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Japanese chemical giant Sumitomo Chemical group has spent approximately ¥15 billion (A$177 million) on Botanical Resources Australia, a Tasmanian pyrethrum business.

Tidal energy developer Atlantis Resources remains on track to deliver power to the Scottish power grid from the MeyGen site in the coming year, according to an end-of-year statement issued by the company earlier this week.

Support services for victims and witnesses, the police and other relevant authorities are stretched to the limits because of staff shortages, travel restrictions or other demands related to Covid-19.

On 15 March 2020, following the announcement by President Ramaphosa regarding South Africa’s precautionary measures that must be put in place to prevent the contraction and spread of COVID-19, South Africans came face to face with the stark re...

The government of Indonesia wanted to improve land and water management in the Citarum River Basin, and requested assistance from the Asian Development Bank (ADB) to develop a long-term integrated water resources management (IWRM) investment program as part of its strategic road map. In December 2008, ADB approved a multitranche financing facility (MFF) for the Integrated Citarum Water Resources Management Investment Program to support the implementation of the IWRM road map in the basin. A periodic financing request was formulated to implement priority activities from the road map.

The project’s key objective was to demonstrate an innovative integrated ecosystem and water resources management that will improve the environmental conditions in the Baiyangdian Basin in Hebei province, southwest of Beijing. It focused on the need to conserve Baiyangdian Lake—one of the most important and vulnerable ecosystems in the People’s Republic of China (PRC). It would also contribute to achieving the goals of the Baoding municipality’s Eleventh Five-Year Environmental Protection Plan.

ADB is proposing a project to deliver climate adaptive solutions for water resources management and modernize outdated irrigation and drainage systems within the Amu Darya and selected reaches of the Zarafshan irrigation system.

ADB signed an agreement today to provide $8.32 million in financing to the Government of Pakistan to enable vital preparatory work ahead of a series of major projects to enhance water availability and increase agricultural...

Surgical procedures are performed in the United States in a wide variety of clinical settings and with variation in clinical outcomes. In May 2012, the Task Force for Children’s Surgical Care, an ad hoc multidisciplinary group comprising physicians representing specialties relevant to pediatric perioperative care, was convened to generate recommendations to optimize the delivery of children’s surgical care. This group generated a white paper detailing the consensus opinions of the involved experts. Following these initial recommendations, the American College of Surgeons (ACS), Children’s Hospital Association, and Task Force for Children’s Surgical Care, with input from all related perioperative specialties, developed and published specific and detailed resource and quality standards designed to improve children’s surgical care (https://www.facs.org/quality-programs/childrens-surgery/childrens-surgery-verification). In 2015, with the endorsement of the American Academy of Pediatrics (https://pediatrics.aappublications.org/content/135/6/e1538), the ACS established a pilot verification program. In January 2017, after completion of the pilot program, the ACS Children’s Surgery Verification Quality Improvement Program was officially launched. Verified sites are listed on the program Web site at https://www.facs.org/quality-programs/childrens-surgery/childrens-surgery-verification/centers, and more than 150 are interested in verification. This report provides an update on the ACS Children’s Surgery Verification Quality Improvement Program as it continues to evolve.

There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples. Analyses for these applications assume that mutagenic mechanisms have a distinct relationship with neighboring bases that allows them to be distinguished. Direct support for this assumption is limited to a small number of simple cases, e.g., CpG hypermutability. We have evaluated whether the mechanistic origin of a point mutation can be resolved using only sequence context for a more complicated case. We contrasted single nucleotide variants originating from the multitude of mutagenic processes that normally operate in the mouse germline with those induced by the potent mutagen N-ethyl-N-nitrosourea (ENU). The considerable overlap in the mutation spectra of these two samples make this a challenging problem. Employing a new, robust log-linear modeling method, we demonstrate that neighboring bases contain information regarding point mutation direction that differs between the ENU-induced and spontaneous mutation variant classes. A logistic regression classifier exhibited strong performance at discriminating between the different mutation classes. Concordance between the feature set of the best classifier and information content analyses suggest our results can be generalized to other mutation classification problems. We conclude that machine learning can be used to build a practical classification tool to identify the mutation mechanism for individual genetic variants. Software implementing our approach is freely available under an open-source license.

Reactive oxygen and nitrogen species have been implicated in many biological processes and diseases, including immune responses, cardiovascular dysfunction, neurodegeneration, and cancer. These chemical species are short-lived in biological settings, and detecting them in these conditions and diseases requires the use of molecular probes that form stable, easily detectable, products. The chemical mechanisms and limitations of many of the currently used probes are not well-understood, hampering their effective applications. Boronates have emerged as a class of probes for the detection of nucleophilic two-electron oxidants. Here, we report the results of an oxygen-18–labeling MS study to identify the origin of oxygen atoms in the oxidation products of phenylboronate targeted to mitochondria. We demonstrate that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants. We therefore conclude that boronates can be used as probes to track isotopically labeled oxidants. This suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems. We discuss the implications of these results for understanding the mechanism of conversion of the boronate-based redox probes to oxidant-specific products.

Site-specific recombinases, such as Cre, are a widely used tool for genetic lineage tracing in the fields of developmental biology, neural science, stem cell biology, and regenerative medicine. However, nonspecific cell labeling by some genetic Cre tools remains a technical limitation of this recombination system, which has resulted in data misinterpretation and led to many controversies in the scientific community. In the past decade, to enhance the specificity and precision of genetic targeting, researchers have used two or more orthogonal recombinases simultaneously for labeling cell lineages. Here, we review the history of cell-tracing strategies and then elaborate on the working principle and application of a recently developed dual genetic lineage-tracing approach for cell fate studies. We place an emphasis on discussing the technical strengths and caveats of different methods, with the goal to develop more specific and efficient tracing technologies for cell fate mapping. Our review also provides several examples for how to use different types of DNA recombinase–mediated lineage-tracing strategies to improve the resolution of the cell fate mapping in order to probe and explore cell fate–related biological phenomena in the life sciences.

The COVID-19 pandemic has placed unprecedented pressure on societies worldwide, given the pandemic's rapid, often deadly spread. In health care, the pandemic has raised the pressing question of how society should allocate scarce resources during a crisis.

The newly launched #SmithsonianEdu campaign highlights 1.7 million online tools geared specifically toward students and teachers

'We have seen this before.' Global health scholars have issued a clarion call about the needless loss of life expected because of a foreseeable prospect of 'slow and inadequate access to supplies' to control COVID-19 in sub-Saharan Africa. They say what is unfolding now is similar to when lifesaving diagnostics and treatments came to the region long after they were available elsewhere.

The National Venture Capital Association (NVCA) is closely monitoring the outbreak of the coronavirus (COVID-19) and is working diligently to address the VC industry’s needs and provide resources that aim to help firms and portfolio companies during this challenging time. This webpage provides important information and resources to venture-backed companies about the federal response to COVID-19, including tax credits, loan opportunities, and sick leave. NVCA will update this information as it becomes available.

Keep on reading: Coronavirus Information and Resources for VCs and Startups

Safeguarding public health requires rethinking our relationship to the environment and the inequities that drive its destruction

-- Read more on ScientificAmerican.com

“I am pleased to welcome Ignacia back to the Department and the Environment and Natural Resources Division,” said Attorney General Holder.

“The history of the Environment and Natural Resources Division reminds us of the importance of our nation’s public lands and natural resources to the development of this country, and the important role of the division in protecting these resources for future generations,” said Attorney General Holder.

Ignacia S. Moreno, Assistant Attorney General for the Environment and Natural Resources Division, welcomes the members of the division’s senior leadership.

The settlement, which will require legislative and judicial approval to become effective, is fair to the plaintiffs, is responsible for the United States, and provides a path forward for the future.

It is always a pleasure for me to see my long-time friends at the D.C. Bar. I have been a D.C. Bar member since 1991 – that is 20 years – and have served on various Bar committees and participated in pro bono activities sponsored by the Bar.

Marking the eighth annual Earth Day Service Celebration today, Deputy Attorney General James Cole and Assistant Attorney General Ignacia S. Moreno commended volunteers from the Justice Department’s Environment and Natural Resources Division as they began work on a future Community Greening Center near Marvin Gaye Park in Northeast Washington, D.C.

As part of Attorney General Eric Holder’s call for cost-cutting measures to streamline operations and reduce spending during a time of constrained funding, the Department of Justice today announced that it will realign functions in various offices, lower lease costs by consolidating or reducing office space and continue to look for ways to more effectively utilize the department’s resources.

“The tragedy at Upper Big Branch will never be forgotten, and the families affected by it will never be made completely whole again. Today’s agreement represents the largest-ever resolution in a criminal investigation of a mine disaster and will ensure appropriate steps are taken to improve mine safety now and will fund research to enhance mine safety in the future,” said Attorney General Holder.

The Department of Justice and the Department of the Interior announced today that Freeport-McMoRan Corporation and Freeport-McMoRan Morenci Inc. have agreed to pay $6.8 million to settle federal and state natural resource damages claims related to the Morenci copper mine in southeastern Arizona.

The Residential Mortgage-Backed Securities (RMBS) Working Group announced new resources today in the ongoing effort to investigate misconduct, including the launch of a RMBS website to report fraud and the creation of a coordination team to facilitate the various investigations underway around the country.

Northern States Power Co. will begin cleanup of the Ashland/Northern States Power Lakefront Superfund Site in Northwestern Wisconsin under a settlement the Department of Justice and the Environmental Protection Agency (EPA) announced today.

Another important step toward cleaning up the Quanta Resources Superfund site in Edgewater, N.J., was announced today by the Department of Justice and the U.S. Environmental Protection Agency.

Assistant Attorney General Ignacia S. Moreno announced today the publication of the Environment and Natural Resources Division’s (ENRD) Fiscal Year 2012 Accomplishments Report. The full report, which details the division’s work across the nation during FY2012, is posted at www.justice.gov/enrd/Current_topics.html.

The Department of Justice’s Office on Violence Against Women today announced a new Mentor Court Initiative to support criminal and civil domestic violence courts across the country.

The Justice Department’s Environment and Natural Resources Division (ENRD) today released its Fiscal Year (FY) 2013 Accomplishments Report detailing its work alongside other federal agencies.

"Earth Day is another reminder to me of that commitment, a commitment that the Department of Justice is dedicated not only to protecting the people of our country, but also to protecting its natural resources."

The Health Impact Project’s toolkit contains resources that help communities, agencies, and other organizations take action to improve public health. The toolkit offers a collection of health impact assessments, guides, and other research to support policymakers’ efforts to consider health when making decisions across sectors, such as housing, planning, and education.

Emport LLC is pleased to introduce new training programs and materials to augment its food safety and allergen control portfolio.

With the COVID-19 impact making itself apparent on a daily basis as the numbers climb and organizations respond, the effects on the pharma and biotech sector also shifts. Yesterday FDA announced a new concentration of agency assets to be focused … Continue reading →

Since 2013, hundreds of thousands of refugees have migrated southward to Jordan to escape the Syrian civil war. The migration has put major stress on Jordan’s water resources, a heavy burden for a country ranked among the most water-poor in the world, even prior to the influx of refugees. However, the refugee crisis also coincided […]

As countries around the world fall into a recession due to the coronavirus, what effects will this economic downturn have on Africa? Brahima S. Coulibaly joins David Dollar to explain the economic strain from falling commodity prices, remittances, and tourism, and also the consequences of a recent G-20 decision to temporarily suspend debt service payments…

Every region across the country experiences some level of digital disconnection. This can range from Brownsville, Texas, where just half of households have an in-home broadband subscription, to Portland, Ore., where all but a few pockets of homes are connected. Many more communities, such as Louisville, Ky., fall somewhere in the middle. In Louisville, most…

As countries around the world fall into a recession due to the coronavirus, what effects will this economic downturn have on Africa? Brahima S. Coulibaly joins David Dollar to explain the economic strain from falling commodity prices, remittances, and tourism, and also the consequences of a recent G-20 decision to temporarily suspend debt service payments…

This discussion was on topics spanning coal, natural resources and their valuation, regulation, and more – an Australian perspective. Key Speaker: Dr. Brian Fisher, AO PSM, Managing Director, BAEconomics Pvt. Ltd., Australia Discussion points: How is resource allocation done, and exports viewed (especially of coal)? How has thinking on a carbon tax evolved (Australia has…