Precision optimization of physicality, vitality, and longevity. Officially adopted by federal law enforcement agencies, special operations units, and fire rescue departments.

Hussein Tarraf serves as the owner of Tarraf and Associates PC

Michael G. Botwinick, CFP, is lauded for his contributions to the financial sector as a distinguished wealth advisor

Roger "Rick" P. Molina is noted for his longstanding success as a seasoned fire and building inspection expert

Donation links remain live to raise money for college scholarships; renowned designer Barbara Bates donates a $2,000 custom jacket for a donor drawing

Ash Shetty, CFA, is a distinguished expert in fixed-income analysis affiliated with PineBridge Investments

Radioisotopic Power Sources are now one step closer to commercialization. As an alternative source of energy, they combine the persistence and reliability of a power plant with the convenience and mobility of a battery.

On June 7, 2021, the U.S. Supreme Court refused NCFM's earlier case, deferred to Congress, where six U.S. Senators opposed "draft[ing] our daughters", precluding women from registering. An archaic insult to our Constitution, men, and women.

MusicFab, a leading provider of music converter solutions, is proud to announce the release LINE MUSIC Converter. This cutting-edge software empowers music enthusiasts to effortlessly convert their favorite tracks from LINE MUSIC for offline playback

Unlock the Ultimate Music Experience

Jon Andrew Wingent, CFP, is a wealth advisor at Morton Wealth

CLARA Analytics announced that it hired Eugene Wong as chief financial officer. Eugene Wong Wong brings more than 15 years of finance and operating experience to his new role with the…

The Virginia Workers’ Compensation Commission announced that chairman Wesley G. Marshall was elected to the International Workers’ Compensation Foundation board of trustees. Wesley G. Marshall Marshall was elected to a three-year…

ACF Form is an awesome tool. It can be used in many scenarios. But when it comes to front-end display, it can become tricky to make it compatible with the actual WordPress theme. In this tutorial we’ll see how to make ACF Form use Bootstrap 4 logic. Deregister native ACF Form front styles First, we […]

What an adventure! ACF Extended is celebrating its 1.5 years of existence. Created in March 2019 to meet the needs of the most demanding ACF developers, the plugin has just passed the 20.000 active installations mark and is now approaching the stable version. Today, it’s time to talk about its future. ???? A Brief History […]

Florida's Chief Financial Officer is asking the state's 1st District Court of Appeal to revisit its definition of heart disease under a 2023 decision dealing with presumptive claims by first…

Liquid biopsies have emerged as a powerful tool in modern medicine, enabling non-invasive detection and monitoring of diseases such as cancer. At the foref

"Yona finally meets Jaeha, the Green Dragon. Unfortunately, Jaeha has no desire to follow her on her quest! Yona offers to help Jaeha and his fellow pirates, so Captain Gi-gan challenges her with a perilous quest to test her courage." -- Cover.

"In order to free the port town of Awa from an evil tyrant, Yona and her friends team up with Jaeha, the Green Dragon, and his fellow pirates. While Hak and the others are fighting Yang Kum-ji's forces, Yona and Yun infiltrate a human trafficking operation! When the enemy closes in and things look dire, what will Yona do?" -- Page [4] cover.

U-Boot for BeagleBone Green (git version)

Sherry has held CFO positions for the past ten years. “His passion and expertise will be critical as we continue to expand our capabilities to solve the biggest pain points for contractors all across the country," said Ara Mahdessian, ServiceTitan co-founder and CEO.

Andy Kelso was named COO; Shane Lawrence, CFO; Brinnon Williams, vice president of residential business; and David Archer, vice president of commercial business.

Ucf Football Suffers 1st Aac Loss Of Season At East Carolina

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The four-flap cups are currently available in several other international markets like Canada and Indonesia – and this month, it’s finally time for U.S. fans to try them out. 

UCF entered Tuesday’s game ranked last in the Big 12 in field-goal accuracy (39%) and last in 3-point shooting (22%), but shot 54% (32 of 59) against the Owls. That included a season-best 46% (13 of 28) from 3.

Although no Knights were selected in this year's NFL Draft, multiple former UCF players signed as undrafted free agents with NFL teams.

The spring portal opened April 15, and moves are expected to take place before the 15-day window closes.

Liten to Ann Diddlebock speak on teams that work. Get her perspective as a CFO and enjoy! We borrow this podcast from our friend at International Toolkit

The hiring of a new CFO and COO comes on the heels of Bone Dry Roofing's financial performance in 2023, which included revenue exceeding $183 million.

WorkWave has appointed Greg Doran as its new CFO, leveraging his 25+ years of SaaS and finance experience to drive growth and expand the company's innovative solutions and partnerships.

LGCF, the French wine exporting company, relies on Körber’s Warehouse Management System, Warehouse Control System, voice and gamification solutions to accelerate the performance at 14 logistics sites.

Colgate-Palmolive India is experiencing growth in the expanding oral care market. The company reported a 10% rise in revenue. However, it recognizes market difficulties like fluctuating demand and rising costs. Colgate remains dedicated to improving oral health awareness in India. It aims to achieve this through education and product innovation. The company is focused on sustainability and social responsibility initiatives.

“We will first want to focus on growth in terms of top line and margins will take care of themselves. With a lot of operating efficiencies coming in, margin should take care of itself but we follow our mantra of “nothing at the cost of market and nothing at the cost of margin. So we will balance both together.”

I actually got paid to do this.

For three years (from 1996 to 1999) I worked as a Public Information and Consultation Advisor for the Federal Treaty Negotiation Office in British Columbia. It was essentially my job to talk to angry and racist non-native people about the land claims settlements we, the federal government, were negotiating with First Nations.

One thing that helped me do this job was a story I heard Utah Phillips tell at the 1997 Vancouver Folk Music Festival. Seems one day he was told of an old cowboy in New Mexico who was dying. This old cowboy had ridden on some of the last cattle drives on the Great Plains in the 1800s and had scores of songs in his head about that time. Utah made an effort to go visit him on his death bed way out in the desert. When he got to the cowboy's cabin, a nurse answered the door, said he was expected and asked him to wait in the sitting room while she got the cowboy ready for the visitor.

The cowboy was an avid reader and had many hundreds of books. As he was waiting Utah scanned the shelves and saw what was what. He was surprised and shocked to see tract after tract from the John Birch Society, a virulent right wing political movement that clashed deeply with Utah's own hard left politics. Utah reflected on the predicament he was in. Here was this cowboy full of all of these songs, and there was this irresolvable political gap between them.

But thinking on it more, Utah realized that the REASON the cowboy had so many political books is that he didn't actually KNOW much about politics. In fact if he were to ask the old man about politics, he knew the old man would only give him lies, stuff that he didn't believe but that was recited out of the books. Utah Phillips noted that there was not one book on cowboys or cowboy music on the book shelves, and that's what Utah was there for. He entered the bedroom of the dying cowboy and passed a lovely day trading songs and stories of the cattle drives of the 19th century.

In conclusion Utah said "You know, if you talk to people about what they know, they will always tell you the truth."

That line stayed with me as I ventured in cowboy country shortly afterwards. I was meeting with a group of loggers and ranchers in Williams Lake, in the interior of British Columbia and they were a hard crew. Every month we met and every month they told me that they didn't want any land claims settlements with the "goddamn Indians" in their area. One guy, a man I'll call Bob used to go on and on about "you can't make deals with Indians, they can't be trusted, they're no good with their word..." That sort of thing.

Now I am Aboriginal myself, and this rankled after a while. But keeping Utah's words in mind I challenged Bob one day and said, "Bob, you know, I'm Indian and I'm trustworthy and you can make deals with me. I know for a fact that what you're saying is bullshit. It's lies. So I'm not going to ask you about Indians anymore. Instead I'm going to talk to you about something you do know about, and that is logging. Why don't you take me out to see your operation?"

Bob agreed and the next day I met him at 5:00am with a thermos of coffee and a box of Tim Hortons and we climbed into his F350 and headed out into the Cariboo Mountains. We drove for two hours and the whole time we talked about logging and what it's like being in the business, what kind of markest he was trying to develop, and how much he loved his new machinery He talked about his new feller-buncher like he was a dad with a newborn. Gone was the intransigent racist and here beside me was an interesting man, telling me the truth about what he loved.

When we got out to the cut block where his crew was working, he radioed them in and they came down to get coffee and donuts. Of the 12 guys he had working for him, six were First Nations. I laughed when I met them and asked them if they knew Bob's opinions on the trustworthiness of Indians. "Oh yeah," One of them laughed. "He's an old blowhard!"

But Bob countered by saying that THESE guys were great, that they had been with him for coming on 20 years. THEY were different.

We laughed. Really hard. We talked for a while about what THESE guys felt about land claims and they all had different opinions. Respect arose in the space of nuance and reflection.

So many people parrot opinions. In fact opinions are so often just a front for something else, the yawning abyss of ignorance. Very few people hold fixed opinions about things that matter deeply to them. Instead the hold nuanced and thoughtful interests. That's not to say that I wouldn't claw your eyes out if you hurt my child, but that's different from having an opinion on Tiger Woods or abortion or whether or not Obama is doing a good job. Most of us aren't Tiger, a pregnant woman facing a choice or the President. Most opinions are shallow, and the holder of them guards their superficiality with outrage and emotion to prevent you from getting close and discovering nuance. People hold opinons out of fear or loyalty. But when it comes to something you really care about, it's less about an opinion and more about the nuanced, many layered, complex fabric of knowledge, practical, theoretical, aspirational and emotional

From that day on, I never again talked to Bob about First Nations people, but he became a very involved person in our advisory committee because he had a piece of his heart staked in the process. I came to respect him very much, even though he continued to blow hard against my rookie colleagues and say stupid racist things that somewhere he must have believed. He did it just to put them off guard, to protect his own vulnerabilities and mask his fear. I came to respect what lay beneath the opinion, which was a real fear that land claims would ruin his logging operation. I dismissed the racism but respected Bob and what was really at stake for him. And I think he came to respect me too.

It was the best job I ever had.

[17:45, 4/4/2023] Juan Camilo Bueno: r[18:33, 4/4/2023] Juan Camilo Bueno: La Luciérnaga se enciende para hablar del caso en contra del expresidente de Estados Unidos, Donald Trump. Además, le contamos sobre el polémico viaje de Francia Márquez a Africa. También, ¿porqué fue tendencia el ICFES del presidente Petro?La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

An unexpected but endearing valentine to the 1940s and 50s.

Deputy Premier and Minister of Home Affairs Walter Roban travelled overseas to attend the Green Overseas Climate Finance Forum. A Government spokesperson said, “The Ministry of Home Affairs is pleased to advise that the Deputy Premier and Minister of Home Affairs, the Hon. Walter Roban, JP, MP, travelled overseas this weekend to represent Bermuda at […]

I'm very interested in eLearning designs that try to entwine content and exercise so thoroughly that the learner almost constructs their instruction – even if...

Customers are asked to do a mandatory battery check over safety concerns, and to reach out to Canyon if they are affected
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The cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane anion channel that plays a key role in controlling transepithelial fluid movement. Excessive activation results in intestinal fluid loss during secretory diarrheas, whereas CFTR mutations underlie cystic fibrosis (CF). Anion permeability depends both on how well CFTR channels work (permeation/gating) and on how many are present at the membrane. Recently, treatments with two drug classes targeting CFTR—one boosting ion-channel function (potentiators) and the other increasing plasma membrane density (correctors)—have provided significant health benefits to CF patients. Here, we present an image-based fluorescence assay that can rapidly and simultaneously estimate both CFTR ion-channel function and the protein's proximity to the membrane. We monitor F508del-CFTR, the most common CF-causing variant, and confirm rescue by low temperature, CFTR-targeting drugs and second-site revertant mutation R1070W. In addition, we characterize a panel of 62 CF-causing mutations. Our measurements correlate well with published data (electrophysiology and biochemistry), further confirming validity of the assay. Finally, we profile effects of acute treatment with approved potentiator drug VX-770 on the rare-mutation panel. Mapping the potentiation profile on CFTR structures raises mechanistic hypotheses on drug action, suggesting that VX-770 might allow an open-channel conformation with an alternative arrangement of domain interfaces. The assay is a valuable tool for investigation of CFTR molecular mechanisms, allowing accurate inferences on gating/permeation. In addition, by providing a two-dimensional characterization of the CFTR protein, it could better inform development of single-drug and precision therapies addressing the root cause of CF disease.

The Wnt/β-catenin pathway is one of the major pathways that regulates embryonic development, adult homeostasis, and stem cell self-renewal. In this pathway, transcription factors T-cell factor and lymphoid enhancer factor (TCF/LEF) serve as a key switch to repress or activate Wnt target gene transcription by recruiting repressor molecules or interacting with the β-catenin effector, respectively. It has become evident that the protein stability of the TCF/LEF family members may play a critical role in controlling the activity of the Wnt/β-catenin signaling pathway. However, factors that regulate the stability of TCF/LEFs remain largely unknown. Here, we report that pVHL binding protein 1 (VBP1) regulates the Wnt/β-catenin signaling pathway by controlling the stability of TCF/LEFs. Surprisingly, we found that either overexpression or knockdown of VBP1 decreased Wnt/β-catenin signaling activity in both cultured cells and zebrafish embryos. Mechanistically, VBP1 directly binds to all four TCF/LEF family members and von Hippel-Lindau tumor-suppressor protein (pVHL). Either overexpression or knockdown of VBP1 increases the association between TCF/LEFs and pVHL and then decreases the protein levels of TCF/LEFs via proteasomal degradation. Together, our results provide mechanistic insights into the roles of VBP1 in controlling TCF/LEFs protein stability and regulating Wnt/β-catenin signaling pathway activity.

Nov. 2, 2023 — Researchers from the Argonne Leadership Computing Facility (ALCF), the University of St. Thomas, and the University of Illinois Chicago (UIC) won first place and “best workflow” […]

The post ALCF Team Wins 1st Place and Best Workflow at 2023 IEEE SciVis Contest appeared first on HPCwire.

RUTHERFORD, N.J., Dec. 5, 2023 — Intelligent Light has announced it has been selected by AFWERX for a Direct-to-Phase II contract in the amount of $1.15 Million focused on IntelliTwin […]

The post AFWERX Selects IntelliTwin as the Realizable Digital Thread for HPC-scale CFD appeared first on HPCwire.

Penn State moved up in this week's College Football Playoff rankings.

Where did Texas A&M land in the latest CFP bracket? Here’s the College Football Playoff picture for the Aggies and their path to the championship.

Where did Georgia land in the latest CFP bracket and rankings? Here’s the College Football Playoff picture for the Bulldogs and path to championship.

Miami landed 9th in the latest CFP bracket. Here’s the College Football Playoff picture for the Hurricanes and path to the championship.