The heavy nuclear-powered missile cruiser Admiral Nakhimov, which is undergoing repairs and extensive modernization at Sevmash shipyard, will begin trials in the upcoming autumn of 2024, the Commander-in-Chief of the Russian Navy, Admiral Alexander Moiseyev told TASS. "The Admiral Nakhimov is to go to sea for factory sea trials in the autumn of 2024. She is to be transferred to the Navy in 2025," he said during the Army-2024 Forum. Admiral Nakhimov of Project 1144.2M has been under repair since 1999, although the works started 2013. During the modernization, the cruiser will receive a universal shipborne firing system 3S14 to carry Kalibr, Onyx, or Zircon cruise missiles.

Nearly two-thirds of shoppers step into a store without a specific purchase in mind, looking to be inspired by retailers who can craft the ideal ambience through digital screens and interactive kiosks. 

The conflict between Iran and Israel did not reach a heated stage this timeб but the parties tested their level of readiness for full-fledged war. Russia could benefit from the conflict in the Middle East, but not in the long term. The market reacted weakly to Iran's attack on Israel on Sunday, April 14. Gold and oil prices showed almost no reaction. The price of gold rose by 0.8 percent to $2,379 per troy ounce, according to trading data on Monday, April 15. At the same time, Brent is trading steadily at $90.4 per barrel, WTI — at $85.6. The conflict appears to have been frozen for a short time unless Israel responds to Iran within a week. The situation is expected to aggravate, but not now — the parties have tested their combat readiness, but preferred not to go full throttle yet.

[Sports] :
The South Korean men's national football team faces Iraq in the World Cup qualifier match on Tuesday night at home. Considered the toughest opponent for South Korea in the third round of the Asian qualifiers, a win against the Middle Eastern squad will give the Taegeuk Warriors a huge boost in their ...

[more...]

[Sports] :
South Korea defeated Iraq 3-2 on Tuesday in a 2026 FIFA World Cup qualifier. The national football team, led by head coach Hong Myung-bo, won the match at Yongin Mireu Stadium in Yongin, south of Seoul, in its Group B match in the third round of the Asian qualification tournament.  Captain Son Heung-min ...

[more...]

The synthesis of a chiral isothiourea, namely, (4aR,8aR)-3-phenyl-4a,5,6,7,8,8a-hexahydrobenzo[4,5]imidazo[2,1-b]thiazol-9-ium bromide, C15H17N2S+·Br−, with potential organocatalytic and anti-inflammatory activity is reported. The preparation of the heterocycle of interest was carried out in two high-yielding steps. The hydrobromide salt of the isothiourea of interest provided suitable crystals for X-ray diffraction analysis, the results of which are reported. Salient observations from this analysis are the near perpendicular arrangement of the phenyl ring and the mean plane of the heterocycle. This conformational characteristic may be relevant with regard the stereoselectivity induced by the chiral isothiourea in asymmetric reactions. Furthermore, evidence was found for the existence of an S...Br− halogen bond.

Complex I (proton-pumping NADH:ubiquinone oxidoreductase) is the first component of the mitochondrial respiratory chain. In recent years, high-resolution cryo-EM studies of complex I from various species have greatly enhanced the understanding of the structure and function of this important membrane-protein complex. Less well studied is the structural basis of complex I biogenesis. The assembly of this complex of more than 40 subunits, encoded by nuclear or mitochondrial DNA, is an intricate process that requires at least 20 different assembly factors in humans. These are proteins that are transiently associated with building blocks of the complex and are involved in the assembly process, but are not part of mature complex I. Although the assembly pathways have been studied extensively, there is limited information on the structure and molecular function of the assembly factors. Here, the insights that have been gained into the assembly process using cryo-EM are reviewed.

The large Bunyavirales order includes several families of viruses with a segmented ambisense (−) RNA genome and a cytoplasmic life cycle that starts by synthesizing viral mRNA. The initiation of transcription, which is common to all members, relies on an endonuclease activity that is responsible for cap-snatching. In La Crosse virus, an orthobunyavirus, it has previously been shown that the cap-snatching endonuclease resides in the N-terminal domain of the L protein. Orthobunyaviruses are transmitted by arthropods and cause diseases in cattle. However, California encephalitis virus, La Crosse virus and Jamestown Canyon virus are North American species that can cause encephalitis in humans. No vaccines or antiviral drugs are available. In this study, three known Influenza virus endonuclease inhibitors (DPBA, L-742,001 and baloxavir) were repurposed on the La Crosse virus endonuclease. Their inhibition was evaluated by fluorescence resonance energy transfer and their mode of binding was then assessed by differential scanning fluorimetry and microscale thermophoresis. Finally, two crystallographic structures were obtained in complex with L-742,001 and baloxavir, providing access to the structural determinants of inhibition and offering key information for the further development of Bunyavirales endonuclease inhibitors.

The crystal structures of 4-benzyl-1H-pyrazole (C10H10N2, 1) and 3,5-di­amino-4-benzyl-1H-pyrazole (C10H12N4, 2) were measured at 150 K. Although its different conformers and atropenanti­omers easily inter­convert in solution by annular tautomerism and/or rotation of the benzyl substituent around the C(pyrazole)—C(CH2) single bond (as revealed by 1H NMR spectroscopy), 1 crystallizes in the non-centrosymmetric space group P21. Within its crystal structure, the pyrazole and phenyl aromatic moieties are organized into alternating bilayers. Both pyrazole and phenyl layers consist of aromatic rings stacked into columns in two orthogonal directions. Within the pyrazole layer, the pyrazole rings form parallel catemers by N—H⋯N hydrogen bonding. Compound 2 adopts a similar bilayer structure, albeit in the centrosymmetric space group P21/c, with pyrazole N—H protons as donors in N—H⋯π hydrogen bonds with neighboring pyrazole rings, and NH2 protons as donors in N—H⋯N hydrogen bonds with adjacent pyrazoles and other NH2 moieties. The crystal structures and supra­molecular features of 1 and 2 are contrasted with the two known structures of their analogs, 3,5-dimethyl-4-benzyl-1H-pyrazole and 3,5-diphenyl-4-benzyl-1H-pyrazole.

Lopinavir is a potent protease inhibitor that is used as a first-line pharmaceutical drug for the treatment of HIV. The multi-component solvated Lopinavir crystal, systematic name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-di­methyl­phen­oxy)acetamido]-4-hy­droxy-1,6-di­phenyl­hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide–ethane-1,2-diol–water (8/3/7) 8C37H48N4O5·3C2H6O2·7H2O, was prepared using evaporative methods. The crystalline material obtained from this experimental synthesis was characterized and elucidated by single-crystal X-ray diffraction (SC-XRD). The crystal structure is unusual in that the unit cell contains 18 mol­ecules. The stoichiometric ratio of this crystal is eight Lopinavir mol­ecules [8(C37H48N4O5)], three ethane-1,2-diol mol­ecules [3(C2H6O2)] and seven water mol­ecules [7(H2O)]. The crystal packing features both bi- and trifurcated hydrogen bonds between atoms.

Mirakl has announced its partnership with

Tina Turner performing, used in the documentary "Tina." ; Credit: Dave Hogan/Getty Images/HBO

This content is from Southern California Public Radio. View the original story at SCPR.org.

Chris Rock as Detective Zeke Banks in the film "Spiral."; Credit: Lionsgate

This content is from Southern California Public Radio. View the original story at SCPR.org.

Emirates NBD and...

Federal prosecutors secured their first guilty plea Wednesday in the Justice Department's sprawling conspiracy case involving the Oath Keepers extremist group in connection with the Jan. 6 attack on the U.S. Capitol.

At a hearing in federal court in Washington, D.C., Graydon Young pleaded guilty to one count of conspiracy and one count of obstruction of an official proceeding. The 55-year-old Florida resident agreed to cooperate with investigators, which could prove critical as the government pursues the remaining defendants in the high-profile case.

Young is one of 16 people associated with the Oath Keepers to be charged with conspiracy, obstruction and other offenses over the Capitol riot. Prosecutors say the defendants coordinated their efforts and actions to try to disrupt Congress' certification of the Electoral College count on Jan. 6.

More than 500 people have been charged so far in connection with the Capitol breach, but the Oath Keepers conspiracy case is one of the most closely watched because of the allegations and the link to an extremist organization.

Young is the second defendant linked to the Oath Keepers to plead guilty. Jon Schaffer pleaded guilty to obstructing an official proceeding and entering restricted grounds with a dangerous weapon in April.

According to Young's statement of offense, he coordinated with his co-conspirators ahead of Jan. 6 and used encrypted messaging apps to maintain "operational security."

On the day itself, the document says, Young and some of his co-conspirators pushed through U.S. Capitol Police lines guarding the Capitol and into the building.

"Mr. Young believed that he and the co-conspirators were trying to obstruct, influence, and impede an official proceeding, that is, a proceeding before Congress, specifically, Congress's certification of the Electoral College vote," the document says.

At Wednesday's hearing, Judge Amit Mehta read that passage to Young to ensure that it was accurate.

"Yes, sir," Young replied, "that is correct."

According to the plea deal, Young has agreed to cooperate fully with prosecutors, including sitting for interviews with investigators and testifying before the grand jury and at trial.

The government, meanwhile, has agreed to dismiss the remaining charges against him. Even so, Mehta said Young is facing a possible prison sentence of 5 to 6 1/2 years under the sentencing guidelines.

Wednesday brought another significant development in the Capitol investigation.

Anna Morgan-Lloyd, a 49-year-old from Indiana who described Jan. 6 as the "best day ever," became the first Capitol riot defendant to be sentenced.

Morgan-Lloyd was not accused of taking part in any of the violence at the Capitol. She pleaded guilty to a single misdemeanor count of "parading, demonstrating, or picketing in a Capitol building."

Judge Royce Lamberth sentenced her to three years of probation and no jail time.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Pro-Trump supporters storm the U.S. Capitol following a rally with then-President Donald Trump on Jan. 6.; Credit: Samuel Corum/Getty Images

An alleged member of the Oath Keepers has pleaded guilty to charges connected to the Jan. 6 breach of the U.S. Capitol and agreed to cooperate with the government in its conspiracy case against the extremist group.

Mark Grods entered a plea of guilty to one count of conspiracy and one count of obstruction of an official proceeding. According to the statement of offense, the conspiracy's aim was to stop Congress' certification of the Electoral College count.

The plea marks another step forward for prosecutors pursuing a broader conspiracy case against 16 alleged members or associates of the Oath Keepers, a far-right, anti-government group. Last week, one of the defendants in that case pleaded guilty to conspiracy and obstruction, and agreed to cooperate with investigators.

Grods, who was charged separately but admitted to having coordinated with members of the Oath Keepers, has also agreed to cooperate with the government, including testifying before a grand jury or at trial.

In a court filing, prosecutors said Grods' case "is part of an ongoing grand jury investigation and plea negotiation related to United States v. Thomas Caldwell, et al.," which is the government's Oath Keepers conspiracy case.

At a court hearing Wednesday in Washington, D.C., just blocks from the Capitol, U.S. District Court Judge Amit Mehta went over the charges and the terms of Grods' plea deal, and told him his estimated sentencing guidelines range was 51 to 63 months.

"How do you plead on count one, the charge of conspiracy, sir?" Mehta asked.

"Guilty," Grods said.

"Count two, obstruction of an official proceeding, how do you plead, sir?" Mehta asked.

"Guilty," Grods replied again.

In his statement of offense, Grods admits to bringing firearms to Washington, D.C., and then stashing them across the Potomac River at a Virginia hotel — a detail the government says buttresses its argument that the Oath Keepers prepared for violence on Jan. 6.

The government alleges the group planned to store weapons in Virginia and ferry them into Washington, D.C., on Jan. 6 if the situation in the city got messy.

Grods' statement of offense says on Jan. 6, he rode in a golf cart with others through the city before parking a few blocks away from the Capitol and walking the rest of the way. He then linked up with other alleged Oath Keepers, who forged their way through the crowd, up the steps of the Capitol in a military-style "stack" formation and into the building itself.

Other members of the "stack" have been charged in the Oath Keepers conspiracy case.

Four minutes after entering the Capitol, the statement of offense says, Grods left the building as police shot pepper balls at a wall near him.

Two days after the assault on the Capitol, an unnamed individual told Grods to "make sure that all signal comms about the op has been deleted and burned," according to the statement of offense, which Grods confirmed he had done.

It is unclear how much additional information Grods will be able to provide investigators, but his plea agreement — the second in the span of a week — may prompt other defendants in the case to cut deals with prosecutors as well.

Overall, charges have now been brought against more than 500 individuals related to the riot at the Capitol.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Scientific evidence links mold and other factors related to damp conditions in homes and buildings to asthma symptoms in some people with the chronic disorder, as well as to coughing, wheezing, and upper respiratory tract symptoms in otherwise healthy people, says a new report from the Institute of Medicine of the National Academies.

Use of protective face coverings will be one of many strategies used to slow or prevent transmission of the flu virus in the event of a pandemic, even though scientific evidence about the effectiveness of inexpensive, disposable medical masks and respirators against influenza is limited.

While the U.S. Department of Veterans Affairs (VA) provides mental health care of comparable or superior quality to care provided in private and non-VA public sectors, accessibility and quality of services vary across the VA health system, leaving a substantial unmet need for mental health services among veterans of the recent wars in Afghanistan and Iraq, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Half-facepiece reusable elastomeric respirators are an effective and viable option for protecting health care workers from exposure to airborne transmissible contaminants or infectious agents — for example, influenza virus — during day-to-day work or with a sudden or rapid influx of patients, such as during a public health emergency, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Limitations in existing health studies have resulted in insufficient evidence to determine whether U.S. troops’ exposure to burn pit emissions and other airborne hazards in Southwest Asia are linked to adverse respiratory health outcomes, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Science academies from the G-7 nations issued statements urging their governments to take action on four global challenges — developing antiviral drugs to prepare for future pandemics, speeding progress on decarbonization, protecting the oceans and sea ice, and implementing a One Health approach to zoonotic disease and antimicrobial resistance.

Up until now, scientists had only recognized a single species of giraffe made up of several subspecies. But, according to the most inclusive genetic analysis of giraffe relationships to date, giraffes actually aren't one species, but four. For comparison, the genetic differences among giraffe species are at least as great as those between polar and brown bears.

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The brand is introducing new flavors across categories and dayparts, including April's pancake of the month and new Sonic the Hedgehog partnership.

Ciranda and Terviva, a regenerative food and ag innovation company, have launched sustainable Ponova oil through a new partnership.  

Solvaira Specialties has announced that it will now be offering VIDOFIBRES BF Sugar Beet Fiber products.

According to Technomic's 2018 Pizza Consumer Trend Report, 83 percent of U.S. consumers eat pizza at least once per month, with 43 percent opting for pizza every week.

The products are aimed at helping snack and bakery producers develop items with less sugar.

In 2009 under President Barack Obama, the economic stimulus package of 2009 was signed into law. Egg Geo was a regional engineering and contracting company in the southeastern United States with robust business in our central Florida offices.

The Inflation Reduction Act of 2022 has delivered good news in the form of federal income tax credits and accelerated depreciation deductions that help make geothermal a more attractive option.

One of the most common OSHA violations is respiratory protection. Let’s dive into why and what’s required to be compliant.

The OSHA standard on respiratory protection, general industry is one of the top 10 most frequently penalized OSHA standards for FY 2022.

The danger presented by airborne contaminants, though very real, is sometimes not immediately obvious, which is why respiratory protection in contaminated environments must mean more than throwing on whatever mask is handy.

New Pureflo- Supplied Air Respirators for grinding, welding and painting. Respirators are NIOSH approved with ANSI Head, Eye - Face Protection, along with three welding lens options, optional left front window, QR Suspension, APF of 1000.

VelocityEHS, the global leader in cloud-based environment, health, safety (EHS) and sustainability solutions, announced today it has acquired Spiramid, developer of the most advanced and easy-to-use system for managing industrial hygiene (IH). The acquisition adds Spiramid’s occupational safety & health software and unparalleled IH expertise to the most trusted EHS platform in the industry.

The hierarchy of controls for respiratory protection is a system designed to minimize or eliminate exposure to airborne contaminants.

The Challenge was a three-phase, $350,000 competition aimed at improving respirator fit evaluation.

Empower Thrive Magazine inviting individuals to share inspiring stories of triumph and perseverance on their website. They aim to empower readers with stories of courage and resilience. Submissions from individuals overcoming challenges and obstacles

TeleCloud is thrilled to announce its recent acquisition of DiRAD's Nextphone customer base, further strengthening its position in the industry.

Antony Jackson Arumairaj is an established critical care physician and dedicated educator

M. Glenn Baxter's spiritual journey over last 5 years has opened his eyes through the laws of nature into the metaphysical life force vibrational resonance to connect and flow in Oneness with The Absolute Trinity Creator of Universe.

Sure enough, when God send you, He equips you and makes a way!

Beat the holiday shopping rush and get eyewear gift ideas to give back this Christmas

Ravikiran Dharmavaram is an expert in data and analytics usage with more than 25 years of industry experience

Akira Olsen is a dedicated expert in mental health care and psychological education

This Partnership is a significant milestone in 1st Class Medical's commitment to advancing respiratory health awareness, education, and support for individuals affected by chronic obstructive pulmonary disease (COPD) and other lung conditions.

Monira Haque, MD, is lauded for her expertise in surgical pathology and hematopathology

Ira B. Shaw is recognized for his expertise as the director of information technology for the Alabama Bureau of Pardons and Paroles

Lennie Kyomuhangi Bazira, MB, is an esteemed medical professional who focuses on women's and children's health

Dr. Indira Narayanan, MBBS, MD, FNNF, FIAP, FNAMS, is lauded for her work in newborn care and global maternal and newborn health and nutrition