The U.S. Education Department says the states need more evidence to use the popular admissions test to measure high school achievement.

The U.S. Department of Education continues to quietly approve and negotiate over states' teacher-evaluation systems as part of its No Child Left Behind Act waiver process.

The Dahme-Spreewald administrative district’s local building inspection authority confirmed the completion of Terminal T1 at BER on 28 April following the completion of the construction work.

The Delaware Department of Agriculture announced today that the USDA approved the state plan submitted for the Delaware Domestic Hemp Production Program. Delaware is now the second state on the East Coast to receive approval to administer a domestic hemp program.

Agency: DOT Closing Date: 5/12/2020

DNREC announced the creation of a new permit program that establishes regulatory conditions for the sandblasting of outdoor water tanks to remove lead-based paint. Contractors often use sandblasting to remove paint from water tanks in preparation for repainting them. Effective immediately, all water tank sandblasting projects involving removal of lead paint are required to have an air quality permit from DNREC that will ensure sufficient containment measures are taken to prevent the release of lead paint chips into the environment.

On June 20, Gov. John Carney signed enabling legislation (House Bill 193) moving Delaware a step closer to a reinsurance program beginning in 2020. NEW CASTLE (Aug. 20, 2019) – The Department of Health and Social Services (DHSS) received approval today from the Centers for Medicare and Medicaid Services (CMS) for a 1332 State Innovation […]

Lewes --

WHEN: 6:00 a.m. until 9:00 a.m. on Sunday, April 5, 2020

WHERE: Route 24/John J. Williams Highway between Hollymount Road and Robinsonville Road at Burtons Pond near Lewes

WHAT: DelDOT announces to motorists that a portion of Route 24/John J. Williams Highway will be closed at Burtons Pond for the removal of the barge at the pond. [More]

Political observers see the fielding of Doval as the Prime Minister’s assertion on the issue of developments linked to changes in the citizenship law which have triggered protests across the country.

Novalead’s technology has a track record of successfully discovering repurposed drug candidates with its lead drug candidate currently being in Phase 3 trials in India, for diabetic foot ulcers.

RBI grants In-principle Approval to 10 Small Finance Banks

With the leaders busy wrecking in front of him, Scott McLaughlin calmly won Saturday's virtual IndyCar Series race on the oval at Indianapolis Motor Speedway.

VÉLIZY-VILLACOUBLAY, France and NEW YORK — August 19, 2019 – Dassault Systèmes SE (Dassault Systèmes) (Euronext Paris: #13065, DSY. PA) and Medidata Solutions, Inc. ("Medidata") (NASDAQ: MDSO) announced that Medidata stockholders have approved on August 16, 2019 the proposed acquisition of Medidata by Dassault Systèmes. At a special meeting of Medidata stockholders held on August 16, 2019, 78% of Medidata’s total outstanding common stock voted in favor of the proposed acquisition and...

A pair of applications filed by the Klamath River Renewal Corporation today with the Federal Energy Regulatory Commission puts into official motion a long-standing plan to remove four hydroelectric plants on the Klamath River.

On Monday, Duke Energy announced a proposal to make what it says is the largest investment in electric vehicle (EV) infrastructure ever in the Southeast – a $76 million initiative to spur EV adoption across the state.

Genex Power Limited has secured all environmental approvals required to develop the 250-MW Kidston Pumped Storage Hydro Project (K2-Hydro).

This week, Duke Energy announced that regulators have approved two projects involving energy storage worth about $30 million.

Solar Wind Energy Tower Inc. won approval from an Arizona city to develop a $1.5 billion project that would use ambient desert heat to create a draft to generate electricity, in a concrete colossus that would be the tallest structure in North America.

The approval rating of the Moon Jae-in government has hit a low of 67.1 percent largely due to North Korea nuclear issues. The rating has fallen for three consecutive weeks. As for the approval rating of the ruling Minjoo Party has declined for four weeks in a row to 49.3 percent. Pollster Realmeter said on September 18 that a survey commissioned by CBS-TV revealed that the ratio of those who thought positively about the way the current government has performed was 67.1 percent, down by 2.0 p...

After nine years pursuing her claim against her employer, Michelle Alabaster walked away with an award of just £204.53.  However, the impact of the decisions of the ECJ, and now the Court of Appeal in the maternity pay case of Ala...

The Community Infrastructure Levy (Amendment) (England) (No. 2) Regulations 2019 are due to come into force on 1 September 2019. The 2019 Regulations were introduced by the Government earlier this year, alongside their response to the technical cons...

A US regulator on Thursday pulled approval for dozens of companies making industry-standard masks in China, citing substandard performance, and warned health care providers to reconsider using any of the now-blacklisted products.After the US Food and Drug Administration’s determination that many of the made-in-China N95-style masks filter out less than 95 per cent of particulate matter – the filtration level that gives the N95 mask its name – the approved number of manufacturers dropped to 14…

President Moon Jae-in's approval rating has stood at over 60 percent for a third week running despite the dire state of the economy.Moon, who marks his third year in office this weekend, seems to owe his recovered popularity to the relatively smooth handling of the coronavirus epidemic. But it also ...

Japan has fast-tracked the approval of the anti-viral drug remdesivir to be used to treat COVID-19 patients in that country.Speaking to reporters Friday in Tokyo, Japanese Chief Cabinet Secretary Yoshihide Suga confirmed the rare fast-track, four-day approval of remdesivir by the Ministry of Health,...

* LILLY RECEIVES U.S. FDA APPROVAL FOR RETEVMO™ (SELPERCATINIB), THE FIRST THERAPY SPECIFICALLY FOR PATIENTS WITH ADVANCED RET-DRIVEN LUNG AND THYROID CANCERS

Title: Prostate Cancer Vaccine May Get FDA Approval
Category: Health News
Created: 4/27/2010 8:10:00 AM
Last Editorial Review: 4/27/2010 12:00:00 AM

Title: Study: Ovary Removal Doesn't Raise Heart Risk
Category: Health News
Created: 4/26/2011 1:54:00 PM
Last Editorial Review: 4/26/2011 12:00:00 AM

Title: FDA Panel Urges Approval of Hepatitis C Drug
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: Afinitor Approval Expanded to Include Benign Kidney Tumors
Category: Health News
Created: 4/27/2012 2:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

ABSTRACT

All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for virulence, conferring resistance to phagocytosis during the infection. Recent studies revealed that the "decorations" of the EPA polymer, encoded by genetic loci that are variable between isolates, underpin the biological activity of this surface polysaccharide. In this work, we investigated the structure of the EPA polymer produced by the high-risk enterococcal clonal complex Enterococcus faecalis V583. We analyzed purified EPA from the wild-type strain and a mutant lacking decorations and elucidated the structure of the EPA backbone and decorations. We showed that the rhamnan backbone of EPA is composed of a hexasaccharide repeat unit of C2- and C3-linked rhamnan chains, partially substituted in the C3 position by α-glucose (α-Glc) and in the C2 position by β-N-acetylglucosamine (β-GlcNAc). The so-called "EPA decorations" consist of phosphopolysaccharide chains corresponding to teichoic acids covalently bound to the rhamnan backbone. The elucidation of the complete EPA structure allowed us to propose a biosynthetic pathway, a first essential step toward the design of antimicrobials targeting the synthesis of this virulence factor.

IMPORTANCE Enterococci are opportunistic pathogens responsible for hospital- and community-acquired infections. All enterococci produce a surface polysaccharide called EPA (enterococcal polysaccharide antigen) required for biofilm formation, antibiotic resistance, and pathogenesis. Despite the critical role of EPA in cell growth and division and as a major virulence factor, no information is available on its structure. Here, we report the complete structure of the EPA polymer produced by the model strain E. faecalis V583. We describe the structure of the EPA backbone, made of a rhamnan hexasaccharide substituted by Glc and GlcNAc residues, and show that teichoic acids are covalently bound to this rhamnan chain, forming the so-called "EPA decorations" essential for host colonization and pathogenesis. This report represents a key step in efforts to identify the structural properties of EPA that are essential for its biological activity and to identify novel targets to develop preventive and therapeutic approaches against enterococci.

• France Galop lobbied Emmanuel Macron for go-ahead
• Longchamp one of three meetings to take place on Monday

France Galop, the ruling body of French racing, confirmed on Saturday it will resume with meetings at Longchamp, Toulouse and Compiegne on Monday, but only after what is believed to have been urgent behind-the-scenes lobbying by Edouard de Rothschild, FG’s president, late on Friday night that persuaded Emmanuel Macron, the French president, to finally give his approval to the resumption.

De Rothschild thanked Macron and Édouard Philippe, France’s prime minister, for their efforts in a tweet in the early hours of Saturday morning that confirmed racing had seen off last-minute objections to its return.

New surveys out Thursday show President Donald Trump’s approval rating for his handling of the coronavirus pandemic is underwater in four critical states while governors receive high marks.

Environmental Working Group has launched EWG Verified, a label that will help consumers spot products that meet stringent ingredient and transparency requirements

It may soon be easier for shoppers to find beauty products without toxic chemicals. The Environmental Working Group nonprofit launched a new label this month called EWG Verified, which certifies personal care products as free from chemicals of concern.

The program is an extension of the group’s work with the Skin Deep database, which for more than a decade now has given tens of millions of visitors information on the chemical contents and relative safety of their favorite cosmetics and shampoos.

Before the pill was approved by the FDA on May 9, 1960, there were few contraceptive options available to young women. It revolutionized family planning and the sex lives of millions of Americans.

Making fuzz-free fuss-free

Defending A-League champions Sydney FC move to the top of the ladder after putting on a clinic to hammer the Newcastle Jets 4-1 in a one-sided affair at Leichhardt Oval.

New episodes return May 6 at 9/8c.

The number of home loans issued in Australia rose 1.5 per cent in February, but still fell short of forecasts.

NRL clubs will be able to resume training from May 4 as the competition charges towards its planned restart three weeks later.

Roche’s antibody test for Covid-19 has been given the CE mark and has been issued Emergency Use Authorisation from the US Food and Drug Administration.

New era for lymphoma, leukemia, possibly other cancers

Agency moves toward more accelerated reviews

The approval gives NSCLC patients whose tumours carry the MET exon 14 skipping mutation a new treatment option

As cancer research reveals the genetic basis of the disease, pharmaceutical companies are pursuing targeted therapies that address certain groups of patients. One such drug from Novartis won FDA approval Wednesday, making it the first therapy cleared by the agency to treat patients whose non-small cell lung cancer (NSCLC) carries a certain genetic mutation. The […]

In this video explainer, Christopher Robertson discusses the Right to Try Act and off-label use of pharmaceuticals with Alison Bateman-House.

The post Access to Drugs Before FDA Approval: Video Explainer with Christopher Robertson appeared first on Bill of Health.