Leipzig : Toeplitz & Deuticke, 1887.

Leipzig : Toeplitz & Deuticke, 1888.

Heidelberg : Winter, 1900.

Berlin : A. Hirschwald, 1850.

Stuttgart : Enke, 1904.

Breslau : W.G. Korn, 1833.

Leipzig : S. Hirzel, 1899.

Berlin : A. Hirschwald, 1893.

The problem of accurately measuring the similarity between graphs is at the core of many applications in a variety of disciplines. Graph kernels have recently emerged as a promising approach to this problem. There are now many kernels, each focusing on different structural aspects of graphs. Here, we present GraKeL, a library that unifies several graph kernels into a common framework. The library is written in Python and adheres to the scikit-learn interface. It is simple to use and can be naturally combined with scikit-learn's modules to build a complete machine learning pipeline for tasks such as graph classification and clustering. The code is BSD licensed and is available at: https://github.com/ysig/GraKeL.

This eruption is the longest since 2018 when the volcano caused a deadly tsunami

Happy birthday Vijay Deverakonda: Tollywood's 'Dear Comrade' who auctioned his first Filmfare Award for charity  The New Indian Express

DRAKE - DARK LANE DEMO TAPES

Are you unhappy with your credit provider? Have you been given more debt than you can afford to pay back? Help is at hand, and it’s just an SMS away.

The cleverly designed SideTrak Portable Monitor gives you a second screen that can stay attached to your laptop, even while traveling.

The Razer Kraken Ultimate wired gaming headset brings powerful bass, programmable lighting, and an excellent microphone to your PC.

The first 20 minutes of a business owner's work day may determine the success or failure of the business, says a franchise expert

Border Roads Organisation has completed the construction of road from Dharchula to Lipulekh on China Border.

According to the project details, the state government is proposing to develop this non-major port to meet the increasing cargo demand in the state. It is expected to be an all-weather port with world-class terminal facilities, well suited to meet the present and future needs of the trades and also suitable to develop as a major port.

The Marrakech film festival, which was held from November 29 to December 7, had Gitanjali Rao’s hand-painted animated film Bombay Rose vying for the festival's top prize, the Golden Star.

This comes in the backdrop of the Uttarakhand government contemplating a change in the traditions of the opening of the famed Himalayan temples. 

AMTRAK BRIDGE PAINTING, NEW CASTLE COUNTY, FY20

At 26, Rakhi Birla became the youngest minister in Delhi as she joined Arvind Kejriwal's cabinet when the Aam Aadmi Party (AAP) first came to power in 2013. Later, the two-time MLA from Mangolpuri...

Looking to learn? There's a bunch of new RAKs (Rapid Adoption Kits) available online now!

1) Indago 19.09 Better Driver Tracing and More

Are you new to Indago and not sure where to start? Luckily, there’s a new Rapid Adoption Kit for you: the Indago 19.09 Overview RAK! This neat package contains everything you need to get your debugging started through Indago. In four short labs, plus a brief introductory lab, you’ll have all the basics of Indago 19.09 down—the Indago working environment, the SmartLog, how Indago interacts with the rest of the Cadence Verification Suite, and how Indago uses HDL driver tracing.

Lab 1 discusses the various debugging tools included in Indago and teaches you how to customize your Indago windows and environment settings. Lab 2 covers the SmartLog feature and talks about analyzing and filtering its messages to suit your needs, as well as how to interact with the waveform marker. Lab 3 is an interactive Indago debugging experience—it’ll walk you through how to use Indago and its features in an actual working environment: setting breakpoints, using simulator commands in the Indago console, toolbars, switches, and more. Lab 4 is all things HDL tracing—recording debug data, an introduction to debug assertions, waveform visualizations, driving expression analysis, and single-step driver tracing, among other things.

Interested? Check out the RAK here.

2) IXCOM MSIE: Faster Palladium Build Time

Got several testbenches you want to compile with the same DUT and tests and you want to do it fast? With IXCOM, all you have to do to compile those different testbenches is use the xrun command for each after compiling your DUT. But what exactly is IXCOM, and how does one start using it? This quick RAK can help—here, you’ll learn the basics of using MSIE features with IXCOM, complete with an example to get you started. Using MSIE can vastly improve your build times with Palladium and using IXCOM is the best way to shrink that tedious rebuild time as small as it can get. Check out this RAK here.

3)  JasperGold Control and Status Register Verification App Automates UVM Register Map Verification

New to the JasperGold Control and Status Register (CSR) Verification App for your UVM testbenches? Don’t worry; there’s a RAK for that! This eponymous RAK can get you up and running with this in no time, helping you automate your checks from UVM register map specs. With this RAK, you’ll learn the basics of the JasperGold CSR, how to use JasperGold CSR’s Proof Accelerator, and more. CSR features a model-based approach to predicting a register’s expected value, supports pipeline interfaces, all IP-XACT access policies, and it can fully model any expected register value. It also supports register aliases, read and write semantics, and separate read/write data latencies in any given field.

If this functionality sounds up your alley, you can take a look at this RAK here.

All engineers can enhance their mixed-signal low-power structural verification productivity by learning while doing with a PIEA RAK (Power Intent Export Assistant Rapid Adoption Kit). They can verify the mixed-signal chip by a generating macromodel for their analog block automatically, and run it through Conformal Low Power (CLP) to perform a low power structural check.  

The power structure integrity of a mixed-signal, low-power block is verified via Conformal Low Power integrated into the Virtuoso Schematic Editor Power Intent Export Assistant (VSE-PIEA). Here is the flow.

Applying the flow iteratively from lower to higher levels can verify the power structure.

Cadence customers can learn more in a Rapid Adoption Kit (RAK) titled IC 6.1.5 Virtuoso Schematic Editor XL PIEA, Conformal Low Power: Mixed-Signal Low Power Structural Verification.

• To read the overview presentation, click on following link: PIEA Overview
• To download this PIEA RAK click on following link: PIEA RAK Download

The RAK includes Rapid Adoption Kit with demo design (instructions are provided on how to setup the user environment). It Introduces the Power Intent Export Assistant (PIEA) feature that has been implemented in the Virtuoso IC615 release.  The power intent extracted is then verified by calling Conformal Low Power (CLP) inside the Virtuoso environment.

• Last Update: 11/15/2012.
• Validated with IC 6.1.5 and CLP 11.1

The RAK uses a sample test case to go through PIEA + CLP flow as follows:

• Setup for PIEA
• Perform power intent extraction
• CPF Import: It is recommended to Import macro CPF, as oppose to designing CPF for sub-blocks. If you choose to import design CPF files please make sure the design CPF file has power domain information for all the top level boundary ports
• Generate macro CPF and design CPF
• Perform low power verification by running CLP

It is also recommended to go through older RAKs as prerequisites.

• Conformal Low Power, RTL Compiler and Incisive: Low Power Verification for Beginners
• Conformal Low Power: CPF Macro Models
• Conformal Low Power and RTL Compiler: Low Power Verification for Advanced Users

To access all these RAKs, visit our RAK Home Page to access Synthesis, Test and Verification flow

Note: To access above docs, use your Cadence credentials to logon to the Cadence Online Support (COS) web site. Cadence Online Support website https://support.cadence.com/ is your 24/7 partner for getting help and resolving issues related to Cadence software. If you are signed up for e-mail notifications, you can receive new solutions, Application Notes (Technical Papers), Videos, Manuals, and more.

You can send us your feedback by adding a comment below or using the feedback box on Cadence Online Support.

Sumeet Aggarwal

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Here's a great FL4K Rakk build for Mayhem 10 that essentially makes you immune to all damage. ......

Move over Martians, Earth has already been invaded by little green aliens, but how did parakeets become one of the most successful invasive species ever?

Move over Martians, Earth has already been invaded by little green aliens, but how did parakeets become one of the most successful invasive species ever?

Title: Raking Your Leaves to the Edge of Your Yard an Invitation to Ticks
Category: Health News
Created: 3/22/2020 12:00:00 AM
Last Editorial Review: 3/23/2020 12:00:00 AM

Key Points

Key Points

Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation in the myeloid differentiation primary response 88 (MYD88) gene. The MYD88 L265P mutant results in the activation of interleukin-1 receptor associated kinase (IRAK). To probe IRAK/MYD88 signaling in PEL, we employed CRISPR/Cas9 technology to generate stable deletion clones in BCBL-1Cas9 and BC-1Cas9 cells. To look for off-target effects, we determined the complete exome of the BCBL-1Cas9 and BC-1Cas9 cells. Deletion of either MYD88, IRAK4, or IRAK1 abolished interleukin-1 beta (IL-1β) signaling; however, we were able to grow stable subclones from each population. Transcriptome sequencing (RNA-seq) analysis of IRAK4 knockout cell lines (IRAK4 KOs) showed that the IRAK pathway induced cellular signals constitutively, independent of IL-1β stimulation, which was abrogated by deletion of IRAK4. Transient complementation with IRAK1 increased NF-B activity in MYD88 KO, IRAK1 KO, and IRAK4 KO cells even in the absence of IL-1β. IL-10, a hallmark of PEL, was dependent on the IRAK pathway, as IRAK4 KOs showed reduced IL-10 levels. We surmise that, unlike B cell receptor (BCR) signaling, MYD88/IRAK signaling is constitutively active in PEL, but that under cell culture conditions, PEL rapidly became independent of this pathway.

IMPORTANCE One hundred percent of primary effusion lymphoma (PEL) cases are associated with Kaposi sarcoma-associated herpesvirus (KSHV). PEL cell lines, such as BCBL-1, are the workhorse for understanding this human oncovirus and the host pathways that KSHV dysregulates. Understanding their function is important for developing new therapies as well as identifying high-risk patient groups. The myeloid differentiation primary response 88 (MYD88)/interleukin-1 receptor associated kinase (IRAK) pathway, which has progrowth functions in other B cell lymphomas, has not been fully explored in PEL. By performing CRISPR/Cas9 knockout (KO) studies targeting the IRAK pathway in PEL, we were able to determine that established PEL cell lines can circumvent the loss of IRAK1, IRAK4, and MYD88; however, the deletion clones are deficient in interleukin-10 (IL-10) production. Since IL-10 suppresses T cell function, this suggests that the IRAK pathway may serve a function in vivo and during early-stage development of PEL.

विजय देवरकोंडा (Vijay Devarakonda) आज के समय में तेलुगू फिल्मों के सफल एक्टर्स में गिने जाते हैं। आज विजय अपना 31वां जन्मदिन मना रहे हैं। इतनी कम उम्र में ही विजय की फैन फॉलोइंग कोरोड़ों में है। विजय का जन्म 9 मई, 1989 में हैदराबाद में हुआ था।

उत्तराखंड बोर्ड की परीक्षाएं इसी महीने हो सकती हैं। वहीं बोर्ड का रिजल्ट भी 10 जून से पहले घोषित किया जा सकता है।

उत्तराखंड में छह और कोरोना पॉजिटिव मरीज ठीक हो चुके हैं। अब राज्य में 45 मरीज ठीक हो चुके हैं। वहीं राज्य में कुल पॉजिटिव मरीजों की संख्या 61 है।

अस्थि विर्सजन से रोक हटने से कई लोगों ने राहत की सास ली है। वे अब श्मशान घाटों में रखीं परिजनों की अस्थियों को गंगा में विर्सजित कर सकेंगे।

प्रदेश के ऐसे लोग जो दूसरे राज्य में नौकरी या अन्य काम करते हैं और निजी वाहन से जाना चाहते हैं, वह http://smartcitydehradun.uk.gov.in/e-pass पर आवेदन कर ई-पास बनवा सकते हैं।

उत्तराखंड के ऊधमसिंह नगर जिले में शनिवार को चार नए मामले सामने आए हैं। अब राज्य में कुछ मरीजों की संख्या 67 हो गई है।

शनिवार को दोपहर बाद उत्तराखंड के पहाड़ी इलाकों में मौसम बदल गया। वहीं अधिकतर मैदानी इलाकों में बादल छाए रहे।

उत्तर प्रदेश के गोरखपुर जिले में कोरोना पॉजिटिव मरीजों की संख्या बढ़कर चार हो गई है।

उत्तराखंड में कोरोना वायरस संक्रमण के मद्देनजर अब सिर्फ हरिद्वार जनपद ही रेड जोन में बचा है। स्वास्थ्य मंत्रालय ने ऊधमसिंह नगर और अल्मोड़ा जनपद को ग्रीन जोन घोषित कर दिया है।