chai PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids By www.jlr.org Published On :: 2020-12-01 Hideaki KugeDec 1, 2020; 61:1747-1763Research Articles Full Article
chai Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis [Genomics and Proteomics] By www.jbc.org Published On :: 2020-12-04T00:06:05-08:00 Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of proteolysis are debated. Identification of the N and C termini of LC fragments is instrumental to understanding involved processes and enzymes. We investigated the N and C terminome of the LC proteoforms in fibrils extracted from the hearts of two AL cardiomyopathy patients, using a proteomic approach based on derivatization of N- and C-terminal residues, followed by mapping of fragmentation sites on the structures of native and fibrillar relevant LCs. We provide the first high-specificity map of proteolytic cleavages in natural AL amyloid. Proteolysis occurs both on the LC variable and constant domains, generating a complex fragmentation pattern. The structural analysis indicates extensive remodeling by multiple proteases, largely taking place on poorly folded regions of the fibril surfaces. This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils. Full Article
chai Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids [Research Articles] By www.jlr.org Published On :: 2020-10-01T00:05:17-07:00 The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has implicated ceramides with different LCBs and N-acyl chains in distinct biological processes; moreover, they may play different roles in disease states and possibly even act as prognostic markers. We now demonstrate that the half-life, or turnover rate, of ceramides containing diverse N-acyl chains is different. By means of a pulse-labeling protocol using stable-isotope, deuterated free fatty acids, and following their incorporation into ceramide and downstream SLs, we show that very-long-chain (VLC) ceramides containing C24:0 or C24:1 fatty acids turn over much more rapidly than long-chain (LC) ceramides containing C16:0 or C18:0 fatty acids due to the more rapid metabolism of the former into VLC sphingomyelin and VLC hexosylceramide. In contrast, d16:1 and d18:1 ceramides show similar rates of turnover, indicating that the length of the sphingoid LCB does not influence the flux of ceramides through the biosynthetic pathway. Together, these data demonstrate that the N-acyl chain length of SLs may not only affect membrane biophysical properties but also influence the rate of metabolism of SLs so as to regulate their levels and perhaps their biological functions. Full Article
chai PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids [Research Articles] By www.jlr.org Published On :: 2020-12-01T00:05:39-08:00 The plasma membrane of neurons consists of distinct domains, each of which carries specialized functions and a characteristic set of membrane proteins. While this compartmentalized membrane organization is essential for neuronal functions, it remains controversial how neurons establish these domains on the laterally fluid membrane. Here, using immunostaining, lipid-MS analysis and gene ablation with the CRISPR/Cas9 system, we report that the pancreatic lipase-related protein 2 (PLRP2), a phospholipase A1 (PLA1), is a key organizer of membrane protein localization at the neurite tips of PC12 cells. PLRP2 produced local distribution of 1-oleoyl-2-palmitoyl-PC at these sites through acyl-chain remodeling of membrane phospholipids. The resulting lipid domain assembled the syntaxin 4 (Stx4) protein within itself by selectively interacting with the transmembrane domain of Stx4. The localized Stx4, in turn, facilitated the fusion of transport vesicles that contained the dopamine transporter with the domain of the plasma membrane, which led to the localized distribution of the transporter to that domain. These results revealed the pivotal roles of PLA1, specifically PLRP2, in the formation of functional domains in the plasma membrane of neurons. In addition, our results suggest a mode of membrane organization in which the local acyl-chain remodeling of membrane phospholipids controls the selective localization of membrane proteins by regulating both lipid-protein interactions and the fusion of transport vesicles to the lipid domain. Full Article
chai Former chair of BMA GP Committee wins right to tribunal for unfair dismissal By www.bmj.com Published On :: 2024-11-12T01:31:10-08:00 An employment judge has cleared the way for Farah Jameel, a former chair of the BMA’s General Practitioners Committee for England (GPCE), to go ahead with claims of discrimination and unfair dismissal against the association over her removal from the post during maternity leave.Jameel, who was elected the first female chair in November 2021, was put on temporary suspension in 2022 after complaints by BMA staff. The BMA told her in August 2023 that her contract was being terminated.The contract described her as a contractor providing consultancy services rather than an employee. But in a preliminary ruling the employment judge Natasha Joffe has held that Jameel was in reality an office holder and an employee, opening the way for her claims to proceed to a full hearing by an employment tribunal.The GPCE passed a vote of no confidence in Jameel in July 2023, as a means of electing a new... Full Article
chai Planet Fitness makes second bid to buy out Blink Fitness chain in bankruptcy By www.upi.com Published On :: Wed, 06 Nov 2024 16:59:01 -0500 Planet Fitness is seeking to further grow its number of locations in a second bid for the Blink Fitness chain of workout facilities, according to new reports. Full Article
chai AlmaLinux OS Foundation Chair to Discuss Embracing Diversity in Open Source at SC24 By www.hpcwire.com Published On :: Thu, 07 Nov 2024 14:00:42 +0000 FORT MYERS, Fla., Nov. 7, 2024 — The AlmaLinux OS Foundation, the nonprofit that stewards the free and community-governed open source enterprise Linux distribution, today announced that chair benny Vasquez is […] The post AlmaLinux OS Foundation Chair to Discuss Embracing Diversity in Open Source at SC24 appeared first on HPCwire. Full Article
chai Meet the Indiana Teacher Running to Unseat the State's House Education Chair By blogs.edweek.org Published On :: Tue, 30 Oct 2018 00:00:00 +0000 "I'm running because I'm not happy with the state of education," said veteran educator Kevin Leineweber, who is one of several teachers running for the state's legislature this year. Full Article Indiana
chai Marny Xiong, School Board Chair and Social Justice Champion, Dies at 31 of COVID-19 By www.edweek.org Published On :: Thu, 11 Jun 2020 00:00:00 +0000 The daughter of Hmong refugees was an outspoken advocate for minority communities. She was elected to the St. Paul, Minn., school board in 2017. Full Article Minnesota
chai Georgia football outside CFP bracket: What selection committee chair said about Bulldogs By sports.yahoo.com Published On :: Wed, 13 Nov 2024 03:12:38 GMT Georgia football tumbled nine spots in the College Football Playoff rankings Tuesday and fell out of the 12-team bracket. What committee chair said Full Article article Sports
chai Interview with Ambassador Hans Hoogeveen, Chair of the Programme Committee By www.fao.org Published On :: Thu, 31 May 2018 00:00:00 GMT Q: Ambassador, how did the Programme Committee in its recent session judge FAO's contribution to the eradication of hunger, food insecurity and malnutrition? Ambassador Hoogeveen: [...] Full Article
chai A Human Chain Helped a U.K. Bookshop Move to Its New Location By www.smithsonianmag.com Published On :: Fri, 02 Nov 2018 17:25:21 +0000 Some 250 volunteers transported more than 2,000 books Full Article
chai CME Group Announces Employment Agreement Extension for Chairman and Chief Executive Officer Terry Duffy By www.cmegroup.com Published On :: Thu, 07 Nov 2024 11:14:00 -0600 Chief Financial Officer Lynne Fitzpatrick Appointed to President and CFO Chief Operating Officer Julie Holzrichter to Step Down and Assume Advisory Role Suzanne Sprague to Succeed Holzrichter CHICAGO, Full Article Press Release CME Group
chai SolidWorks Helps TiLite Wheelchairs Save $400,000 a Year By www.solidworks.com Published On :: Mon, 09 Nov 2009 00:00:00 -0500 SolidWorks Drives Custom 3D CAD Models, Helping the Company Outperform Competition Full Article
chai California State University, Chico uses SolidWorks software to design award-winning wheelchair By www.solidworks.com Published On :: Wed, 14 Sep 2005 00:00:00 -0500 New design increases user leverage and mobility, and keeps hands clean Full Article
chai G‘Reee’n Chair Developed in SOLIDWORKS Software Uses Recycled Video Game Plastic By www.solidworks.com Published On :: Mon, 03 Nov 2008 00:00:00 -0500 Designed and Tested in SOLIDWORKS and SOLIDWORKS Simulation, Each Reee Chair Made of Plastic From Nine Recycled Game Consoles Full Article
chai Gustavo Nader named Huck Chair in Molecular, Cellular and Integrative Physiology By www.psu.edu Published On :: Thu, 17 Oct 2024 11:22:53 -0400 Gustavo Nader, professor of kinesiology and physiology in the Penn State College of Health and Human Development, has been named the Dorothy Foehr Huck and J. Loyd Huck Chair in Molecular, Cellular and Integrative Physiology by the Huck Institutes of the Life Sciences. Full Article
chai Supply chain leak hints at two potential Apple home automation releases set for 2026 By appleinsider.com Published On :: Tue, 12 Nov 2024 11:51:00 +0000 An Apple supplier may have been tapped to build an Apple-designed smart home camera and future health-focused AirPods, according to analyst Ming-Chi Kuo.Tapo smart cameras compatible with Apple HomeKitAfter Apple abandoned the decade-long Apple Car project, rumors suggested Apple would increase investments in the smart home and AI. While Apple Intelligence has been released to the public, there has been little evidence of Apple's new commitment to the smart home beyond rumors of a smart monitor.A new supply chain-based rumor from analyst Ming-Chi Kuo suggests an Apple supplier named Goertek has been tapped with orders for two products due in 2026. The first is a smart home camera, and the second is a set of AirPods with more health-focused features. Rumor Score: ???? Possible Continue Reading on AppleInsider | Discuss on our Forums Full Article
chai Invasive flathead catfish impacting Susquehanna’s food chain, researchers find By www.psu.edu Published On :: Fri, 18 Oct 2024 00:36:02 -0400 Flathead catfish — native to the Mississippi River basin — were first detected in the Susquehanna River in Pennsylvania in 2002, according to the U.S. Geological Survey. In the two decades since then, the invasive species has spread throughout the river basin. The impact of the large predator on the waterway’s food webs and ecology was unknown, but now a team including researchers from Penn State is beginning to understand what Susquehanna flatheads are eating and how their presence is affecting native aquatic species in the river. Full Article
chai Penn State Smeal's Palumbo-Miele named 2024 Women in Supply Chain award winner By www.psu.edu Published On :: Tue, 08 Oct 2024 15:28:46 -0400 Donna Palumbo-Miele, executive director of the Center for Supply Chain Research at the Penn State Smeal College of Business, has been awarded the 2024 Women in Supply Chain award by Food Logistics and Supply & Demand Chain Executive. Full Article
chai Marny Xiong, School Board Chair and Social Justice Champion, Dies at 31 of COVID-19 By www.edweek.org Published On :: Thu, 11 Jun 2020 00:00:00 +0000 The daughter of Hmong refugees was an outspoken advocate for minority communities. She was elected to the St. Paul, Minn., school board in 2017. Full Article School+boards
chai Q&A with outgoing Board of Trustees Chair Matt Schuyler By www.psu.edu Published On :: Fri, 08 Nov 2024 15:00:00 -0500 After four years as chair of the Penn State Board of Trustees, Matt Schuyler’s leadership term officially ends during the trustees’ meeting today (Nov. 8). Schuyler first joined the board in 2015 as an at-large trustee and will continue serving as a member of the board through the end of his term in 2026. Full Article
chai Kleppinger, Sokolov elected Board of Trustees chair, vice chair By www.psu.edu Published On :: Fri, 08 Nov 2024 16:12:47 -0500 The Penn State Board of Trustees voted to elect David Kleppinger as chair and Rick Sokolov as vice-chair during its regular meeting on Nov. 8 on the University Park campus. Full Article
chai News24 Business | Tito Mboweni appointed as chairman of property group By www.news24.com Published On :: Tuesday Feb 01 2022 13:38:09 Accelerate Property Fund owns Fourways Mall, along with other smaller shopping centres and other properties in Johannesburg and Cape Town. Full Article
chai Namechain: The Next Major Project from the Creators of Ethereum Name Service, Explained By www.gadgets360.com Published On :: Tue, 12 Nov 2024 17:14:59 +0530 ENS Labs will be launching its own layer-2 blockchain network, called Namechain by the end of 2025. The network is being built atop the Ethereum blockchain and will use scaling technology called zero-knowledge rollups to make transactions more cost and time efficient. Full Article
chai Sobhita Dhulipala-Naga Chaitanya Wedding: The Venue And Its Association With Akkineni's Legacy By www.ndtv.com Published On :: Tue, 12 Nov 2024 18:46:51 +0530 The couple got engaged on August 8 Full Article
chai Viral Now: Vlogger Dips Leftover Diwali Snacks In Chai, Foodies React By food.ndtv.com Published On :: Fri, 08 Nov 2024 11:35:42 +0530 A light-hearted video showing leftover Diwali faral (Maharashtrian snacks) being eaten with tea has got foodies talking on Instagram. Full Article
chai Watch: When Pankaj Tripathi Shared His "Special" Masala Chai Recipe By food.ndtv.com Published On :: Mon, 11 Nov 2024 15:38:29 +0530 Pankaj Tripathi revealed a surprising ingredient that he adds to his tea to make it special. Full Article
chai Watch: Man Collects Free Ketchup Packets From Fast Food Chains, Here's How Much He Got Home By food.ndtv.com Published On :: Mon, 11 Nov 2024 18:27:00 +0530 The free ketchup collection video has gone viral on Instagram, clocking more than 10 million views. Full Article
chai Delaware Department of Agriculture Awards Over $665,000 for Innovative Projects to Improve Food Supply Chain By news.delaware.gov Published On :: Mon, 24 Jul 2023 17:36:23 +0000 The Delaware Department of Agriculture (DDA) today announced it is awarding $665,872 in funding to 12 projects through the First State Food System Program. The program, managed by the Delaware Council on Farm and Food Policy, strengthens the local food system by supporting the broad food supply chain spectrum. Full Article Department of Agriculture News ARPA Delaware Council on Farm and Food Policy First State Food System Program food supply chain grants
chai DNREC Unveils Delaware’s First Publicly Available All-Terrain Wheelchair By news.delaware.gov Published On :: Fri, 12 Jul 2024 17:25:35 +0000 The Delaware Department of Natural Resources and Environmental Control unveiled its new Action Trackchair an all-terrain wheelchair donated from the Ford Bronco Wild Fund June 12 at the Deerfield Clubhouse at White Clay Creek State Park. The event highlighted accessibility improvements statewide and featured the first publicly accessible all-terrain wheelchair available for public use in the state of Delaware. Delaware was the recipient of a nationally competitive grant for one of seven AXIS model Trackchairs provided through the Bronco Wild Fund Access Grants and the National Association of State Park Directors (NASPD). Full Article Department of Natural Resources and Environmental Control Division of Parks and Recreation New Castle County News Accessibility Action Trackchairs Delaware State Parks dnrec
chai Opioid Fund Co-Chairs Release Roadmap to Recalibrate Use of Settlement Funds By news.delaware.gov Published On :: Mon, 28 Oct 2024 21:52:21 +0000 WILMINGTON, Del. – As the first year of grantmaking comes to a close, Co-Chairs Attorney General Kathy Jennings and Lt. Governor Bethany Hall-Long shared the results of the third-party report from independent contractor Social Contract with recommendations to maximize the impact of the governing body overseeing Delaware’s opioid settlement funds. The report, Enhancing Use […] Full Article News
chai Lollipop Chainsaw Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Lollipop Chainsaw Gaming. Know detailed info about Lollipop Chainsaw configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article Gaming
chai Vandeput's Data Science for Supply Chain Forecasting (book excerpt) By blogs.sas.com Published On :: Fri, 21 May 2021 17:17:15 +0000 I am gratified to see the continuing adoption of Forecast Value Added by organizations worldwide. FVA is an easy to understand and easy to apply approach for identifying bad practices in your forecasting process. And I'm particularly gratified to see coverage of FVA in two new books, which the authors [...] The post Vandeput's Data Science for Supply Chain Forecasting (book excerpt) appeared first on The Business Forecasting Deal. Full Article Uncategorized Data Science for Supply Chain Forecasting FVA Nicolas Vandeput
chai "We Talked About...": Sundar Pichai Recalls Last Meeting With Ratan Tata By www.ndtv.com Published On :: Thu, 10 Oct 2024 07:52:42 +0530 Ratan Tata, born on December 28, 1937, is the Chairman of Ratan Tata Trust, two of the largest private-sector-promoted philanthropic trusts in India. Full Article
chai WANTED: Police are looking for man allegedly linked to the murder of Fredville Taxi Association chairperson By www.iol.co.za Published On :: Mon, 11 Nov 2024 12:02:27 GMT Full Article
chai Lee-Jay Cho Endowed Chair By www.eastwestcenter.org Published On :: Wed, 30 Nov 2022 08:12:59 +0000 Lee-Jay Cho Endowed Chair laupolaj Tue, 11/29/2022 - 22:12 Jan 31, 2022 North Korea South Korea Economics Full Article
chai Bank of Thailand tempers anxiety about chair By www.bangkokpost.com Published On :: Wed, 13 Nov 2024 05:11:00 +0700 Satit Limpongpan, chairman of the selection committee tasked with choosing the new board chairman of the Bank of Thailand, has confirmed the position will not have any influence on the central bank's monetary policy. Full Article
chai to write a chairpersons report By english.al-akhbar.com Published On :: to write a chairpersons report Full Article
chai Asia-Pacific Trade Facilitation Report 2024: Promoting Sustainability and Resilience of Global Value Chains By www.adb.org Published On :: 2024-04-01 This report examines the progress of trade facilitation in Asia and the Pacific, highlights recent trends in paperless trade, and evaluates the impact of trade facilitation initiatives on trade costs and overall trade. Full Article
chai GMS Cross-Border Livestock Health and Value Chains Improvement Project By www.adb.org Published On :: 2025 The project will reduce trans-boundary animal diseases (TAD), food safety and zoonotic disease risks and strengthen livestock value chains and COVID-19 responses through investments in infrastructure, capacity building and policy support. The project will have the following outcome: health, value chains, and formal trade of livestock and livestock products improved. The project will be aligned with the following impact: GMS vision as a leading supplier of safe and environmentally friendly agriculture products realized. Full Article
chai 3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis By www.medicinenet.com Published On :: Thu, 18 Aug 2022 00:00:00 PDT Title: 3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid CrisisCategory: Health NewsCreated: 8/18/2022 12:00:00 AMLast Editorial Review: 8/18/2022 12:00:00 AM Full Article
chai The Changing Role of a Chair and DA: Follow-Up from the 2023 ADFM Annual Conference Session [Family Medicine Updates] By www.annfammed.org Published On :: 2024-09-23T14:00:14-07:00 Full Article
chai Musical chairs on Virgin board By www.theaustralian.com.au Published On :: Tue, 03 Jan 2017 13:00:00 GMT Richard Branson’s Virgin Group has swapped out its envoy on Virgin Australia’s board, putting in Warwick Negus. Full Article
chai Former CFL commissioner Mark Cohon joins Northern Super League as board chair By www.cbc.ca Published On :: Tue, 12 Nov 2024 10:17:56 EST Mark Cohon, who brought the CFL back to Ottawa with the Redblacks as CFL commissioner, is joining the new Northern Super League as chair of its board of directors. Full Article Sports/Soccer
chai Former CHC Board Chairs Sharon Callahan and Nick Colucci Named as 2025 MAHF Inductees By cohealthcom.org Published On :: Fri, 25 Oct 2024 20:39:55 +0000 Two former board chairs of the Coalition for Healthcare Communication (CHC) were named as the Medical Advertising Hall of Fame (MAHF) 2025 inductees – Sharon Callahan, former Chief Client Officer at Omnicom Health Group (OHG), and Nick Colucci, former Chairman and CEO of Publicis Health/COO of Publicis Groupe North America. The inductees will be honored […] Full Article CHC News chc MAHF Nick Colucci Sharon Callahan
chai Groupe Renault Unveils Plans for Alpine - Groupe Renault Chairman and CEO Carlos Ghosn today announced plans for a new Alpine sports car By www.multivu.com Published On :: 17 Feb 2016 17:30:00 EST Groupe Renault Chairman and CEO Carlos Ghosn today announced plans for a new Alpine sports car and unveiled the Alpine Vision show car. Full Article Auto Sports New Products Services Trade show news MultiVu Video
chai El Departamento de Transporte de EE.UU. pone a disposición herramientas-y campaña para mejorar la seguridad de los niños a bordo de vehículos - Chairs :60 By www.multivu.com Published On :: 03 Oct 2014 10:38:00 EDT Chairs :60 Full Article Publicidad Transporte Noticias infantiles Aviso de Contenido para Radio TV Seguridad Pública Distrito de Columbia
chai VICHY Announces the First Annual VICHY EXPOSOME GRANT - Watch the video of Pr Jean Krutmann, Chair of the Jury explaining the Exposome concept By www.multivu.com Published On :: 02 Mar 2016 11:00:00 EST Watch the video of Pr Jean Krutmann, Chair of the Jury explaining the Exposome concept Full Article Healthcare Hospitals Household Consumer Cosmetics Medical Pharmaceuticals New Products Services Survey Polls & Research Clinical Trials Medical Discoveries MultiVu Video
chai "You're Being Lied To": Pennsylvania County Elections Chair Debunks Claims of Voter Fraud By www.democracynow.org Published On :: Mon, 04 Nov 2024 08:15:06 -0500 As Donald Trump and Kamala Harris campaign in Pennsylvania on the last day before the presidential election, false claims of voter fraud are spreading. “The truth is, none of these lies have been about election integrity. It’s always been about power,” says Neil Makhija, chair of the board of elections in Montgomery County, Pennsylvania — the battleground state that “could decide the election” — in a video essay featured by The New York Times. Makhija joins Democracy Now! to discuss his work expanding access to the vote and debunking the myth of mass voter fraud. Full Article