SAS  Episode Analytics 3.1 requires the ability to capture user interactions with the user interface for auditing purposes. To support the required functionality a new table has been add

     Lens and tear film lipids are as unique as the systems they reside in. The major lipid of the human lens is dihydrosphingomylein, found in quantity only in the lens. The lens contains a cholesterol to phospholipid molar ratio as high as 10:1, more than anywhere in the body. Lens lipids contribute to maintaining lens clarity, and alterations in lens lipid composition due to age are likely to contribute to cataract. Lens lipid composition reflects adaptations to the unique characteristics of the lens: no turnover of lens lipids or proteins; the lowest amount of oxygen than any other tissue and contains almost no intracellular organelles. The tear film lipid layer (TFLL) is also unique. The TFLL is a thin, 100 nm layer of lipid on the surface of tears covering the cornea that contributes to tear film stability. The major lipids of the TFLL are wax esters and cholesterol esters that are not found in the lens. The hydrocarbon chains associated with the esters are longer than those found anywhere in the body, as long as 32 carbons, and many are branched. Changes in the composition and structure of the 30,000 different moieties of TFLL contribute to the instability of tears. The focus of the current review is how spectroscopy has been used to elucidate the relationships between lipid composition, conformational order and function and the etiology of cataract and dry eye.

Crisis in the international order 23 January 2023 — 6:00PM TO 7:00PM Anonymous (not verified) 8 December 2022 Chatham House and Online

Why societies are challenging the international order?

Major global challenges, including the climate, refugee crises and the global pandemic, are increasingly revealing shortcomings in our international system and are bringing to the forefront calls for a more just world. But what is justice? 
 
Calls for justice come in many forms and from many directions - from the fair distribution of resources to the recognition of indigenous rights. While for some there is consensus on the importance of multilateral cooperation to tackle global issues, there is a sharp North/South divide at the centre of debates on issues such as the climate crisis, racial justice, and international law. Countries from the global South are demanding more equitable and redistributive solutions, for example in the distribution of COVID-19 vaccines, while the Global North seek the status quo. 
 
North/South division slows progress on reform. Some political actors are starting to challenge the very foundations of our global order, a move that could dramatically change the global system as we know it. 

Key questions to consider include:

• Why are there tensions between the global North and South?
• How can these issues be addressed?
• Does the global North ‘owe’ the global South some form of justice? Which form of justice?
• If these issues are not addressed, what are the implications for the current international order?

This event is held in conjunction with International Affairs.

As with all members events, questions from the audience drive the conversation.

Read the transcript.

A new nuclear order 7 February 2023 — 6:00PM TO 7:00PM Anonymous (not verified) 26 January 2023 Chatham House and Online

In conversation with Rafael Mariano Grossi.

For more than half a century, the global nuclear non-proliferation framework has supported international security and facilitated the expansion of the many peaceful applications of nuclear science and technology. 

What is happening today in Ukraine, Iran and North Korea, not only challenges the way we deal with the existential threat of nuclear weapons, but also the impact it could have on addressing another existential threat – climate change.

Russia’s invasion of Ukraine is the biggest test to global resolve both in avoiding nuclear conflict and in ensuring the safety of one of the biggest nuclear power programmes in Europe.

Rafael Mariano Grossi of the International Atomic Energy Agency discusses key questions on global nuclear cooperation including:

• The impact of the war in Ukraine and issues with Iran and North Korea on countries’ risk assessment with regards to nuclear non-proliferation.

• What the IAEA’s on-the-ground presence and the director general’s missions to Ukraine, particularly the Zaporizhzhia Nuclear Power Plant, tells us about what is necessary – now and in the long term – to ensure the safety and security of nuclear material under all circumstances.

• The role of ensuring nuclear energy can play its vital part in mitigating climate change now and in the future.

As with all member events, questions from the audience drive the conversation.

Read the transcript.

Belarus-EU border crisis reveals wider security threat Expert comment NCapeling 8 December 2021

By engineering a crisis at the Belarus border, Lukashenka is attempting to exacerbate vulnerabilities within the EU. Securitizing migration is not the answer.

When thousands of migrants began freezing to death in the forests on the Belarus border with Poland, Belarusian leader Aliaksandr Lukashenka was forcing the European Union (EU) into a tough choice – either give in to blackmail and welcome migrants whose attempts to trespass the EU border were a result of his policy of luring them to Belarus to put pressure on the EU, or keep the borders closed and declare solidarity with Poland despite its known mistreatment and illegal pushbacks of potential asylum-seekers.

Lukashenka’s action was aptly exploiting three key pressure points of the EU – as a normative power where the human dignity of migrants is overlooked while the European border and coastguard agency Frontex stands by, as a geopolitical actor seeking to externalize its migration problem by signing readmission agreements with transit countries, and as a community of values with the EU-Poland dispute over rule of law.

His approach is typical ‘dictaplomacy’ and democracies which have confronted such a ‘continuation of war by other means’ in their past dealings with dictatorships know that blackmail mostly serves to divert attention away from a rogue leader’s misdemeanours towards his own population. But if this had been game of chess the EU would have been in check.

Thankfully checkmate was avoided – so far – as a compromise was found following weeks of heightened diplomatic efforts. Lukashenka was forced to back-pedal and take care of the migrants, and no humanitarian corridor was needed as the EU sent funds and took measures to support organizations providing shelter for the migrants in Belarus, while airlines and governments in the source countries were pressured to restrict flights to Minsk and started repatriating part of the migrants.

Causing a nuisance

‘Operation Gateway’ – the outline of which was allegedly drawn several years ago and tested by Russia in 2016 at its own borders with Norway and Finland – certainly caused a nuisance, but it ultimately backfired as Lukashenka now has to manage the remaining 2,000-5,000 migrants who refused to be flown back, as well as facing increased international sanctions. However, the fact that Angela Merkel had to personally call him made it look as if Lukashenka did not back down for nothing.

The EU and NATO, including the UK, only reacted collectively to this crisis once it was already out of hand, leaving questions over whether this experience of Lukashenka’s dictaplomacy is a wake-up call to boost resilience against rogue warfare, and to upgrade strategic assessments of the ‘Lukashenka problem’ too.

Back in June, the Belarus ministry of foreign affairs (MFA) announced its withdrawal from the Eastern Partnership and the visa facilitation and readmission agreement with the EU, while Lithuania sent early warnings about a ‘hybrid attack’ at its own border with Belarus. In August, Der Spiegel reported details of an alleged smuggling scheme whereby Tsentr Kurort – a company closely linked to the Administration of the President of Belarus with offices in the Middle East – was handling the shipping, accommodation, and relocation of migrants.

The smuggling of migrants was entirely predictable as Lukashenka has hinted many times Belarus could stop ‘protecting the EU from armed migrants’ seeking to enter it illegally. He has upped his rhetoric beyond notions of hybrid warfare by saying he needs Russian nuclear-capable bombers to ‘help him navigate the migrant crisis’, even hinting Belarus could station both Russian nuclear weapons and S-400 anti-aircraft missile systems. This shows Lukashenka is feeling increasingly cornered – which could lead to more unpredictable security crises.

Russia and Belarus are deepening relations

Although there is no smoking gun pointing to direct Russian involvement in orchestrating the hybrid attack at the EU’s borders, a new step in the military rapprochement between the two countries came when Putin and Lukashenka approved a new Military Doctrine of the Union-State of Russia and Belarus – a non-public document including a joint concept of migration policy. Lukashenka has also come off the fence over Crimea by openly accepting the legality of the peninsula’s integration with Russia.

Given Russia is also sabre-rattling over Ukraine, the risk of an accidental escalation into armed conflict is increasing in what feels like a return to classic Cold War logic, with the difference that the East is now offensively using the South for confronting the West. In recognition of the threat, the UK has joined the US, Canada, and the EU in the fresh sanctions on Belarus.

Private prison stocks soared Monday after President-elect Donald Trump announced immigration hardliner Tom Homan as the nation's next "border czar." GeoGroup jumped 4.5%, while CoreCivic increased 6.3%.

Oil giant Shell emerged victorious Tuesday from a Dutch court where it was appealing a ruling ordering it to slash its global carbon emissions by 45% by the end of the decade in line with the Paris climate agreement.

Canada ordered striking dock workers back to the ports of Vancouver, Prince Rupert and Montreal on Tuesday to clear out more than a week of container congestion bound for the United States and Canada.

Oil giant Shell emerged victorious Tuesday from a Dutch court where it was appealing a ruling ordering it to slash its global carbon emissions by 45% by the end of the decade in line with the Paris climate agreement.

The Pentagon on Monday ordered all Department of Defense civilian employees to be fully vaccinated against COVID-19 by no later than Nov. 22.

Researchers have a clearer picture than ever before of how common conditions that involve aggressive behavior emerge and how treatment can help

Private prison stocks soared Monday after President-elect Donald Trump announced immigration hardliner Tom Homan as the nation's next "border czar." GeoGroup jumped 4.5%, while CoreCivic increased 6.3%.

Canada ordered striking dock workers back to the ports of Vancouver, Prince Rupert and Montreal on Tuesday to clear out more than a week of container congestion bound for the United States and Canada.

Although common ‘disorders’ (e.g., eating disorders, anxiety, and depression) look different on the surface, there are some common underlying mechanisms. One of these is checking. I’m going to go explain the role of checking in a selection of common mental health problems. Checking in Health Anxiety Examples: – Person goes to the Dr for blood […]

The post CBT: How Checking Contributes to Mental Health Problems (Eating Disorders, Depression, Anxiety) appeared first on Dr Alice Boyes.

Gov. Kate Brown ordered the public release of annual school performance ratings last week after Oregon's biggest newspaper reported that a Brown appointee had delayed the release of the statistical rankings until after the high-stakes gubernatorial election Nov. 6.

"We have a responsibility to save lives," Ohio Gov. Mike DeWine said on Twitter. "We could have waited to close schools, but based on advice from health experts, this is the time to do it."

Kentucky Attorney General Daniel Cameron has joined a private school in a lawsuit against Gov. Andy Beshear, arguing that a school closure order not only violated state law but also the First Amendment.

The injunction would have let private religious schools reopen despite the governor's order barring in-person instruction.

Danville Christian Academy is seeking emergency relief from the COVID-19 closure order after losing in federal appeals court.

Kentucky Attorney General Daniel Cameron has joined a private school in a lawsuit against Gov. Andy Beshear, arguing that a school closure order not only violated state law but also the First Amendment.

Dougherty County, a largely black school district in an region heavily affected by coronavirus, is no longer subject to desegregation orders first imposed in 1963.

Challengers of state executive orders, to open schools for in-person instruction in some places and keep them closed in others, are having difficulty getting meaningful relief from the courts.

Yang Hu
Feb 24, 2021; 41:1699-1715
BehavioralSystemsCognitive

Bruce S. McEwen
Jan 2, 2020; 40:12-21
Viewpoints

Evdokia Menelaou
Aug 8, 2012; 32:10925-10939
BehavioralSystemsCognitive

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the effects of PDE4B variation on phenotypes with translational relevance to psychiatric disorders, we focused on PDE4B missense variant M220T, which is present in the human genome as rare coding variant rs775201287. When expressed in HEK-293 cells, PDE4B1-M220T exhibited an attenuated response to a forskolin-elicited increase in the intracellular cAMP concentration. In behavioral tests, homozygous Pde4b^M220T male mice with a C57BL/6JJcl background exhibited increased reactivity to novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditioning, and enhanced spatial memory, accompanied by an increase in cAMP signaling pathway-regulated expression of BDNF in the hippocampus. In response to a traumatic event (10 tone–shock pairings), neuronal activity was decreased in the cortex but enhanced in the amygdala and hippocampus of Pde4b^M220T mice. At 24 h post-trauma, Pde4b^M220T mice exhibited increased startle hyperreactivity and decreased plasma corticosterone levels, similar to phenotypes exhibited by PTSD patients. Trauma-exposed Pde4b^M220T mice also exhibited a slower decay in freezing at 15 and 30 d post-trauma, demonstrating enhanced persistence of traumatic memories, similar to that exhibited by PTSD patients. These findings provide substantive mouse model evidence linking PDE4B variation to PTSD-relevant phenotypes and thus highlight how genetic variation of PDE4B may contribute to PTSD risk.

Plasticity in the subcortical motor basal ganglia–thalamo–cerebellar network plays a key role in the acquisition and control of long-term memory for new procedural skills, from the formation of population trajectories controlling trained motor skills in the striatum to the adaptation of sensorimotor maps in the cerebellum. However, recent findings demonstrate the involvement of a wider cortical and subcortical brain network in the consolidation and control of well-trained actions, including a brain region traditionally associated with declarative memory—the hippocampus. Here, we probe which role these subcortical areas play in skilled motor sequence control, from sequence feature selection during planning to their integration during sequence execution. An fMRI dataset (N = 24; 14 females) collected after participants learnt to produce four finger press sequences entirely from memory with high movement and timing accuracy over several days was examined for both changes in BOLD activity and their informational content in subcortical regions of interest. Although there was a widespread activity increase in effector-related striatal, thalamic, and cerebellar regions, in particular during sequence execution, the associated activity did not contain information on the motor sequence identity. In contrast, hippocampal activity increased during planning and predicted the order of the upcoming sequence of movements. Our findings suggest that the hippocampus preorders movements for skilled action sequences, thus contributing to the higher-order control of skilled movements that require flexible retrieval. These findings challenge the traditional taxonomy of episodic and procedural memory and carry implications for the rehabilitation of individuals with neurodegenerative disorders.

Yukon appeal court Justice Karen Horsman granted a temporary stay of the requirement on Friday, the latest development in an ongoing legal battle over the property between the territorial government, cabin-owner Len Tarka and tenant Eric DeLong. 

The president of the Canadian Japanese Cultural Centre of Hamilton is Mitchell Akira Kawasaki — an Olympian, judo master, on-call mail carrier and recent recipient of an award from the Japanese government.

Nulaid owner Quantum Foods has been ordered to reinstate a nonexecutive director it removed after requesting to see the legal advice it relied on in refusing a shareholders' meeting request for board changes.

Marloes Achterveld, from the Netherlands, shares about falling in love with the people of Curarrehue in southern Chile during OM Chile's Intensive Missions Training.

The US order, which is being reported for the first time, comes just weeks after TSMC notified the Commerce Department that one of its chips had been found in a Huawei AI processor, as Reuters reported last month.

Series of changes come after reports of Highmark premium notice errors Dozens of complaints have been registered with the Delaware Department of Insurance after Highmark Blue Cross Blue Shield processed hundreds of customer birthdates incorrectly, leading to notices of higher July 1 premiums for many Medicare Supplement participants, including those in the company’s Medigap Blue […]

In early October, Deepinder Goyal shared a post showing various moments from their day as delivery agents

The viral video of ice cube pakoras has received 6.2 million views.

DOVER – Revenue from a new opioid impact fee created by the Delaware General Assembly in 2019 will be used to prevent overdose deaths and provide new services to those seeking treatment for their substance use disorder, the Delaware Department of Health and Social Services (DHSS) and Sen. Stephanie Hansen announced Wednesday. DHSS Secretary Molly […]

Delaware Secretary of State Jeff Bullock has placed xylazine, also known as “Tranq”— a non-opioid drug used primarily in veterinary medicine—in Schedule III of the Uniform Controlled Substance Act. Tranq has been used increasingly as an additive in opioid abuse to create a “zombie-like” condition for users. Secretary Bullock’s actions follow a recommendation from the […]

Pursuant to 29 Del.C. §10119(3), Delaware Secretary of State Jeff Bullock has renewed an Emergency Order placing xylazine, also known as “Tranq”, temporarily in Schedule III in the state of Delaware. The Emergency Order took effect June 2, 2023, and was effective 120 days. The public threat posed by xylazine continues. Therefore, the renewal of […]

Attorney General Kathy Jennings released the following statement regarding Governor Carney’s announcement of a forthcoming executive order on police reform: Governor Carney demonstrated real leadership today. Banning chokeholds, ending the practice of ruining kids’ lives by posting their mugshots online while they are presumed innocent, participating in the national use-of-force database, and implementing greater officer […]

Comes after initiating joint effort with federal and state partners Attorney General Kathy Jennings announced today that, due to the work of her office, along with the federal Consumer Protection Financial Bureau and 11 other states, a Delaware bankruptcy court approved a stipulated judgment that will require bankrupt student lender Prehired to provide more than […]

Members will submit recommendations to the Governor, Legislature and Criminal Justice Council by March 2018 WILMINGTON, Del. – Governor John Carney on Wednesday released the following statement after signing Executive Order #11 to reestablish the Juvenile Justice Advisory Group, which will examine ways to prevent youth from entering or re-entering the juvenile and criminal justice […]

Members of the Delaware Nutrient Management Commission approved an emergency order during their October 4 meeting to allow for a 180-day extension for properly staged poultry litter in Delaware Crop fields beginning on November 1.

In observance of National Pearl Harbor Remembrance Day, a time to honor the patriots who perished, commemorate the valor of all those who defended our Nation, and recommit ourselves to carrying forth the ensuing peace and reconciliation that brought a better future for our world, Governor Carney in conjunction with President Biden, has ordered both […]

President Biden ordered flags at all U.S. government buildings and facilities to be flown at half-staff until sunset on May 16, 2022 in memory of the more than 1 million Americans who have died from COVID-19.

As a mark of respect for the victims of the senseless acts of violence perpetrated on May 6, 2023, in Allen, Texas, and in concurrence with the President Biden’s order, Governor John Carney has ordered both the U.S. and Delaware flags at state buildings and facilities be flown at half-staff until sunset on May 11, 2023.