Mike Tyson’s new line of boxing glove-shaped cannabis gummies launched exclusively in Colorado this week, and the reason why might come as a surprise.

When it opens on Sept. 14, Pure Elevations will be among the city’s first public consumption spaces.

As public support for marijuana decriminalization grows, new research is shedding light on the drug’s impact on sleep and memory.

A celebration of Vienna, in music by Strauss, Schubert, Suppé, Kreisler, and more.

Karrueche Tran discusses Chris Brown relationship drama.

A cluster of antennas located on Trunk Island in Harrington Sound are helping BAMZ to track the movements of migratory birds. A spokesperson said, “An inconspicuous cluster of antennas mounted atop an old utility pole on Trunk Island in Harrington Sound is gathering remarkable bird conservation data. “It was erected in August 2019 when BAMZ […]

BE Solar’s Director of Sales Joanna Frith has obtained the North American Board of Certified Energy Practitioners [NABCEP] PV Associate Certificate, with the company noting that she is the first woman in Bermuda to accomplish this. A spokesperson said, “BE Solar’s Director of Sales, Joanna Frith is the first woman in Bermuda to obtain the NABCEP […]

[Written by Stephen Wright] Karting driver Scott Barnes will look to return to top form when he races in the third round of the Stars Championship Series, the Clash at the Club, in Cincinnati, Ohio, this weekend. Barnes, who competes in the Shifter Masters and ROK classes, knows he needs some impressive displays at the […]

Karting driver Scott Barnes finished fourth overall in the Shifter Masters class and won the Rok class in the third round of the Stars Championship Series, the Clash at the Club, in Cincinnati, Ohio, at the weekend. Competing at the Motorsports Country Club, Barnes came second in heat one, tenth in heat two, and fourth […]

“More than sixty cannabis plants in various stages of growth” were “seized and subsequently destroyed,” the police confirmed. A police spokesperson said, “Shortly before 6:00 p.m. on Tuesday, September 3, 2024, police officers were on mobile patrol when they had occasion to attend a property in the area of Mission Lane, Pembroke. “A check of the […]

Date: October 25, 2024

Location: India, United Kingdom

Tags:

During the early reign of King Charles III (Charles the Simple) in West Francia, the area was besieged by Viking invasions, while the memory of the previous and frequent Saracen incursions was still fresh in the minds of the general populace. The Saracens were Muslim - mostly Berbers from Africa – and had only let up on the Franks because they’d been pushed back by the Vikings. The local nobles were left largely to fend the Vikings off on their own.

In Paladins of the West Kingdom, players assume the role of these unnamed nobles (most likely Dukes), working to keep the region safe and spread their faith (historically: Christianity).  I really enjoy this theme, and in fact, playing the game nurtured my interest in the historical kingdom of West Francia.  That’s why I can tell you that while the rulebook notes that the King lends his Paladins to the nobles to aid them in their quest, I’m giving all the credit for the loan to the designers, Shem Phillips and S J MacDonald.  Paladins are a fictional group of knights in French lore (think of them as similar to the Knights of the Round Table in British lore),  or alternatively, a translation of the Frankish royal title of Palatine Count, which was a noble that focused mostly on judicial and governing matters and was not known as a knight.

I’ve won a few and lost a few games of Paladins. It’s a worker placement game that incorporates card drafting.  At the beginning of every round, players draw the next three Paladin cards in their deck and choose one to play for the round, one to put back on top of their Paladin deck to draw during the next round, and one to put at the bottom of their Paladin deck. Each Paladin boosts faith, influence, or strength (usually more than one of these), and also provides a special benefit. If you’ve got players prone to analysis paralysis, this is where they may get stalled, especially in the first few rounds. After Paladins are selected and put into play, workers for the round are selected by each player and put into their personal resource supply. You have many stations on your player board to place your workers during the round,  and when you do so, your moves are independent and walled off from your opponents (they cannot tamper with your player board or placement of your workers on it). However, there is one area on the general board (the King’s Favour card area) where you can also place your workers and those spots are competitive. Also contributing to player interaction – some of the stations on your player board where you place workers allow you to move resources (monks and outposts) from your player board to the main board, consuming a competitive spot that provides a placement reward. And all the resource cards on display around the main board – the townsfolk you can hire, the walls you can build, the outsiders you can attack or convert, the tavern cards you draw workers from, and the suspicion cards you gain $$$ from, are all lucrative items for which players must compete. So we’ve got a good mix of independent action and player interaction in Paladins.  There are not a lot of opportunities for  “take that” behavior in this game, other than perhaps timing your draw of suspicion cards to trigger an inquisition when you know your opponents will suffer a penalty and be forced to take on more debt.

Giving the game more intellectual weight, worker placement on your board and the actions workers trigger often have additional requirements beyond number and types (i.e., colors) of workers. The actions triggered by worker placement may be constrained by your strength, faith, or influence level. And some spots or actions triggered by placing workers in those spots require money or provisions. All of these prerequisites can be gained as rewards from prior actions triggered by various worker placement, so much of the game is finding the most efficient ways to obtain prerequisites associated with the series of actions you’d like to take as the game progresses. I worried this decision making would be a weak point for analysis paralysis (I’m a pretty good candidate for testing potential AP, as I’m prone to it) and while there can be a bit of that during the game, nothing excessive was logged during our plays.  

The artists (Shem Phillips on graphic design and Mihajlo Dimitrievski on illustrations) have printed helpful indicators next to each placement location on boards and cards to identify any prerequisites as well as rewards. It’s an example of how the designers have worked with the artists to layer meaningful game information into the layers of artwork. In fact, all of the symbols implemented across the game components are really quite helpful. Bonus: once you familiarize yourself with them in one of the West Kingdom games, you’ll have learned them for the entire series as the artists reuse the same symbols in all three titles.

Beyond the iconography, the illustrations and other artwork are lovely. As with the iconography, the same style of artwork is implemented across the entire series and it carries the theme well. There was a good mix of cisgender representation, but not a lot of racial diversity, especially as would be suggested by the historical setting of the game (for example, Berbers in the area had skin tones ranging from light to to dark brown).

The components for Paladins of the West Kingdom are well made.

There are wooden meeples, an assortment of foldable boards constructed from cardboard, and various plastic coated card decks. We found the rulebook to be clear and direct, and there weren’t any items we had to look up online. It would have been nice if the designers included a player aid in the components, but I was able to compensate for the oversight by downloading a detailed player aid another user uploaded to the forums on BoardGameGeek.com.

Paladins of the West Kingdom is my favorite game of the West Kingdom series. All of the worker types and available actions make sense within the context of the theme, the mechanisms (worker placement, card drafting) integrate tightly with the scoring system to provide opportunities for building a victory point engine, and the game is complex and interesting yet still accessible for new players. The game is also a great value at its price point (approx $50) given you’ll get dozens of multiplayer games in before even a hint of same-o same-o creeps in. Many games with comparable replayability and complexity are double the price of Paladins. There’s also a solo play mode, which provides an additional way to explore the game.

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Publisher: Renegade Game Studios
Players: 1-4 (We played with 2)
Actual Playing Time (vs the guideline on the box): About 2 hours per game
Game type: card drafting, worker placement
Retail Price: $50

Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.

1. Chennai doctor stabbed by assilants posing as patients  The Times of India
2. Chennai Doctor Stabbed 7 Times By Son Of Woman Who Had Cancer  NDTV
3. Doctor stabbed by patient’s attendant at Kalaignar Centenary Super Speciality Hospital in Chennai  The Hindu
4. Patient's son stabs doctor 7 times in Chennai hospital, arrested  India Today
5. Doctor stabbed multiple times in Tamil Nadu government hospital by patient’s relative  Deccan Herald

HATERS GONNA HATE

Carry Smith wrote her PhD thesis on the Voting Rights Act and challenges to the right to vote in Georgia. Now dig this: Smith, the expert on challenges to voting rights, lost her vote because a Republican vigilante challenged her registration—along with 900 other Savannah voters—until she was forced to... READ MORE

Looking for a hugely entertaining alphabet book that also has an uplifting message of empowerment for young readers? I highly recommend T. REXES CAN'T TIE THEIR SHOES by Anna Lazowski and Steph Laberis, launching June 29th, 2021 from Doubleday Books For Young Readers. The back matter also has an alphabetized factoid list of "all the amazing things animals CAN do!"

This is an alphabet book that can be appreciated by grown-ups as well as young readers, with lots of potential discussion points. The illustrations of animals in ridiculous situations are so SOOOOO FUN --- omigosh, even as I'm writing this post, I went back to look through the digital ARC and can't decide which is my favourite, though I'm leaning toward the "Cheetahs can't chew bubble gum" page.

I asked debut picture book author Anna Lazowski if she had any advice for young writers, and here's what she said:

"Write what you want to write, because as you move through the publishing process, it will become incredibly important for you to truly believe in your work. The rejections in this industry are endless, and they come at every stage. Critique partners might reject elements of your manuscript, agents will reject your work, and once you're on submission to editors, they will reject your work. Then once you're finally published, some reviewers will reject your work. If you don't fully believe in your stories, this will be extremely hard to take. It's hard as it is, so make sure you're all in on the work you're doing. It will make the rest a little bit easier to navigate."

Wise advice. Thank you, Anna! And congrats to you and Steph on your upcoming launch!

----

Also see other Advice For Young Writers and Illustrators From Children's Book Creators and my other Interviews With Children's Book Creators.

Image at the top of this post was created for my new #BookADay book journal. For more info about Donalyn Miller's #BookADay challenge, see Donalyn's post in the Nerdy Book Club blog.

I’ve developed a survey to give to people who slipped me into their not-friend category. Since I’m a person with no ability to cope with nuance, answers to all questions are yes/no. 1. Were you ever my real friend?  I want to know if you needed me like I needed you, but I don’t want […]

The post Questionnaire for everyone who stopped talking to me appeared first on Penelope Trunk Careers.

The Vienna Dioscurides is an early 6th-century copy of De Materia Medica, a manuscript first created by the ancient Greek physician and pharmacologist Dioscurides. A precursor to all modern pharmacopeias, it remained in practical use until about 1600. The Vienna Dioscurides contains more than 400 pictures of animals and plants and is the earliest known manuscript to use a solid gold background. It is also the oldest surviving illustrated treatise on what type of animal?

A polymath born in Persia around 980 CE, Avicenna was, among other things, an astronomer, chemist, mathematician, poet, and the foremost physician and philosopher of his time. The Canon of Medicine, one of his most famous works, remained a standard medical text at many Islamic and European universities until the 18th century. Called the "doctor of doctors," Avicenna is regarded as the father of modern medicine. How old was Avicenna when he began studying medicine? Discuss

Haley Batten, Christopher Blevins, Riley Amos, Madigan Munro and Bradyn Johnson weigh in on what the Olympics mean to them.
( Photos: 6, Comments: 53 )

Here’s how cannabis use became prohibited—and the science of its biological, psychological, and social effects.

The seed for the current project was sown last year when a similarly-themed exposition was given pride of place at the Bundestag, the German parliament building in Berlin.

Air Force veteran and former Turning Point USA spokesperson Anna Paulina Luna has just announced she is running for the U.S. Congress against Democratic Congressman Charlie Crist in Florida’s 13th congressional district.

The post Air Force veteran Anna Luna runs Charlie Crist appeared first on Shark Tank.

Kieran McKenna describes Ipswich's 2-1 victory at Tottenham - their first Premier League win in 22 years - as a "massive moment" and validation for the players' hard work.

Did you know that the Marines just celebrated their 249th birthday? This is one helluva tribute.

The post VETERAN’S DAY: You’re Gonna Love What One Patriotic Coffee Company Did For The Marines! appeared first on Clash Daily.

The rare feat of winning both the Two Oceans and Soweto marathons has marked Onalenna Khonkhobe’s breakthrough season, establishing him as one of South Africa’s rising road-running stars.

Cheng Chu
Proc. Amer. Math. Soc. 152 (), 5289-5297.
Abstract, references and article information

Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR. Although the well-known poly(ADP-ribosylating) (PARylating) PARPs primarily function in the DNA damage response, many noncanonical mono(ADP-ribosylating) (MARylating) PARPs are associated with cellular antiviral responses. We recently demonstrated robust up-regulation of several PARPs following infection with murine hepatitis virus (MHV), a model coronavirus. Here we show that SARS-CoV-2 infection strikingly up-regulates MARylating PARPs and induces the expression of genes encoding enzymes for salvage NAD synthesis from nicotinamide (NAM) and nicotinamide riboside (NR), while down-regulating other NAD biosynthetic pathways. We show that overexpression of PARP10 is sufficient to depress cellular NAD and that the activities of the transcriptionally induced enzymes PARP7, PARP10, PARP12 and PARP14 are limited by cellular NAD and can be enhanced by pharmacological activation of NAD synthesis. We further demonstrate that infection with MHV induces a severe attack on host cell NAD+ and NADP+. Finally, we show that NAMPT activation, NAM, and NR dramatically decrease the replication of an MHV that is sensitive to PARP activity. These data suggest that the antiviral activities of noncanonical PARP isozyme activities are limited by the availability of NAD and that nutritional and pharmacological interventions to enhance NAD levels may boost innate immunity to coronaviruses.

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection, leading to high morbidity and mortality. Currently, bronchoalveolar lavage (BAL) is used in hospitals for VAP diagnosis and guiding treatment options. Although BAL collection procedures are invasive, alternatives such as endotracheal aspirates (ETA) may be of diagnostic value, however, their use has not been thoroughly explored. Longitudinal ETA and BAL were collected from 16 intubated patients up to 15 days, of which 11 developed VAP. We conducted a comprehensive LC–MS/MS based proteome and metabolome characterization of longitudinal ETA and BAL to detect host and pathogen responses to VAP infection. We discovered a diverse ETA proteome of the upper airways reflective of a rich and dynamic host-microbe interface. Prior to VAP diagnosis by microbial cultures from BAL, patient ETA presented characteristic signatures of reactive oxygen species and neutrophil degranulation, indicative of neutrophil mediated pathogen processing as a key host response to the VAP infection. Along with an increase in amino acids, this is suggestive of extracellular membrane degradation resulting from proteolytic activity of neutrophil proteases. The metaproteome approach successfully allowed simultaneous detection of pathogen peptides in patients' ETA, which may have potential use in diagnosis. Our findings suggest that ETA may facilitate early mechanistic insights into host-pathogen interactions associated with VAP infection and therefore provide its diagnosis and treatment.

DNA polymerase from bacteriophage T7 undergoes large, substrate-induced conformational changes that are thought to account for high replication fidelity, but prior studies were adversely affected by mutations required to construct a Cys-lite variant needed for site-specific fluorescence labeling. Here we have optimized the direct incorporation of a fluorescent un-natural amino acid, (7-hydroxy-4-coumarin-yl)-ethylglycine, using orthogonal amber suppression machinery in Escherichia coli. MS methods verify that the unnatural amino acid is only incorporated at one position with minimal background. We show that the single fluorophore provides a signal to detect nucleotide-induced conformational changes through equilibrium and stopped-flow kinetic measurements of correct nucleotide binding and incorporation. Pre-steady-state chemical quench methods show that the kinetics and fidelity of DNA replication catalyzed by the labeled enzyme are largely unaffected by the unnatural amino acid. These advances enable rigorous analysis to establish the kinetic and mechanistic basis for high-fidelity DNA replication.

FC Cincinnati midfielder Marco Angulo has died from injuries he sustained from a car crash, the MLS franchise and Ecuadorian Football Association announced Tuesday. He was 22.

What's the connection between long-term health and financial stability? Neuroscientist Wendy Suzuki and HSBC Global Private Banking and Wealth's CEO Annabel Spring explore the critical components of a good life — and how simple actions like exercise and financial planning can boost your present and future well-being. They discuss how to maximize your sense of joy, transform your anxiety into a force for good and keep your brain healthy over the course of your life. (This content is made possible by HSBC. It however does not necessarily reflect the views of HSBC.)

Dan Skillings Jr. sidelined by surgery for Cincinnati Bearcats basketball

Notre Dame sophomore guard Hannah Hidalgo is on the Women’s Basketball Coaches Association (WBCA) Wade Watch List. She's among 15 players being watched as a potential winner of the oldest, most prestigious player of the year award. She was a Region I finalist for…

Yasmin L. Hurd
Oct 16, 2019; 39:8250-8258
Symposium and Mini-Symposium

During adolescence, cannabis experimentation is common, and its association with interindividual variations in brain maturation well studied. Cellular and molecular underpinnings of these system-level relationships are, however, unclear. We thus conducted a three-step study. First, we exposed adolescent male mice to -9-tetrahydrocannabinol (THC) or a synthetic cannabinoid WIN 55,212-2 (WIN) and assessed differentially expressed genes (DEGs), spine numbers, and dendritic complexity in their frontal cortex. Second, in human (male) adolescents, we examined group differences in cortical thickness in 34 brain regions, using magnetic resonance imaging, between those who experimented with cannabis before age 16 (n = 140) and those who did not (n = 327). Finally, we correlated spatially these group differences with gene expression of human homologs of mouse-identified DEGs. The spatial expression of 13 THC-related human homologs of DEGs correlated with cannabis-related variations in cortical thickness, and virtual histology revealed coexpression patterns of these 13 genes with cell-specific markers of astrocytes, microglia, and a type of pyramidal cells enriched in dendrite-regulating genes. Similarly, the spatial expression of 18 WIN-related human homologs of DEGs correlated with group differences in cortical thickness and showed coexpression patterns with the same three cell types. Gene ontology analysis indicated that 37 THC-related human homologs are enriched in neuron projection development, while 33 WIN-related homologs are enriched in processes associated with learning and memory. In mice, we observed spine loss and lower dendritic complexity in pyramidal cells of THC-exposed animals (vs controls). Experimentation with cannabis during adolescence may influence cortical thickness by impacting glutamatergic synapses and dendritic arborization.

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA

Paraglider Ben Lewis remembers spinning around wildly as he got pulled up higher and higher into the violent storm. That was when he realized, about 6,700 metres up in the sky and still rising, that he was not likely to see his family again.

Automotive aftermarket manufacturer designs failure points out of parts with 3D CAD software

Canadian by birth, but Papua New Guinean at heart, Anna Stanton shares how God led her to serve with OM Ireland.

Flathead catfish — native to the Mississippi River basin — were first detected in the Susquehanna River in Pennsylvania in 2002, according to the U.S. Geological Survey. In the two decades since then, the invasive species has spread throughout the river basin. The impact of the large predator on the waterway’s food webs and ecology was unknown, but now a team including researchers from Penn State is beginning to understand what Susquehanna flatheads are eating and how their presence is affecting native aquatic species in the river.

Anna shares her journey from Germany to Africa and finally to Albania where she uses her professional skills to work with children with disabilities.

A government doctor was stabbed seven times in Chennai Wednesday morning by a young man - whose mother was being treated for cancer by the same doctor - who posed as an employee of the Kalaignar Centenary Hospital.

A government doctor was stabbed seven times in Chennai Wednesday morning by a young man - whose mother was being treated for cancer by the same doctor - who posed as an employee of the Kalaignar Centenary Hospital.

Prashanth Neel’s Bagheera, starring Sriimurali as a vigilante IPS officer, comes to Netflix for streaming this December. Known for its compelling storyline and powerful cast, including Prakash Raj and Rukmini Vasanth, Bagheera captivated cinema-goers and emerged as a Diwali hit. Netflix’s acquisition marks a significant step for Kannada cinema on the platform, with Bagheera joining other Hombale Films projects. The exact streaming date remains unconfirmed, but fans can expect the movie in early December.

Actor Mukesh Khanna, who played the titular role in the original show, shared the teaser of the show on his Instagram on Saturday

Shaktimaan, which originally aired in 1997 on Doordarshan, became one of the most popular superhero shows in India