HER2-targeted therapies are approved only for HER2-positive breast and gastric cancers. We assessed the safety/tolerability and activity of the novel HER2-targeted antibody–drug conjugate trastuzumab deruxtecan (T-DXd) in 60 patients with pretreated, HER2-expressing (IHC ≥ 1+), non-breast/non-gastric or HER2-mutant solid tumors from a phase I trial (NCT02564900). Most common (>50%) treatment-emergent adverse events (TEAE) were nausea, decreased appetite, and vomiting. Two drug-related TEAEs were associated with fatal outcomes. The confirmed objective response rate (ORR) was 28.3% (17/60). Median progression-free survival (PFS) was 7.2 [95% confidence interval (CI), 4.8–11.1] months. In HER2-mutant non–small cell lung cancer (NSCLC), ORR was 72.7% (8/11), and median PFS was 11.3 (95% CI, 8.1–14.3) months. Confirmed responses were observed in six tumor types, including HER2-expressing NSCLC, colorectal cancer, salivary gland cancer, biliary tract cancer, endometrial cancer, and HER2-mutant NSCLC and breast cancer. Results suggest T-DXd holds promise for HER2-expressing/mutant solid tumors.

BACKGROUND AND PURPOSE:

It is not known how radiomics using ultrasound images contribute to the detection of BRAF mutation. This study aimed to evaluate whether a radiomics study of gray-scale ultrasound can predict the presence or absence of B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation in papillary thyroid cancer.

BACKGROUND AND PURPOSE:

The use of invasive cerebral angiography with CTA for active treatment of patients with suspected ischemic strokes has been increasing recently. This study aimed to identify the incidence of postcontrast acute kidney injury using baseline renal function when CTA and cerebral angiography were performed sequentially.

BACKGROUND AND PURPOSE:

Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.

Focused ultrasound, the researchers hope, could revolutionize treatment for conditions from Alzheimer's to epilepsy to brain tumors -- and even help repair the devastating damage caused by stroke.

Trump admin allegedly told CDC its reopening guide would "never see the light of day."

Russian President Vladimir Putin marked Victory Day, the anniversary of the defeat of Nazi Germany in World War II, in a ceremony shorn of its usual military parade and pomp by the coronavirus pandemic. In neighboring Belarus, however, the ceremonies went ahead in full, with tens of thousands of people in the sort of proximity that has been almost unseen in the world for months. Victory Day is Russia’s most important secular holiday and this year’s observance had been expected to be especially large because it is the 75th anniversary, but the Red Square military parade and a mass procession called The Immortal Regiment were postponed as part of measures to stifle the spread of the virus.

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The cult pop star shares her self-isolation favourites, including Dua Lipa’s disco and Daft Punk’s dystopias

• The best arts and entertainment during self-isolation

Isolation has definitely been a test, but I’m really lucky: I’m able to work on new music while quarantined with my best friends in Toluca Lake, Los Angeles. I’ve been super active on Twitter and Instagram, and playing Animal Crossing and Mario Kart with my fans after sharing my Nintendo Switch codes online – it’s really important for me to check in on my fans as I worry about them a lot. They have truly kept me sane, so I’m keeping an eye open for anybody that needs to talk.

Related: Belle and Sebastian's lockdown listening: 'I have a dance-off with my kids every night'

'Practising mindfulness is like going to a gym, you have to exercise the muscle and it works with anxiety'

The Department of Defense needs technology experts to migrate its roughly 500 disparate cloud environments into a unified system to help the military work better and faster. The Joint Enterprise Defense Infrastructure (JEDI) contract -- which has bee...

The zingers flew as Tom Brady, Tiger Woods, Peyton Manning and Phil Mickelson hyped their upcoming golf match. Which legend talked the best smack?

The gloves are officially off, because Barack Obama has made his feelings known about the way his predecessor has handled the coronavirus pandemic, and the former Prez did NOT mince words. Obama was speaking with members of the Obama Alumni Ass'n,…

Tom Hoover, senior medical business development manager – Americas, assembly technologies, at global technology and manufacturing company, Emerson, explains how ultrasonic plastic welding is improved through improved force control.

The ruling JD(U) on Saturday slammed AAP for claiming that it bore the cost of ferrying migrant workers from Delhi to their home in Bihar, saying the party was speaking "half-truth" as the Arvind Kejriwal government has sought reimbursement of the payment.

Cade Metz’s article for Wired titled “Hackers Don’t Have to Be Human Anymore. This Bot Battle Proves It” described a curious event that took place in Las Vegas on August 4, 2016. The first Defense Advanced Research Projects Agency (DARPA) Cyber Grand Challenge witnessed seven teams compete for cyber security supremacy. Unlike traditional hacking contests,…

This series of infographics reveals the bizarre discoveries made by volunteers during the 2017 International Coastal Cleanup.

In “fishing” for plastic to create new things, Plastic Whale Circular Furniture tackles a number of problems at once.

The next game-changing technology might not be in the form of an electric car with a longer range, or more efficient solar panels, but rather a better way to dry your clothes.

A new study shows a major difference between EPA estimates and actual landfill numbers.

The dead ones washing up on beaches are "just the tip of the iceberg."

Plastic waste has been diverted from the city's shoreline to create a cost-effective, green space alternative.

The city hopes to combat overtourism by getting visitors off the beaten track and doing more useful things.

A six-year dispute over mislabeled shipping containers has been settled, but the world can learn an important lesson from this.

Are solar-powered trash cans a fuel-saving, money-saving way to keep the streets clean? Or are they worse than regular trash cans?

These photos reveal the horror of our disposable, consumerist culture and how it's ruining the most beautiful places on Earth.

This short film, while focused on the island of Kauai, highlights the challenges and crises we will all have to face on our island planet.

Sixty-five porters and 75 yaks labored over two years to bring more than eight tons of trash down from the slopes of Mount Everest -- and into the hands of local artists.

Recycled Mississippi is traveling the length of one of America's iconic rivers, which also happens to be one of the most polluted, and filming a documentary along the way.

Starting in 2015, it will be illegal to leave computers and other electronic for curb-side pickup, as part of an effort to fight e-waste.

Landfill gas (LFG) isn't quite as sexy as some other alternative energy sources like wind or solar; still, TreeHugger thinks its an important part of our collective renewable energy portfolio. Plus, it's cool that landfills (and the stuff that fills

Some places have looked at paying people to recycle, but others think it makes more sense to charge people for their waste instead. When the UK talked about implementing a "pay-as-you-throw" scheme for trash, our readers were

Some 200 bald eagles are scavenging the goods at Cedar Hills Regional Landfill and dumping the leftovers in suburban backyards.

The Polluted Water Popsicles project is meant to shock viewers into realizing how serious water contamination is in Taiwan.

Artist Thomas Dambo and his team of elves built this wonderful recycled village in Copenhagen where DIYers can make all of their gifts for free.

New research finds that on just two remote islands alone, nearly 600,000 crabs are killed every year by plastic debris.

Students will have to take home any waste that is not recyclable or compostable.

Handmade from discarded items, this collection of young designers' chic jewelry shows that 'waste' is merely a mentality, not a fact.

Plastic pollution in our oceans is a big deal. These designers went out and collected some to create this surprising collection of items that look quite luxurious.

The award-winning DropBucket is a recycled cardboard trash can that can be reused and/or recycled.

How urban waste management is wising up.

This dismal finding shows that our eating culture needs a serious overhaul.

Surely there's a way to ditch our wasteful, disposable habits.

Today, September 6th, Trash Tycoon officially launches! It's been a long, hard, fun road getting to this point, and we owe a special thanks to all the beta testers who have been playing and submitting bugs and comments on the forums.

Waste Management CEO Jim Fish made an appearance on CNBC's "Mad Money" to discuss the trash collector company's three-month performance and what's ahead.

If you're like anyone else, it's hard to escape garbage moments made possible by shortsighted people who aren't thinking with everyone's best interest in mind. There are crook landlords, people stealing crap, and some massive disrespect just floating around the world. This trashiness belongs on Garbage Island.

American singer Ciara, who is expecting her second child with National Football League (NFL) star hubby Russell Wilson, has some advice for pregnant women during the COVID-19 pandemic. Several hospitals and healthcare facilities in many countries have decided to ban partners from accompanying pregnant women for their doctor's appointments or entering the delivery room.

In a recent interview with Good Morning America, Ciara spoke about how pregnant women should make optimum use of technology to involve their partners during the maternity period.

Ciara revealed how she had to FaceTime Russell so that he could experience the ultrasound with her. "It was the first time we ever had that kind of experience and it was really a moment that marked the time we are living in... we made the best of it, but it was definitely surreal. I took tons and tons of videos, tons and tons of photos during the ultrasound and made the best of that. Also, what we do in our house is we sing to the belly," Ciara said.

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