carbon Carbon emissions all at sea: why was shipping left out of the Paris Climate Agreement? Insights Blog By oecdinsights.org Published On :: Wed, 04 May 2016 09:11:00 GMT A stern warning for climate change, and our health - Shipping brings us 90% of world trade and has increased in size by 400% in the last 45 years. Cargo ships, tankers and dry-bulk tankers are an essential element of a globalised world economy, but they are thirsty titans and they won’t settle for diet drinks. There are up to 100,000 working vessels on the ocean and some travel an incredible 2/3 of the distance to the moon in one year. Full Article
carbon Carbon pricing efforts are falling short, but even modest collective action can deliver significant progress, OECD says By www.oecd.org Published On :: Mon, 26 Sep 2016 11:00:00 GMT Current carbon prices are falling short of the levels needed to reduce greenhouse gas emissions driving climate change, but even moderate price increases could have a significant impact, according to new OECD research. Full Article
carbon The High Level Breakfast on Institutional Investors and the Low Carbon Transition By www.oecd.org Published On :: Mon, 11 Dec 2017 10:24:00 GMT One focus of tomorrow’s One Planet Summit, organised by President Macron, is “to determine how those working in public and private finance can innovate to support and accelerate our common efforts to fight climate change.” Full Article
carbon Report: Decarbonising Maritime Transport - Pathways to zero-carbon shipping by 2035 By www.itf-oecd.org Published On :: Mon, 26 Mar 2018 13:44:00 GMT This report examines what would be needed to achieve zero CO2 emissions from international maritime transport by 2035. It assesses measures that can reduce shipping emissions effectively and describes possible decarbonisation pathways that use different combinations of these measures; and reviews under which conditions these measures could be implemented and presents concrete policy recommendations. Full Article
carbon The Czech economy is thriving but boosting skills and productivity and transitioning to a low-carbon productive model is vital to sustainable and inclusive growth By www.oecd.org Published On :: Mon, 16 Jul 2018 14:00:00 GMT The Czech economy is thriving, with robust employment, expanding exports and falling government debt. Efforts should now focus on boosting workforce skills and innovation to improve labour supply and productivity, further reduce poverty and inequality, and green the economy, according to two new OECD reports. Full Article
carbon Few countries are pricing carbon high enough to meet climate targets By www.oecd.org Published On :: Tue, 18 Sep 2018 11:00:00 GMT Governments need to raise carbon prices much faster if they are to meet their commitments on cutting emissions and slowing the pace of climate change under the Paris Agreement, according to a new OECD report. Full Article
carbon Power struggle: Decarbonising the electricity sector - Effects of climate policies, policy misalignments and political economy factors on decarbonisation - Environment Working Paper By doi.org Published On :: Wed, 28 Nov 2018 08:10:00 GMT This report investigates the effects of select climate policies, non-climate policies, as well as political economy factors on the decarbonisation of electricity in OECD countries from 2000 to 2015. Effects are analysed on the three phases of decarbonisation: (1) increasing the share of renewables installed, (2) increasing the use of renewables in generation, and (3) reducing the emissions from electricity. Full Article
carbon OECD, UN Environment and World Bank call for a radical shift in financing for a low-carbon, climate-resilient future By www.oecd.org Published On :: Wed, 28 Nov 2018 18:00:00 GMT The OECD, UN Environment and World Bank Group today called on leaders of G20 countries to do more to enable a radical shift of investment into low-carbon, climate-resilient infrastructure as a way to limit the impact of climate change. Full Article
carbon Key takeaways from the High-Level Breakfast on Institutional Investors and the Low-carbon Transition By www.oecd.org Published On :: Wed, 12 Dec 2018 18:05:00 GMT On 10 December in Katowice, the 9th annual High-Level Breakfast on Institutional Investors and the Low-carbon Transition, co-hosted by the OECD and the Institutional Investors Group on Climate Change (IIGCC), highlighted significant progress in mobilising green institutional investment, as well as important remaining challenges. Full Article
carbon Article: The Trillion-Dollar Question: How Can We Unlock the Money Needed to Transition to a Low-Carbon Economy? By warontherocks.com Published On :: Fri, 04 Jan 2019 11:18:00 GMT At a time when nationalism is rising and individual countries are facing a growing array of threats, it is critical that we recognize a shared and unprecedented global challenge: We need to double our infrastructure in the next decade to meet global development needs, while achieving a systematic shift away from business-as-usual, carbon-intensive options to low-emissions, resilient infrastructure, to avoid catastrophic climate change. Full Article
carbon Latvian economy is thriving, but boosting productivity, improving social protection and transitioning to a low-carbon productive model are vital for sustainable and inclusive growth By www.oecd.org Published On :: Wed, 29 May 2019 09:00:00 GMT The Latvian economy is thriving, with strong job growth driving convergence with more advanced economies. Efforts should now focus on reducing inequality, responding to the challenges posed by population ageing and making growth stronger, inclusive and greener, according to two new OECD reports. Full Article
carbon Taxes on polluting fuels are too low to encourage a shift to low-carbon alternatives By www.oecd.org Published On :: Fri, 20 Sep 2019 11:00:00 GMT Taxing polluting sources of energy is an effective way to curb emissions that harm the planet and human health, and the income generated can be used to ease the low-carbon transition for vulnerable households. Yet 70% of energy-related CO2 emissions from advanced and emerging economies are entirely untaxed, offering little incentive to move to cleaner energy, according to a new OECD report. Full Article
carbon Carbon Pricing and Competitiveness: Are they at Odds? - Environment Working Paper By www.oecd-ilibrary.org Published On :: Thu, 21 Nov 2019 16:00:00 GMT This paper reviews ex-post empirical assessments on the impact of carbon pricing on competitiveness in OECD and G20 countries in the electricity and industrial sectors. Most of these assessments find no statistically significant effects of carbon pricing or energy prices on different dimensions of competitiveness, including net imports, foreign direct investments, turnover, value added, employment, profits, productivity, and innovation. Full Article
carbon Workshop: Indicators of local transition to low-carbon economy (Regional Growth Core Schönefelder Kreuz, Germany) By www.oecd.org Published On :: Mon, 10 Sep 2012 00:00:00 GMT The Regional Growth Core Schönefelder Kreuz and the Technical University of Applied Sciences Wildau in partnership with the OECD Local Economic and Employment Development Programme (LEED) are working on defining and collecting measurable indicators at the regional/ local level that can inform over time of transition to low-carbon economic and industrial activities. Full Article
carbon Report: Green growth in the Benelux - Indicators of local transition to a low-carbon economy in cross-border regions (Benelux) By www.oecd.org Published On :: Thu, 23 May 2013 13:21:00 GMT This paper discusses the results of the 2011-2012 OECD LEED study of measuring green growth in the Benelux countries (Belgium, The Netherlands and Luxembourg). The study paid particular attention to the challenges of measuring the transition to a low-carbon economy in cross-border areas as they have additional levels of complexity when it comes to measuring and monitoring their low-carbon transition. Full Article
carbon Countries should make carbon pricing the cornerstone of climate policy, says OECD By www.oecd.org Published On :: Wed, 09 Oct 2013 11:31:00 GMT Credible and consistent carbon pricing must be the cornerstone of government actions to tackle climate change, according to a new OECD report. Full Article
carbon Carbon taxes and emissions trading are cheapest ways of reducing CO2, OECD says By www.oecd.org Published On :: Mon, 04 Nov 2013 12:00:00 GMT Carbon taxes and emission trading systems are the most cost-effective means of reducing CO2 emissions, and should be at the centre of government efforts to tackle climate change,according to a new OECD study. Full Article
carbon Project: Measuring the potential of green growth: Indicators of local transition to a low-carbon economy By www.oecd.org Published On :: Mon, 06 Jan 2014 14:21:00 GMT This LEED project aims to to define key indicators of area-based transition to a low-carbon economy. The objective is to define measurable indicators at regional/local level that can inform over time of transition to low-carbon economic and industrial activities. Full Article
carbon How partnerships can spur our transition to a low-carbon economy By www.oecd.org Published On :: Thu, 28 May 2015 15:34:00 GMT For the past decade or so, there has been a lot of debate in policy circles on how to get governments and the private sector to work together more collaboratively in order to catalyse the transition to green growth. The good news is that in that time many factors have come together to make this more of a reality. Full Article
carbon Webinar - Decarbonizing Development: Three Steps to a Zero-Carbon Future By www.greengrowthknowledge.org Published On :: Thu, 28 May 2015 18:46:00 GMT On 28 May 2015, the Green Growth Knowledge Platform (GGKP) webinar will examine how proper planning can help lay the foundation for both a stable climate and good development path; explore how countries can create the right enabling environment so that the needed technology, infrastructure and financing are available; and discuss how countries can carefully manage the transition, given vital political economy considerations. Full Article
carbon Aligning Policies for a Low-carbon Economy By www.oecd.org Published On :: Fri, 03 Jul 2015 10:54:00 GMT This major report produced in co-operation with the International Energy Agency (IEA), the International Transport Forum (ITF) and the Nuclear Energy Agency (NEA) identifies the misalignments between climate change objectives and policy and regulatory frameworks across a range of policy domains (investment, taxation, innovation and skills, trade, and adaptation) and activities at the heart of climate policy. Full Article
carbon Webinar: COP21 and beyond: Aligning Policies for a Low-carbon Economy By www.greengrowthknowledge.org Published On :: Mon, 05 Oct 2015 12:13:00 GMT Addressing climate change requires urgent policy action to drive a global infrastructure and technological transformation. The latest report 'Aligning Policies for a Low-carbon Economy' presents the first diagnosis of the alignments of policy and regulatory frameworks with climate policy goals. Join the Green Growth Knowledge Platform (GGKP) for a webinar exploring these issues on 5 October 2015, 15:00-16:30 (Paris time). Full Article
carbon Southeast Asia Expert Seminar: Aligning Policies for the Transition to a low-carbon Economy - Reconciling Environmental, Social and Economic Objectives By www.oecd.org Published On :: Wed, 04 Nov 2015 14:41:00 GMT The OECD and the Ministry of Finance of Indonesia (Fiscal Policy Agency) held an expert seminar on 4-5 November, 2015 in Bogor, Indonesia. The event brought together representatives from the ASEAN line ministries, research organisations and other key international organisations to share their knowledge and expertise on the topic. This event was supported by the OECD Knowledge Sharing Alliance. Full Article
carbon Higher price on carbon needed to effectively tackle climate change By www.oecd.org Published On :: Mon, 07 Dec 2015 11:00:00 GMT OECD urges efforts to better price carbon as new analysis finds that 90% of CO2-emissions are priced below EUR 30 per tonne, a low-end estimate of climate damage, and 60% are not priced at all. Effective Carbon Rates in the OECD and Selected Partner Economies calculates effective carbon rates (ECR) on CO2-emissions from energy use for 41 countries which together use 80% of global emissions. Full Article
carbon Carbon pricing efforts are falling short, but even modest collective action can deliver significant progress, OECD says By www.oecd.org Published On :: Mon, 26 Sep 2016 11:00:00 GMT Current carbon prices are falling short of the levels needed to reduce greenhouse gas emissions driving climate change, but even moderate price increases could have a significant impact, according to new OECD research. Full Article
carbon Effective Carbon Rates - OECD Insigths Blog By oecdinsights.org Published On :: Tue, 11 Oct 2016 14:55:00 GMT On the latest OECD Insights blog post, Mr. Kurt van Dender, Head of the Tax and Environment Unit at the OECD’s Centre for Tax Policy and Administration explains the necessary requirements to deeply cut greenhouse gas emissions in order to implement the COP21 Paris Agreement. Full Article
carbon Raising revenues through carbon pricing can help improve energy affordability By www.oecd.org Published On :: Thu, 11 May 2017 11:00:00 GMT This report uses household level data covering 20 OECD countries to analyse energy affordability at current energy prices and explores how these indicators change in response to a simulated energy tax reform. The report finds that higher energy prices, needed to cut harmful carbon emissions and air pollution, can also help achieve social policy objectives. Full Article
carbon Carbon taxes and emissions trading are cheapest ways of reducing CO2, OECD says By www.oecd.org Published On :: Mon, 04 Nov 2013 12:00:00 GMT Carbon taxes and emission trading systems are the most cost-effective means of reducing CO2 emissions, and should be at the centre of government efforts to tackle climate change,according to a new OECD study. Full Article
carbon Effective carbon rates: Key findings for Germany By www.oecd.org Published On :: Mon, 17 Sep 2018 11:00:00 GMT This country note for Germany provides detail on the proportion of CO2 emissions from energy use subject to different effective carbon rates (ECR), as well as on the level and components of average ECRs in each of the six economic sectors (road transport, off-road transport, industry, agriculture and fishing, residential & commercial, and electricity). Full Article
carbon The Jobs Potential of a Shift towards a low-carbon Economy By www.oecd.org Published On :: Sun, 03 Jun 2012 00:00:00 GMT The Jobs Potential of a Shift towards a low-carbon Economy” provides an in-depth analysis of how green growth will reshape labour markets. It also describes the role that labour market and skill policies can play in maximising the benefits of economic greening for workers Full Article
carbon Workshop: Indicators of local transition to low-carbon economy (Regional Growth Core Schönefelder Kreuz, Germany) By www.oecd.org Published On :: Mon, 10 Sep 2012 00:00:00 GMT The Regional Growth Core Schönefelder Kreuz and the Technical University of Applied Sciences Wildau in partnership with the OECD Local Economic and Employment Development Programme (LEED) are working on defining and collecting measurable indicators at the regional/ local level that can inform over time of transition to low-carbon economic and industrial activities. Full Article
carbon Report: Green growth in the Benelux - Indicators of local transition to a low-carbon economy in cross-border regions (Benelux) By www.oecd.org Published On :: Thu, 23 May 2013 13:21:00 GMT This paper discusses the results of the 2011-2012 OECD LEED study of measuring green growth in the Benelux countries (Belgium, The Netherlands and Luxembourg). The study paid particular attention to the challenges of measuring the transition to a low-carbon economy in cross-border areas as they have additional levels of complexity when it comes to measuring and monitoring their low-carbon transition. Full Article
carbon Project: Measuring the potential of green growth: Indicators of local transition to a low-carbon economy By www.oecd.org Published On :: Mon, 06 Jan 2014 14:21:00 GMT This LEED project aims to to define key indicators of area-based transition to a low-carbon economy. The objective is to define measurable indicators at regional/local level that can inform over time of transition to low-carbon economic and industrial activities. Full Article
carbon Workshop: Indicators of local transition to low-carbon economy (Regional Growth Core Schönefelder Kreuz, Germany) By www.oecd.org Published On :: Mon, 10 Sep 2012 00:00:00 GMT The Regional Growth Core Schönefelder Kreuz and the Technical University of Applied Sciences Wildau in partnership with the OECD Local Economic and Employment Development Programme (LEED) are working on defining and collecting measurable indicators at the regional/ local level that can inform over time of transition to low-carbon economic and industrial activities. Full Article
carbon Report: Green growth in the Benelux - Indicators of local transition to a low-carbon economy in cross-border regions (Benelux) By www.oecd.org Published On :: Thu, 23 May 2013 13:21:00 GMT This paper discusses the results of the 2011-2012 OECD LEED study of measuring green growth in the Benelux countries (Belgium, The Netherlands and Luxembourg). The study paid particular attention to the challenges of measuring the transition to a low-carbon economy in cross-border areas as they have additional levels of complexity when it comes to measuring and monitoring their low-carbon transition. Full Article
carbon Project: Measuring the potential of green growth: Indicators of local transition to a low-carbon economy By www.oecd.org Published On :: Mon, 06 Jan 2014 14:21:00 GMT This LEED project aims to to define key indicators of area-based transition to a low-carbon economy. The objective is to define measurable indicators at regional/local level that can inform over time of transition to low-carbon economic and industrial activities. Full Article
carbon Carbon Capture and Long-Term Storage: Analysis of 2010 Survey By www.oecd.org Published On :: Tue, 07 May 2013 15:05:00 GMT This is an analysis of a 2010 survey regarding carbon capture and long-term storage (CCS). It provides information that helps understand the hazards of CO2 sequestration and the risks to human health and environmental safety. It also identifies accident scenarios, including those associated with CO2 capture and compression, storage prior to transport and injection for geological storage. Full Article
carbon Emission scenario document on formulation and application of thermal and carbonless copy paper By www.oecd.org Published On :: Fri, 11 Apr 2014 11:22:00 GMT This document provides information on the sources, use patterns, and potential release pathways of chemicals used in the manufacture of thermal and carbonless copy paper. It presents approaches for estimating the environmental releases of and occupational exposures to additives and components used in thermal and carbonless copy paper coatings. Full Article
carbon Indian FTR Carbon And FTR Rally Listed On Company's India Website — India Launch Soon? By www.drivespark.com Published On :: Tue, 05 May 2020 18:38:28 +0530 Indian Motorcycles unveiled the FTR Carbon globally a few days ago. The FTR Carbon is now the flagship model in the FTR range and as the name suggests, the motorcycle gets a bunch of new carbon fibre body panels. As far Full Article
carbon Impacts on groundwater quality from abandoned hydrocarbon wells - GOV.UK By www.gov.uk Published On :: Tue, 22 Oct 2019 07:00:00 GMT Impacts on groundwater quality from abandoned hydrocarbon wells GOV.UK Full Article
carbon Decacarbonyl(μ-ethylidenimino-1κN:2κC)-μ-hydrido-triangulo-triosmium(3 Os–Os) By scripts.iucr.org Published On :: 2019-10-22 The title complex, [Os3(C2H4N)H(CO)10] or [Os3(CO)10(μ-H)(μ-HN=C—CH3-1κN:2κC)], was synthesized in 41.6% yield by reactions between Os3(CO)11(CH3CN) and 2,4,6-trimethylhexahydro-1,3,5-triazine. The central osmium triangle has two OsI atoms bridged by a hydride ligand and a μ-HN= C—CH3-1κN:2κC triazine fragment. Three CO ligands complete the coordination sphere around each OsI atom, while the remaining Os0 atom has four CO ligands. Each Os atom exhibits a pseudo-octahedral coordination environment, discounting the bridging Os—Os bond. Full Article text
carbon Ethyl 5-[(ethoxycarbonyl)oxy]-5,5-diphenylpent-2-ynoate By scripts.iucr.org Published On :: 2019-11-15 The title compound, C22H22O5, crystallizes with two molecules in the asymmetric unit, one of which shows disorder of its ethyl acetate group over two sets of sites in a 0.880 (2):0.120 (2) ratio. The C≡C distances in the two molecules are almost the same [1.1939 (16) and 1.199 (2) Å], but the Csp3—C≡C angles differ somewhat [175.92 (12) and 172.53 (16)°]. In the crystal, several weak C—H⋯O interactions are seen. Full Article text
carbon Dicaesium tetramagnesium pentakis(carbonate) decahydrate, Cs2Mg4(CO3)5·10H2O By scripts.iucr.org Published On :: 2020-02-11 The title carbonate hydrate, Cs2Mg4(CO3)5·10H2O, was crystallized at room temperature out of aqueous solutions containing caesium bicarbonate and magnesium nitrate. Its monoclinic crystal structure (P21/n) consists of double chains of composition 1∞[Mg(H2O)2/1(CO3)3/3], isolated [Mg(H2O)(CO3)2]2– units, two crystallographically distinct Cs+ ions and a free water molecule. The crystal under investigation was twinned by reticular pseudomerohedry. Full Article text
carbon Crystal structure of dicarbonyl[μ2-methylenebis(diphenylphosphane)-κ2P:P'][μ2-2-(2,4,5-trimethylphenyl)-3-oxoprop-1-ene-1,3-diyl](triphenylphosphane-κP)ironplatinum(Fe—Pt)–dichloromet By scripts.iucr.org Published On :: 2019-11-22 The title compound, [FePt(C12H12O)(C18H15P)(C25H22P2)(CO)2]·2C7H8·CH2Cl2 or [(OC)2Fe(μ-dppm)(μ-C(=O)C(2,4,5-C6H2Me3)=CH)Pt(PPh3)], represents an example of a diphosphane-bridged heterobimetallic dimetallacyclopentenone complex resulting from a bimetallic activation of 1-ethynyl-2,4,5-trimethylbenzene and a metal-coordinated carbonyl ligand. The bridging μ2-C(=O)C(2,4,5-C6H2Me3)=CH unit (stemming from a carbon–carbon coupling reaction between CO and the terminal alkyne) forms a five-membered dimetallacyclopentenone ring, in which the C=C bond is π-coordinated to the Fe centre. The latter is connected to the Pt centre through a short metal–metal bond of 2.5770 (5) Å. In the crystal, the complex is solvated by one dichloromethane and two toluene molecules. Full Article text
carbon Crystal structures of trans-acetyldicarbonyl(η5-cyclopentadienyl)(1,3,5-triaza-7-phosphaadamantane)molybdenum(II) and trans-acetyldicarbonyl(η5-cyclopentadienyl)(3,7-diacetyl-1,3,7-tr By scripts.iucr.org Published On :: 2020-03-17 The title compounds, [Mo(C5H5)(COCH3)(C6H12N3P)(CO)2], (1), and [Mo(C5H5)(COCH3)(C9H16N3O2P)(C6H5)2))(CO)2], (2), have been prepared by phosphine-induced migratory insertion from [Mo(C5H5)(CO)3(CH3)]. The molecular structures of these complexes are quite similar, exhibiting a four-legged piano-stool geometry with trans-disposed carbonyl ligands. The extended structures of complexes (1) and (2) differ substantially. For complex (1), the molybdenum acetyl unit plays a dominant role in the organization of the extended structure, joining the molecules into centrosymmetrical dimers through C—H⋯O interactions with a cyclopentadienyl ligand of a neighboring molecule, and these dimers are linked into layers parallel to (100) by C—H⋯O interactions between the molybdenum acetyl and the cyclopentadienyl ligand of another neighbor. The extended structure of (2) is dominated by C—H⋯O interactions involving the carbonyl groups of the acetamide groups of the DAPTA ligand, which join the molecules into centrosymmetrical dimers and link them into chains along [010]. Additional C—H⋯O interactions between the molybdenum acetyl oxygen atom and an acetamide methyl group join the chains into layers parallel to (101). Full Article text
carbon The crystal structures of Fe-bearing MgCO3 sp2- and sp3-carbonates at 98 GPa from single-crystal X-ray diffraction using synchrotron radiation By scripts.iucr.org Published On :: 2020-04-21 The crystal structure of MgCO3-II has long been discussed in the literature where DFT-based model calculations predict a pressure-induced transition of the carbon atom from the sp2 to the sp3 type of bonding. We have now determined the crystal structure of iron-bearing MgCO3-II based on single-crystal X-ray diffraction measurements using synchrotron radiation. We laser-heated a synthetic (Mg0.85Fe0.15)CO3 single crystal at 2500 K and 98 GPa and observed the formation of a monoclinic phase with composition (Mg2.53Fe0.47)C3O9 in the space group C2/m that contains tetrahedrally coordinated carbon, where CO44− tetrahedra are linked by corner-sharing oxygen atoms to form three-membered C3O96− ring anions. The crystal structure of (Mg0.85Fe0.15)CO3 (magnesium iron carbonate) at 98 GPa and 300 K is reported here as well. In comparison with previous structure-prediction calculations and powder X-ray diffraction data, our structural data provide reliable information from experiments regarding atomic positions, bond lengths, and bond angles. Full Article text
carbon Structure and mechanism of copper–carbonic anhydrase II: a nitrite reductase By scripts.iucr.org Published On :: 2020-02-21 Nitric oxide (NO) promotes vasodilation through the activation of guanylate cyclase, resulting in the relaxation of the smooth muscle vasculature and a subsequent decrease in blood pressure. Therefore, its regulation is of interest for the treatment and prevention of heart disease. An example is pulmonary hypertension which is treated by targeting this NO/vasodilation pathway. In bacteria, plants and fungi, nitrite (NO2−) is utilized as a source of NO through enzymes known as nitrite reductases. These enzymes reduce NO2− to NO through a catalytic metal ion, often copper. Recently, several studies have shown nitrite reductase activity of mammalian carbonic anhydrase II (CAII), yet the molecular basis for this activity is unknown. Here we report the crystal structure of copper-bound human CAII (Cu–CAII) in complex with NO2− at 1.2 Å resolution. The structure exhibits Type 1 (T-1) and 2 (T-2) copper centers, analogous to bacterial nitrite reductases, both required for catalysis. The copper-substituted CAII active site is penta-coordinated with a `side-on' bound NO2−, resembling a T-2 center. At the N terminus, several residues that are normally disordered form a porphyrin ring-like configuration surrounding a second copper, acting as a T-1 center. A structural comparison with both apo- (without metal) and zinc-bound CAII (Zn–CAII) provides a mechanistic picture of how, in the presence of copper, CAII, with minimal conformational changes, can function as a nitrite reductase. Full Article text
carbon Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX By scripts.iucr.org Published On :: 2019-08-22 Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX–inhibitor complexes using X-ray and neutron crystallography, a CA IX surface variant (CA IXSV; the catalytic domain with six surface amino-acid substitutions) has been developed that can be routinely crystallized. Here, the preparation of protiated (H/H), H/D-exchanged (H/D) and deuterated (D/D) CA IXSV for crystallographic studies and their structural comparison are described. Four CA IXSV X-ray crystal structures are compared: two H/H crystal forms, an H/D crystal form and a D/D crystal form. The overall active-site organization in each version is essentially the same, with only minor positional changes in active-site solvent, which may be owing to deuteration and/or resolution differences. Analysis of the crystal unit-cell packing reveals different crystallographic and noncrystallographic dimers of CA IXSV compared with previous reports. To our knowledge, this is the first report comparing three different deuterium-labelled crystal structures of the same protein, marking an important step in validating the active-site structure of CA IXSV for neutron protein crystallography. Full Article text
carbon Tiny creatures collected 100 years ago confirm accelerating carbon uptake in Antarctic Ocean By insider.si.edu Published On :: Thu, 03 Mar 2011 15:16:46 +0000 Tiny Antarctic marine creatures collected 100 years ago by British Royal Navy explorer Robert Falcon Scott are giving scientists new clues about polar environmental change. The post Tiny creatures collected 100 years ago confirm accelerating carbon uptake in Antarctic Ocean appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Science & Nature carbon dioxide climate change conservation biology National Museum of Natural History
carbon Development will reduce carbon stored in forests, Smithsonian & Harvard scientists predict By insider.si.edu Published On :: Mon, 16 Apr 2012 13:07:11 +0000 When most people look at a forest, they see walking trails, deer yards, or firewood for next winter. But scientists at the Harvard Forest and […] The post Development will reduce carbon stored in forests, Smithsonian & Harvard scientists predict appeared first on Smithsonian Insider. Full Article Science & Nature biodiversity carbon dioxide conservation conservation biology Forest Global Earth Observatory Smithsonian Conservation Biology Institute Smithsonian Environmental Research Center