Blueprint, published: Wed, 6 May 2020

This IBM® Redpaper™ publication is intended as an architecture and configuration guide to set up the IBM System Storage™ for the SAP HANA tailored data center integration (SAP HANA TDI) within a storage area network (SAN) environment.

In the previous two tutorials, you learned how to write a basic OpenWhisk Clojure application. In Part 3, I'll show you how to improve any such application. First, you'll learn how to support arguments that include double quotes. Then you'll learn how to use a permanent database (Cloudant) instead of a variable to store the information.

Passwords are not a complete security solution; they can be stolen or shared. In this tutorial, you learn how to use a random string delivered by email as a second authentication factor. I also discuss several methods for risk analysis, which is used by the application to decide whether a second factor is warranted.

In this article, you learn how to use the IBM Cloud to write a Node.js application for an organization’s front desk, which needs to log visitors in and out. Along the way you will learn how to use Node.js, the Express HTTP server library, and a Cloudant database. You will learn how to do this in the highly available IBM Cloud. This is a basic introduction to Node.js programming on the IBM Cloud platform.

In the first article in this series, you learned how to build a Node.js application on the IBM Cloud. However, that application was not very responsive or visually appealing. In this article you learn how to use the Bootstrap theme for your application to look better, and how to use the AngularJS library to make it more responsive.

The Northern Territory Chief Minister says plans for a water theme park in Darwin are not dead in the water yet, despite his Government formally rejecting all expressions of interest in the project submitted so far.

Now that Western Australia's moratorium on fracking has been lifted, can gas from the Kimberley prove that it is economically viable?

Celonis has launched the next generation of its platform, enabling customers and partners to develop purpose-built Operational Applications.

Learn how IBM is how incorporating WAI-ARIA techniques and examples into: IBM accessibility guidelines, product accessibility reviews by the IBM Accessibility Architecture Review Board, and automated accessibility testing via IBM Rational Policy Tester.

IBM advocacy partner, the Carl and Ruth Shapiro Family National Center for Accessible Media at WGBH (NCAM) received the FCC Chairman's Award for Advancement in Accessibility for Mobile Applications for their development of the Media Access Mobile (MAM) solution. MAM is designed to serve visitors to entertainment venues and cultural institutions who are deaf, hard-of-hearing, blind or visually impaired, or who speak languages other than English.

Most U.S. state departments of transportation (DOTs) are collecting weigh-in-motion data with a wide variety of sensor types and using them in a variety of applications. Many agencies use WIM data to aid in pavement design, although most are not currently using a Pavement ME (mechanistic-empirical) Design application. WIM for bridge and asset management purposes is used much less often. The TRB National Cooperative Highway Research Program's NCHRP Synthesis 546: Use of Weigh-in-Motion Data for Pavement, ...

Self-consolidating concrete (SCC) is a highly flowable, nonsegregating concrete that is placed without any mechanical consolidation. TRB will conduct a webinar on Thursday, June 11, 2020, from 1:00 PM to 3:00 PM Eastern to discuss how SCC may be used to fill heavily congested or irregularly shaped members in bridge applications more easily while providing improved in-place quality and surface finish.The use of SCC may also decrease construction costs due to the reduced labor requirements during construct...

IBM (NYSE: IBM) annonce aujourd'hui un élargissement de son portefeuille de stockage flash pour aider les clients à extraire beaucoup plus rapidement la valeur issues des données afin d’en tirer un avantage concurrentiel. IBM a lancé trois nouvelles baies « tout-flash » dotées d’une performance de pointe – une latence minimum de 250μs (microsecondes) - afin de résoudre le défi consistant à accéder rapidement à un grand volume de données pour les applications et les workloads cloud.

IBM (NYSE: IBM) a annoncé aujourd'hui une nouvelle plateforme communautaire basée sur le Cloud pour les applications de cybersécurité. IBM Security Connect est la première plateforme Cloud de sécurité reposant sur des technologies fédérées ouvertes, avec l'IA en son centre, pour analyser les données de sécurité sur des outils et des environnements non connectés auparavant.

One of Australia’s leading digital banks taps cognitive technology to simplify the home loan application process with innovative virtual assistan

Just a short note that the memorial article “Analysis and applications: The mathematical work of Elias Stein” has just been published in the Bulletin of the American Mathematical Society.  This article was a collective effort led by Charlie Fefferman, Alex Ionescu, Steve Wainger and myself to describe the various mathematical contributions of Elias Stein, who […]

Let's talk about Blockchain. Goal is to use this forum topic to highlight its usefulness to programming language theory and practice. If you're familiar with existing research efforts, please share them here. In addition, feel free to generate ideas for how Blockchain could improve languages and developer productivity.

As one tasty example: Blockchain helps to formalize thinking about mutual knowledge and common knowledge, and potentially think about sharing intergalactic computing power through vast distributed computing fabrics. If we can design contracts in such a way that maximizes the usage of mutual knowledge while minimizing common knowledge to situations where you have to "prove your collateral", third-party transactions could eliminate a lot of back office burden. But, there might be benefits in other areas of computer science from such research, as well.

Some language researchers, like Mark S. Miller, have always dreamed of Agoric and the Decades-Long Quest for Secure Smart Contracts.

Some may also be aware that verification of smart contracts is an important research area, because of the notorious theft of purse via logic bug in an Ethereum smart contract.

'Whenever there's a trillion dollars out on the street that quickly, the fraudsters are going to come out of the woodwork'

strataconf: Building Big Data applications now easier http://t.co/jaATalPL4P Hadoop analytic engines simplify creation of low-cost, scalable apps

Ning Zhang, Jia Wu and Liwei Zhang
Math. Comp. 89 (2020), 1867-1894.
Abstract, references and article information

Shukai Du and Francisco-Javier Sayas
Math. Comp. 89 (2019), 1745-1782.
Abstract, references and article information

Ricardo G. Durán, Enrique Otárola and Abner J. Salgado
Math. Comp. 89 (2020), 1581-1603.
Abstract, references and article information

Kathrin Bringmann, Matthew Krauel and Michael Tuite
Trans. Amer. Math. Soc. 373 (2020), 3261-3293.
Abstract, references and article information

The Government today announced the establishment of a LawTech Fund to help law firms and barristers' chambers procure and upgrade information technology (IT) systems and arrange lawtech training courses for their staff.

In a statement, the Department of Justice said the LawTech Fund, established under the Anti-epidemic Fund, will be open for applications from April 28 and cater to small and medium-size law firms as well as barristers’ chambers.

Applications will be accepted for two months and those eligible can receive a reimbursement of up to $50,000.

The Law Society of Hong Kong and the Hong Kong Bar Association will establish a joint committee to assess the applications and arrange funding disbursement.

More than 60% of law firms and 50% of barristers' chambers in Hong Kong are expected to benefit from the funding.

As for funding eligibility, law firms or chambers must have five or fewer practising lawyers as at April 8 and at the time of granting the subsidy.

The subsidies must be used for procuring and upgrading IT systems, including but not confined to video-conferencing facilities. The lawtech training that is to receive the subsidy must be recognised and approved by the joint committee.

The application form and guidance notes are available at the homepages of the Law Society and the Bar Association.

The Secretary for Justice has given an outline of the fund and discussed lawtech in her blog.

More than 40,000 new niches at two columbaria in Tuen Mun and Fanling will open for applications from May 11, the Food & Environmental Hygiene Department announced today.

Tsang Tsui Columbarium in Tuen Mun will provide 22,680 standard niches and 220 large niches, while Wo Hop Shek Columbarium in Fanling will provide 21,720 standard niches and 330 large niches for application.

The department said applicants should only file one application form to apply for either a large or standard niche for the same deceased person.

It said applicants have to fill in the particulars of at least three deceased people when applying for a large niche.

Since the type and number of niches available in the two columbaria are different, the chance of successful allocation varies, the department added.

The application deadline is June 10.

Click here for details.

Ryan A. Ristau
Nov 1, 2013; 26:211-215
From Research to Practice

The Government will launch the Subsidy Scheme for Beauty Parlours, Massage Establishments & Party Rooms under the second round of the Anti-epidemic Fund on May 11.

A sum of $1.1 billion has been earmarked for the scheme, which is expected to benefit 12,400 beauty parlours and massage establishments as well as 500 party rooms.

The subsidy is expected to be disbursed from late this month.

Under the scheme, each eligible beauty parlour or massage establishment will receive a one-off tiered subsidy of $30,000, $60,000 or $100,000, depending on its number of workers.

Each eligible party room will receive a one-off subsidy of $40,000.

Applications will only be accepted online. The application deadline is May 17.

The scheme also covers premises which are operated by social enterprises.

For premises with business registration, social enterprise operators should file their applications through the online application system.

Those without business registration should directly approach the Hong Kong Council of Social Service at 2864 2993 or by email to obtain its certification and submit their applications.

Call 1836 188 or send an email for enquiries.

(Fundação de Amparo à Pesquisa do Estado de São Paulo) Thanks to its magnetic properties, the material -- zinc-doped manganese chromite -- can be used in a range of products, from gas sensors to data storage devices.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

The Government today announced that applications are open for several support schemes following the funding approval of the second round of the Anti-epidemic Fund and other relief measures by the Legislative Council Finance Committee.

The Club-house Subsidy Scheme, which provides a one-off subsidy of $100,000 to eligible club-houses, is now open for application. The deadline for application is May 18.

Upon submission of the completed application form and supporting documents, the disbursement of subsidies could generally be made in around two weeks.

The Travel Agents & Practitioners Support Scheme and the Hotel Sector Support Scheme are also open for applications, with the deadlines on June 15 and May 18 respectively.

The Subsidy Scheme for the Refuse Transfer Station Account Holders for Transporting Municipal Solid Waste, which offers a one-off subsidy of $8,000 to each of the eligible private municipal solid waste collectors operating in the first quarter, was also endorsed.

To ease the application procedures, the Environmental Protection Department will post cheques to recipients of this special subsidy in about a week after the funding endorsement.

Meanwhile, the total guarantee commitment of the Special 100% Loan Guarantee under the SME Financing Guarantee Scheme has been increased to $50 billion.

The maximum loan amount per enterprise has been increased to $4 million and the principal moratorium arrangement has been extended to the first 12 months.

The Special 100% Loan Guarantee will start receiving applications from April 20 and the application period has been extended to one year.

Guan-Da Syu
Apr 17, 2020; 0:R120.001936v1-mcp.R120.001936
Review

Protein microarrays are crucial tools in the study of proteins in an unbiased, high-throughput manner, as they allow for characterization of up to thousands of individually purified proteins in parallel. The adaptability of this technology has enabled its use in a wide variety of applications, including the study of proteome-wide molecular interactions, analysis of post-translational modifications, identification of novel drug targets, and examination of pathogen-host interactions. In addition, the technology has also been shown to be useful in profiling antibody specificity, as well as in the discovery of novel biomarkers, especially for autoimmune diseases and cancers. In this review, we will summarize the developments that have been made in protein microarray technology in both in basic and translational research over the past decade. We will also introduce a novel membrane protein array, the GPCR-VirD array, and discuss the future directions of functional protein microarrays.

When you run SAS Deployment Wizard to install or update SAS 9.4 software, the file system is examined. If any files that the wizard needs to delete are found to be locked, they are reported as unwritable f

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Joseph Tran
Oct 1, 2012; 30:173-178
Practical Pointers

The Small Business Administration will resume accepting Paycheck Protection Program loan applications at 10:30 a.m. EST on April 27 from “approved lenders on behalf of any eligible borrower,” the agency said.