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Cannonier Supports #ChooseBDA Campaign

“It is important to support, as much as we can, our local businesses,” OBA Leader Craig Cannonier said, adding that “I am happy to give my backing to the new #ChooseBDA campaign.” Mr. Cannonier said, “While the health of Bermudians is paramount, it is obvious to everyone by now that this is going to be […]

(Click to read the full article)




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Bermuda Pride LBGTQI Facebook Cover Designs

With Bermuda’s first Pride Parade set to take place this Saturday [Aug 31] a new set of Facebook timeline covers is available, incorporating the ‘official’ rainbow colours and, of course, a Bermudian theme. In explaining why the Bermuda Pride logo includes extra stripes, the Bermuda Pride website notes, “In organising Bermuda’s first ever Pride we […]

(Click to read the full article)




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Local Business Owners Launch Digital Campaign

The digital campaign #ChooseBDA was launched on Sunday May 3rd on Instagram and Facebook as an effort by a small group of business owners to “help bring awareness to the major impact local small businesses has on the island’s overall economy.” “These founding business owners hail from different sectors of the economy [retail, service, hospitality, […]

(Click to read the full article)




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Turini Featured In High-End Shoe Campaign

Luxury retailer Nordstrom is opening the doors of its newly built Manhattan flagship location next month, and Bermudian style influencer Shiona Turini is helping the Seattle-based chain to celebrate.. In the lead-up to the grand opening of the seven-storey, 320,000-square-foot store on West 57th Street Nordstrom has teamed with 14 footwear brands and their social […]

(Click to read the full article)




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Bermudian Teen In Polo Ralph Lauren Campaign

A Bermudian teenager is featured as a model in Polo Ralph Lauren’s cruise campaign that launched this month after the American fashion brand was encouraged by the Bermuda Tourism Authority [BTA] to shoot on the island. Polo selected 13-year-old Dellwood Middle School student Sweden Bashir from a casting call and featured him with other models […]

(Click to read the full article)




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Videos: Meet The Winning Local Designers

As the winners of the Carnival Costume Design Challenge, local designers Colita Cook-Shillingford and Barbie Paynter will see their costumes launched tomorrow [Feb 1] at the NOVA Mas International costume presentation and launch party. NOVA Mas explained that Colita Cook-Shillingford and Barbie Paynter participated in the Cultural Apprenticeship program that was facilitated last year between […]

(Click to read the full article)




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Teachers Union Sign Off On Job Descriptions

The Bermuda Union of Teachers said they have signed off on the long awaited Job Descriptions for Para-educators and Educational Therapist Assistants. A spokesperson said, “The Bermuda Union of Teachers is happy to reveal that after a twenty year battle for clarity, this Union has signed off on the long awaited Job Descriptions [JD] for […]

(Click to read the full article)




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Impact Mentoring To Launch New Campaign

Impact Mentoring Academy will be launching a new capital campaign, which involves a seven-year strategic plan. A spokesperson said, “Impact Mentoring Academy is launching a new capital campaign to form a bridge to the future of education in Bermuda! “The seven-year strategic plan [2018-2025] is focused on transitioning the academy into the premier site for […]

(Click to read the full article)




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Tarik Hill Jailed For ‘Horrific Campaign Of Abuse’

After being found guilty of multiple charges including false imprisonment, bodily harm and rape, Tarik Hill, 35, was sentenced in a UK Court to a custodial term of 15 years and an extended licence period of five years. A statement from the UK Met Police said, “A man has been sentenced to jail after carrying out a sustained […]

(Click to read the full article)




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Court: Officer Resigns After Court Conviction

A 34-year-old man has resigned his position as a police officer after pleading guilty to an offence in relation to destroying traffic tickets. 34-year-old Kyle Wheatley admitting to planning with others to pervert the course of justice by destroying traffic tickets issued to motorists who were alleged to have committed traffic offences. Speaking at a […]

(Click to read the full article)




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Video: Significance & Value Of Hosting AC35

America’s Cup Bermuda Chairman Peter Durhager and CEO Mike Winfield outlined the long-term value and importance of Bermuda’s accomplishment in a post event overview, and said that “detailed analysis and economic and social impact reports will be forthcoming in October 2017.” The 24-minute live video replay is below: The statement from the ACBDA is below: Mr. […]

(Click to read the full article)




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Dr Gibbons: ‘Significant Contribution Of AC35'

Former Minister Dr Grant Gibbons said that “as the OBA Government Minister with responsibility for the 2017 America’s Cup, I was pleased to read PWC’s independent assessment of the event, which clearly demonstrates the significant contribution AC35 made to Bermuda’s economy over the past three years and will continue to make well into the future.” […]

(Click to read the full article)




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R&Q Acquires Vigneron Insurance Company

Randall & Quilter Investment Holdings Ltd. [R&Q] has acquired the Montana captive insurer, Vigneron Insurance Company Inc. [VICI] from a wholly owned private investment holding company. “VICI underwrote deductible reimbursement policies to cover the obligations under insurance policies taken out by affiliated entities,” the company said. R&Q intends to merge VICI into R&Q’s Vermont captive consolidator […]

(Click to read the full article)




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TRB Straight to Recording for All: Landscape Design Practices for Roadside Water Management

TRB released a straight-to-recording series in April that presents highlights and findings of the NCHRP Domestic Scan 16-02 on Landscape Design Practices for Roadside Water Management . This scan investigated how transportation agencies are applying principles and practices of green infrastructure (GI) for roadside water management to mitigate adverse impacts of flooding, drought, and temperature extremes affecting their infrastructure. The videos are available on-demand at no charge. Presenters: Garrett...




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Assorted Calibers Podcast Ep 098: Erin Takes the Reigns

Hello Internet! In This Episode: It’s a “Nothing But Weer’d Beard Segments” show, so Erin takes over in order to have some time on-air! Erin and Weer’d discuss certain states relaxing their quarantine, Dick’s Sporting Goods feeling the consequences of … Continue reading




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TRB Webinar: Designing Landscapes to Enhance Roadside Water Management

How do transportation agencies apply principles of green infrastructure (GI) to roadside water management? TRB is hosting a webinar on Monday, May 18, 2020 from 2:00 to 3:30 PM Eastern that aims to answer this question. Presenters will identify how GI may be used to mitigate impacts of flooding, drought, and temperature extremes that affect infrastructure. This webinar draws on research from the National Cooperative Highway Research Program (NCHRP) Domestic Scan Program 16-02: Leading Landscape Design Pr...




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Impacts on Practice: Redesigning the Communications Center at Phoenix–Mesa Gateway Airport

As a reliever airport for the Phoenix Sky Harbor International Airport, Phoenix–Mesa Gateway Airport must keep track of information for nearly 300,000 aircraft operations and 1.4 million passengers a year. To meet this challenge, the airport developed an innovative, digitally connected solution with the help of ACRP Research Report 182: Guidancefor Planning, Design, and Operationsof Airport Communications Centers . The TRB Airport Cooperartive Research Program's ACRP Impacts on Practice 182: Redesigning ...



  • http://www.trb.org/Resource.ashx?sn=cover_acrp_iop_182

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ACRP Impacts on Practice - Wayfinding and Signing Guidelines for Airports

The September 2015 issue of TRB’s Airport Cooperative Research Program (ACRP) Impacts on Practice explores how Philadelphia International Airport, Fort Lauderdale-Hollywood International Airport, and Changi Airport in Singapore applied guidance from ACRP Report 52 : Wayfinding and Signing Guidelines for Airport Terminals and Landside to help passengers find their way in and around an airport.



  • http://www.trb.org/Resource.ashx?sn=IOP2015Septcover

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Guidebook for Preparing and Using Airport Design Day Flight Schedules

TRB’s Airport Cooperative Research Program (ACRP) Research Report 163: Guidebook for Preparing and Using Airport Design Day Flight Schedules explores the preparation and use of airport design day flight schedules (DDFS) for operations, planning, and development. The guidebook is geared towards airport leaders to help provide an understanding of DDFS and their uses, and provides detailed information for airport staff and consultants on how to prepare one.



  • http://www.trb.org/Resource.ashx?sn=acrp_rpt_163cover

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'Doom Eternal' updates will add supercharged demons and a fresh campaign

Whatever you think of Doom Eternal right now, id and Bethesda are determined to spice it up going forward. They’ve hinted at what’s coming next for the hellish shooter, starting with a preview of the game’s first free update. The simply titled Update...




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safety signs in hell




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Drug Lord's Hippos Make Their Mark on Foreign Ecosystem

Scientists published the first assessment of the impact that invasive hippos imported by drug lord Pablo Escobar are having on Colombian aquatic ecosystems. The hippos are changing the area's water quality by importing large amounts of nutrients and organic material from the surrounding landscape.




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Not Dead; Or, Making Sure Life Signs Continue

In short… I overdid it last year. I wrote two new books for publication in the first six months. Also during that time I expanded a previously written book by at least 25%, a lot of reference material for which didn’t really exist yet. Over the rest of the year, I wrote the second half […]




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GitHub Codespaces: VS Code was 'designed from the get-go' for this, says Microsoft architect

A compelling addition to repo house – but is the Redmond flavour too strong?

GitHub had a lot to say about its plans at its virtual Satellite event yesterday, but the most far-reaching was the advent of Codespaces, the ability to edit code online, integrated into the GitHub user interface.…




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FYI: Your browser can pick up ultrasonic signals you can't hear, and that sounds like a privacy nightmare to some

High-frequency audio could be used to stealthily track netizens

Technical folks looking to improve web privacy haven't been able to decide whether sound beyond the range of human hearing poses enough of a privacy risk to merit restriction.…




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Apple owes us big time for bungled display-killing cable design in MacBook Pro kit, lawsuit claims

iGiant not only screwed up the wiring, it knew it was shipping dodgy gear, it is claimed

Apple is potentially facing a class-action lawsuit over the failure of displays on its MacBook Pro line.…




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7/13/14 - Has she resigned herself




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Finding a Suitable Web Design Company

With Internet marketing and Search engine optimization, crucial components to owning a company site, most web designers are adding SEO to their arsenal of capabilities. The concern is that most of these designers neglect to understand the whole picture of… Continue Reading




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Make your restaurant decorative with finest interior design

Interior decoration is a tremendously crucial element of any kind of dining establishment. If you are in the planning stages of opening up a dining establishment, if you already own one and also are thinking about making adjustments, you will… Continue Reading




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The Best Cell Phone Signal Booster

Mobile phones have become a must for this generation. They are the devices that are the most helpful for all. You can talk to your loved ones, play music, play videos, play games and do many more other things. In… Continue Reading




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Featured - Biotech update: Life Tech layoffs sign of the times?

 Last week the biotech community in San Diego suffered a tough blow as many positions were eliminated as part of a plan to save $20 million dollars in the hopes that Life Tech will please their investors.  People who lost jobs included veterans with the company, many who were loyal and hard-working to the almighty borg of biotechs, sacrificing their nights, vacations, and weekend; (read more)

Source: Suzy - Discipline: BioTech




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CEACAM1 and molecular signaling pathways to expand the liver transplant donor pool

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.




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Retrograde nerve growth factor signaling abnormalities in familial dysautonomia

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.




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(H)Elping nerve growth factor: Elp1 inhibits TrkA’s phosphatase to maintain retrograde signaling

Nerve growth factor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons to the targets of those axons. How this occurs when axons contain a plethora of proteins that can silence those signals has long perplexed the neurotrophin field. In this issue of the JCI, Li et al. suggest an answer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonomia (FD) causes peripheral neuropathy. They describe a distinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off those signals. This finding helps explain the innervation deficits prominent in FD and reveals a unique role for Elp1 in the regulation of NGF-dependent TrkA activity.




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A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy

An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using several preclinical tumor models as well as clinical specimens, we identified a mechanism whereby CD8+ T cell activation in response to programmed cell death 1 (PD-1) blockade induced a programmed death ligand 1/NOD-, LRR-, and pyrin domain–containing protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby dampening the resulting antitumor immune response. The genetic and pharmacologic inhibition of NLRP3 suppressed PMN-MDSC tumor infiltration and significantly augmented the efficacy of anti–PD-1 antibody immunotherapy. This pathway therefore represents a tumor-intrinsic mechanism of adaptive resistance to anti–PD-1 checkpoint inhibitor immunotherapy and is a promising target for future translational research.




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TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β–dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases.




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Amy Goodman interviews Tavis Smiley, Cornel West on the 2012 Election & Why Calling Obama “Progressive” Ignores His Record. Democracy Now: Friday, November 9, 2012.

Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading




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Bernie Sanders asks what is Hillary Clinton campaigning on

Vermont Sen. Bernie Sanders talks about the need for a "serious debate about serious issues," and whether he plans to challenge Hillary Clinton for the Democratic nomination. Sanders also adds that America needs to hear Hillary Clinton's opinions on the TPP, middle class struggles, and the Keystone XL pipeline. Continue reading




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Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip during political campaigns

SANDERS: ... there is more coverage about the political gossip of a campaign, about raising money, about polling, about somebody saying something dumb, or some kid works for a campaign sends out something stupid on Facebook, right? We can expect that to be a major story. But what your job is, what the media's job is, is to say, look, these are the major issues facing the country. We're a democracy. People have different points of view. Let's argue it. Continue reading




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Senator Bernie Sanders warns the press not to underestimate him in the 2016 campaign for the Democratic nomination for President of the United States

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading




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Debbie Lusignan the Sane Progressive calls out Bernie Sanders for failing to contest the election fraud in the Democratic primaries

Bernie Sanders would have already won this nominating contest if we had received an accurate accounting of the vote. It is deeply troubling the Senator would be sending out surrogates to talk about his allegiance to the Democratic party and Clinton in general in the face of the Party instituting theft against its own constituents. It is no mystery HOW to win. Count the votes and contest fraud. A tough Sane Progressive call out. Continue reading




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Bernie Sanders betrays his supporters with his announcement of voting for Hillary Clinton and signals his intentions of his endorsement at the convention

Leaders of political revolutions never quit before the official battle begins, and say that they will vote for and support their enemies. When the moment arrived of walking all that endless talk of Bernie Sanders about fighting his political revolution, he caved out of self interest Continue reading




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Jill Stein is right about our foreign policy and Hillary Clinton is all wrong!

Unlike Hillary Clinton, Jill Stein would not continue to expand our military budget and presence in the world but would curtail both, saving American taxpayers trillions of dollars and saving the world millions, if not billions, of lives. Listen to her present a rational, humane foreign policy in this interview on The Young Turks Town Hall meeting held October 21, 2016. Continue reading




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Jill Stein is right about our foreign policy and Hillary Clinton is all wrong!

In an interview with Cenk Uygur on The Young Turks TYT show on October, 21, 2016, Jill Stein was asked what would she do to ensure the protection of Estonia from an invasion from Russia. I found her response to … Continue reading



  • Accountants CPA Hartford

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on significance

I remember reading somewhere that if the earth was shrunk to the size of a pool ball, or a pool ball expanded to the size of the earth, the earth would be the smoother of the two.

captured
camera
lens
focal length
aperture
shutter speed
shooting mode
exposure bias
metering mode
ISO
flash
image quality
RAW converter
image editor
plugins (etc)
cropped?
4.10pm on 7/4/16
Fujifilm X-T1
XF 10-24mm f/4 R OIS
14.5mm
f/5.6
1/125
aperture priority
0.7
average
200
no
RAW
Camera Raw
Photoshop CC (2014)
none
2x1 (& stretched a bit)




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Theresa May seeks third Brexit vote Friday after promising to resign

European Union leaders have offered Britain a Brexit extension until May 22.





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IBM Named a Leader in Gartner Magic Quadrant for Multichannel Campaign Management

IBM today announced that for the seventh consecutive year, Gartner, Inc. has named IBM as a leader in the April 2017 Gartner Magic Quadrant for Multichannel Campaign Management.




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Fusion Genomics Turns to IBM Cloud to Help Support Advances Designed to Conquer Global Pandemics

IBM today announced that Vancouver-based company Fusion Genomics selected IBM’s cloud capabilities to help advance Fusion’s ability to detect pandemics before they happen. Fusion Genomics has developed disruptive DNA and RNA technology that it believes can positively identify infectious diseases and enhance the surveillance of emerging pathogens like MERS, SARS, avian flu, and swine flu.



  • IBM Cloud Computing

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Re-Designed Height-Weight Chart

Now it is set up so that any click off of the main menu leads you to a whole spectrum of bodies at a particular height. Check it out! Also, in the middle of the big and tall men, there are two guys standing next to each other who happen to both be wearing kilts.