sam

News24 | Booker Prize 2024: Samantha Harvey's Orbital soars with astronauts' earth reflections

By www.news24.com
Published On :: Wednesday Nov 13 2024 09:00:20

Samantha Harvey's Orbital wins the Booker Prize. The 136-page space novel explores astronauts' reflections on Earth, touching on mourning, desire, and the climate crisis.


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News24 Business | Samsung issues rare apology for poor results in tech 'crisis'

By www.news24.com
Published On :: Wednesday Oct 09 2024 09:38:21

Samsung Electronics issued a rare apology and acknowledged on Tuesday it was facing a "crisis" over its technological competitiveness, reflected in a disappointing profit guidance, despite a global AI boom.


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Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes [Microbiology]

By www.jbc.org
Published On :: 2020-12-04T00:06:05-08:00

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation.


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Screening Room: For Sama

By f1.media.brightcove.com
Published On :: Tue, 01 Oct 2019 00:00:00 +0100


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N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation [Molecular Bases of Disease]

By www.jbc.org
Published On :: 2020-12-18T00:06:18-08:00

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling, and endocytosis. GlcNAc is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting platelet-derived growth factor receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, whereas genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone)-induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage. Our data identify N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggest that oral GlcNAc may be neuroprotective in demyelinating diseases like MS.


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sam

Not the same old African story

By www.chathamhouse.org
Published On :: Tue, 02 Aug 2022 09:28:05 +0000

Not the same old African story The World Today mhiggins.drupal 2 August 2022

Nollywood studio boss Mo Abudu and author Dipo Faloyin discuss how Africans are redefining how the world sees them.

Mo Abudu
EbonyLife’s latest TV drama series, Blood Sisters, was in Netflix’s global top 10. It’s a thriller and it may be slightly melodramatic because we Nigerians are melodramatic. But it deals with universal themes. Nigerians are no different to anyone else. I want EbonyLife productions increasingly to appeal to anyone in the world, even if it’s in our language. Oloture, one of our films, was about human trafficking. It was all done in pidgin English and subtitled. I watch a lot of Korean dramas and Spanish dramas that are subtitled. A good story is a good story.

Dipo Faloyin
The influence that African countries have had on the West, from music, food and film to literature, science and technology, is something people find difficult to take seriously. So, it’s good to see Netflix and other production companies take it more seriously. How has your discussion with them changed since the early days?

Mo Abudu
I have been going to an entertainment market in Cannes called Mipcom for about 12 years, and at first no one had any interest in African content. So, we focused on doing local content for local markets. Now, different communities around the world want representation in content that speaks to them. Specific countries are also saying to streamers: ‘What’s your local content strategy?’ 

I’m not telling broadcasters to commission original African content as a charity project – they can make money from this

Mo Abudu


Netflix was the first of the streamers to come into Africa, and it now has an Africa office. Amazon has also made inroads recently. Disney is arriving. In the United States and Britain, they just need to maintain subscriber numbers, but real growth for them is going to be in Asia and Africa. 

I’m not telling broadcasters or distributors to commission original African content as a charity project – they can make money from this. Within five days of launch, Blood Sisters registered 11 million hours of viewing on Netflix around the world. It was made on a budget five times smaller than productions outside Africa. But we need to be among the gatekeepers, too. 

Moving beyond Hollywood

Dipo Faloyin
The challenge that many creatives across Africa have is that people [elsewhere] don’t necessarily feel like they relate to this continent. They see ‘Africa’ and its cultures as very distant. Instead of intricate, specific stories, simple stories of simple people have been pushed about the continent. 

I still get asked questions like, ‘But, what should we do about Africa’s problems?’ My response is, ‘Stop seeing Africa as just a problem.’ 

—

A still from the Nigerian film ‘Oloture’, released in 2022, which deals with issues of human trafficking.

Mo Abudu
I was speaking at the Qatar Economic Forum recently and the panel started off talking about the ‘problems of Africa’ – and I had to jump in and say, ‘I get you guys talking about the problems, I’m not an economist, I’m just an entrepreneur, but from an entrepreneurial perspective, we have resources – like cobalt from the Democratic Republic of Congo that’s in all of our mobile phones.’ 

The problem is, we ship out all our resources and by the time they come back to us, they are 10-times more expensive than we can afford. I keep saying that they need to know they need us as much as we need them.
 
Dipo Faloyin
There are certainly issues within the continent like there are everywhere else; but more accurate stories will help people have a better sense of the context in which so many communities and their lives have been built up. 

Mo Abudu
The West doesn’t seem to have any interest in making films about Africa unless it’s about the worst of Africa: the slave trade, the Rwandan genocide, blood diamonds. That seems to be what has defined us. 

Dipo Faloyin
If you ask most people around the world to close their eyes and picture Africa, two images will come up: safari, and poverty and strife. Until the age of 12, I grew up in Lagos, a metropolis with no wild animals running around. There are slums, of course, but also traffic, shopping centres and overpriced restaurants. 

Writers who pitch ideas to Vice.com where I work often still don’t differentiate African countries. They’ll say, ‘There’s been a coup in Mali. Why can’t Africa get its head around democracy?’, and I remind them a small minority of countries on the continent is under any form of authoritarian rule. 

It’s frustrating that this perception hasn’t changed. For us to break through we need big cultural institutions – Hollywood, museums, literature – to allow people from across the regions to tell these stories. We are rarely portrayed as protagonists and forward thinkers. But I’m excited for the future.


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sam

Fighting over ‘white gold’: Sesame in Ethiopia and Sudan

By www.chathamhouse.org
Published On :: Mon, 03 Apr 2023 17:57:35 +0000

Fighting over ‘white gold’: Sesame in Ethiopia and Sudan Expert comment LJefferson 3 April 2023

The supply chain of a seemingly innocuous cash crop – sesame – has intersected with transnational conflict dynamics, exacerbating tensions between Ethiopia and Sudan.

Late 2020 saw the beginning of the devastating war in Tigray and the occupation of a disputed region on the Ethiopia–Sudan border – Al Fashaga – by the Sudanese army. These shocks disrupted settled patterns of land ownership and control in both Ethiopia’s volatile north and Sudan’s borderlands, historically the heart of the sesame and oilseed production that is economically vital to both countries.

These seemingly harmless cash crops are now embedded in local, subnational and national political contestations in both countries. Sesame value chains are being reshaped, with power and profits being used to entrench the grip of political and armed actors who are reinforcing new patterns of land control and driving informal and illicit trade – impacting the coping mechanisms of local communities and threatening to fuel further conflict.

Regional rivalries drive contestation over the Ethiopia supply chain

Internal borders between most of Ethiopia’s regions are marked by boundary disputes, which often degenerate into violent conflict. The most important is between the Tigray and Amhara regions. Since the war began in 2020, the Amhara region has annexed vast areas of western and southern Tigray, which the Amhara region claims were taken from them by Tigray 30 years ago, after the Tigray People’s Liberation Front (TPLF) dominated ethnic coalition came to power.

Conflict has exacerbated a steady decline in formal revenues from sesame exports, dropping over $115 million from 2016 to 2021.

Ethiopia’s exports of spices, oilseeds and pulses brought in over half a billion dollars in 2021, roughly a quarter of the country’s total export revenues and second only to coffee. The sector has been rocked by the war in the north, which accounted for much of Ethiopia’s sesame production, with an estimated 500,000 hectares of sesame fields taken out of cultivation during the 2021 growing season. Conflict has exacerbated a steady decline in formal revenues from sesame exports, dropping over $115 million from 2016 to 2021.

Alongside falling production, the previously integrated value chain has been disrupted and decentralized by political fragmentation and land competition between Amharas and Tigrayans. Before the war, the agricultural sector in Western Tigray/Welkait was dominated by Tigrayan business interests, through the TPLF’s regional endowment fund EFFORT, a business conglomerate including subsidiaries such as Guna Trading House, and Hiwot Agricultural Mechanization.

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Two-minute video explainer: Supply chains, land contestation and conflict in the Horn of Africa

The taking of the area by Amhara forces in late 2020 saw the control over agricultural supply chains shift to actors from the Amhara region, amid contestation between regional officials, businessmen and security actors, backed by political elites. Thousands of displaced ethnic Tigrayan inhabitants of the area have been replaced by ethnic Amharas, enticed to settle there by the Amhara regional government’s offer of grants and leases for land which promise better livelihoods. The sesame they farm is now largely exported through informal and illicit channels, with profits used to reinforce de facto regional control.    

But there is also contestation within the Amhara region over the land and sesame supply chain between sub-regional elites from Gojjam, Gondar and indigenous Welkaites. Welkaites, who were marginalized under TPLF rule, believed that by aligning themselves with powerful Amharas they would reclaim land and influence. But this has not been fully realized, with the local administration reliant on Amhara region subsidies, rather than the federal budget. With little support from the federal government, local Welkait officials are strengthening their ties with Eritrea.

The Ethiopian government’s pursuit of peace with Tigray may lead it to turn away from the Amhara region, which could result in a renewed showdown between Amhara and Tigrayan forces.

At the national level, regional contestation over the control over Western Tigray/Welkait feeds into shifting political alliances between the Amhara, Tigrayans and Oromo which threaten the sustainability of the peace agreement struck between the federal government and TPLF in November 2022 – despite efforts by the government to defer the thorny issue.

While the constitutional return of the land to Tigray remains unlikely anytime soon, there is a feeling that Amhara control over Western Tigray/Welkait is no longer certain. The Ethiopian government’s pursuit of peace with Tigray may lead it to turn away from the Amhara region, despite their alliance during and before the war, which could result in a renewed showdown between Amhara and Tigrayan forces.

The prospect of losing territory could also heighten Amhara nationalist claims on Al Fashaga – the loss of which was partly offset by gaining Western Tigray/Welkait – leading to renewed conflagration with Sudan, outside of federal direction. Eritrea’s presence and alliance with Amhara militias remains a concern, given Asmara’s demonstrable ability to inflame tensions.  

Sudan’s securocrats battle over resources to entrench political power

The war in northern Ethiopia was also used opportunistically by the Sudanese Armed Forces (SAF) to take control of the fertile Al Fashaga borderland. This roughly 250 sq km area had been awarded to Sudan when the boundary was initially demarcated by the British in 1903, a ruling that remained contested by Ethiopia. An uneasy truce had seen Ethiopian farmers cultivate the land under nominal Sudanese administration; a settlement that collapsed in 2020 when thousands of predominantly Amhara farmers were evicted.

Local Sudanese farmers have also lost out – with some not compensated for the loss of lands to their own military, with land given to people from other parts of the country, and through lost relationships with Ethiopian farmers, labourers and investors.

The Sudanese military now allegedly controls more than 90 per cent of the disputed areas and security-linked companies and investors have moved into the lucrative sesame sector, re-routing the supply chain, which used to flow largely through Ethiopian markets. These companies are connected to Sudan’s Military Industrial Corporation, a vast conglomerate of business subsidiaries controlled by SAF – which is headed by General Abdel Fattah al-Burhan.

Competition between Sudanese security actors fuels volatile political rivalries, and further entrenches military control of economic resources.

The commander of the paramilitary Rapid Support Forces, General Mohamed Hamdan Dagolo (or Hemedti), also has interests in agriculture, through his family business Al-Junaid. Both sit at the top of Sudan’s Sovereign Council. Hemedti’s competition with Burhan has seen him develop relations with Ethiopia’s prime minister – counter-balanced by recent rapprochement between Abiy and Burhan – as well as senior Amhara leaders, including over business activities.

Moreover, competition between Sudanese security actors fuels volatile political rivalries, and further entrenches military control of economic resources, undermining civilians at a time when pro-democracy forces are seeking to restore a reform-minded government. One of the key challenges for a new civilian government will be to quickly build up a domestic revenue base to compete with the economic heft of the country’s prominent security institutions, which will demand taking on military-controlled holdings in civic sectors such as agriculture, including sesame.

Informal and illicit trade reinforces conflict dynamics

This context has driven the informalization of trade, with cash crops such as sesame increasingly exported outside of formal channels and connected to other illicit cross-border activities between Ethiopia and Sudan. Indications are that sesame production in Western Tigray/Welkait has recovered significantly during the current 2022/23 harvest season. However, rather than contributing much needed currency to soften Ethiopia’s forex crisis, the Amhara elite-controlled supply chain is primarily being used to secure a variety of regional interests.


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Multi-sample mass spectrometry-based approach for discovering injury markers in chronic kidney disease

By www.mcponline.org
Published On :: 2020-12-20

Ji Eun Kim
Dec 20, 2020; 0:RA120.002159v1-mcp.RA120.002159
Research


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sam

Problem Notes for SAS®9 - 66511: A Russian translation shows the same value for two different variables in the Define Value dialog box for the Reply node in SAS Customer Intelligence Studio

By
Published On :: Mon, 24 Aug 2020 14:23:55 EST

In SAS Customer Intelligence Studio,  when you add  Reply- node variable values in the Define Value dialog box, you might notice that two identically labeled data-grid variables are


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Problem Notes for SAS®9 - 66496: Titles and footnotes do not span the full width of a page when you use the COLUMNS= option with the TAGSETS.RTF_SAMPLE tagset

By
Published On :: Thu, 20 Aug 2020 10:19:10 EST

Titles and footnotes do not span the entire width of the page when you use the COLUMNS= option with a value that is greater than 1 with the TAGSETS.RTF_SAMPLE tagset. When a value that is greater than 1 is specified for th


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High-speed Analysis of Large Sample Sets - How Can This Key Aspect of the Omics Be Achieved? [Perspective]

By www.mcponline.org
Published On :: 2020-11-01T00:05:37-07:00

High-speed analysis of large (prote)omics sample sets at the rate of thousands or millions of samples per day on a single platform has been a challenge since the beginning of proteomics. For many years, ESI-based MS methods have dominated proteomics because of their high sensitivity and great depth in analyzing complex proteomes. However, despite improvements in speed, ESI-based MS methods are fundamentally limited by their sample introduction, which excludes off-line sample preparation/fractionation because of the time required to switch between individual samples/sample fractions, and therefore being dependent on the speed of on-line sample preparation methods such as liquid chromatography. Laser-based ionization methods have the advantage of moving from one sample to the next without these limitations, being mainly restricted by the speed of modern sample stages, i.e. 10 ms or less between samples. This speed matches the data acquisition speed of modern high-performing mass spectrometers whereas the pulse repetition rate of the lasers (>1 kHz) provides a sufficient number of desorption/ionization events for successful ion signal detection from each sample at the above speed of the sample stages. Other advantages of laser-based ionization methods include the generally higher tolerance to sample additives and contamination compared with ESI MS, and the contact-less and pulsed nature of the laser used for desorption, reducing the risk of cross-contamination. Furthermore, new developments in MALDI have expanded its analytical capabilities, now being able to fully exploit high-performing hybrid mass analyzers and their strengths in sensitivity and MS/MS analysis by generating an ESI-like stable yield of multiply charged analyte ions. Thus, these new developments and the intrinsically high speed of laser-based methods now provide a good basis for tackling extreme sample analysis speed in the omics.


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Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein [Review]

By www.mcponline.org
Published On :: 2020-07-31T13:35:11-07:00

Mass spectrometry-based glycoproteomics has gone through some incredible developments over the last few years. Technological advances in glycopeptide enrichment, fragmentation methods, and data analysis workflows have enabled the transition of glycoproteomics from a niche application, mainly focused on the characterization of isolated glycoproteins, to a mature technology capable of profiling thousands of intact glycopeptides at once. In addition to numerous biological discoveries catalyzed by the technology, we are also observing an increase in studies focusing on global protein glycosylation and the relationship between multiple glycosylation sites on the same protein. It has become apparent that just describing protein glycosylation in terms of micro- and macro-heterogeneity, respectively the variation and occupancy of glycans at a given site, is not sufficient to describe the observed interactions between sites. In this perspective we propose a new term, meta-heterogeneity, to describe a higher level of glycan regulation: the variation in glycosylation across multiple sites of a given protein. We provide literature examples of extensive meta-heterogeneity on relevant proteins such as antibodies, erythropoietin, myeloperoxidase and a number of serum and plasma proteins. Furthermore, we postulate on the possible biological reasons and causes behind the intriguing meta-heterogeneity observed in glycoproteins.


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sam

Developments in Mass Spectrometry for Glycosaminoglycan Analysis: A Review [Review]

By www.mcponline.org
Published On :: 2020-09-16T09:35:59-07:00

This review covers recent developments in glycosaminoglycan (GAG) analysis via mass spectrometry (MS). GAGs participate in a variety of biological functions, including cellular communication, wound healing, and anticoagulation, and are important targets for structural characterization. GAGs exhibit a diverse range of structural features due to the variety of O- and N-sulfation modifications and uronic acid C-5 epimerization that can occur, making their analysis a challenging target. Mass spectrometry approaches to the structure assignment of GAGs have been widely investigated, and new methodologies remain the subject of development. Advances in sample preparation, tandem MS techniques (MS/MS), on-line separations and automated analysis software have advanced the field of GAG analysis. These recent developments have led to remarkable improvements in the precision and time efficiency for the structural characterization of GAGs.


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sam

Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites [Review]

By www.mcponline.org
Published On :: 2020-09-16T09:35:59-07:00

O-GlcNAcylation, the addition of a single N-acetylglucosamine residue to serine and threonine residues of cytoplasmic, nuclear, or mitochondrial proteins, is a widespread regulatory post-translational modification. It is involved in response to nutritional status and stress and its dysregulation is associated with diseases ranging from Alzheimer’s to diabetes.  While the modification was first detected over thirty-five years ago, research into the function of O-GlcNAcylation has accelerated dramatically in the last ten years due to the development of new enrichment and mass spectrometry techniques that facilitate its analysis.  This article summarizes methods for O-GlcNAc enrichment, key mass spectrometry instrumentation advancements, particularly those that allow modification site localization, and software tools that allow analysis of data from O-GlcNAc modified peptides.


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sam

Multi-sample mass spectrometry-based approach for discovering injury markers in chronic kidney disease [Research]

By www.mcponline.org
Published On :: 2020-12-20T09:35:16-08:00

Urinary proteomics studies have primarily focused on identifying markers of chronic kidney disease (CKD) progression. Here, we aimed to determine urinary markers of CKD renal parenchymal injury through proteomics analysis in animal kidney tissues and cells and in the urine of patients with CKD. Label-free quantitative proteomics analysis based on liquid chromatography-tandem mass spectrometry was performed on urine samples obtained from 6 normal controls and 9, 11, and 10 patients with CKD stages 1, 3, and 5, respectively, and on kidney tissue samples from a rat CKD model by 5/6 nephrectomy. Tandem mass tag-based quantitative proteomics analysis was performed for primary cultured glomerular endothelial cells (GECs) and proximal tubular epithelial cells (PTECs) before and after inducing 24-h hypoxia injury. Upon hierarchical clustering, out of 858 differentially expressed proteins (DEPs) in the urine of CKD patients, the levels of 416 decreased and 403 increased sequentially according to the disease stage, respectively. Among 2965 DEPs across 5/6 nephrectomized and sham-operated rat kidney tissues, 86 DEPs showed same expression patterns in the urine and kidney tissue. After cross-validation with two external animal proteome datasets, 38 DEPs were organized; only 10 DEPs, including serotransferrin, gelsolin, poly ADP-ribose polymerase 1, neuroblast differentiation-associated protein AHNAK, microtubule-associated protein 4, galectin-1, protein S, thymosin beta-4, myristoylated alanine-rich C-kinase substrate, and vimentin were finalized by screening human GECs and PTECs data. Among these ten potential candidates for universal CKD marker, validation analyses for protein S and galectin-1 were conducted. Galectin-1 was observed to have a significant inverse correlation with renal function as well as higher expression in glomerulus with chronic injury than protein S. This constitutes the first multi-sample proteomics study for identifying key renal-expressed proteins associated with CKD progression. The discovered proteins represent potential markers of chronic renal cell and tissue damage and candidate contributors to CKD pathophysiology.


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sam

Sam LaPorta, Tristan Wirfs, Dalton Kincaid among injured in NFL's Week 10

By www.upi.com
Published On :: Mon, 11 Nov 2024 09:54:18 -0500

All-Pro left tackle Tristan Wirfs and tight ends Sam LaPorta and Dalton Kincaid were among key players injured in Week 10 of the NFL season.


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sam

India plans lunar sample mission for 2028

By www.upi.com
Published On :: Thu, 31 Oct 2024 17:51:30 -0400

India is eying a return to the moon in 2028, aiming to collect 6.6 pounds of lunar samples from an area thought to be rich in water and ice near the lunar south pole, the Indian Space Research Organization has announced.


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sam

Teacher Demoralization Isn't the Same as Teacher Burnout

By www.teachermagazine.org
Published On :: 2020-11-12T00:00:00-05:00

The pandemic has made it harder for teachers to access the moral rewards of their work, writes education professor Doris A. Santoro.


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sam

Diurnal Fluctuations in Steroid Hormones Tied to Variation in Intrinsic Functional Connectivity in a Densely Sampled Male

By www.jneurosci.org
Published On :: 2024-05-29

Hannah Grotzinger
May 29, 2024; 44:e1856232024-e1856232024
BehavioralSystemsCognitive


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Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male

By www.jneurosci.org
Published On :: 2024-09-18

Elle M. Murata
Sep 18, 2024; 44:e0573242024-e0573242024
BehavioralSystemsCognitive


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sam

THE HINDU: Agriculture can't remain the same, says FAO official

By www.fao.org
Published On :: Wed, 09 Dec 2015 00:00:00 GMT

With rapid soil degradation, fast depletion of groundwater, excessive use of pesticides-fertilizers and extreme weather events all collectively putting stress on farming and forestry, it is time to recognise the [...]


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Scientists Think a Skeleton Found in a Well Is the Same Man Described in an 800-Year-Old Norse Text

By www.smithsonianmag.com
Published On :: Tue, 29 Oct 2024 15:56:38 +0000

The remains were discovered during excavations in 1938. Now, researchers have learned new information about his identity by analyzing DNA from his tooth


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The same beautiful threads

By www.om.org
Published On :: Sat, 17 Aug 2019 04:49:17 +0000

“Listening to their testimonies, I’ve begun to envision their stories as a collection of clues, a series of scenes revealing the fingerprints of something—or Someone—beyond our deepest imagination,” says Chris. “The people I talked with hail from a variety of backgrounds—atheist German to Cambodian Buddhist—but the tapestries of their lives reveal the same beautiful threads, pointing unmistakably to a Designer.“


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Carruthers rink begins search for new 2nd after Samagalski steps back

By www.cbc.ca
Published On :: Tue, 12 Nov 2024 17:50:31 EST

Team Reid Carruthers has started the search for a new second after Derek Samagalski's decision to step back from the Winnipeg-based rink.


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  • Sports/Olympics/Winter Sports/Curling
sam

8-year-old Sammy Wong to perform with K-W Symphony musicians

By www.cbc.ca
Published On :: Fri, 08 Nov 2024 07:00:00 EST

Sammy Wong, 8, of Waterloo has been playing the violin since he was 5 years old. He has been rehearsing for an upcoming concert with the musicians of the K-W Symphony on Saturday night at the Registry Theatre in Kitchener. The show, titled Prodigio del Violino:An Evening with Sammy Wong, will feature the music of Mozart and Vivaldi.


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sam

Same Game, Better Ice Rinks with Sport Systems Unlimited and SolidWorks Software

By www.solidworks.com
Published On :: Tue, 07 Jul 2009 00:00:00 -0500

Maker of NHL Hockey Boards Uses SolidWorks and Robotics to Speed Production by More than 60 Percent


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sam

Different Paths to the Same Goal: College and Career Readiness

By blogs.edweek.org
Published On :: Thu, 07 Mar 2019 00:00:00 +0000

Two recent studies of Teach to One: Math highlight the tension in math between grade-level-based accountability systems and approaches to instruction that enable more personalized paths to college and career readiness.


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Viral country singer Sam Barber brings his ‘Restless Mind’ to Penn State Nov. 7

By www.psu.edu
Published On :: Fri, 01 Nov 2024 09:13:37 -0400

Viral country singer-songwriter and former reality-star contestant Sam Barber will bring his “Restless Mind” tour to Happy Valley at 7:30 p.m. Thursday, Nov. 7, in Eisenhower Auditorium.


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sam

Different languages, same Father God

By www.om.org
Published On :: Tue, 07 Feb 2012 15:52:37 +0000

Whether praying in Cantonese or Albanian, believers are one in heart.


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sam

Vouchers Are Not the Same as 'School Choice'

By www.edweek.org
Published On :: Tue, 28 Feb 2017 00:00:00 +0000


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sam

Brandywine Student Spotlight: Samantha Pitcher

By www.psu.edu
Published On :: Mon, 07 Oct 2024 12:03:12 -0400

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.


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sam

Samara Joy to perform ‘A Joyful Holiday’ on Dec. 3 in Eisenhower Auditorium

By www.psu.edu
Published On :: Thu, 07 Nov 2024 14:35:57 -0500

Three-time Grammy Award-winning vocalist Samara Joy will perform her third annual “A Joyful Holiday” featuring the McLendon Family in concert at 7:30 p.m. Tuesday, Dec. 3, in Eisenhower Auditorium.


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sam

Life will never be the same

By www.om.org
Published On :: Fri, 21 Feb 2014 09:07:33 +0000

As families devastated by the recent fire in a Bangladesh slum rebuild their lives, the team helps, and individuals tell their stories.


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sam

UK Writer Samantha Harvey Wins 2024 Booker For 136-Page Novel "Orbital"

By www.ndtv.com
Published On :: Wed, 13 Nov 2024 11:34:44 +0530

Samantha Harvey's "Orbital" is the second-shortest novel to win the award and the first to be set in space.


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sam

Apple Vision Pro 2 to Launch Between Fall of 2025 and Spring 2026 With Same Design as Current Model: Mark Gurman

By www.gadgets360.com
Published On :: Mon, 11 Nov 2024 15:01:54 +0530

Apple unveiled its first mixed-reality headset Vision Pro at WWDC last year. Rumours about its successor have been circulating online for a while, and now Bloomberg's Mark Gurman has suggested the launch timeline for the next generation Apple Vision Pro. Gurman claims that the upcoming model will have a similar design as the current model.


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sam

Samsung Galaxy Z Flip FE Tipped to Be Powered by Same Chipset as Galaxy S24 Series

By www.gadgets360.com
Published On :: Mon, 11 Nov 2024 17:06:57 +0530

Samsung Galaxy Z Flip FE is rumoured to launch next year, joining the South Korean technology conglomerate’s flagship foldable smartphone lineup as an affordable alternative to the Z Flip series model for buyers. Despite the rumour mill suggesting that it might cut down on some features in an attempt to be priced affordably, a tipster has revealed that the purported smartphone could be powered by the same Exynos processor as the flagship Galaxy S24 series.


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sam

Samsung Galaxy S23 5G vs Samsung Galaxy S24 5G: Which is Better?

By www.gadgets360.com
Published On :: Tue, 12 Nov 2024 14:39:14 +0530

The Samsung Galaxy S23 5G and Samsung Galaxy S24 5G are available at a starting price of Rs 41,999 and Rs 57,499 during the festive sale. Both models offer some premium design language and come equipped with the latest hardware. In this comparison, we will talk in-depth about both the models and which one you should consider.


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Samsung Galaxy Ring Now Available in Qatar, Romania, UAE and More Markets

By www.gadgets360.com
Published On :: Wed, 13 Nov 2024 10:25:26 +0530

Samsung Galaxy Ring’s availability has been expanded to several Gulf countries and eastern European markets, the company announced on Tuesday. The smart wearable is available in a total of nine sizes, three finishes, and boasts features such as AI-powered health tracking and sleep monitoring courtesy of various sensors. It is touted to deliver up to seven days of battery life on a single charge and runs on the Samsung Health platform.


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Report Finds Gender Disparity in Auto Insurance Premiums, Women Charged More for Same Coverage

By news.delaware.gov
Published On :: Tue, 01 Mar 2022 15:48:08 +0000

Legislative effort to end rating practice announced Insurance Commissioner Trinidad Navarro and the Consumer Federation of America (CFA) today released Gender Disparities in Auto Insurance Pricing, a new report that shows many women are being charged more by auto insurers based solely on their gender. Data shows that many Delaware women pay more per year […]


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UK Writer Samantha Harvey Wins 2024 Booker For 136-Page Novel "Orbital"

By www.ndtv.com
Published On :: Wed, 13 Nov 2024 11:29:36 +0530

Samantha Harvey's "Orbital" is the second-shortest novel to win the award and the first to be set in space.


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The Mezzanine Gallery to Exhibit “Explorations through Materiality” by Samara Weaver

By news.delaware.gov
Published On :: Wed, 01 Jun 2022 14:24:46 +0000

The Delaware Division of the Arts’ Mezzanine Gallery presents artist Samara Weaver’s exhibition, Explorations Through Materiality, running June 3 through 24, 2022. Guests are invited to attend a Meet-the-Artist Reception to be held Friday, June 3, from 5-7 p.m. as part of Art Loop Wilmington. 


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DSAMH Announces Funding Availability to Address Rising Overdose Deaths Among Black, African American Communities

By news.delaware.gov
Published On :: Fri, 30 Jun 2023 19:36:01 +0000

NEW CASTLE – The Delaware Division of Substance Abuse and Mental Health (DSAMH) announces the launch of the Health Equity Advancement Project, consisting of two funding opportunities that seek to develop strategies for addressing rising opioid overdose deaths among Black and African American communities in Delaware. DSAMH will award eight mini grants as well as […]


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  • Delaware Health and Social Services
  • Division of Substance Abuse and Mental Health
  • News
  • Behavioral Health Consortium
  • Delaware Department of Health and Social Services
  • DSAMH
  • overdoses in delaware
  • Substance Abuse
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DNREC Study Finds PFAS in Surface Water Samples

By news.delaware.gov
Published On :: Tue, 24 Sep 2024 12:30:15 +0000

The Department of Natural Resources and Environmental Control released findings from DNREC’s comprehensive study on PFAS (per- and polyfluoroalkyl substances) in surface waters across Delaware.


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Samsung Galaxy Note 10 Lite Review

By www.digit.in
Published On :: 2023-09-22T13:09:00+05:30

Read the in depth Review of Samsung Galaxy Note 10 Lite Mobile Phones. Know detailed info about Samsung Galaxy Note 10 Lite configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.


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Samsung S5620 Monte - capacitive touch, 3.2MP, Wi-Fi & GPS, under Rs. 12,390 Review

By www.digit.in
Published On :: 2023-09-22T13:09:00+05:30

Read the in depth Review of Samsung S5620 Monte - capacitive touch, 3.2MP, Wi-Fi & GPS, under Rs. 12,390 Mobile Phones. Know detailed info about Samsung S5620 Monte - capacitive touch, 3.2MP, Wi-Fi & GPS, under Rs. 12,390 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.


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Samsung Galaxy S10e Review

By www.digit.in
Published On :: 2023-09-22T13:09:00+05:30

Read the in depth Review of Samsung Galaxy S10e Mobile Phones. Know detailed info about Samsung Galaxy S10e configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.


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Samsung B5310 CorbyPro - TouchWiz UI, QWERTY, Wi-Fi & GPS, under Rs. 13,900 Review

By www.digit.in
Published On :: 2023-09-22T13:09:00+05:30

Read the in depth Review of Samsung B5310 CorbyPro - TouchWiz UI, QWERTY, Wi-Fi & GPS, under Rs. 13,900 Mobile Phones. Know detailed info about Samsung B5310 CorbyPro - TouchWiz UI, QWERTY, Wi-Fi & GPS, under Rs. 13,900 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.


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Samsung Galaxy Tab A7 10.4 (2020) Review

By www.digit.in
Published On :: 2023-09-22T13:09:00+05:30

Read the in depth Review of Samsung Galaxy Tab A7 10.4 (2020) Tablets. Know detailed info about Samsung Galaxy Tab A7 10.4 (2020) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.


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Samsung Galaxy Watch 3 Review

By www.digit.in
Published On :: 2023-09-22T13:09:00+05:30

Read the in depth Review of Samsung Galaxy Watch 3 Wearable Devices. Know detailed info about Samsung Galaxy Watch 3 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.


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