Title: Men Who Are Obese While Young Can Pay a Price Later
Category: Health News
Created: 4/29/2013 8:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM

Title: Whole Blood Best for Youngest Heart Surgery Patients: Study
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: Heroin Use Surges Among Whites Who Abuse Prescription Painkillers
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM

Title: Burger King to Sell 'Veggie' Whopper Nationwide
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

Title: No Evidence COVID-19 Survivors Are Immune: WHO
Category: Health News
Created: 4/27/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Title: Can AI Predict Who Will Develop Diabetes?
Category: Health News
Created: 3/31/2020 12:00:00 AM
Last Editorial Review: 3/31/2020 12:00:00 AM

Title: U.S. Issues Highest Travel Alert for China as WHO Declares Health Emergency
Category: Health News
Created: 1/31/2020 12:00:00 AM
Last Editorial Review: 2/3/2020 12:00:00 AM

Drivers with blood-alcohol levels below legal limits cause 15% of all crash deaths that involve alcohol, a study in the March issue of the American Journal of Preventive Medicine finds.

North Carolina is developing a unique and innovative infrastructure to support integrated physical, behavioral, and social health care. Efforts by the North Carolina Department of Health and Human Services, the Foundation for Health Leadership & Innovation, Cone Health, Atrium Health, and the One Charlotte Health Alliance advance our understanding of how to best operationalize the design and payment of integrated services. Best practices such as the collaborative care and primary care behavioral health models reduce inefficiencies and disparities by bringing together teams of primary care and behavioral health care providers.

Teams fail when they cannot achieve a common goal. They also fail when they do not have one. In baseball, different goals between players and staff are unusual. Everyone wants to win. In neurology, where teams may be loosely defined and comprise people from many disciplines, goals differ. A win for you may not be a win for me.

Screening for Chlamydia trachomatis and Neisseria gonorrhoeae at the pharyngeal, urogenital, and anorectal sites is recommended for men who have sex with men (MSM). Combining the three individual-site samples into a single pooled sample could result in significant cost savings, provided there is no significant sensitivity reduction. The aim of this study was to examine the sensitivity of pooled samples for detecting chlamydia and gonorrhea in asymptomatic MSM using a nucleic acid amplification test. Asymptomatic MSM who tested positive for chlamydia or gonorrhoea were invited to participate. Paired samples were obtained from participants prior to administration of treatment. To form the pooled sample, the anorectal swab was agitated in the urine specimen transport tube and then discarded. The pharyngeal swab and 2 ml of urine sample were then added to the tube. The difference in sensitivity between testing of pooled samples and individual-site testing was calculated against an expanded gold standard, where an individual is considered positive if either pooled-sample or individual-site testing returns a positive result. All samples were tested using the Aptima Combo 2 assay. A total of 162 MSM were enrolled in the study. Sensitivities of pooled-sample testing were 86% (94/109; 95% confidence interval [CI], 79 to 92%]) for chlamydia and 91% (73/80; 95% CI, 83 to 96%) for gonorrhea. The sensitivity reduction was significant for chlamydia (P = 0.02) but not for gonorrhea (P = 0.34). Pooling caused 22 infections (15 chlamydia and 7 gonorrhoea) to be missed, and the majority were single-site infections (19/22). Pooling urogenital and extragenital samples from asymptomatic MSM reduced the sensitivity of detection by approximately 10% for chlamydia but not for gonorrhea.

MYC translocations, a hallmark of Burkitt lymphoma, occur in 5-15% of diffuse large B-cell lymphoma, and have a negative prognostic impact. Numerical aberrations of MYC have also been detected in these patients, but their incidence and prognostic role are still controversial. We analyzed the clinical impact of MYC increased copy number on 385 patients with diffuse large B-cell lymphoma screened at diagnosis for MYC, BCL2, and BCL6 rearrangements. We enumerated the number of MYC copies, defining as amplified those cases with an uncountable number of extra-copies. The prevalence of MYC translocation, increased copy number and amplification was 8.8%, 15%, and 1%, respectively. Patients with 3 or 4 gene copies, accounting for more than 60% of patients with MYC copy number changes, had a more favorable outcome compared to patients with >4 copies or translocation of MYC, and were not influenced by the type of treatment received as first-line. Stratification according to the number of MYC extra-copies showed a negative correlation between an increasing number of copies and survival. Patients with >7 copies or the amplification of MYC had the poorest prognosis. Patients with >4 copies of MYC showed a similar, trending towards worse prognosis compared to patients with MYC translocation. The survival of patients with >4 copies, translocation or amplification of MYC seemed to be superior if intensive treatments were used. Our study underlines the importance of fluorescence in situ hybridization testing at diagnosis of diffuse large B-cell lymphoma to detect the rather frequent and clinically significant numerical aberrations of MYC.

The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic environmental Gram-negative bacilli responsible for a variety of infections in both humans and animals. Beyond its large genetic diversity, its genetic organization in genogroups was recently confirmed through the whole-genome sequencing of human and environmental strains. As they are poorly represented in these analyses, we sequenced the whole genomes of 93 animal strains to determine their genetic background and characteristics. Combining these data with 81 newly sequenced human strains and the genomes available from RefSeq, we performed a genomic analysis that included 375 nonduplicated genomes with various origins (animal, 104; human, 226; environment, 30; unknown, 15). Phylogenetic analysis and clustering based on genome-wide average nucleotide identity confirmed and specified the genetic organization of Smc in at least 20 genogroups. Two new genogroups were identified, and two previously described groups were further divided into two subgroups each. Comparing the strains isolated from different host types and their genogroup affiliation, we observed a clear disequilibrium in certain groups. Surprisingly, some antimicrobial resistance genes, integrons, and/or clusters of attC sites lacking integron-integrase (CALIN) sequences targeting antimicrobial compounds extensively used in animals were mainly identified in animal strains. We also identified genes commonly found in animal strains coding for efflux systems. The result of a large whole-genome analysis performed by us supports the hypothesis of the putative contribution of animals as a reservoir of Stenotrophomonas maltophilia complex strains and/or resistance genes for strains in humans.

IMPORTANCE Given its naturally large antimicrobial resistance profile, the Stenotrophomonas maltophilia complex (Smc) is a set of emerging pathogens of immunosuppressed and cystic fibrosis patients. As it is group of environmental microorganisms, this adaptation to humans is an opportunity to understand the genetic and metabolic selective mechanisms involved in this process. The previously reported genomic organization was incomplete, as data from animal strains were underrepresented. We added the missing piece of the puzzle with whole-genome sequencing of 93 strains of animal origin. Beyond describing the phylogenetic organization, we confirmed the genetic diversity of the Smc, which could not be estimated through routine phenotype- or matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF)-based laboratory tests. Animals strains seem to play a key role in the diversity of Smc and could act as a reservoir for mobile resistance genes. Some genogroups seem to be associated with particular hosts; the genetic support of this association and the role of the determinants/corresponding genes need to be explored.

In this retrospective study, whole-genome sequencing (WGS) data generated on an Ion Torrent platform was used to predict phenotypic drug resistance profiles for first- and second-line drugs among Swedish clinical Mycobacterium tuberculosis isolates from 2016 to 2018. The accuracy was ~99% for all first-line drugs and 100% for four second-line drugs. Our analysis supports the introduction of WGS into routine diagnostics, which might, at least in Sweden, replace phenotypic drug susceptibility testing in the future.

We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium falciparum. First, from standard growth inhibition assays, we identified 173 molecules with antimalarial activity (50% effective concentration [EC₅₀] ≤ 10 μM), which included 62 additional molecules over previously known antimalarial candidates from the Pathogen Box. We identified 90 molecules with EC₅₀ of ≤1 μM, which had significant effect on the ring-trophozoite transition, while 9 molecules inhibited the trophozoite-schizont transition and 21 molecules inhibited the schizont-ring transition (with ≥50% parasites failing to proceed to the next stage) at 1 μM. We therefore rescreened all 173 molecules and validated hits in microscopy to prioritize 12 hits as selective blockers of the schizont-ring transition. Seven of these molecules inhibited the calcium ionophore-induced egress of Toxoplasma gondii, a related apicomplexan parasite, suggesting that the inhibitors may be acting via a conserved mechanism which could be further exploited for target identification studies. We demonstrate that two molecules, MMV020670 and MMV026356, identified as schizont inhibitors in our screens, induce the fragmentation of DNA in merozoites, thereby impairing their ability to egress and invade. Further mechanistic studies would facilitate the therapeutic exploitation of these molecules as broadly active inhibitors targeting late-stage development and egress of apicomplexan parasites relevant to human health.

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

By cause of the rising number of expats in Vietnam, the lease market for foreigners has significantly expanded in recent years. However, foreign tenants and their landlords should consider the following legal advice to avoid unwanted risk.

Publisher Wired Productions and developer Camel 101 have delayed psychological horror game, Those Who Remain, from May 15 to May 28 for the PlayStation 4, Xbox One and Windows PC via Steam. 

View the official release date trailer below:

Here is an overview of the game:

As the lights go out, the embers of darkness are stoked in the sleepy town of Dormont.

Whispers of disappearances carry through the town as a burgeoning, uneasy and irrational fear begins to spread and darkness comes to be an unwelcome reflection to Those Who Remain.

Some mistakes should never happen, not when your life is complete – and yet they do. Edward had the good life, a beautiful wife and the perfect little girl, yet finds himself several whiskeys down and driving through the night of Dormont to end his secret affair – in a bid to fix his mistakes.

As Edward pulls into the Golden Oak Motel, he is unaware just how much this night will change his life…

Key Features:

The horrors and darkness that thrive in the corner of every eye are torn loose…

Those Who Remain places you in an up-close, psychological horror story set in the sleepy town of Dormont – a town in a spiralling split from the fabric of reality, warped by darkness and the deeds of the Citizens who reside.

Confront the uncomfortable horrors reflected by the darkness and survive the night of Dormont as Edward is confronted with a test of his sanity, morality and the shadows of evil that lurks below.

• Darkness Has Eyes -Navigate and survive the encroaching darkness and stay in the protection of the light by any means[br]
• Worlds Torn Asunder – Pave your way ahead by moving between Dormont and its dark otherworldly counterpart to further solve the mysteries held within the dark
• Conscience of Choice – Choose to help any surviving citizens of Dormont you encounter or leave them to the darkness. Innocence cannot always be assumed, and the township of Dormont hides a cursed trove of secrets
• Savor your Sanity – Keep your sanity in check as you delve deeper into the darkness of Dormont – expected rules of the real world have been torn apart
• Follow your Path – Your decisions and choices will determine the fate of Edward, through multiple different branching outcomes

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443413/those-who-remain-delayed-to-may-28-for-ps4-xbox-one-and-steam/

We’re used to tweaking our digital selves to look thinner or more attractive. A new generation of Instagram filters could drastically change how we perceive ourselves

Can you really be addicted to your smartphone? Daria Kuss has shown that it is only a problem for a small number of people - and she knows how to help

When Earth and Venus formed, they both had global magma oceans deep underground. Earth’s has turned solid by now, but Venus’s may still remain hidden

After more than three long years, the Justice Department has finally lived up to its name by dropping charges against my former boss, former National Security Adviser and retired Army Lt. Gen. Michael Flynn. He should have never been prosecuted.

The SnotBot project uses drones, data, and deep learning to tell us about the health of whales and the oceans

Class of Heroes decides to do a physical version after all. The Big Huge Games folks get more bad news. Quin teaches us about fictional...

New research finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis, but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

From a veteran fire chief to a 93-year-old Holocaust survivor, over 71,000 people have died in the United States from the ongoing novel coronavirus pandemic.Those we've lost come from all backgrounds and walks of life and include the very people -- first responders and medical staff, who are working so diligently to stem the tide of the infection and care for the sick. Variously described as heroes, caring educators and loving family members, they will never be forgotten. ...

For weeks after Ahmaud Arbery was killed while running down a road in coastal southern Georgia, there were few public developments in the case of a 25-year-old unarmed black man who was shot while being pursued by two white men with weapons in February.Then a graphic video of the shooting surfaced online, spurring widespread outrage.Within days, the Georgia Bureau of Investigation had taken over the case. The video was criticized by celebrities and politicians alike, including President Donald Trump, who called the footage "very, very disturbing," and former Vice President Joe Biden, the presumptive Democratic presidential nominee, who said Arbery had essentially been "lynched before our very eyes."And in a major turn, the authorities announced Thursday night that they had arrested two suspects in the case and charged them with murder and aggravated assault.The video -- which by Friday officials had described as "a very important piece" of evidence in moving forward with criminal charges -- was first posted by WGIG, a radio station in Brunswick, Georgia, which said it had obtained the footage from an anonymous source.But in a twist emblematic of the small-town politics that have defined the case, that source turned out to be a criminal defense lawyer in town who had informally consulted with the suspects.The lawyer, Alan Tucker, said in an interview Friday that the video had come from the cellphone of a man who had filmed the episode and that he later gave the footage to the radio station. Tucker's role was confirmed by Scott Ryfun, who oversees the station's programming.Asked why he had leaked the video, Tucker said he had wanted to dispel rumors that he said had fueled tension in the community. "It wasn't two men with a Confederate flag in the back of a truck going down the road and shooting a jogger in the back," Tucker said."It got the truth out there as to what you could see," he added. "My purpose was not to exonerate them or convict them."The video, taken from inside a vehicle, shows Arbery running when he comes upon a white truck, with one man standing next to its open driver's-side door and another in the bed of the pickup. Arbery runs around the truck and disappears briefly from view. Then the man standing outside the truck tussles with him, and three gunshots are heard.The authorities identified Travis McMichael, 34, as the person who shot Arbery. His father, Gregory McMichael, 64, a retired investigator at the local district attorney's office, was also charged.Before the charges were filed this week, two prosecutors had recused themselves from handling the case, citing professional ties to Gregory McMichael. Tucker, too, said he had been an acquaintance of McMichael's from their work in legal circles.Reports suggest Tucker had consulted with the McMichael family in some capacity during the investigation, although it is not clear to what extent. Reached by The Washington Post before his arrest Thursday, Gregory McMichael referred questions to Tucker.Tucker declined to comment on his conversations with the McMichaels on Friday, citing attorney-client privilege."I'm not going to tell you what I told them or what they told me," he said, using profanity to say that any conversations -- had they occurred, he said -- were none of the public's business.At times during the interview, a woman could be heard in the background whispering suggested answers to Tucker.By Friday afternoon, Tucker said that it had been decided that he would not be retained as the lawyer for either of the McMichaels, and it was unclear who was representing them.Tucker said he would not be representing anyone else involved in the case, as the authorities announced Friday that they were pursuing a number of leads, including investigating the man who took the video.The man, Roddie Bryan, lives in the neighborhood. He had shared the video with the police before sharing it with Tucker and was cooperating with the authorities, his lawyer, Kevin Gough, said in an interview Friday evening."Mr. Bryan has never tried to hide anything from anybody," Gough said. "If anybody wanted a copy of the video, he would give it to them."But he said the added attention, including the scrutiny from the authorities, had come as a shock to his client, a mechanic who had since lost his job and received threats. "The atmosphere down here is very volatile," Gough said. "People are in fear. That's all a result of the last few days."The latest developments in the case on Friday fell on Arbery's birthday, when he would have turned 26. Thousands of people commemorated the occasion by running 2.23 miles, a nod to Feb. 23, the date he was killed.This article originally appeared in The New York Times.(C) 2020 The New York Times Company

The I, Daniel Blake star on her parents’ generosity, working in a call centre and her love of ice-cream

Born in London, Squires, 32, studied at Rose Bruford College in London. She starred in the Ken Loach film, I, Daniel Blake in 2016, earning a Bafta nomination and winning most promising newcomer at the British Independent Film awards. Her West End debut in Cat On A Hot Tin Roof followed in 2017. Her television work includes The Miniaturist and Collateral; in the autumn she will play the lead in the Channel 4 drama, Adult Material.

What is your greatest fear?
Snakes.

From his fateful game of chess to a moving turn in The Diving Bell and the Butterfly, Von Sydow was the last standard bearer of Bergman’s high-minded movie idiom

•Max von Sydow dies aged 90
•A life in pictures

The opening of the seventh seal in the Book of Revelation, disclosing the truth of God’s existence and the second coming, will result in a mysterious silence in the kingdom of heaven – then the sound of trumpets and the thunderous uproar of Earth’s apocalyptic ending. In the movies, no actor has ever represented these ideas more seriously, nor shown humanity’s anguish in the face of God’s implacable silence or unassuageable anger more clearly, than Max von Sydow. He was virtually a book of revelation in himself.

The passionate severity of Von Sydow – and his ability to impersonate the ascetic nobility of some impossibly remote priestly or knightly order but with very human flaws – formed the bedrock of Ingmar Bergman’s The Seventh Seal and the staggering series of films he was to make with Bergman in the 1950s and 1960s. Beyond that, he virtually epitomised an entire, distinctively high-minded attitude to cinematic art in Europe. His films for Bergman were composed in a movie idiom that drew on Ibsen and Strindberg, Sjöström and Dreyer – and of which, since Bergman’s death in 2007, Von Sydow could be said to be the final standard bearer.

The singer who played a key role in early rock music's popularity died Saturday at 87 years old.

The U.S. Justice Department on Thursday abruptly asked a judge to drop criminal charges against Donald Trump's former national security adviser Michael Flynn following mounting pressure from the Republican president and his political allies on the right.

People born prematurely may have weaker hearts that recover less well after exercise, potentially explaining their increased risk of heart disease

The former Stoke and Leicester player is a forgotten legend of English football, still the only player of East Asian heritage to play for England

Five U.S. Senate Republicans introduced a bill on Wednesday seeking a review of U.S. participation in the World Health Organization and other international institutions, after President Donald Trump's administration suspended U.S. contributions to the U.N. health agency and accused it of mishandling the coronavirus pandemic.

The leaders of U.S. congressional foreign affairs committees wrote to nearly 60 countries on Friday asking them to support Taiwan's participation in the World Health Organization, citing the need for the broadest effort possible to fight the coronavirus pandemic.

One Arsenal star is on the list of the top ten Premier League players for increased transfer value in 2019.

Beggs was on a leave of absence from the post when the Challenger space shuttle broke apart 73 seconds after launch on Jan. 28, 1986, killing all seven aboard

Ariana Grande has reportedly been granted a restraining order against a fan who was found trespassing at her home.

Relationships that suffer as a result of unreconcilable politics may force you to make a decision. To make that less distressing, choose consciously.

"The process will account for wide variations in abuse and provide a pathway for survivor healing," Richard Schulte, one of the lawyers for the men, said in the university's statement.

Jordan Goudreau once pushed a plan to protect U.S. schools. Then he moved on to a more daring pursuit, which also didn't end well.

Trial is notable for highlighting land and nature defender murders that ordinarily go unpunished

The sentencing on Thursday of seven men accused of murdering the Honduran environmentalist Berta Cáceres is only partial justice, but it should inspire anyone committed to ending the slaughter of land and nature defenders around the globe.

A court in Tegucigalpa handed down guilty verdicts on all but one of the eight accused, including two employees of the hydro-electric dam company that the indigenous Lenca woman had been campaigning against before her assassination on 2 March 2016.

Former Los Angeles Lakers player Shannon Brown was arrested last week for allegedly firing a gun at two people who entered his Georgia home that was listed for sale.

Fed up with invasive species and sterile landscapes, Douglas Tallamy urges Americans to go native and go natural

Tasked with curbing a 1907 outbreak, Esther Pohl emphasized the importance of clean, vermin-free environments