There are 130 major college football teams, spread across 41 states and competing in 10 conferences, save for a handful of independents. The goal is to have all those teams start the upcoming season at the same time - whether that's around Labor Day as scheduled or later - and play the same number of games. Despite the best intentions of conference leaders, the possibility exists of college football being played in SEC country before it begins in Pac-12 territory - or something else entirely.

Miscarriage.

Rentzenbrink, Cathy -- Family.

Climatic changes.

Stuttgart : F. Enke, 1891.

Berlin : J. Springer, 1899.

Cheltenham : printed for G.A. Williams, librarian, [1823]

Bristol : Wright, 1905.

[London?]

Siekmann, Francis Heinrich Ernst, 1830-1917.

Structural plasticity of dendritic spines is a key component of the refinement of synaptic connections during learning. Recent studies highlight a novel role for the NMDA receptor (NMDAR), independent of ion flow, in driving spine shrinkage and LTD. Yet little is known about the molecular mechanisms that link conformational changes in the NMDAR to changes in spine size and synaptic strength. Here, using two-photon glutamate uncaging to induce plasticity at individual dendritic spines on hippocampal CA1 neurons from mice and rats of both sexes, we demonstrate that p38 MAPK is generally required downstream of non-ionotropic NMDAR signaling to drive both spine shrinkage and LTD. In a series of pharmacological and molecular genetic experiments, we identify key components of the non-ionotropic NMDAR signaling pathway driving dendritic spine shrinkage, including the interaction between NOS1AP (nitric oxide synthase 1 adaptor protein) and neuronal nitric oxide synthase (nNOS), nNOS enzymatic activity, activation of MK2 (MAPK-activated protein kinase 2) and cofilin, and signaling through CaMKII. Our results represent a large step forward in delineating the molecular mechanisms of non-ionotropic NMDAR signaling that can drive shrinkage and elimination of dendritic spines during synaptic plasticity.

SIGNIFICANCE STATEMENT Signaling through the NMDA receptor (NMDAR) is vitally important for the synaptic plasticity that underlies learning. Recent studies highlight a novel role for the NMDAR, independent of ion flow, in driving synaptic weakening and dendritic spine shrinkage during synaptic plasticity. Here, we delineate several key components of the molecular pathway that links conformational signaling through the NMDAR to dendritic spine shrinkage during synaptic plasticity.

The pint-sized institution, which opened last year, is filled with 1,000 feline-themed knickknacks that journeyed with their owners from Ukraine

After four months of unexpected dimming, the red supergiant star has perked back up, and astronomers may have a new explanation for the fluke

In the late 1300s, tea was introduced to Japan from mainland China, transported in delicate jars. Over the years, as drinking tea became a prized activity in Japan, so too did the jars in which it was stored

The Kevin Koe curling team has split with second Colton Flasch after being eliminated from the recent men's national championship in Kingston, Ont., in a tiebreaker game. Flasch joined the foursome in 2018.

Is the Republican indulgence of the president bottomless?

RIESLING is perhaps the most famous, unappreciated, abused and generally misunderstood wine of all time and it’s probably also the one most of us cut our teeth on many years ago.

OK, most of us will never be able to enjoy the first growths from Bordeaux, but you don't have to spend a grand on a bottle to realise that when it comes to cabernet and merlot blends, Bordeaux is still the region to beat.

IT would appear that nostalgia is in the air this season as I've never fielded more questions about sherry in my 25 years in the wine game. If that translates into sales there will be some very happy Spaniards in Jerez this year and it’s about time.

It has been the major success story of the alcohol industry in recent years. Once thought of as a drink for the older generation, now you will find that gin, be it pink, flavoured or colour changing, has become one of the most popular spirits in the country. There have been no shortage of bars leaping on the bandwagon, to offer up drinks to connoisseurs, but where are the best places to go in Scotland? We’ve narrowed it down to 10 of the best.

IF you’re under 40, or as I like to call it these days, "pre-arthritis", you probably won’t remember the dark days of malbec when you had a 50-50 chance of opening something that would be as rough as sandpaper.

CHRISTMAS is coming, the goose is getting fat and there's no wine as flexible with the varied foods of the season than rioja, so let’s take a seasonal look at our favourite Spaniard.

IF you’re anything like me, these weird alcohol-free January fads are to be avoided so let's raise a glass to a guilt-free month and kick it off with a look at something clean and refreshing to wash the season of excess away.

IT only seems like yesterday that we were in the season to be jolly and, all of a sudden, romance is in the air. Before we know it, we’ll all be rolling eggs down a hill but, in the meantime, I guess we should take a look at rose, the wines of love.

With the Six Nations rugby in full flow (come on, Scotland – I’m forever the optimist) now is a great time to look at amazing beverages from all the nations competing.

WEEK two of the lockdown and I don't know about you, but I’m feeling a bit playful, so how about instead of a boring old wine column, we take a look at a drink that can be fun for all the family?

While lockdown has seen some people turn to DIY, it doesn't all have to be on the home or garden.

With the Janus case looming before the Supreme Court, teachers' unions are knocking on doors to try to boost membership and mitigate financial loss.

The change to the Title II program will benefit Southern states, while Michigan, New York, and Pennsylvania, among others, will see their allocations shrink.

Gov. Jeb Bush has warned that Florida won't meet class-size limits without taking such steps as expanding private school vouchers, lifting restrictions on the number of charter schools, and moving to year-round schedules.

The American Academy of Pediatrics recommends routine alcohol screening for all adolescents. Problem-based substance use screens for adolescents exist, but have limitations. A consumption-based alcohol screen could provide an empirically validated, very brief method to screen youth for alcohol-related problems.

National sample data indicate that frequency of alcohol use has high sensitivity and specificity in identifying youth with alcohol-related problems. A range of age-specific frequency cut scores perform well; specific cut points can be selected based on the screening context. (Read the full article)

Some studies reveal an association between exposure to alcohol consumption in movies and youth drinking, but the evidence is sparse.

Exposure to alcohol consumption in movies is associated with youth binge drinking, is little influenced by cultural differences between countries (Germany, Iceland, Italy, Netherlands, Poland, and Scotland), and is specific to movie alcohol, not movie smoking, depictions. (Read the full article)

First drink before age 15 greatly increases the likelihood for later alcohol abuse or dependence. Separate investigations have linked many variables to alcohol initiation, but few have attempted to identify the optimal combination of predictors for age of alcohol initiation.

This article supports the screening questions selected in the joint National Institute on Alcohol Abuse and Alcoholism and the American Academy of Pediatrics initiative to identify and initiate intervention in youth at risk for early use of alcohol. (Read the full article)

Evidence regarding effectively screening and counseling adolescents about unhealthy alcohol use is accumulating. Young adults aged 18 to 24, those most at risk for excess alcohol consumption, are often not asked or counseled by physicians about unhealthy alcohol use.

In 2010 among US 10th graders (age 16), 36% drank, 28% binged, and 23% were drunk in the past month; although 82% saw a doctor, 54% were asked about drinking but only 17% were advised to reduce or stop drinking. (Read the full article)

Several experimental and observational studies reveal an association between exposure to alcohol consumption in movies and youth drinking, but little is known about the effect of such exposure on drinking onset among low-risk adolescents.

In a longitudinal study, exposure to alcohol consumption in movies was associated with drinking initiation in a sample of adolescents from 6 European countries who had never drunk alcohol and were attitudinally nonsusceptible to future use at the time of exposure. (Read the full article)

Youth drinking is associated with adult drinking. Alcohol policies can influence youth and adult drinking. However, it is unknown whether alcohol policies influence youth drinking patterns directly or through their effect on adult drinking.

Alcohol policies, including population-oriented policies, are protective for youth drinking. The effect of population-oriented policies may be mediated though effects on adults. These findings suggest that efforts to reduce youth drinking should rely on policies that address all age groups. (Read the full article)

Intervention strategies are needed to reduce underage drinking. Meta-analyses of youth alcohol brief interventions (BIs) conclude that therapist-delivered BIs are efficacious; however, to maximize public health impact, recommendations include using technology to streamline intervention delivery, for which evidence is lacking.

A single-session BI, delivered by a computer or therapist in the emergency department, shows promise for underage drinkers. Findings for the stand-alone computer BI are particularly appealing given the ease of future implementation. (Read the full article)

Tangy and pulpy tomatoes make for an incredible addition to a heart-healthy diet. Here's how drinking home-made, fresh tomato juice may help.

Green Tea Benefits: क्या आप जानते हैं कि ग्रीन टी का सेवन वर्कआउट ड्रिंक (Workout Drink) के रूप में...

A pharmacist died and his boss was left hospitalised after the pair drank a chemical concoction they had developed in an effort to treat coronavirus, police said Saturday. The men worked for a herbal...

DNREC the Delaware Division of Public Health are now accepting project proposals from state, county and municipal governments, and conservation districts, for matching grants for wastewater, surface water, and drinking water project planning.

The Division of Public Health (DPH) is announcing that the Lewes Board of Public Works (BPW) has issued a drinking water notice to customers after tests showed elevated levels of lead in the water. DPH received notification late last week from BPW that drinking water samples collected in August showed an exceedance of the EPA Action Level for lead. Lab analysis found that the 90th percentile result of 26.5 ug/L exceeded the EPA Action Level of 15 ug/L. Sampling consisted of 10 samples collected in different parts of the BPW service area with results ranging from non-detect to 38.4 ug/L.

DNREC, with the Division of Public Health, is now accepting project proposals for matching grants for waste, surface, and drinking water project planning.

he Delaware Division of Public Health’s Drinking Water State Revolving Fund (DWSRF) is currently accepting project proposals from public drinking water systems for Safety Assessments and Feasibility Evaluations (SAFE) grants. Proposals must be received by August 15, 2019.

DNREC's Environmental Finance Office and the Delaware Division of Public Health will host a State Revolving Loan Fund public workshop Thursday, July 25