed on Leave After Trump Assassination Attempt By deneenborelli.com Published On :: Fri, 23 Aug 2024 19:57:50 +0000 Commentary by Susan Crabtree originally published by RealClearPolitics and RealClearWire Three weeks ago, Acting Secret Service Director Ronald Rowe angrily pushed back on senators’ calls to immediately fire or discipline key agents directly responsible for the security failures that led to the assassination attempt against former President Trump at last month’s campaign rally in Butler, … Full Article Commentaries News
av The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2 [Computational Biology] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 The QT interval is a recording of cardiac electrical activity. Previous genome-wide association studies identified genetic variants that modify the QT interval upstream of LITAF (lipopolysaccharide-induced tumor necrosis factor-α factor), a protein encoding a regulator of endosomal trafficking. However, it was not clear how LITAF might impact cardiac excitation. We investigated the effect of LITAF on the voltage-gated sodium channel Nav1.5, which is critical for cardiac depolarization. We show that overexpressed LITAF resulted in a significant increase in the density of Nav1.5-generated voltage-gated sodium current INa and Nav1.5 surface protein levels in rabbit cardiomyocytes and in HEK cells stably expressing Nav1.5. Proximity ligation assays showed co-localization of endogenous LITAF and Nav1.5 in cardiomyocytes, whereas co-immunoprecipitations confirmed they are in the same complex when overexpressed in HEK cells. In vitro data suggest that LITAF interacts with the ubiquitin ligase NEDD4-2, a regulator of Nav1.5. LITAF overexpression down-regulated NEDD4-2 in cardiomyocytes and HEK cells. In HEK cells, LITAF increased ubiquitination and proteasomal degradation of co-expressed NEDD4-2 and significantly blunted the negative effect of NEDD4-2 on INa. We conclude that LITAF controls cardiac excitability by promoting degradation of NEDD4-2, which is essential for removal of surface Nav1.5. LITAF-knockout zebrafish showed increased variation in and a nonsignificant 15% prolongation of action potential duration. Computer simulations using a rabbit-cardiomyocyte model demonstrated that changes in Ca2+ and Na+ homeostasis are responsible for the surprisingly modest action potential duration shortening. These computational data thus corroborate findings from several genome-wide association studies that associated LITAF with QT interval variation. Full Article
av In conversation with David Miliband: Finding a new approach to tackle conflict, climate and extreme poverty By www.chathamhouse.org Published On :: Thu, 15 Aug 2024 09:57:13 +0000 In conversation with David Miliband: Finding a new approach to tackle conflict, climate and extreme poverty 11 September 2024 — 5:00PM TO 5:45PM Anonymous (not verified) 15 August 2024 Chatham House and Online David Miliband discusses how the climate crisis, extreme poverty and conflict are becoming inextricably linked and how the global community must respond. Combatting the climate crisis, ending protracted conflicts, and alleviating poverty are three of the greatest priorities for international action. However, these three challenges become increasingly concentrated in a handful of countries. The subsequent feedback loop makes addressing these challenges even more complex.The International Rescue Committee’s (IRC’s) work in crisis-affected communities highlights this new geography of crisis. Just 16 countries, which are both climate-vulnerable and conflict-affected. This represents 43% of all people living in extreme poverty, 44% of all people affected by natural disasters and 79% of all people in humanitarian need. This trend towards the concentration of crisis is only deepening. In three decades, the number of conflict-affected, climate-vulnerable states has increased from 44% to more than two-thirds.Affected countries - like Sudan, Myanmar, and Syria - are also among the least supported financially. Debt burdens are siphoning away critical resources needed for adaptation and resilience. Humanitarian aid budgets are being slashed by donor governments. The private sector refuses to invest in these communities they view as too risky. And the international financial institutions meant to alleviate poverty and spur climate action are not well-designed to work with crisis-affected states or local communities. With the upcoming COP29 Summit in Azerbaijan focused on the New Collective Quantified Goal for climate finance, vulnerable communities will be watching closely whether they will get support in their fight against the worst impacts of the climate crisis.Conflict, the climate crisis, and extreme poverty are taking their toll. But how can the world best respond?Key questions to be discussed during the session include:At a time of political disruption, how does the West engage with vulnerable countries? What actions should be prioritised in providing support to such countries?Can global institutions evolve to better protect vulnerable and displaced people from conflict and climate-risk, particularly as geopolitical rivalries reduce space for cooperation?What is the UK’s role in supporting climate action in fragile states and how does this align with its agenda on the Sustainable Development Goals and extreme poverty? Full Article
av Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-12-04T00:06:06-08:00 The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities. Full Article
av PaxDb, a Database of Protein Abundance Averages Across All Three Domains of Life By www.mcponline.org Published On :: 2012-08-01 M. WangAug 1, 2012; 11:492-500Technological Innovation and Resources Full Article
av Trypsin Cleaves Exclusively C-terminal to Arginine and Lysine Residues By www.mcponline.org Published On :: 2004-06-01 Jesper V. OlsenJun 1, 2004; 3:608-614Technology Full Article
av The aftermath: Navigating a Taliban-led Afghanistan By www.chathamhouse.org Published On :: Fri, 20 Aug 2021 10:38:43 +0000 The aftermath: Navigating a Taliban-led Afghanistan Expert comment NCapeling 20 August 2021 In the coming weeks, governments and international organizations must work through an approach to the Taliban takeover of Afghanistan. It will not be simple. A failure to acknowledge that the legitimate, elected representatives of Afghanistan are no longer in control of territory or institutions, and to refuse to deal with those that are, will only make for further misery for a population which has already endured decades of violence and poverty. But to recognize the Taliban risks condemning tens of thousands of Afghan women, children, and men to brutal repression and, for some, potential death, as well as mocking the human rights and rule of law which the US and its allies sought to promote in Afghanistan, and globally, as cornerstones of values-based foreign policies. The dilemma western governments find themselves in is one they have studiously sought to avoid despite mounting evidence that, without a negotiated deal, a Taliban takeover was only a matter of time. As late as 6 August, the UN Security Council refused to countenance appeals by the UN mission and Afghan civil society activists to press the Taliban and the government to negotiate a ceasefire. The US reiterated its refrain that it ‘will not accept a military takeover of Afghanistan’ and the UK stressed the Taliban’s only route to power was through meaningful engagement in a peace process. Meanwhile, not until 11 August did Germany and the Netherlands stop deporting Afghan migrants despite the pleas of Afghan authorities and refugee organizations that the country was on the brink of crisis. Delaying the inevitable Belief that a military takeover was still some months away may have led diplomats to view dealing with the Taliban as a distant task. The unilateral nature of the US deal with the Taliban and the resistance of the Ghani government to any suggestion of power-sharing arrangements compounded a lack of international coordination and planning on what the conditions for engagement might be. Formal recognition of a Taliban-led government is simply not an option, even for those maintaining a diplomatic presence in Kabul such as China, Iran, Pakistan, and Russia It cannot be delayed further. The scale of the humanitarian crisis in Afghanistan is daunting, with more than half a million displaced by fighting in 2021 alone, almost 17 million facing crisis levels of food insecurity, and nearly half of all children under five malnourished as a consequence of drought and the COVID-19 pandemic. With one of the highest global refugee populations and an estimated up 20-30,000 Afghans fleeing the country weekly – even before the government collapsed – Afghanistan evokes still raw memories of the 2015 Syria migrant crisis for Europe. Pakistan and Turkey, home to some of the largest Afghan refugee communities, have already closed their borders to more. The ongoing chaos at Kabul airport highlights the challenges ahead. But there is a small window – before the UN Security Council is scheduled to review the mandate of the UN mission in Afghanistan by 17 September – for the US and its allies to craft an approach to dealing with the Taliban. Formal recognition of a Taliban-led government is simply not an option, even for those maintaining a diplomatic presence in Kabul such as China, Iran, Pakistan, and Russia. Technically the Afghan republic has not yet dissolved with vice-president Amrullah Saleh, reportedly in hiding in the Panjshir valley, claiming he is the country’s ‘caretaker’ president. Conditions for international acceptance Afghanistan’s ‘enduring partners’ must now focus on building a consensus around five conditions for international acceptance of a Taliban-administered Afghanistan and prevent the Taliban again reaping the benefits of international divisions. The G7 began to articulate some of these conditions but they need to be set out and negotiated with Afghanistan’s neighbours before being formally articulated by the UN Security Council. Adherence to Afghanistan’s human rights obligations. This must specify the rights of women and girls to education and work, the protection of ethnic and religious minorities, and safe passage for all Afghans and internationals leaving the country. Amnesty for all individuals who worked for the Afghan government or international embassies, forces, or aid organizations since 2001. No harbouring of terrorist groups. This has been the central condition for the US deal with the Taliban, and the overriding concern for both China and Russia. Non-lethal public order. The provision of public order to enable supply routes to open, evacuations to continue, and aid to be delivered, is essential and one that Russia has made as a condition for its future relations. Negotiation of inclusive political arrangements with Afghanistan’s political and ethnic factions. Belief that a military takeover was still some months away may have led diplomats to view dealing with the Taliban as a distant task The UN mission in Afghanistan, including its human rights component, and the Al-Qaida Sanctions Committee’s Analytical Support and Sanctions Monitoring Team should be mandated with reporting monthly on the progress toward these five conditions. Their assessments should form the basis for any reconsideration of the Taliban’s status as a terrorist organization. And a negotiated political settlement must be a precondition to the release of the government’s foreign reserves, estimated to be $9.5 billion. Before this, the humanitarian and development aid on which Afghanistan is almost completely reliant must be recalibrated to flow through international agencies. Models such as Hamas-run Gaza, Assad’s Syria, or Aristide’s Haiti, show that while far from effective, it is possible to provide urgent assistance outside government channels. Subscribe to our weekly newsletterOur flagship newsletter provides a weekly round-up of content, plus receive the latest on events and how to connect with the institute. Enter email address Subscribe This is one of the reasons why the Taliban has sought to retain a strong UN presence across Afghanistan and why the UN must be given a more significant political mandate and resources. The World Bank-administered Afghan Reconstruction Trust Fund should remain the principal channel for international funds. It is difficult in the short-term to see the US leading this collective effort, given its defensive and domestic-focused position. It could be a moment for the UK and EU to demonstrate their multilateral commitments and forge a coordinated conditions-based approach to a Taliban-administered Afghanistan at the UN. Going beyond handwringing or gesture politics will be difficult and messy and, ultimately, Afghanistan’s future must be decided by Afghans. Until that day, however, this will save lives. Full Article
av The UK must avoid conflict with Europe and China By www.chathamhouse.org Published On :: Mon, 10 Oct 2022 17:25:44 +0000 The UK must avoid conflict with Europe and China Expert comment NCapeling 10 October 2022 Liz Truss says she wants to take a tough line but any freedom to forge her own foreign policy is a casualty of the economic turmoil following her first budget. The tax-cutting budget from new UK chancellor Kwasi Kwarteng was clearly not inhibited by any apparent concern for the markets’ response. But the interest rate rise it contributed to and the scepticism raining down on the Truss government should force a recognition that economic vulnerability now constrains what the UK tries to do abroad. That would mean taking a more cautious approach than the new UK prime minister seems to want to adopt. The Treasury and the Foreign, Commonwealth and Development Office (FCDO) may sit next to each other in Whitehall’s parade of 18th century buildings, but a huge gulf lies between them. When talking to officials, it is striking how those in one building make decisions without reference to the other. Foreign policy is made with no consideration of the UK’s need to borrow money in the markets, and budgets are written with little calculation of the effect of decisions next door – although the Cabinet Office does at least try to reconcile these. But that approach is a luxury which the budget response and the sharp rise in national debt it will bring makes no longer affordable. Repairing EU trade relations is priority The first lesson is that any worsening of trade relations with the European Union (EU) is not now something the UK can afford to contemplate. The markets would take an even dimmer view of national finances if the UK were to become embroiled in an even more fractious trade dispute with its closest and largest trading partner. The UK cannot afford to talk about taking a tougher line on China – as the prime minister has already done – without clearly knowing what the economic impact would be and being sure voters are prepared to pay this price When campaigning for the Conservative party leadership, Liz Truss talked tough on the Northern Ireland protocol and her unwillingness to compromise much with the EU. Since she became prime minister, sounds from both the UK and EU have been much more conciliatory, with suggestions that a deal could be just a few details away. And yet the Truss government is still pressing ahead with the controversial legislation which would enable the UK unilaterally to walk away from parts of the treaty it signed – the House of Lords will debate the bill and its most contentious measures, such as the extensive new powers it gives ministers, on 11 October. But there are suggestions from officials that, although Truss would lose too much face by withdrawing the legislation, the government may choose not to contest any Lords amendments vigorously. That would be wise. The prime minister should know the financial path she has chosen with her chancellor makes carrying out the threats of walking away from a deal too costly to afford. As it is, the markets are hardly looking with equanimity on the prospect of the UK borrowing £100 billion to shield consumers from rising gas prices. A £43 billion package of proposed tax cuts with no explanation – yet – of how the government will pay for them would be even less comfortable were the UK to take such a hard line on the Northern Ireland protocol that it provokes a trade war with the EU. Brussels can also make those calculations and, for all the recent talk of concessions, is expected to hold fast to its new position. For the same reasons, the UK cannot afford to talk about taking a tougher line on China – as the prime minister has already done – without clearly knowing what the economic impact would be and being sure voters are prepared to pay this price. Years of courting commercial links with China mean they now weave their way through the UK economy. The dependence of universities on Chinese students and the income they bring is already well-known and heavily debated – but the exposure of the UK economy to digital technology and components from China is even greater, and China is now the largest source of imports for the UK with £63.6 billion or 13.3 per cent of all goods imports according to the Office for National Statistics. When campaigning for the Conservative party leadership, Liz Truss talked tough on the Northern Ireland protocol and her unwillingness to compromise much with the EU. Since she became prime minister, sounds from both the UK and EU have been much more conciliatory Much of that was laptops, computers, telecoms and phones as well as toys and clothes; there are few households or offices that will not have these products. China is also the sixth largest destination for UK exports, with £18.8 billion or 5.8 per cent of goods exports, much of it machinery and cars. Scottish Liberal Democrat peer Lord Purvis expressed concern at these figures because of the implication that the UK’s ability to take a tough line with China on human rights was now enormously circumscribed. And defence and intelligence chiefs are also warning of the UK’s vulnerability. Taking a hard line needs context There are signs the government is concerned enough to begin to map out this economic vulnerability but no signs that it yet has a full picture. Without knowing the economic hit of a frostier relationship, and confidence the House of Commons accepts it, Liz Truss would be brave to label China ‘a threat to national security’ – as her supporters indicated during the leadership campaign – when she updates the integrated review of defence and security in the coming months. Of course, foreign policy should not be inspired by commercial concerns alone. There are wider reasons to develop a clearer China strategy to help lay out a more consistent future path. On his recent trip to East Asia, UK foreign secretary James Cleverly heard from UK partners that they were disconcerted by the lurch from George Osborne’s ‘golden years’ to the Truss charge of a China ‘threat’. When Liz Truss was UK foreign secretary, some forecast she would pursue mercantilism given her focus on forging post-Brexit trade deals but, as it turned out, that was not the spirit of her tenure. Full Article
av Can the world avoid a new nuclear arms race? By www.chathamhouse.org Published On :: Wed, 16 Oct 2024 10:32:13 +0000 Can the world avoid a new nuclear arms race? 18 November 2024 — 6:00PM TO 7:00PM Anonymous (not verified) 16 October 2024 Chatham House and Online Leading experts discuss how states are expanding nuclear arsenals amid rising geopolitical challenges. Leading experts discuss how states are expanding nuclear arsenals amid rising geopolitical challenges. The Doomsday Clock stands at 90 seconds to midnight – the closest to global catastrophe it has ever been. As geopolitical competition intensifies, nuclear risks are resurging at an alarming rate. The collapse of key arms control agreements, such as the Intermediate-Range Nuclear Forces (INF) Treaty, has removed crucial safeguards against arms races. Efforts to extend or replace existing treaties face significant hurdles in the current geopolitical climate.Nuclear rhetoric has become more aggressive, as evidenced by Russian and North Korean nuclear threats. Several nuclear-armed states are also engaging in extensive modernization programmes of their nuclear arsenals, potentially fuelling a new arms race.Despite these pressures, the number of nuclear possessor states has held steady so far. The ongoing Iranian efforts to build nuclear weapons is the closest attempt by a new state to acquire nuclear weapons. As the global security environment becomes more and more tense, existing nuclear possessor states increasingly rely on their nuclear weapons. This might threaten the global consensus against nuclear proliferation.This session examines these competing pressures and propose strategies to reduce the risks of nuclear weapons use and proliferation. Our expert panel explores diplomatic initiatives, technical measures, and policy innovations to address these critical challenges.This expert panel discusses key questions including:Are we already in the middle of a global nuclear arms race?How can international arms control treaties be negotiated in the current geopolitical environment?Does a new US president change the nuclear calculus? Is the US still able to reassure allies of its ‘extended deterrence’?How can we reduce the risk of additional proliferation? Which states might want to acquire nuclear weapons and what can we do about it?The institute occupies a position of respect and trust, and is committed to fostering inclusive dialogue at all events. Event attendees are expected to uphold this by adhering to our code of conduct. Full Article
av Evan Davis In Conversation With Christian Ulbrich, CEO, JLL By f1.media.brightcove.com Published On :: Thu, 20 Sep 2018 00:00:00 +0100 Full Article
av Evan Davis In Conversation With Sir Howard Davies, Chairman of RBS By f1.media.brightcove.com Published On :: Wed, 31 Oct 2018 00:00:00 +0000 Full Article
av Can Europe Save the Liberal International Order? By f1.media.brightcove.com Published On :: Fri, 23 Nov 2018 00:00:00 +0000 Full Article
av Is Responsible State Behaviour in Cyberspace Achievable? By f1.media.brightcove.com Published On :: Wed, 05 Dec 2018 00:00:00 +0000 Full Article
av Chatham House Primer: ‘Leaving on WTO Terms’ By f1.media.brightcove.com Published On :: Mon, 11 Mar 2019 00:00:00 +0000 Full Article
av Tectonic Politics: Navigating New Geopolitical Risks By f1.media.brightcove.com Published On :: Wed, 05 Jun 2019 00:00:00 +0100 Full Article
av Undercurrents: Episode 43 - The UK Election, and Svyatoslav Vakarchuk on the Future of Ukraine By f1.media.brightcove.com Published On :: Thu, 19 Dec 2019 00:00:00 +0000 Full Article
av Undercurrents: Episode 46 - Understanding Decolonization, and China’s Response to Coronavirus By f1.media.brightcove.com Published On :: Mon, 24 Feb 2020 00:00:00 +0000 Full Article
av How Concerning Is the New Coronavirus Outbreak? By f1.media.brightcove.com Published On :: Wed, 26 Feb 2020 00:00:00 +0000 Full Article
av Undercurrents: Episode 50 - The Coronavirus Communications Crisis, and Justice in Myanmar By brightcove.hs.llnwd.net Published On :: Thu, 23 Apr 2020 00:00:00 +0100 Full Article
av The Climate Briefing: Episode 4 - Coronavirus and Climate Change By brightcove.hs.llnwd.net Published On :: Wed, 13 May 2020 00:00:00 +0100 Full Article
av A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent By www.jlr.org Published On :: 1989-04-01 M el-SaadaniApr 1, 1989; 30:627-630Articles Full Article
av Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI By www.jlr.org Published On :: 1990-03-01 JE HixsonMar 1, 1990; 31:545-548Articles Full Article
av Chatham House awarded major centenary grant to establish Stavros Niarchos Foundation Wing By www.chathamhouse.org Published On :: Tue, 16 Apr 2019 11:32:22 +0000 Chatham House awarded major centenary grant to establish Stavros Niarchos Foundation Wing News Release sysadmin 16 April 2019 Chatham House has been awarded a transformational £10m grant ahead of its upcoming 2020 centenary. Full Article
av Sir David Attenborough and the BBC Studios Natural History Unit awarded Chatham House Prize 2019 for ocean advocacy By www.chathamhouse.org Published On :: Mon, 18 Nov 2019 13:13:54 +0000 Sir David Attenborough and the BBC Studios Natural History Unit awarded Chatham House Prize 2019 for ocean advocacy News Release sysadmin 18 November 2019 The 2019 Chatham House Prize is awarded to Sir David Attenborough and Julian Hector, head of BBC Studios Natural History Unit, for the galvanizing impact of the Blue Planet II series on tackling ocean plastic pollution. Full Article
av New UK bill can fight fresh wave of online racist abuse By www.chathamhouse.org Published On :: Wed, 21 Jul 2021 08:24:28 +0000 New UK bill can fight fresh wave of online racist abuse Expert comment NCapeling 21 July 2021 The Euros final and Grand Prix put online abuse once more in the spotlight. The UK’s Online Safety Bill provides a strong framework for tackling the problem. The ugly online abuse targeted at members of the England football team following the Euros final, and then at Lewis Hamilton after the British Grand Prix, was not only hateful to the individuals concerned, but divisive for the UK more broadly. More needs to be done to regulate online platforms to avoid the spread of such abuse at scale. Online platforms are making increasing efforts to ‘self-regulate’ in order to tackle online abuse. Over the past year, Facebook and Twitter have strengthened their policies on hateful speech and conduct, such as Facebook’s policy banning Holocaust denial. Both have become more vigilant at deplatforming those who violate their terms of service, such as Donald Trump, and at removing online abuse using a combination of machines and humans. Twitter announced in the 24 hours following the Euros final that it had removed more than 1,000 tweets, and permanently suspended several accounts, for violating its rules. But inevitably not all abusive posts are picked up given the scale of the issue and, once the post has been seen, arguably the damage is done. Platforms have also partnered with NGOs on initiatives to counter hate speech and have launched initiatives to tackle the rise in coordinated inauthentic behaviour and information operations that seek to sow distrust and division. But while these efforts are all laudable, they are not enough. The UK government’s Online Safety Bill, published in May 2021, aims to tackle harmful content online by placing a duty of care on online platforms The root of the problem is not the content but a business model in which platforms’ revenue from advertising is directly linked to engagement. This encourages the use of ‘recommender’ algorithms which amplify divisive content by microtargeting users based on previous behaviour, as seen not just with racist abuse but also other toxic content such as anti-vaccination campaigns. Abusers can also remain anonymous, giving them protection from consequences. Creating a legal duty of care The UK government’s Online Safety Bill, published in May 2021, aims to tackle harmful content online by placing a duty of care on online platforms to keep users safe and imposing obligations tailored to the size, functionality, and features of the service. Social media companies will be expected to comply with their duties by carrying out risk assessments for specified categories of harm, guided by codes of practice published by the independent regulator, OFCOM. The bill gives OFCOM the power to fine platforms up to £18 million or ten per cent of global turnover, whichever is higher, for failure to comply. Following the Euros final, the UK government spoke of referring some racist messages and conduct online to the police. But only a small proportion of it can be prosecuted given the scale of the abuse and the fact only a minority constitutes criminal activity. The majority is ‘lawful but harmful’ content – toxic and dangerous but not technically falling foul of any law. When addressing ‘lawful but harmful’ material, it is crucial that regulation negotiates the tension between tackling the abuse and preserving freedom of expression. The scale at which such expression can spread online is key here – freedom of speech should not automatically mean freedom of reach. But it is equally important that regulation does not have a chilling effect on free speech, as with the creeping digital authoritarianism in much of the world. When addressing ‘lawful but harmful’ material, it is crucial that regulation negotiates the tension between tackling the abuse and preserving freedom of expression The Online Safety Bill’s co-regulatory approach aims to address these tensions by requiring platforms within the scope of the bill to specify in their terms and conditions how they deal with content on their services that is legal but harmful to adults, and by giving the regulator powers to police how platforms enforce them. Platforms such as Facebook and Twitter may already have strong policies on hate speech – now there will be a regulator to hold them to account. Devil is in the detail How successful OFCOM is in doing so will depend on the precise powers bestowed on it in the bill, and how OFCOM chooses to use them. It’s still early days - the bill will be scrutinized this autumn by a committee of MPs before being introduced to parliament. This committee stage will provide an opportunity for consideration of how the bill may need to evolve to get to grips with online abuse. These latest two divisive and toxic episodes in UK sport are only likely to increase pressure from the public, parliament, and politicians for the bill to reserve robust powers for OFCOM in this area. If companies do not improve at dealing with online abuse, then OFCOM should have the power to force platforms to take more robust action, including by conducting an audit of platforms’ algorithms, enabling it to establish the extent to which their ‘recommender’ settings play a part in spreading hateful content. Currently, the bill’s definition of harm is confined to harm to individuals, and the government has stated it does not intend this bill to tackle harm to society more broadly. But if racist abuse of individuals provokes racist attacks more widely, as has happened, the regulator should be able to take that wider context into account in its investigation and response. Responses to the draft bill so far indicate challenges ahead. Some argue the bill does not go far enough to tackle online abuse, especially on the issue of users’ anonymity, while others fear the bill goes too far in stifling freedom of expression, labelling it a recipe for censorship. Parliamentary scrutiny will need to take into account issues of identity, trust, and authenticity in social networks. While some call for a ban on the cloak of anonymity behind which racist abusers can hide online, anonymity does have benefits for those in vulnerable groups trying to expose hate. Subscribe to our weekly newsletterOur flagship newsletter provides a weekly round-up of content, plus receive the latest on events and how to connect with the institute. Enter email address Subscribe An alternative approach gaining attention is each citizen being designated a secure digital identity, which would both provide users with greater control over what they can see online and enable social media platforms to verify specific accounts. Instituted with appropriate privacy and security safeguards, a secure digital ID would have benefits beyond social media, particularly in an online COVID-19 era. The online public square is global so countries other than the UK and international organizations must also take measures. It is encouraging to see synergies between the UK’s Online Safety Bill and the EU’s Digital Services Act, published in draft form in December 2020, which also adopts a risk-based, co-regulatory approach to tackling harmful online content. And the UK is using its G7 presidency to work with allies to forge a more coherent response to internet regulation at the international level, at least among democratic states. Addressing the scourge of online hate speech is challenging so the UK’s Online Safety Bill will not satisfy everyone. But it can give the public, parliament, and politicians a structure to debate these crucial issues and, ultimately, achieve more effective ways of tackling them. Full Article
av Counter-terrorism measures and sanctions: How to avoid negative consequences for humanitarian action? By www.chathamhouse.org Published On :: Wed, 21 Jul 2021 13:15:52 +0000 Counter-terrorism measures and sanctions: How to avoid negative consequences for humanitarian action? 9 September 2021 — 2:00PM TO 3:30PM Anonymous (not verified) 21 July 2021 Online Exploring current endeavours to address the tensions between counter-terrorism measures, sanctions and humanitarian action. Counter-terrorism measures address broad forms of support to terrorist acts. Their expansion, internationally and domestically, has given rise to new points of friction with international humanitarian law. Unless the measures include adequate safeguards, they can impede humanitarian action. Country-specific sanctions imposed for other objectives, such as ending conflicts or protecting civilians, raise similar challenges for humanitarian action. These problems are not new, but solutions at international and national level remain elusive. At this panel event, which marks the launch of a new Chatham House research paper, panellists explore current endeavours to address the tensions between counter-terrorism measures, sanctions and humanitarian action. What are the current dynamics and developments at Security Council level? What are the opportunities now that the UK is developing its independent sanctions strategy? What challenges do counter-terrorism requirements in funding agreements for humanitarian action pose? What is necessary to make progress? Full Article
av The UK must not sleepwalk into leaving the ECHR By www.chathamhouse.org Published On :: Fri, 17 Mar 2023 18:57:59 +0000 The UK must not sleepwalk into leaving the ECHR Expert comment NCapeling 17 March 2023 Talk of the UK leaving the European Convention on Human Rights (ECHR) keeps rearing its head with little thought for the real impact. Withdrawal from the European Convention on Human Rights (ECHR) has not been firmly ruled out as a potential UK government policy option to allow easier implementation of its controversial new measures to deport asylum seekers to Rwanda. This, in the context of a UK general election looming and tackling the ‘small boats problem’ being one of the five priorities of UK prime minister Rishi Sunak. In recent months, ECHR withdrawal has come up in relation to the UK’s controversial draft Illegal Migration Bill, the (now shelved) bill of rights, and – perhaps most significantly – the Northern Ireland Protocol deal with implications for the Good Friday Agreement. But leaving the ECHR – and likely the Council of Europe – would be counterproductive for the UK’s global leadership. UK values and priorities will be undermined The only other countries in the region outside of the Council of Europe, Russia and Belarus, both had sanctions imposed on them by the UK for their human rights record. Russia was expelled from the Council of Europe in 2022 due to its aggression in Ukraine and, although the UK would be deciding to remove itself from Europe’s oldest and largest intergovernmental human rights body, the optics would not be good. This is especially true considering the UK’s vocal support for Ukraine in international forums, including its intervention in Ukraine’s case against Russia before the International Court of Justice and, potentially, in a separate case against Russia before the European Court of Human Rights itself. If the UK withdraws from the ECHR, the EU would be entitled to terminate important provisions concerning international law enforcement and judicial cooperation in criminal justice matters More significantly and closer to home, the ECHR is a fundamental part of the Good Friday Agreement. It is difficult to argue UK withdrawal would not breach the agreement. As well as risking damage to intercommunal relations, such a breach is likely to significantly harm strategic relations with the US – and President Biden is set to visit Northern Ireland and the Republic of Ireland to mark the 25th anniversary of the Good Friday Agreement. It would also damage relations with the UK’s closest neighbours, Ireland, and the European Union (EU), with whom the prime minister has only recently scored credits for securing the Northern Ireland Protocol deal. If the UK withdraws from the ECHR, the EU would be entitled to terminate important provisions concerning international law enforcement and judicial cooperation in criminal justice matters under Article 692 of the UK-EU Trade and Cooperation Agreement, further isolating the UK from allies who share its legal and other values. Withdrawal would be in the name of sovereignty but with little thought to the practical implications on rights and few perceived gains from doing so. But the idea could easily gain traction by erroneously conflating the Strasbourg court and Council of Europe (of which the UK is a member) with the European Union (which the UK has left). This means leaving the ECHR could easily be confused as a post-Brexit ‘tidy up’ exercise of taking back control from the EU when the reality is the UK would be withdrawing from a completely different regional body. It would also be at odds with the UK’s Integrated Review Refresh which, reassuringly, contains references to the UK’s commitment to the rule of law, ‘respect for the fundamental principles of the UN Charter and international law’, and ‘universal human rights that underpins our democracy’. This would make the UK far less able to champion international law and influence states with long records of human rights violations, and run contrary to UK strategic priorities such as tackling aggression from Russia and China, its support for multilateralism, and its global legal leadership. There are many reasons beyond simply human rights concerns which are preventing migrants being deported to Rwanda All this loss would come for little gain. Before going down this path, there must be a clearer understanding about exactly what concerns there are about the ECHR, and whether they stand up to scrutiny. Are they about UK sovereignty, specific issues about the European Court of Human Rights, or about the rights and obligations contained in the Convention? The latter would raise a far bigger question on the UK’s commitment to other international treaties, such as the International Covenant on Civil and Political Rights and the UN Convention on Rights of the Child, as many ECHR obligations also exist elsewhere in both common law and international law. The need for cool heads and a long-term view The significant concerns surrounding proposals in the Illegal Migration bill have been well-documented, including in relation to obligations under the ECHR and UN Refugee Convention. There are many reasons beyond simply human rights concerns which are preventing migrants being deported to Rwanda, including the fact there are insufficient countries with which the UK has agreements to allow for deportation. Full Article