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Deep-Earth diamonds may contain gassy relics from the early solar system

Scientists studying diamonds from deep within Earth’s mantle found evidence of a reservoir of rocks and gas that may be nearly as old as the planet itself.




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Saturn unseats Jupiter as planet with the most moons in our solar system

Astronomers discovered 20 new moons around Saturn, bringing its total to 82.




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Meet the second confirmed interstellar object to enter our solar system

The comet, 2I/Borisov, comes from another planetary system, but bears a remarkable resemblance to local space rocks.




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How measles virus triggers immune system ‘amnesia’

In addition to causing disease itself, the virus destroys immune cells trained to respond to other pathogens the body has encountered before.




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Editorial: 'Bedlam' shows us what we've done to our mental health system

Psychiatrist Kenneth Rosenberg's film brings together many strands of American dysfunction: mental healthcare, incarceration, homelessness, policing, race. It provides few answers but helps us ask the right questions.




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Editorial: Coronavirus outbreak gives colleges a chance to revive a system already breaking

The coronavirus epidemic has superheated the issues confronting colleges and their students in ways that will reverberate for years, if not forever.




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Op-Ed: COVID-19 has broken the U.S. health system. Now what?

22 million Americans have filed jobless claims in recent weeks. Millions of them have also lost their employer-based health insurance at the worst possible time.




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Op-Ed: How California's smog alert system could be adapted to fight the coronavirus

California could restart its economy by creating a "virus alert" system that would regulate COVID risk by automatically reinstating shelter-in-place orders when infection or death rates get too high.




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Foster Care System In West Virginia Struggles To Help Children During The Pandemic

The coronavirus shutdown is straining a foster care system in West Virginia. Home visits have shifted to online check-ins, and referrals have plummeted as schools are now closed.




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SYSTEM UPDATE: 5 Mother’s Day gifts for the ‘Gamer Mom’

You can always get your mom flowers for Mother’s Day, or chocolate, or your standard Mother’s Day gift. Or, if your mom is anything like mine, you can go in a completely different direction.




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Out of work and out of money: New Yorkers remain frustrated by overburdened state unemployment system

Gov. Cuomo said he understands the worries of those out of work during the coronavirus pandemic — but the sentiment offered little solace to those who have been watching their bank accounts dwindle for weeks with no relief in sight.




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Child-care providers need supplies, coronavirus guidance as day-care system suffers

California's early childhood care system has long been held together by women such as Tanya García, whose Hollywood duplex is home to two licensed day-care operations serving as many as 28 youngsters — among them the children of healthcare workers and public school teachers.




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Op-Ed: Everything wrong with our food system has been made worse by the pandemic

Trump's executive order to keep meat processing plants open, despite coronavirus risks to workers, is utterly consistent with the federal law's long-standing disregard for food worker safety.




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Fire safety warning as millions work from home to stem spread of Covid-19

Firefighters are issuing urgent #StayHomeStaySafe advice as millions of people enter their first full week of working from home amidst the Coronavirus pandemic




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Brigade response to Government announcement on further steps to reform the building safety system

A Government announcement on further steps to reform the building safety system has been welcomed by London Fire Brigade, but senior firefighters also have concerns it has not gone far enough




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How budget cuts and restrictive policies hobbled the unemployment insurance system

Problems from the surge of jobless claims reflect years of cutbacks and greater restrictions on eligibility.




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Column: Sick of religious limits on care, a hospital seeks to end partnership with Catholic system

The prestigious Hoag Hospital wants to exit its partnership with a Catholic healthcare system.




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Rotting food. Hungry masses. Chaotic supply chains. Coronavirus upends the U.S. food system

During the coronavirus crisis, food producers, distributors and retailers in California, producer of much of the U.S. food supply, scramble to adapt.




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This interior design boot camp puts potential tastemakers through their paces

Designer Kathryn Ireland shares an insider's tricks of the trade with a select few over a jam-packed weekend.




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Review: Income inequality? 'Capital in the Twenty-First Century' says the system needs fixing

Filmmaker Justin Pemberton turns French economist Thomas Piketty's 2013 manifesto on inequality, "Capital in the Twenty-First Century," into an engaging documentary.




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Top tips to lose weight by improving your digestive system



WEIGHT LOSS can be a very hard journey for many people, especially in the current climate where Brits are mid-way through their sixth week in lockdown. However it is possible to lose weight in a healthy way, by not restricting your diet and at the same time, also looking after your digestive system, one of the most important parts of the body. An expert has revealed how to lose weight whilst looking after your body.




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Manufacturing Systems Engineer

ABOUT US OTG Group began with the idea that grouping food vendors together could create an experience that would allow neighbors, friends, and families to connect. Since then, OTG's products have worked hard to develop services that change the way that people think about going out. Off the G




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Senior Systems Engineer I

Software/system Test Engineer responsibilities include but not limited to independently planning and performing test assignments involving definition of test and verification requirements, plans and sequences relative to complex software and hardware subsystems and resolve identified conflicting iss




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Electrical Engineer - Systems Design

Do you want to work with a team of engineering professionals dedicated to excellence at one of Woolperts many locations? Do you want to be part of a Great Place to Work? Are you looking to join a growing cutting edge AEG firm? If so, we want YOU! As a licensed professional Electrical Engineer - i




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Systems Engineer

Polaris Alpha was formed in 2016 through the merger of EOIR Technologies, Intelligent Software Solutions (ISS), PROTEUS Technologies and Intelesys. The Company has approximately 1,200 employees with major offices in Colorado Springs, CO, Fredericksburg, VA, Annapolis Junction, MD, Aberdeen Proving G




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Home security system: How to keep your home safe during lockdown



CRIME rates seem to have dropped in the UK during the lockdown phase of the Government's response to the coronavirus pandemic. However, that doesn't mean you are completely safe. Here's some tips on how to keep your home safe during the lockdown.




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Ontario promises to review long-term care system once pandemic ends

Ontario’s minister of long-term care has announced that the provincial government will conduct a review of the long-term care system once the COVID-19 pandemic settles.




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Letters: Robust health care system needed to combat coronavirus threat

Until we have a vaccine, the road to opening is through a health care system which can handle the infection, a letter to the editor says.

       




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Google and the ecosystem test

I am roaming the halls of Google I/O 2013 and wondering whether Google’s platform passes the ecosystem test. … no platform has become hugely successful without a corresponding ecosystem of vendors building significant businesses on top of the platform. Typically, … Continue reading




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Sen. Ford: Use federal money to bolster vote-by-mail system in Indiana

If there is anything we should be doing at this moment, it is to ensure that elections are safe, accessible and fair, J.D. Ford writes.

       




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Letters: Robust health care system needed to combat coronavirus threat

Until we have a vaccine, the road to opening is through a health care system which can handle the infection, a letter to the editor says.

       




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Coronavirus: Chinese official admits health system weaknesses

China says it will improve public health systems after criticism of its early response to the virus.




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Hackers fool bank security system

Criminal hackers have found ways around new security devices used for online banking.




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Martin Scorsese is right: The real villain isn’t Marvel movies. It’s the broken system.

The director's New York Times op-ed reveals a longing for an age before tent-pole movies and streaming services.




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Jimmy Butler is fitting into the 76ers' system seamlessly

Butler hasn't had much practice time with the 76ers, but he's already acclimating to their preferred way of playing and closing out wins.




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Trump found a way to simultaneously sabotage our health-care and immigration systems

He just took out two birds with one proclamation.




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strataconf: A roundup of healthcare tools used in the field from #hdpalooza http://t.co/0d2x3OlaeC including @MedCPU @SVBiosystems @CHRankings & more

strataconf: A roundup of healthcare tools used in the field from #hdpalooza http://t.co/0d2x3OlaeC including @MedCPU @SVBiosystems @CHRankings & more




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velocityconf: RT @allspaw: Operations and System Safety - always a student http://t.co/1VYBEZYrK8 #devops #velocityconf

velocityconf: RT @allspaw: Operations and System Safety - always a student http://t.co/1VYBEZYrK8 #devops #velocityconf




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Brighten Up Your After-Dark Road-Tripping with Lanmodo’s Vast Automotive Night Vision System

With a bright, 8.2-inch HD display and the flexibility to work in almost any vehicle, the Lanmodo Automotive Vast Night Vision System is a near-perfect alternative to factory-installed systems.

The post Brighten Up Your After-Dark Road-Tripping with Lanmodo’s Vast Automotive Night Vision System appeared first on Vagabondish.




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Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system [Molecular Bases of Disease]

Bacterial type VII secretion systems secrete a wide range of extracellular proteins that play important roles in bacterial viability and in interactions of pathogenic mycobacteria with their hosts. Mycobacterial type VII secretion systems consist of five subtypes, ESX-1–5, and have four substrate classes, namely, Esx, PE, PPE, and Esp proteins. At least some of these substrates are secreted as heterodimers. Each ESX system mediates the secretion of a specific set of Esx, PE, and PPE proteins, raising the question of how these substrates are recognized in a system-specific fashion. For the PE/PPE heterodimers, it has been shown that they interact with their cognate EspG chaperone and that this chaperone determines the designated secretion pathway. However, both structural and pulldown analyses have suggested that EspG cannot interact with the Esx proteins. Therefore, the determining factor for system specificity of the Esx proteins remains unknown. Here, we investigated the secretion specificity of the ESX-1 substrate pair EsxB_1/EsxA_1 in Mycobacterium marinum. Although this substrate pair was hardly secreted when homologously expressed, it was secreted when co-expressed together with the PE35/PPE68_1 pair, indicating that this pair could stimulate secretion of the EsxB_1/EsxA_1 pair. Surprisingly, co-expression of EsxB_1/EsxA_1 with a modified PE35/PPE68_1 version that carried the EspG5 chaperone-binding domain, previously shown to redirect this substrate pair to the ESX-5 system, also resulted in redirection and co-secretion of the Esx pair via ESX-5. Our results suggest a secretion model in which PE35/PPE68_1 determines the system-specific secretion of EsxB_1/EsxA_1.




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Webinar: Reimagining the Role of State and Non-State Actors in (Re)building National Health Systems in the Arab World

Research Event

22 April 2020 - 1:00pm to 2:00pm

Event participants

Fadi El-Jardali, Professor of Health Policy and Systems, American University of Beirut
Moderator: Nadim Houry, Executive Director, Arab Reform Initiative

As new cases of COVID-19 continue to surge, countries around the world struggle to mitigate the public health and economic effects of the virus. It is becoming increasingly clear that an effective pandemic response requires a whole-of-government, whole-of-society approach. In the Arab world, where health systems are already strained by armed conflicts and displaced populations, a whole-of-society response to the pandemic is particularly critical as countries have become increasingly dependent on non-state actors, notably the private sector, for healthcare provision and any response that includes the state alone may not be sufficient to address the pandemic.

In a recent article, Fadi El-Jardali, argued that while the pandemic will have grave health and economic consequences for years to come, it brings with it a valuable opportunity to re-envision the role of state and non-state actors in strengthening health systems. The article addressed the need for increased collaboration between state and non-state actors, and the rethinking of existing cooperation models to provide quality healthcare services for all.  

In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, Dr El-Jardali will discuss how state and non-state actors can collaborate more effectively to address the shortcomings of national health care systems amidst the pandemic and beyond. The article’s author will share insights on the different capacities available in Arab societies that governments can draw upon to ensure that Universal Health Coverage, equity considerations and social justice are at the core of health systems.

You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page.

 

Reni Zhelyazkova

Programme Coordinator, Middle East and North Africa Programme
+44 (0)20 7314 3624




stem

Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system [Molecular Bases of Disease]

Bacterial type VII secretion systems secrete a wide range of extracellular proteins that play important roles in bacterial viability and in interactions of pathogenic mycobacteria with their hosts. Mycobacterial type VII secretion systems consist of five subtypes, ESX-1–5, and have four substrate classes, namely, Esx, PE, PPE, and Esp proteins. At least some of these substrates are secreted as heterodimers. Each ESX system mediates the secretion of a specific set of Esx, PE, and PPE proteins, raising the question of how these substrates are recognized in a system-specific fashion. For the PE/PPE heterodimers, it has been shown that they interact with their cognate EspG chaperone and that this chaperone determines the designated secretion pathway. However, both structural and pulldown analyses have suggested that EspG cannot interact with the Esx proteins. Therefore, the determining factor for system specificity of the Esx proteins remains unknown. Here, we investigated the secretion specificity of the ESX-1 substrate pair EsxB_1/EsxA_1 in Mycobacterium marinum. Although this substrate pair was hardly secreted when homologously expressed, it was secreted when co-expressed together with the PE35/PPE68_1 pair, indicating that this pair could stimulate secretion of the EsxB_1/EsxA_1 pair. Surprisingly, co-expression of EsxB_1/EsxA_1 with a modified PE35/PPE68_1 version that carried the EspG5 chaperone-binding domain, previously shown to redirect this substrate pair to the ESX-5 system, also resulted in redirection and co-secretion of the Esx pair via ESX-5. Our results suggest a secretion model in which PE35/PPE68_1 determines the system-specific secretion of EsxB_1/EsxA_1.




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Global health system needs reform to help deliver SDGs, says new report

24 September 2015

20150922RethinkingGlobalHealthArchitecture.jpg

A Pakistani health worker gives polio vaccines to children in the suburbs of Lahore, Pakistan, February 2015. Photo: Associated Press.

The global health system has contributed significantly to improved health and life expectancy in recent decades. However, the existing architecture needs to be reformed in order to address future challenges and meet the health targets in the Sustainable Development Goals. Rethinking the Global Health System, a new Chatham House report, analyses how fit for purpose the current system is and identifies priority areas for reform. 

The Ebola crisis has shown that weak systems make individual countries more vulnerable and that strong, resilient and equitable systems at country level are needed to protect global health security. There is a pressing need for enhanced global disease surveillance and detection capacity, as well as improved international coordination in responding to emerging health threats.

In addition, addressing determinants of health outside the health sector requires cross-sectoral collaboration and linkages to other policy domains. Historically, the focus has rested on directly reducing illness and death, but the need to address other influences on health outcomes – safe drinking water, proper sewage treatment, good education – is now well recognized.

The report says that stronger leadership in global health is therefore required and the report lends support to calls for the creation of a new organization that would bring together United Nations agencies with health-related mandates – UN-HEALTH. Just as UNAIDS created a more coherent response for HIV, a UN-HEALTH organization could achieve a similar but more wide-reaching effect by bringing together and streamlining all UN agencies working on global health issues.

Professor David Harper, who led the Chatham House project that resulted in the report, said: 

'This report is intended to make a substantial contribution to the international debate on what the world will require of the health architecture of the future. It offers some options for political leaders to consider, but it is just a starting point. More work is urgently needed to develop the ideas introduced in this project and to help generate the high-level political traction that is so vital in any change process.'

Editor's notes

Read the report Rethinking the Global Health System from the Centre on Global Health Security at Chatham House.     

For all enquiries, including requests to speak with the authors of this paper, please contact the press office.

Contacts

Press Office

+44 (0)20 7957 5739




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Let's Emerge From COVID-19 with Stronger Health Systems

26 March 2020

Robert Yates

Director, Global Health Programme; Executive Director, Centre for Universal Health
Heads of state should grasp the opportunity to become universal health heroes to strengthen global health security

2020-03-26-Health-Protest

A "Big Insurance: Sick of It" rally in New York City. Photo by Mario Tama/Getty Images.

As the COVID-19 pandemic presents the greatest threat to human health in over a century, people turn to their states to resolve the crisis and protect their health, their livelihoods and their future well-being.

How leaders perform and respond to the pandemic is likely to define their premiership - and this therefore presents a tremendous opportunity to write themselves into the history books as a great leader, rescuing their people from a crisis. Just as Winston Churchill did in World War Two.

Following Churchill’s advice to “never let a good crisis go to waste”, if leaders take decisive action now, they may emerge from the COVID-19 crisis as a national hero. What leaders must do quickly is to mitigate the crisis in a way which has a demonstrable impact on people’s lives.

Given the massive shock caused by the pandemic to economies across the world, it is not surprising that heads of state and treasury ministers have implemented enormous economic stimulus packages to protect businesses and jobs – this was to be expected and has been welcome.

National heroes can be made

But, in essence, this remains primarily a health crisis. And one obvious area for leaders to act rapidly is strengthening their nation’s health system to stop the spread of the virus and successfully treat those who have fallen sick. It is perhaps here that leaders have the most to gain - or lose - and where national heroes can be made.

This is particularly the case in countries with weak and inequitable health systems, where the poor and vulnerable often fail to access the services they need. One major practical action that leaders can implement immediately is to launch truly universal, publicly-financed health reforms to cover their entire population – not only for COVID-19 services but for all services.

This would cost around 1-2% GDP in the short-term but is perfectly affordable in the current economic climate, given some of the massive fiscal stimuluses already being planned (for example, the UK is spending 15% GDP to tackle COVID-19).

Within one to two years, this financing would enable governments to implement radical supply side reforms including scaling up health workforces, increasing the supply of essential medicines, diagnostics and vaccines and building new infrastructure. It would also enable them to remove health service user fees which currently exclude hundreds of millions of people worldwide from essential healthcare. Worldwide these policies have proven to be effective, efficient, equitable and extremely popular.

And there is plenty of precedent for such a move. Universal health reform is exactly what political leaders did in the UK, France and Japan as post-conflict states emerging from World War Two. It is also the policy President Kagame launched in the aftermath of the genocide in Rwanda, as did Prime Minister Thaksin in Thailand after the Asian Financial Crisis in 2002, and the Chinese leadership did following the SARS crisis, also in 2003.

In China’s case, reform involved re-socialising the health financing system using around 2% GDP in tax financing to increase health insurance coverage from a low level of one-third right up to 96% of the population.

All these universal health coverage (UHC) reforms delivered massive health and economic benefits to the people - just what is needed now to tackle COVID-19 - and tremendous political benefits to the leaders that implemented them.

When considering the current COVID-19 crisis, this strategy would be particularly relevant for countries underperforming on health coverage and whose health systems are more likely to be overwhelmed if flooded with a surge of patients, such as India, Pakistan, Bangladesh, Myanmar, Indonesia and most of sub-Saharan Africa, where many governments spend less than 1% of their GDP on health and most people have to buy services over the counter.

But also the two OECD countries without a universal health system – the United States and Ireland – are seeing the threat of COVID-19 already fuelling the debate about the need to create national, publicly-financed health system. And the presidents of South Africa, Kenya and Indonesia have already committed their governments to eventually reach full population coverage anyway, and so may use this crisis to accelerate their own universal reforms. 

Although difficult to predict which leaders are likely to grasp the opportunity, if some of these countries now fast-track nationwide UHC, at least something good will be coming from the crisis, something which will benefit their people forever. And ensuring everyone accesses the services they need, including public health and preventive services, also provides the best protection against any future outbreaks becoming epidemics.

Every night large audiences are tuning in to press briefings fronted by their heads of state hungry for the latest update on the crisis and to get reassurance that their government’s strategy will bring the salvation they desperately need. To truly improve health security for people across the world, becoming UHC heroes could be the best strategic decision political leaders ever make.





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Webinar: Reimagining the Role of State and Non-State Actors in (Re)building National Health Systems in the Arab World

Research Event

22 April 2020 - 1:00pm to 2:00pm

Event participants

Fadi El-Jardali, Professor of Health Policy and Systems, American University of Beirut
Moderator: Nadim Houry, Executive Director, Arab Reform Initiative

As new cases of COVID-19 continue to surge, countries around the world struggle to mitigate the public health and economic effects of the virus. It is becoming increasingly clear that an effective pandemic response requires a whole-of-government, whole-of-society approach. In the Arab world, where health systems are already strained by armed conflicts and displaced populations, a whole-of-society response to the pandemic is particularly critical as countries have become increasingly dependent on non-state actors, notably the private sector, for healthcare provision and any response that includes the state alone may not be sufficient to address the pandemic.

In a recent article, Fadi El-Jardali, argued that while the pandemic will have grave health and economic consequences for years to come, it brings with it a valuable opportunity to re-envision the role of state and non-state actors in strengthening health systems. The article addressed the need for increased collaboration between state and non-state actors, and the rethinking of existing cooperation models to provide quality healthcare services for all.  

In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, Dr El-Jardali will discuss how state and non-state actors can collaborate more effectively to address the shortcomings of national health care systems amidst the pandemic and beyond. The article’s author will share insights on the different capacities available in Arab societies that governments can draw upon to ensure that Universal Health Coverage, equity considerations and social justice are at the core of health systems.

You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page.

 

Reni Zhelyazkova

Programme Coordinator, Middle East and North Africa Programme
+44 (0)20 7314 3624




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Webinar: Global Economic Recovery and Resilience to Systemic Shocks

Corporate Members Event Webinar

20 May 2020 - 5:00pm to 5:45pm
Add to Calendar

Francesca Viliani, Consultant Researcher, Global Health Programme, Chatham House; Director, Public Health, International SOS

Sven Smit, Co-Chair, McKinsey Global Institute and Senior Partner, McKinsey & Company, Amsterdam

Chair: Creon Butler, Research Director, Trade, Investment & New Governance Models: Director, Global Economy and Finance Programme, Chatham House

 

The outbreak of COVID-19 has demonstrated the wide-ranging and immediate impact a systemic shock can have on the global economy including the financial loss caused by the emergency shutdown of many retail operations, the loss of income for individuals who are forced to stay indoors and the major disruption to supply chains. The longer term impacts are still being realized and depend heavily on the ability of industry and the government to respond effectively to the direct economic shock caused by the pandemic.

Systemic shocks like the COVID-19 pandemic demand immediate responses, but should also encourage governments and industries to re-examine their recovery processes, their resilience and their forward planning. In this webinar, the panellists will discuss the short and long-term impacts of the current crisis and explore how industry can help ensure that the global economy is able to recover from, and build resilience to, future systemic shocks. How do business leaders move from making decisions to reimagining a ‘new normal’ and reforming their practices? What are the critical decisions that businesses should consider when planning for this 'new normal'? And how far can these decisions be based on expected changes to governmental or intergovernmental regulation of different sectors?   

This event is part of a fortnightly series of 'Business in Focus' webinars reflecting on the impact of COVID-19 on areas of particular professional interest for our corporate members and giving circles.

Not a corporate member? Find out more.




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Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

John M. Dietschy
Aug 1, 2004; 45:1375-1397
Thematic Reviews




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Undercurrents: Episode 31 - Re-imagining the Global Food System




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Plaintiff in Chief: President Trump and the American Legal System