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An electrochemical sensor based on enzyme-free recycling amplification for sensitive and specific detection of miRNAs from cancer cells

Analyst, 2020, 145,3353-3358
DOI: 10.1039/D0AN00275E, Paper
Lili Jiang, Yuling Yang, Yuhong Lin, Ziyi Chen, Chao Xing, Chunhua Lu, Huanghao Yang, Shusheng Zhang
A catalyzed hairpin assembly and binding-induced formation of the DNA three-way junction for ultrasensitive electrochemical detection of diverse miRNAs is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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In situ amplified photothermal immunoassay for neuron-specific enolase with enhanced sensitivity using Prussian blue nanoparticle-loaded liposomes

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00417K, Paper
Li-Juan Zhi, Ai-Li Sun, Dianping Tang
Methods based on prussian blue nanoparticles (PBNPs) have been reported for photothermal immunoassays in analytical nanoscience fields but most suffer from low sensitivity and are not beneficial for routine use.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Structure Optimization of Gatastatin for the Development of ?-Tubulin-Specific Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00526




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[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00029




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A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02107E, Communication
Jiaxing Wang, Beverly A Ellis, Bin Zhou, Lisa M. Eubanks, Steven Blake, Kim D Janda
A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A dual-round signal amplification strategy for colorimetric/photoacoustic/fluorescence triple read-out detection of prostate specific antigen

Chem. Commun., 2020, 56,4942-4945
DOI: 10.1039/D0CC01086C, Communication
Chao Jiang, Yan Huang, Ting He, Peng Huang, Jing Lin
A colorimetric/fluorescence/photoacoustic triple read-out detection of prostate specific antigen (PSA) was developed by using a silica coated Au@Ag core–shell nanorod (denoted Au@Ag@SiO2) based enzyme-linked immunosorbent assay (ELISA) system.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] A Chemically Stable Fluorescent Mimic of Dihydroartemisinin, Artemether, and Arteether with Conserved Bioactivity and Specificity Shows High Pharmacological Relevance to the Antimalarial Drugs

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.9b00430




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How to Display Mode-Specific Images

Now that we have most of the basics of HTML and CSS in the browser, we’ve begun implementing new features that I would consider “quality of life” improvements, many of which have been inspired by mobile. One great example is the CSS prefers-color-scheme media query, which allows developers to cater their design to system theme […]

The post How to Display Mode-Specific Images appeared first on David Walsh Blog.




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Customs Amendment (Product Specific Rule Modernisation) Bill 2019 [Provisions] / The Senate, Legal and Constitutional Affairs Legislation Committee

Australia. Parliament. Senate. Legal and Constitutional Affairs Legislation Committee, author, issuing body




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Farmers get area-specific weather advisory service

On Wednesday, farmers across 150 districts in the country got details pertaining to rainfall, temperature, wind speed...




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Site-specific performance / Mike Pearson

Pearson, Mike, 1949-




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Highly Z-selective synthesis of 1,3-oxathiol-2-ylidenes and 4-methylene-oxazolidine-2-thiones via atom-specific 5-exo-dig cyclization of propargyl alcohol with isothiocyanate

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00083C, Paper
S. Antony Savarimuthu, D. G. Leo Prakash, S. Augustine Thomas, Thirumanavelan Gandhi, Mrinal K. Bera
The Z-selectivity observed in imine and alkene motifs after 5-exo-dig cyclization of propargyl alcohol and isothiocyanate is rare in the literature and this selectivity can be attributed to electronic and steric factors of the imine and alkene motif respectively.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Motorola Edge, Motorola Edge+ launched: Here are the specifications, price, availability

Motorola is back in the flagship game with premium Edge series.




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Patient-specific stem cells / edited by Deepak A. Lamba

Hayden Library - QH588.S83 P38 2017




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[ASAP] Photochemical Oxidation Specific to Distorted Aromatic Amines Providing <italic toggle="yes">ortho</italic>-Diketones

Organic Letters
DOI: 10.1021/acs.orglett.0c01190




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[ASAP] Stereospecific Isomerization of Allylic Halides via Ion Pairs with Induced Noncovalent Chirality

Organic Letters
DOI: 10.1021/acs.orglett.0c01200




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Highly luminescent lanthanide complexes with specific coordination structures / Kohei Miyata

Online Resource




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Stereospecific interactions between chiral inorganic nanomaterials and biological systems

Chem. Soc. Rev., 2020, 49,2481-2503
DOI: 10.1039/D0CS00093K, Review Article
Xueli Zhao, Shuang-Quan Zang, Xiaoyuan Chen
Chirality is ubiquitous in nature and plays mysterious and essential roles in maintaining key biological and physiological processes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A new conceptual model of pesticide transfers from agricultural land to surface waters with a specific focus on metaldehyde

Environ. Sci.: Processes Impacts, 2020, 22,956-972
DOI: 10.1039/C9EM00492K, Paper
M. J. Whelan, A. Ramos, R. Villa, I. Guymer, B. Jefferson, M. Rayner
Pesticide losses from agricultural land to water can result in the environmental deterioration of receiving systems.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Stereoisomer specific reaction of hexabromocyclododecane with Fe(II) associated with iron oxides

Environ. Sci.: Processes Impacts, 2020, 22,1026-1036
DOI: 10.1039/C9EM00587K, Paper
Xianmiao Zhang, Kristian K. Roopnarine, Shirley Dong, Urs Jans
We investigated the stereoselective degradation of the brominated flame retardant HBCD by Fe(II) in aqueous suspensions of different iron oxides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Bottlebrush Glycopolymers from 2-Oxazolines and Acrylamides for Targeting Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin and Mannose-Binding Lectin

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00246




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Studies in formal linguistics: universal patterns and language specific parameters / Anna Bloch-Rozmej, Anna Bondaruk (eds.)

Hayden Library - P201.S828 2018




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[ASAP] Site-Specific Siderocalin Binding to Ferric and Ferric-Free Enterobactin As Revealed by Mass Spectrometry

ACS Chemical Biology
DOI: 10.1021/acschembio.9b00741




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[ASAP] Biosynthetic Incorporation of Site-Specific Isotopes in ß-Lactam Antibiotics Enables Biophysical Studies

ACS Chemical Biology
DOI: 10.1021/acschembio.9b01054




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[ASAP] A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography

ACS Chemical Biology
DOI: 10.1021/acschembio.9b01043




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[ASAP] Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00031




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[ASAP] Construction of Bispecific Aptamer–Drug Conjugate by a Hybrid Chemical and Biological Approach

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00071




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[ASAP] Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00118




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Proceedings Eleventh IEEE International Workshop on Rapid System Prototyping. RSP 2000. Shortening the Path from Specification to Prototype [electronic journal].

IEEE / Institute of Electrical and Electronics Engineers Incorporated




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802.3cg-2019 - IEEE Standard for Ethernet - Amendment 5:Physical Layer Specifications and Management Parameters for 10 Mb/s Operation and Associated Power Delivery over a Single Balanced Pair of Condu [electronic journal].




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3D bioprinting: modeling in vitro tissues and organs using tissue-specific bioinks / Dong-Woo Cho, Byoung Soo Kim, Jinah Jang, Ge Gao, Wonil Han, Narendra K. Singh

Online Resource




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[ASAP] Fault Diagnosis Using Novel Class-Specific Distributed Monitoring Weighted Nai¨ve Bayes: Applications to Process Industry

Industrial & Engineering Chemistry Research
DOI: 10.1021/acs.iecr.0c01071




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A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00317D, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hajime Wakui, Yoshikazu Tanaka, Toyoyuki Ose, Isamu Matsumoto, Koji Kato, Yao Min, Taro Tachibana, Masaharu Sato, Kentaro Naruchi, Fayna Garcia Martin, Hiroshi Hinou, Shin-Ichiro Nishimura
We developed new class of designated antibodies targeting of “dynamic neoepitopes” elaborated by disease-specific O-glycosylation at the immunodominant mucin domains.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00154




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Detection of prostate-specific antigen in semen using DNA aptamers: an application of nucleic acid aptamers in forensic body fluid identification

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00371A, Paper
Tetsuya Satoh, Seiya Kouroki, Yusuke Kitamura, Toshihiro Ihara, Kazutoshi Matsumura, Susumu Iwase
In forensics, body fluid identification plays an important role because it aids in reconstructing the crime scene. Therefore, it is essential to develop simple and reliable techniques for body fluid...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A high-throughput plasmonic tongue using an aggregation assay and nonspecific interactions: classification of taste profiles in maple syrup

Anal. Methods, 2020, Advance Article
DOI: 10.1039/C9AY01942A, Paper
Simon Forest, Trevor Théorêt, Julien Coutu, Jean-Francois Masson
A simple colorimetric test detects off-flavour profiles of maple syrups in minutes, which are detectable by the naked eye.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05855




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[ASAP] Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00446




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[ASAP] Poly(carboxypyrrole)s That Depolymerize from Head to Tail in the Solid State in Response to Specific Applied Signals

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c02774




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Quick tip: git-checkout specific files from another branch

The git-checkout command can be used to update specific files or directories in your working tree with those from another branch, without merging in the whole branch. This can be useful when working with several feature branches or using GitHub Pages to generate a static project site.

The git-checkout manual page describes how the git checkout command is not just useful for switching between branches.

When <paths> or --patch are given, git checkout does not switch branches. It updates the named paths in the working tree from the index file or from a named <tree-ish> (most often a commit)…The <tree-ish> argument can be used to specify a specific tree-ish (i.e. commit, tag or tree) to update the index for the given paths before updating the working tree.

In git, a tree-ish is a way of referring to a particular commit or tree. This can be a partial sha or the branch, remote, and tag name pointers.

The syntax for using git checkout to update the working tree with files from a tree-ish is as follows:

git checkout [-p|--patch] [<tree-ish>] [--] <pathspec>…

Therefore, to update the working tree with files or directories from another branch, you can use the branch name pointer in the git checkout command.

git checkout <branch_name> -- <paths>

As an example, this is how you could update your gh-pages branch on GitHub (used to generate a static site for your project) to include the latest changes made to a file that is on the master branch.

# On branch master
git checkout gh-pages
git checkout master -- myplugin.js
git commit -m "Update myplugin.js from master"

The need to update my gh-pages branch with specific files from my master branch was how I first found out about the other uses of the checkout command. It’s worth having a read of the rest of the git-checkout manual page and experimenting with the options.




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CSS: the cascade, specificity, and inheritance

What is the cascade?

The cascade is a mechanism for determining which styles should be applied to a given element, based on the rules that have cascaded down from various sources.

The cascade takes importance, origin, specificity, and source order of style rules into account. It assigns a weight to each rule. When multiple rules apply to a given element, the rule with the greatest weight takes precedence. The result is an unambiguous way to determine the value of a given element/property combination.

Browsers apply the following sorting logic:

  • Find all declarations that apply to a given element/property combination, for the target media type.
  • Sort declarations according to their importance (normal or important) and origin (author, user, or user agent). From highest to lowest precedence:

    1. user !important declarations
    2. author !important declarations
    3. author normal declarations
    4. user normal declarations
    5. user agent declarations
  • If declarations have the same importance and source, sort them by selector specificity.

  • Finally, if declarations have the same importance, source, and specificity, sort them by the order they are specified in the CSS. The last declaration wins.

What is specificity?

Specificity is a method of conflict resolution within the cascade.

Specificity is calculated in a very particular way, based on the values of 4 distinct categories. For explanatory purposes, the CSS2 spec represents these categories using the letters a, b, c, and d. Each has a value of 0 by default.

  • a is equal to 1 if the declaration comes from a style attribute in the HTML (“inline styles”) rather than a CSS rule with a selector.
  • b is equal to the number of ID attributes in a selector.
  • c is equal to the number of other attributes and pseudo-classes in a selector.
  • d is equal to the number of elements and pseudo-elements in a selector.

The specificity is given by concatenating all 4 resulting numbers. More specific selectors take precedence over less specific ones.

For example, the selector #id .class[href] element:hover contains:

  • 1 ID (b is 1)
  • 1 class, 1 attribute selector, and 1 pseudo-class (c is 3)
  • 1 element (d is 1)

Therefore, it has a specificity of 0,1,3,1. Note that a selector containing a single ID (0,1,0,0) will have a higher specificity than one containing any number of other attributes or elements (e.g., 0,0,10,20). This is one of the reasons why many modern CSS architectural patterns avoid using IDs for styling purposes.

What is inheritance?

Inheritance is distinct from the cascade and involves the DOM tree.

Inheritance is the process by which elements inherit the the values of properties from their ancestors in the DOM tree. Some properties, e.g. color, are automatically inherited by the children of the element to which they are applied. Each property defines whether it will be automatically inherited.

The inherit value can be set for any property and will force a given element to inherit its parent element’s property value, even if the property is not normally inherited.

About !important

The above should make it apparent that !important is a separate concept to specificity. It has no effect on the specificity of a rule’s selector.

An !important declaration has a greater precedence than a normal declaration (see the previously mentioned cascade sorting logic), even declarations contained in an element’s style attribute.

[CSS terminology reference]

Translations






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[ASAP] Cell Type-Dependent Specificity and Anti-Inflammatory Effects of Charge-Reversible MSNs-COS-CMC for Targeted Drug Delivery in Cervical Carcinoma

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00004




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[ASAP] Optimizing the Specificity Window of Biomolecular Receptors Using Structure-Switching and Allostery

ACS Sensors
DOI: 10.1021/acssensors.0c00237




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[ASAP] Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)

ACS Sensors
DOI: 10.1021/acssensors.0c00497




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Describing and studying domain-specific serious games / Joke Torbeyns, Erno Lehtinen, Jan Elen, editors

Online Resource




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[ASAP] Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00014




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Screening for Prostate Cancer With the Prostate-Specific Antigen Test: A Review of Current Evidence

Interview with Michael J. Barry, MD, author of Screening for Prostate Cancer With the Prostate-Specific Antigen Test: A Review of Current Evidence