Purpose:

Thymidine kinase 1 (TK1) is downstream to the CDK4/6 pathway, and TK activity (TKa) measured in blood is a dynamic marker of outcome in patients with advanced breast cancer (ABC). This study explores TK1 as a biomarker of palbociclib response, both in vitro and in patients with ABC.

Purpose:

Radium-223 is approved for metastatic castration-resistant prostate cancer (mCRPC) based on improved overall survival, and delay in skeletal related events. However, it is not associated with PSA or radiographic response, which poses a challenge in real-time assessment of its efficacy. Surrogate markers of treatment outcomes may facilitate tailoring treatment duration with radium-223, by limiting the duration of therapy with radium-223 in these patients. Here, we sought to investigate the utility of bone metabolic markers (BMMs) as surrogate markers of response to radium-223 in mCRPC.

Plasma DNA fragmentomics is an emerging area of research covering plasma DNA sizes, end points, and nucleosome footprints. In the present study, we found a significant increase in the diversity of plasma DNA end motifs in patients with hepatocellular carcinoma (HCC). Compared with patients without HCC, patients with HCC showed a preferential pattern of 4-mer end motifs. In particular, the abundance of plasma DNA motif CCCA was much lower in patients with HCC than in subjects without HCC. The aberrant end motifs were also observed in patients with other cancer types, including colorectal cancer, lung cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma. We further observed that the profile of plasma DNA end motifs originating from the same organ, such as the liver, placenta, and hematopoietic cells, generally clustered together. The profile of end motifs may therefore serve as a class of biomarkers for liquid biopsy in oncology, noninvasive prenatal testing, and transplantation monitoring.

Background:

Pancreatic cancer is the third leading cause of cancer death in the United States, and 80% of patients present with advanced, incurable disease. Risk markers for pancreatic cancer have been characterized, but combined models are not used clinically to identify individuals at high risk for the disease.

Background:

Early diagnosis can significantly reduce colorectal cancer deaths. We sought to identify serum PIWI-interacting RNAs (piRNAs) that could serve as sensitive and specific noninvasive biomarkers for early colorectal cancer detection.

Background:

Energy balance–related factors, such as body mass index (BMI), diet, and physical activity, may influence colorectal cancer etiology through interconnected metabolic pathways, but their combined influence is less clear.

Background:

Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Background:

Asian Americans are at higher risk for noncardia gastric cancers (NCGC) relative to non-Hispanic Whites (NHW). Asian Americans are genetically, linguistically, and culturally heterogeneous, yet have mostly been treated as a single population in prior studies. This aggregation may obscure important subgroup-specific cancer patterns.

Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one potential approach to reduce this risk and mitigate lung cancer mortality. Experimental data from our group suggest that kava, commonly consumed in the South Pacific Islands as a beverage to promote relaxation, may reduce lung cancer risk by enhancing NNK detoxification and reducing NNK-derived DNA damage. Building upon these observations, we conducted a pilot clinical trial to evaluate the effects of a 7-day course of kava on NNK metabolism in active smokers. The primary objective was to compare urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL plus its glucuronides, major metabolites of NNK) before and after kava administration as an indicator of NNK detoxification. Secondary objectives included determining kava's safety, its effects on DNA damage, tobacco use, and cortisol (a biomarker of stress). Kava increased urinary excretion of total NNAL and reduced urinary 3-methyladenine in participants, suggestive of its ability to reduce the carcinogenicity of NNK. Kava also reduced urinary total nicotine equivalents, indicative of its potential to facilitate tobacco cessation. Plasma cortisol and urinary total cortisol equivalents were reduced upon kava use, which may contribute to reductions in tobacco use. These results demonstrate the potential of kava intake to reduce lung cancer risk among smokers.

According to Batdongsan.com.vn’s real estate market Q3-2019, Ho Chi Minh City’s District 1 saw the highest housing listing prices in the third quarter due to limited supply.

According to Batdongsan.com.vn’s real estate market report, the third quarter (Q3) of 2019 continued to witness the excitement of many Northern provincial markets. The number of listings and the interest level of users in these provinces and cities have increased sharply.

With a budget of 1 billion VND, the best way for investors to get high-return and low-risk investment in Ho Chi Minh property market in 2015 is choosing one of three segments below: project land, apartment or townhouse in suburbs.

Signs of deceleration of the real estate market have appeared quite clearly in many segments since the beginning of this year, according to Tran Khanh Quang, General Director of Viet An Hoa Real Estate Company.

The Vietnam’s real estate market has clearly seen signs of a downturn in many segments since the beginning of 2018. So how to gain profit from your realty investment?

Tens of thousands of new apartments enter the Ho Chi Minh City market every year, putting pressure on investors who want to reap returns from rental apartments.

window.addEventListener("message", function (message) { var msg = message.data && JSON.parse(message.data); if (msg.name === "hapyak_embedded_experience_aspect_ratio_available") { var hyIframe = document.getElementById("hapyak_embedded_experience_6432"); hyIframe.style.paddingTop = 100 * (1 / […]

The post How to Measure Video Marketing Impact + KPIs for Every Team’s Video Program appeared first on e-Learning Feeds.

A powerful monument to remembrance and reflection. Klein virtually explores London’s quiet streets in the haunting video accompaniment to her track ‘mark’, a beautiful and melancholy standout from her third album, Frozen. Weaving audio collage and plaintive guitar around a stark 10-minute silence, Klein constructs a powerful monument to remembrance and reflection, a tribute to […]

The post Klein pays a haunting tribute to Mark Duggan with ‘mark’ appeared first on FACT Magazine.

Shannon's said: “OCRO HLI RGWR NMIELWIS”

Sustainable fashion collaboration featuring only biodegradable fabrics will be sold online

John Lewis and the fashion brand Mother of Pearl have chosen Earth Day for the launch of their sustainable fashion collaboration, specifically for its geopolitical symbolism.

Earth Day, which celebrates its 50th anniversary on 22 April, seemed an appropriate day to launch a collection bringing rigorous standards of ethical design to mass market fashion. A launch date that pays homage to the planet rather than the artificial seasons of fashion, and dovetails with the concept of timeless, seasonless clothes designed for wardrobe longevity.

This research shows how different populations of people share most of the genetic susceptibilities to developing type 2 diabetes but do have some different genetic variations that can make them more or less susceptible to developing the condition.

Canadian forces were involved in "six long years of fighting," Lt-Gov. Russ Mirasty said, urging people to take a moment to "remember them and to honour their legacy of peace."

The more people we encounter, the higher the risk of virus transmission. So, how do we keep safe when going to the shops?

Liverpool already have one song synonymous with the club but they did attempt to officially do likewise with another. The Reds tried to trademark 'Allez Allez Allez'..

Lucianne Walkowicz says the American Girl doll 'Luciana Vega' stole her name and likeness

To mark Friday's 75th anniversary of the end of World War II in Europe, the British government revealed the final Nazi message intercepted and decoded by U.K. codebreakers as Allied forces were advancing through Germany.

The 50th annual call for environmental reform falls at a time when the health of people and nature has never been more urgent

Fifty years ago today, the first Earth Day was marked in the United States as a peaceful call for environmental reform, following a massive oil spill off the coast of California. Half a century later, this annual day unites millions across the globe, drawing attention to the huge challenges facing our planet.

Now more than ever, Earth Day offers an opportunity for us all to reflect upon our relationship with the planet, amid the most powerful possible message that nature can surprise us at any moment, with devastating consequences for pretty much every individual. It is a time when the health of the planet and its people has never been so important.

Bank of England governor warns of financial collapse linked to climate emergency

• Top asset managers oversee $300bn fossil fuel investments
• Why are asset managers investing in fossil fuel companies?

Companies and industries that are not moving towards zero-carbon emissions will be punished by investors and go bankrupt, the governor of the Bank of England has warned.

Mark Carney also told the Guardian it was possible that the global transition needed to tackle the climate crisis could result in an abrupt financial collapse. He said the longer action to reverse emissions was delayed, the more the risk of collapse would grow.

Dallas Mavericks owner Mark Cuban has been the most outspoken figure in the NBA to push for the season to resume but he made it clear on Thursday that he won’t even consider opening the team’s training facility until everyone is able to get tested for coronavirus. 

It's the lowest reported increase in cases since April 6.

The curious set of numbers shows up in nature and also in human activities.

The famous impact 66 million years ago kicked up soot into the atmosphere that played an even bigger role in blocking sunlight than experts had realized

A new method for reliably identifying the presence of beer or other malted foodstuffs in archaeological finds is described in a new study.

Equity markets rallied on Friday, hitting weekly highs, and oil prices gained as more governments around the world began gradually reopening their economies and Sino-American trade tensions eased.

The fed funds futures market is pricing in negative U.S. interest rates next year, a scenario the Federal Reserve has said it wants to avoid as many doubt that it would be an effective tool to stimulate growth.

A week packed with U.S. economic data is likely to provide investors with more evidence of the extent to which the coronavirus pandemic has hit growth, sharpening the debate on whether a rebound in stocks has been justified amid an unprecedented slowdown.

Read our live coronavirus updates HERE Coronavirus: The symptoms