chai Sm Supplier Management Job At Boeing - Director Planning & Supply Chain By www.avjobs.com Published On :: Fri, 4 Aug 2023 02:01:02 -0400 Sm Supplier Management Job At Boeing Director Planning & Supply Chain Full Article SM Supplier Management
chai DHL Supply Chain: this is a significant step towards decarbonising Tesco’s fleet in Ireland By postandparcel.info Published On :: Wed, 10 Jul 2024 10:38:21 +0000 As part of its ongoing partnership with DHL Supply Chain, Tesco Ireland has taken delivery of 50 state-of-the-art biomethane fuelled trucks which will operate across its country-wide distribution network. Full Article E-Commerce Parcel Retail
chai Wincanton: UK businesses aren’t making enough headway when it comes to reducing emissions in their supply chain operations By postandparcel.info Published On :: Tue, 17 Sep 2024 05:11:55 +0000 New research from Wincanton reveals that two thirds (66%) of UK organisations say they are under pressure to hit their net-zero targets, with logistics seen as key to achieving their goals in this area, according to 83%. Full Article E-Commerce Retail Sustainability
chai Freedom Caucus chairman says Speaker Johnson should be challenged to avoid ‘Soviet-style’ election By www.washingtonexaminer.com Published On :: Wed, 13 Nov 2024 02:24:57 +0000 Freedom Caucus Chairman Andy Harris (R-MD) believes there should be more than one person in the race for House speaker to avoid a “Soviet-style” election following reports that hardline conservatives are hoping to find a challenger for Speaker Mike Johnson (R-LA). So far, Johnson is the only person seeking the speaker’s gavel after alerting his […] Full Article House Congress Freedom Caucus House Republicans Mike Johnson Speaker of the House Washington D.C.
chai Largest ‘Terror Bird’ Fossil Identified — Sat Atop Food Chain 12 Million Years Ago By www.discovermagazine.com Published On :: Mon, 04 Nov 2024 20:15:00 GMT Researchers confirm the terror bird fossil 20 years after its South American discovery, comparing the creature to a massive, carnivorous-like ostrich. Full Article The Sciences
chai New collection: Music Legs Spandex Sheer Pantyhose With Faux Chain Garters Spandex Sheer Pantyhose With Faux Chain Garters By www.newlook.com.sg Published On :: Fri, 5 Mar 2010 01:32:52 +0800 Sheer pantyhose with opaque panty portion and faux chain garterbelt look from Music Legs®. With garter look.Onesize (5'~5'10", 100~175lbs). Full Article
chai New collection: Music Legs Cherry Prints Chiffon Ruffle Trim Garter Belt Spandex Sheer Pantyhose With Faux Chain Garters By www.newlook.com.sg Published On :: Wed, 10 Mar 2010 00:15:11 +0800 Cherry prints stretch fashion tanga from Music Legs®. Chiffon ruffle trim with fine mesh panty and gusset. Very sensual. Decorated with cherry-shaped jewelry on red ribbon bow at the front waistline.Comes with four detachable and adjustable elastic garters together with clips. All clips are made of durable plastics with red satin ribbon trim.Elastic waistband :CircumferenceInchescmMinimum26"66cmMaximum40"102cm Full Article
chai New collection: Music Legs Spandex Sheer Pantyhose With Faux Chain By www.newlook.com.sg Published On :: Fri, 29 Oct 2010 04:23:51 +0800 Sheer pantyhose from Music Legs®. With faux chains design. Highly elastic with high spandex content.Onesize (5'~5'10", 100~175lbs). Full Article
chai Michael Buerk to chair Big Debate at Solihull School By thebirminghampress.com Published On :: Wed, 04 Jun 2014 14:02:44 +0000 Top BBC presenter Michael Buerk is to return to his old school to chair Solihull’s inaugural Big Debate. Full Article Education Politics Solihull G20 Michael Buerk Solihull School
chai Midlands Media Awards: Panel chaired by Sky News Managing Editor By thebirminghampress.com Published On :: Thu, 02 May 2013 08:29:10 +0000 Peter Lowe, Managing Editor of Sky News, is to be chairman of the judging panel for this year’s Midlands Media Awards, shortlisted nominations for which will be announced on Monday, May 13. Full Article Birmingham Business Uncategorized awards press the media West Midlands
chai University event highlights benefits of short food chains By thebirminghampress.com Published On :: Fri, 05 Jul 2013 08:55:51 +0000 The benefits of short food chains and local produce were the focus of an event on Wednesday 3 July organised by Coventry University’s Centre for Agroecology and Food Security Full Article Coventry Environment Farming Food and drink Most recent Coventry University farming sustainable food
chai Consumer sentiment relatively muted in Q2: Noel Tata, Trent chairman By retail.economictimes.indiatimes.com Published On :: Fri, 08 Nov 2024 09:17:04 +0530 Trent Limited, a Tata Group company, witnessed a 40% rise in net sales for the quarter ending in September. The retailer's revenue reached Rs 4036 crore, while net profit saw a 46% increase to Rs 423 crore. Despite the growth, consumer sentiment remained subdued. Trent opened 43 new stores during the quarter, expanding its presence to 184 cities. Full Article
chai Breakin' The Chain By www.musicxray.com Published On :: Tue, 14 May 2024 17:38:19 +0000 http://www.musicxray.com/xrays/2672473 Carolyn202 - Breakin' The Chain Full Article
chai Disidencias de las FARC exigieron al alcalde de Cartagena del Chairá $10.000 millones By www.spreaker.com Published On :: Thu, 09 Nov 2023 15:34:00 +0000 Edilberto Molina, alcalde de Cartagena del Chairá, habla de la extorsión de la que ha sido víctima en los últimos días Full Article
chai Threats to supply chains a top concern for 72% of FTSE 100 companies By www.logisticsit.com Published On :: 72% of FTSE 100 companies list threats to their supply chains amongst their principal risks, shows new research by supply chain management consultancy INVERTO, part of Boston Consulting Group. Full Article
chai Mackey, Prokofiev, Tchaikovsky By www.capradio.org Published On :: Sun, 17 May 2020 23:00:00 GMT MTT conducts Mackey and Tchaikovsky; Gil Shaham plays Prokofiev. Full Article
chai 2 Chainz’s First Two Tapes By www.bet.com Published On :: Tue, 27 May 2014 15:10:00 EDT When he first heard 8Ball and MJG. Full Article 2 Chainz The Message Hip Hop
chai 2 Chainz on Mainstream Ratchet By www.bet.com Published On :: Tue, 27 May 2014 15:19:00 EDT The nucleus of Atlanta rap music. Full Article 2 Chainz Hip Hop atlanta The Message
chai MJ Got Her Anchor Chair By www.bet.com Published On :: Tue, 21 Mar 2017 23:00:00 EDT Will she have to betray Kara to keep the top spot? Full Article Being Mary Jane Gabrielle Union Mary Jane Paul Valarie Pettiford Michael Ealy
chai Lee Daniels: The Director’s Chair By www.bet.com Published On :: Wed, 13 Jan 2016 17:41:00 EST Stars who have been influenced by the iconic filmmaker. Full Article BET Honors Lee Daniels
chai Royal Bermuda Regiment Chainsaw Course By bernews.com Published On :: Sat, 13 Jul 2024 01:40:43 +0000 The Royal Bermuda Regiment is hosting an ongoing Chainsaw Courses, in collaboration with Kingswood Training and Lantra. A spokesperson said, “Led by a team of experienced UK instructors comprising of Mr. Graham Dawdry, Mr. Matt Moss, and Mr. Steve Cackett, this comprehensive course aims to equip soldiers with essential skills in chainsaw maintenance and operation. […] Full Article All News #MilitaryAndRegiment
chai ABIC Appoints Christian Dunleavy As Chairperson By bernews.com Published On :: Wed, 18 Sep 2024 17:55:05 +0000 The Association of Bermuda International Companies [ABIC] announced the appointment of Christian Dunleavy as its new Chairperson, succeeding Patrick Tannock. A spokesperson said, “Mr. Dunleavy, a highly regarded leader in Bermuda’s business community, brings over 25 years of experience in the Bermuda market. He currently serves as Group President of Aspen Insurance, CEO of Aspen […] Full Article All Business News #BermudaBusiness #BusinessExecutives
chai Ascot Appoints Kewsong Lee As Chairman By bernews.com Published On :: Sun, 22 Sep 2024 10:00:23 +0000 Ascot Group Limited announced that Kewsong Lee, the Founder and CEO of BellTower Partners [BellTower], will be appointed Chairman of the Ascot Board of Directors. A spokesperson said, “Ascot Group Limited, the Bermuda-based global specialty insurance company, announced that Kewsong Lee, the Founder and CEO of BellTower Partners [BellTower], will be appointed Chairman of the […] Full Article All Business #BermudaBusiness #BusinessExecutives
chai Kim Swan Reflects On Serving As Chairman By bernews.com Published On :: Sun, 29 Sep 2024 00:38:10 +0000 For the past three years Kim Swan, Junior Minister of Tourism, Culture & Sport has served as Chairman of the Bermuda Government Golf Courses [Port Royal & Ocean View] until September 4th, 2024. “The former PGA European Tour member had been on medical leave since July 11th and Deputy Chairman Vincent Hollinsid presided over the […] Full Article All Sports #BermudaGolf #KimSwan
chai Omar Dill Announced As New FDM Chairperson By bernews.com Published On :: Fri, 01 Nov 2024 17:08:45 +0000 The Free Democratic Movement [FDM] announced that Omar Dill was elected as Party Chairperson by acclamation. A spokesperson said, “The Free Democratic Movement [FDM] proudly announces a new chapter of leadership, with Omar Dill elected as Party Chairperson by acclamation. This transition introduces a refreshed executive team dedicated to advancing the FDM’s mission of empowering […] Full Article All News Politics #BermudaPolitics
chai Piráti po zvolení Hřiba přichází o známé členy. Skončil Kolaja i Michailidu By www.reflex.cz Published On :: Sun, 10 Nov 2024 16:20:00 +0100 Piráty opustil bývalý místopředseda strany a někdejší europoslanec Marcel Kolaja. Na síti X dnes uvedl, že nesouhlasí s dalším směřováním strany. Předsedou Pirátů se v sobotu stal bývalý pražský primátor a nynější primátorův náměstek Zdeněk Hřib, který zároveň prosadil reformu fungování strany. Členství v reakci na to už v sobotu zrušila k 17. listopadu bývalá místopředsedkyně strany Jana Michailidu, která neuspěla ve snaze o znovuzvolení. Členství pozastavil také vedoucí rušeného zahraničního odboru Pirátů Michal Gill, který byl odpůrcem změny stanov. Full Article
chai SPERAS ARC Ti Titanium USB-C keychain flashlight review By the-gadgeteer.com Published On :: Fri, 08 Nov 2024 13:47:02 +0000 REVIEW – I’ve been updating my EDC and talking about it on my YouTube channel for the past few months. My next category to discuss is flashlights and it turned out to be a good choice because I was recently offered the chance to review the SPERAS ARC Ti Titanium USB-C keychain flashlight. Let’s check […] Full Article Reviews EDC Flashlight
chai Manscaped The Chairman Pro Electric Shaver By uncrate.com Published On :: Tue, 12 Nov 2024 17:51:35 -0500 Full Article Grooming
chai Wheelchair, The Early Days By cheezburger.com Published On :: Wed, 25 Mar 2015 02:00:00 -0700 It's a great budget option, unless you're leaking for comfort. Or functionality. ~NSHA Full Article dual use furniture wheelchair wtf
chai Chipotle’s new CEO Scott Boatwright will make millions leading the chain—but only half as much as ex-CEO Brian Niccol By biztoc.com Published On :: Wed, 13 Nov 2024 05:02:33 GMT Chipotle’s new chief executive is Scott Boatwright, a familiar face and name, given that he’s served as the interim CEO since August following former CEO Brian Niccol’s surprise decision to lead a turnaround at Starbucks. And while Boatwright, 52, will get a significant pay boost in his new… Full Article
chai China battery giant CATL would build US plant if Trump allows it, chairman says By biztoc.com Published On :: Wed, 13 Nov 2024 06:51:24 GMT China battery giant CATL would build US plant if Trump allows it, chairman says Trump wants to block Chinese EV, battery imports but open to US plants with American workers Contemporary Amperex Technology (CATL), the world’s top battery maker, will consider building a US plant if president-elect… Full Article
chai ‘South Park’s Timmy Is Inspiring New Bouts of Harassment Against Wheelchair Users By www.cracked.com Published On :: Mon, 11 Nov 2024 15:00:00 -0800 By Keegan Kelly Published: November 11th, 2024 Full Article
chai Author of new Stevie Nicks book is a Princeton professor who loves 'Tusk,' studies Tchaikovsky By www.princeton.edu Published On :: Tue, 04 Oct 2022 09:09:00 -0400 Simon Morrison, author of the new musical biography "Mirror in the Sky,” is a professor of music and Slavic languages and literatures, and a sought-after lecturer in the humanities. Full Article
chai Crafternoon: Create a Beaded Keychain By www.princeton.edu Published On :: Thu, 14 Nov 2024 12:30:00 -0500 Customize a beaded keychain Keep track of your keys (or your prox!). Attach it to a bag, your water bottle, or wear it as a bracelet. All supplies will be provided. Drop-ins welcome! Come for the entire time or only part of the session. Registration is optional, but if you know you’ll be attending please register so we can anticipate the number of people to expect. Full Article
chai Video: Best of Switzerland's Riding Scene in 'Chainz Out - A Piece of Swiss Cheese' By www.pinkbike.com Published On :: Sat, 9 Nov 2024 00:00:00 PST Showing off the best parts of the Swiss riding scene, both on small and on big bikes.( Comments: 4 ) Full Article
chai Adapting national parks for wheelchair hiking By www.pbs.org Published On :: Wed, 13 Apr 2022 02:17:00 +0000 The trails through our public lands weren’t designed for wheelchairs, but new wheelchairs are designed for those trails. National Park Service accessibility specialist Quinn Brett wants parks to catch up with wheelchair technology, increasing access to American wilderness. Full Article
chai Kari Lake’s Campaign Chair Reacts to Election: “No Transparency” (Video) By sonsoflibertymedia.com Published On :: Tue, 12 Nov 2024 19:16:53 +0000 For a second time, Kari Lake has been denied a win in an election. First, it was for governor of Arizona, which was clearly due to election and voter fraud. Now, it appears something similar occurred in her race against Ruben Gallego. Now, the head of her campaign is speaking out and saying that there … Full Article News U.S. News Videos
chai iPhone SE 4 expected to launch in March 2025, supply chain data suggests - Business Standard By news.google.com Published On :: Wed, 13 Nov 2024 05:59:10 GMT iPhone SE 4 expected to launch in March 2025, supply chain data suggests Business StandardiPhone SE4 is likely to launch soon and here are 5 big upgrades we are expecting India TodayApple iPhone SE 4 to launch next year, likely to become the cheapest iPhone to support Apple Intelligence... MoneycontroliPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why Hindustan TimesiPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report Gadgets 360 Full Article
chai velocityconf: @tsantero @garethr No, there's just a lot that goes into producing #velocityconf. Plus the chairs are getting ready for Santa Clara + NY! :) By twitter.com Published On :: Mon, 20 May 2013 16:50:15 +0000 velocityconf: @tsantero @garethr No, there's just a lot that goes into producing #velocityconf. Plus the chairs are getting ready for Santa Clara + NY! :) Full Article
chai As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU By readwrite.com Published On :: Tue, 12 Nov 2024 17:57:33 +0000 Continuing to set records, Pepe Unchained recently achieved a new milestone after reaching $26 million. The project’s presale has now… Continue reading As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU The post As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU appeared first on ReadWrite. Full Article Cryptocurrency
chai Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million By readwrite.com Published On :: Tue, 12 Nov 2024 19:42:22 +0000 November has turned into a remarkable month for cryptocurrency, with Bitcoin and meme coins like Dogecoin, Shiba Inu, and Pepe… Continue reading Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million The post Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million appeared first on ReadWrite. Full Article Cryptocurrency
chai Sport | Here are the 3 candidates in line to replace Bill Beaumont as World Rugby chairman By www.news24.com Published On :: Wednesday Nov 13 2024 09:31:17 The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday. Full Article
chai Chinese supply chains could tip the balance in Ukraine By www.chathamhouse.org Published On :: Wed, 29 Mar 2023 12:43:19 +0000 Chinese supply chains could tip the balance in Ukraine Expert comment NCapeling 29 March 2023 Disrupting supply chains of critical minerals to those supporting Ukraine could give China a key advantage in its wider international trade competition. Direct military intervention from China into the war on Ukraine, with Chinese troops and airmen appearing at the front line, would be highly escalatory and highly unlikely. Equipping Russia with weapons and equipment is much more likely – if indeed it hasn’t already happened – and considering the West is supplying armaments to Ukraine, a joust with western technologies would be an interesting development to follow. But if Chinese weapons underperform in the heat of battle, this may have implications for the current situation with Taiwan and the US, as a poor outcome on the Ukraine front could give the West more confidence over the tensions in the South China Sea. And the use of Chinese weapons in Ukraine would also be a feast for Western technical intelligence to capture. Creating economic disruption A much more likely development for China is to put in place export controls on critical minerals for Western powers supplying arms to Ukraine. This is a significant lever which China has used before during its fishing dispute with Japan in 2010 when hi-tech industrial production in Japan was affected by shortages of China-sourced critical minerals. Once normal supplies were resumed, Japan started to stockpile critical mineral reserves. If China’s default position becomes a total refusal to supply client nations unless end-to-end assurances can be achieved to prove non-military use, the West’s aspirations regarding the Paris 2050 goals will certainly be put in jeopardy In October 2020, the Chinese Communist Party (CCP) passed a new statute enabling – when necessary – restriction of critical mineral supplies to third party nations intending to use them for defence and security applications, adding a ‘versatile weapon to Beijing’s arsenal’ in its trade competition with the US. That legal control has been applied to Lockheed Martin production of Taiwan-bound F-35s and it applies not only to critical minerals mined on the Chinese mainland, but also to Chinese-controlled enterprises within international supply chains, of which there are many. Responding to any such restrictions by opening up new mines and setting up new supply chains can take more than a decade, so the countries involved may need to start stockpiling critical materials as Japan has been doing since 2010. This could result in critical minerals supply chains becoming the issue which splits the current consensus of the West over Ukraine Commodity markets also need to be ready for some interesting price wobbles – a persistent problem in critical minerals extractives investment as is overcoming environmental, social, and governance (ESG) challenges in this new game of global supplies. In addition, those markets include the London Metal Exchange, now owned by Hong Kong Exchanges & Clearing whose biggest shareholder is the Hong Kong government which is struggling to operate with complete independence from Beijing. Splitting the West’s consensus By extending the thinking on China’s potential to throttle global critical mineral supply chains and the ensuing latency of extraction from new mining resources, progress to the Paris Agreement 2050 goals on climate change will inevitably be affected. Given there are no supply chain assurance mechanisms, such as distributed ledger technologies, in place within global mining supply chains, a key issue to overcome would be how the West assures China that critical mineral supplies are not destined for military applications. But if China’s default position becomes a total refusal to supply client nations unless end-to-end assurances can be achieved to prove non-military use, the West’s aspirations regarding the Paris 2050 goals will certainly be put in jeopardy, or even made unachievable. Full Article
chai Mark Carney to chair Chatham House senior advisers By www.chathamhouse.org Published On :: Tue, 17 May 2022 10:05:23 +0000 Mark Carney to chair Chatham House senior advisers News release NCapeling 17 May 2022 Former Bank of England Governor Mark Carney will succeed Sir John Major as chair of Chatham House’s Panel of Senior Advisers. Chatham House is pleased to announce Mark Carney will succeed Sir John Major as chair of the institute’s Panel of Senior Advisers. Chatham House senior advisers bring deep, first-hand experience of the policy and business worlds and use their experience, knowledge and networks to advise the institute’s research agenda and disseminate its policy ideas. Mark Carney is currently United Nations (UN) Special Envoy on Climate Action and Finance, UK prime minister Boris Johnson’s special finance adviser on COP26, as well as vice chairman and head of transition investing at Brookfield Asset Management. We are delighted to benefit from Mark Carney’s wealth of experience at the highest levels of decision-making on international financial policy, crisis management, and sustainability. Robin Niblett, director and chief executive of Chatham House He served as Governor of the Bank of England between 2013 and 2020 and as Governor of the Bank of Canada between 2008 and 2013. Robin Niblett, director and chief executive of Chatham House says: ‘We are delighted to benefit from Mark Carney’s wealth of experience at the highest levels of decision-making on international financial policy, crisis management, and sustainability. ‘His personal commitment to leveraging economic and finance policies to combat climate change aligns with a central plank of the institute’s mission to help governments and societies build a sustainable future. ‘I also want to thank Sir John Major for his invaluable advice and support through such a pivotal time in the institute’s history; we are delighted that he will retain an affiliation as a President Emeritus of Chatham House.’ Sir Nigel Sheinwald, chair of Chatham House, says: ‘Mark Carney is perfectly placed to lead the institute’s Panel of Senior Advisers and help ensure our research is focused on improving international relations in practical ways. ‘His experience and expertise will be of great value as the institute undertakes a leadership transition and welcomes Bronwen Maddox as its new director in the autumn. ‘The Chatham House council greatly appreciates Mark Carney’s engagement in our future success, as we do Sir John’s commitment to the institute these past thirteen years.’ Mark Carney says: ‘I have long respected Chatham House as one of the world’s leading independent institutes on international policy and am honoured to take up the reins from Sir John Major of chairing its eminent Panel of Senior Advisers. Alongside other members of the panel, I look forward to contributing to the relevance and impact of Chatham House’s important work.’ In addition to having been Governor of the Bank of England and the Bank of Canada, Mark Carney also chaired the Financial Stability Board from 2011 to 2018 and, in 2015, established the Task Force on Climate Related Financial Disclosures. In 2021, he launched the Glasgow Financial Alliance for Net Zero, to unite net-zero financial sector-specific alliances from across the world into one industry-wide strategic alliance. Chatham House established the Panel of Senior Advisers in 2009, under Sir John’s Major’s chairmanship, to support the institute in achieving its mission to build a sustainably secure, prosperous and just world. Individually and collectively, members of the panel support the institute in achieving its mission by advising on new topics for debate, offering input to the institute’s research, contributing to its private and public meetings, and disseminating the institute’s ideas across their networks. The panel does not have governance responsibilities, which reside fully with the Chatham House council. Full Article
chai Evan Davis In Conversation With Sir Howard Davies, Chairman of RBS By f1.media.brightcove.com Published On :: Wed, 31 Oct 2018 00:00:00 +0000 Full Article
chai The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism By www.jlr.org Published On :: 2013-09-01 Gijs den BestenSep 1, 2013; 54:2325-2340Reviews Full Article
chai Implications of post-COVID-19 Restructuring of Supply Chains for Global Investment Governance By www.chathamhouse.org Published On :: Tue, 09 Feb 2021 12:54:17 +0000 Implications of post-COVID-19 Restructuring of Supply Chains for Global Investment Governance 14 July 2020 — 9:00AM TO 10:30AM Anonymous (not verified) 9 February 2021 Online As companies rethink and diversify their supply chains in order to enhance resilience, what will this mean for current and future global investment governance? What are the risks of negative effects on inclusivity and transparency? Does this shift create an opportunity to advance good governance of cross-border investment practices? This event is part of the Inclusive Governance Initiative, which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world. Full Article
chai Seeded fibrils of the germline variant of human {lambda}-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability [Molecular Biophysics] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment corresponding to the fibril protein from patient FOR005, together with fibrils formed by protein sequence variants that are derived from the closest germline (GL) sequence. Both analyzed fibril structures were seeded with ex-vivo amyloid fibrils purified from the explanted heart of this patient. We find that residues 11-42 and 69-102 adopt β-sheet conformation in patient protein fibrils. We identify arginine-49 as a key residue that forms a salt bridge to aspartate-25 in the patient protein fibril structure. In the germline sequence, this residue is replaced by a glycine. Fibrils from the GL protein and from the patient protein harboring the single point mutation R49G can be both heterologously seeded using patient ex-vivo fibrils. Seeded R49G fibrils show an increased heterogeneity in the C-terminal residues 80-102, which is reflected by the disappearance of all resonances of these residues. By contrast, residues 11-42 and 69-77, which are visible in the MAS solid-state NMR spectra, show 13Cα chemical shifts that are highly like patient fibrils. The mutation R49G thus induces a conformational heterogeneity at the C terminus in the fibril state, whereas the overall fibril topology is retained. These findings imply that patient mutations in FOR005 can stabilize the fibril structure. Full Article
chai Africa Aware: Supply chains, land contestation, conflict By www.chathamhouse.org Published On :: Thu, 30 Mar 2023 10:50:19 +0000 Africa Aware: Supply chains, land contestation, conflict Audio NCapeling 30 March 2023 This episode examines relations between Ethiopia and Sudan as part of an XCEPT project mini-series. The war in northern Ethiopia since November 2020, and subsequent conquest of disputed farmlands in Al-Fashaga by the Sudanese army on the Ethiopia-Sudan border, has brought into focus the importance of agricultural commodities such as sesame as a potential driver of land contestation and conflict. The panel discusses the interrelation of commodity and conflict supply chains, land contestation, and boundary disputes in the Horn of Africa, with a particular focus on the regions of Wolkait/Western Tigray in northwest Ethiopia and Al Fashaga in eastern Sudan. This podcast was produced with support from the Cross-Border Conflict Evidence, Policy and Trends (XCEPT) project, funded by UK Aid from the UK government. Full Article