UK GOVERNMENT RECOGNISES ROUTE TO MARKET CHALLENGES AND SHOWS SIGNIFICANT SHIFT IN APPROACH FOR UK RENEWABLES On 2 March 2020, the UK Department for Business, Energy and Industrial Strategy (BEIS) published a consultation on the Contracts for Differ...

ISLAMABAD: The Foreign Office on Friday said it had summoned a senior Indian diplomat to register a strong protest over the Indian ceasefire violations along the Line of Control .The statement by the FO said that in the unprovoked Indian firing across the LoC in Nezapir and Rakchikri sectors, six...

An exceptionally well-preserved specimen of the articulated rhodophyte Permocalculus, compared with P. tenellus sensu Elliott, 1955, is described from fine-grained Upper Permian limestones of the Khuff Formation of Saudi Arabia. Longitudinal medullary and sheaf-like cortical filaments extend through the uniserial series of elongate-globular, concave- and convex-terminating, interlocking segments for which they are interpreted to have functioned in articulation. The filaments tend to splay and branch laterally into the cortex where they terminate at the pores. At the terminal aperture, the filaments extend as bifurcating and possibly trifurcating branches and may serve as the origin of a new segment. Numerous elongate-globular chambers, up to five in each row and intimately involved with the filaments, are developed in the outer medulla and are considered to represent reproductive sporangia. The specimen is considered to have occupied predominantly low-energy, normal to slightly elevated salinity, shallow conditions within the subtidal regime of a lagoon.

Oncolytic virotherapy can lead to systemic antitumor immunity, but the therapeutic potential of oncolytic viruses in humans is limited due to their insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). Here, we showed that locoregional oncolytic virotherapy upregulated the expression of PD-L1 in the TME, which was mediated by virus-induced type I and type II IFNs. To explore PD-1/PD-L1 signaling as a direct target in tumor tissue, we developed a novel immunotherapeutic herpes simplex virus (HSV), OVH-aMPD-1, that expressed a single-chain variable fragment (scFv) against PD-1 (aMPD-1 scFv). The virus was designed to locally deliver aMPD-1 scFv in the TME to achieve enhanced antitumor effects. This virus effectively modified the TME by releasing damage-associated molecular patterns, promoting antigen cross-presentation by dendritic cells, and enhancing the infiltration of activated T cells; these alterations resulted in antitumor T-cell activity that led to reduced tumor burdens in a liver cancer model. Compared with OVH, OVH-aMPD-1 promoted the infiltration of myeloid-derived suppressor cells (MDSC), resulting in significantly higher percentages of CD155⁺ granulocytic-MDSCs (G-MDSC) and monocytic-MDSCs (M-MDSC) in tumors. In combination with TIGIT blockade, this virus enhanced tumor-specific immune responses in mice with implanted subcutaneous tumors or invasive tumors. These findings highlighted that intratumoral immunomodulation with an OV expressing aMPD-1 scFv could be an effective stand-alone strategy to treat cancers or drive maximal efficacy of a combination therapy with other immune checkpoint inhibitors.

The B.C. Lions made sure to count every last penny when announcing a new contract for free-agent quarterback Mike Reilly ahead of the 2019 Canadian Football League season. Reilly, who had ...

For the first time since taking over as commissioner of the Canadian Football League in July of 2017, Randy Ambrosie was finally forced to publicly reveal the financial truth about ...

Canadian Football League Commissioner Randy Ambrosie said the most likely scenario is to cancel the season because of the coronavirus pandemic.

Rob Vanstone has a sporting suggestion as to how a scaled-down Canadian Football League could salvage a semblance of a season.

CFL commissioner Randy Ambrosie says the most likely scenario for the league is a cancelled 2020 season during the COVID-19 pandemic.

CFL, CFLPA were scheduled to meet Friday to continue talks on potential contingency plans due to the COVID-19 pandemic. It was first gathering after CFL commissioner Randy Ambrosie's admission Thursday night the most likely scenario for the league is a cancelled 2020 season.

"Our best-case scenario for this year is a drastically truncated season," Randy Ambrosie said. "And our most likely scenario is no season at all.''

The group originally released the chart-topping track in 2005

“My family and I have made the decision to return to Oregon,” the 36-year-old said in a video address posted Thursday on the Lions website.

This plan for the $150 million in aid, presented by commissioner Randy Ambrosie, comes off as so half-baked, so riddled with holes and obfuscation that it’s impossible to rally behind it in its current incarnation.

The 34-year-old from Richmond Hill returns to Kingston, where he spent three seasons as coach of the OHL’s Frontenacs.

CFL commissioner Randy Ambrosie said the CFL lost collectively about $20 million last year and its future is “very much in jeopardy.”

Le commissaire a évoqué l’annulation de la saison.

Chief financial officer of contracting firm Downer EDI and former Qantas senior executive Kevin Fletcher has died.

CFL commissioner Randy Ambrosie will testify at a House of Commons standing committee on finance on Thursday. The appearance on a videoconference will come nine days after news broke that the CFL had asked the federal government for up to $150 million in financial assistance during the COVID-19 pandemic.

Gilead Sciences have announced that Andrew Dickinson has been appointed as Chief Financial Officer (CFO) effective 1 November.

Dickinson currently serves as the company’s Executive Vice President of Corporate Development and Strategy and in his new role will become part of a senior leadership team reporting directly to Chairman and Chief Executive Officer Daniel O’Day.

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James M. Davis, 60, the former chief financial officer of Houston-based Stanford Financial Group (SFG), pleaded guilty today to fraud and obstruction charges related to a $7 billion scheme to defraud investors.

Don W. Watson, former chief financial officer (CFO) of CSK Auto Corp. (CSK), pleaded guilty today in U.S. District Court for the District of Arizona to conspiracy to commit securities and mail fraud in connection with a scheme to misstate the company’s reported earnings from 2001 through 2006.

Michael R. Elliott, former chief financial officer of Caremerica Inc., pleaded guilty today to conspiring to defraud the Internal Revenue Service (IRS), the Justice Department and IRS announced.

Ronald E. Burrell, former chief executive officer (CEO) of Caremerica Inc., and Michael R. Elliott, former chief financial officer (CFO) of Caremerica Inc., were sentenced today in Wilmington, N.C.

The former chief executive officer and former chief financial officer of ArthroCare Corp., a publicly traded medical device company based in Austin, Texas, were charged for their alleged leading roles in a $400 million scheme to defraud the company’s shareholders and members of the investing public by falsely inflating ArthroCare’s earnings by tens of millions of dollars, announced Acting Assistant Attorney Mythili Raman of the Department of Justice’s Criminal Division and U.S. Attorney Robert Pitman of the Western District of Texas.

A federal jury today convicted the former chief executive officer and the former chief financial officer of ArthroCare Corporation, a publicly traded medical device company based in Austin, Texas, for orchestrating a fraud scheme that resulted in shareholder losses of over $400 million.

The American Herbal Products Association submitted nearly 100 pages of comments to the Food and Drug Administration Center for Food Safety and Applied Nutrition identifying ways to improve regulations, guidance documents and enforcement practices to better protect public health.

Tiger Global-backed Games24X7 has appointed Rahul Tewari as its first CFO.

The post People Digest: Games24X7 appoints CFO; MedGenome names India CEO appeared first on DealStreetAsia.

He guided Zuora from startup through a successful IPO and subsequent quarters as a public company.

The post SaaS unicorn Freshworks appoints ex-Zuora executive Tyler Sloat as CFO appeared first on DealStreetAsia.

Flipkart Group CFO Emily McNeal has quit to pursue a career opportunity outside the Walmart Group.

The post India: Flipkart names Sriram Venkataraman as CFO of its commerce biz appeared first on DealStreetAsia.

Africa’s extreme vulnerability to the disruption of international supply chains during the COVID-19 pandemic highlights the need to reduce the continent’s dependence on non-African trading partners and unlock Africa’s business potential. While African countries are right to focus their energy on managing the immediate health crisis, they must not lose sight of finalizing the Africa…

Africa’s extreme vulnerability to the disruption of international supply chains during the COVID-19 pandemic highlights the need to reduce the continent’s dependence on non-African trading partners and unlock Africa’s business potential. While African countries are right to focus their energy on managing the immediate health crisis, they must not lose sight of finalizing the Africa…

Ethiopia, Eritrea, Sudan political updates Ethiopia-Eritrea relations continue to thaw, as on Sunday, May 3, Eritrean president Isaias Afwerki, Foreign Minister Osman Saleh, and Presidential Advisor Yemane Ghebreab, visited Ethiopia, where they were received by Prime Minister Abiy Ahmed. During the two-day diplomatic visit, the leaders discussed bilateral cooperation and regional issues affecting both states,…

Africa’s extreme vulnerability to the disruption of international supply chains during the COVID-19 pandemic highlights the need to reduce the continent’s dependence on non-African trading partners and unlock Africa’s business potential. While African countries are right to focus their energy on managing the immediate health crisis, they must not lose sight of finalizing the Africa…

Africa’s extreme vulnerability to the disruption of international supply chains during the COVID-19 pandemic highlights the need to reduce the continent’s dependence on non-African trading partners and unlock Africa’s business potential. While African countries are right to focus their energy on managing the immediate health crisis, they must not lose sight of finalizing the Africa…

Ethiopia, Eritrea, Sudan political updates Ethiopia-Eritrea relations continue to thaw, as on Sunday, May 3, Eritrean president Isaias Afwerki, Foreign Minister Osman Saleh, and Presidential Advisor Yemane Ghebreab, visited Ethiopia, where they were received by Prime Minister Abiy Ahmed. During the two-day diplomatic visit, the leaders discussed bilateral cooperation and regional issues affecting both states,…

Ethiopia, Eritrea, Sudan political updates Ethiopia-Eritrea relations continue to thaw, as on Sunday, May 3, Eritrean president Isaias Afwerki, Foreign Minister Osman Saleh, and Presidential Advisor Yemane Ghebreab, visited Ethiopia, where they were received by Prime Minister Abiy Ahmed. During the two-day diplomatic visit, the leaders discussed bilateral cooperation and regional issues affecting both states,…

Ethiopia, Eritrea, Sudan political updates Ethiopia-Eritrea relations continue to thaw, as on Sunday, May 3, Eritrean president Isaias Afwerki, Foreign Minister Osman Saleh, and Presidential Advisor Yemane Ghebreab, visited Ethiopia, where they were received by Prime Minister Abiy Ahmed. During the two-day diplomatic visit, the leaders discussed bilateral cooperation and regional issues affecting both states,…

Ethiopia, Eritrea, Sudan political updates Ethiopia-Eritrea relations continue to thaw, as on Sunday, May 3, Eritrean president Isaias Afwerki, Foreign Minister Osman Saleh, and Presidential Advisor Yemane Ghebreab, visited Ethiopia, where they were received by Prime Minister Abiy Ahmed. During the two-day diplomatic visit, the leaders discussed bilateral cooperation and regional issues affecting both states,…

Ethiopia, Eritrea, Sudan political updates Ethiopia-Eritrea relations continue to thaw, as on Sunday, May 3, Eritrean president Isaias Afwerki, Foreign Minister Osman Saleh, and Presidential Advisor Yemane Ghebreab, visited Ethiopia, where they were received by Prime Minister Abiy Ahmed. During the two-day diplomatic visit, the leaders discussed bilateral cooperation and regional issues affecting both states,…

Executive Summary Are climate finance contributor countries, multilateral aid agencies and specialized funds using widely accepted best practices in foreign assistance? How is it possible to measure and compare international climate finance contributions when there are as yet no established metrics or agreed definitions of the quality of climate finance? As a subjective metric, quality…

The peripatetic international designer explains it all in Core77

CFL bulbs, or compact fluorescent light bulbs: energy savings Commonly referred to as CFLs, compact fluorescent lamps or compact fluorescent light bulbs, the energy-saving bulbs have escaped the stereotype of buzzing, flickery, washed-out lights to

On a recent trip to the south of Spain, I visited the beautiful Cathedral of Seville, amongst the largest of all medieval and Gothic cathedrals, in terms of both area and volume. According to Wikipedia, the interior is the