By Matt Solomon Published: November 12th, 2024

Pioneering Indian Muslim feminist Rokeya Sakhawat Hossain (1880-1932) wrote speculative science fiction, manifestoes, radical reportage, and incisive essays that transformed her experience of enforced segregation into unique interventions against gender oppression everywhere. Her radical imagination links the realities of living in a British colony to the technological and scientific breakthroughs of her time, the effects of hauntingly pervasive systems of sexual domination, and collective dreams of the future, forging a visionary, experimental body of work. If her contemporary B. R. Ambedkar urged the “annihilation of caste,” Rokeya demands nothing less than the annihilation of sexism, with education as the primary instrument of this revolution. Her brilliant wit and creativity reflect profoundly on the complexities of undoing deep-seated gender supremacy and summon her readers to imagine hitherto undreamed freedoms.

Samantha Harvey has won the 2024 Booker Prize for her science fiction novel Orbital. The novel follows six international astronauts as they orbit the Earth for one day of their nine-month space mission.

Director Wendy Sachs attributes the steep rise in antisemitism to social media, from where so many young people get news that has no validation.

The following article, The Public Has Spoken: Kamala Harris Has No Chance, was first published on The Black Sphere.

Who would have believed that the public would revolt so heavily on this issue, particularly given how much effort Democrats have put into shutting us down...

Continue reading The Public Has Spoken: Kamala Harris Has No Chance ...

The following article, BROKE: Kamala Harris the Overdraft Queen, was first published on The Black Sphere.

Not only has her presidential run tanked, but so has her credit score. "I'll take 'Now I know Kamala is Black for $2000', Alex"!

Continue reading BROKE: Kamala Harris the Overdraft Queen ...

By Jason Cohen NewsNation host Chris Cuomo argued Thursday that President-elect Donald Trump defeated Vice President Kamala Harris because of voter backlash against excessive liberal ideology. Trump’s election victory was fueled partly by increased support from Hispanic and black men. Cuomo, on “The Chris Cuomo Project,” suggested voters cast their ballots for Trump over Harris based on “a gross […]

The post Chris Cuomo Says Trump Won Because Of ‘Wokeism Run Amok’ appeared first on Liberty Unyielding.

From rejection at Benfica to new Manchester United head coach, BBC Sport charts the rise of Ruben Amorim.

The government wants to create a smoke-free generation and restrict the sale and marketing of vapes.

They are accused of hate speech as rights groups say the law is being used to restrict freedoms.

Delhi woke up to a thick layer of smog on Wednesday morning as pollution levels soared in the city.

Former referee Rebecca Welch talks to BBC Sport's Emma Sanders after being inducted into the Hall of Fame at the National Football Museum.

1. Pakistani TikToker Imsha Rehman deactivates social media accounts after explicit video leaked online  Hindustan Times
2. Pakistani Influencer Imsha Rehman Deactivates Social Media Accounts After Private Video Leaks  NDTV
3. Now Pakistani TikToker Imsha Rehman’s alleged obscene video leaked online  The Times of India
4. After Minahil Malik, another Pakistani TikTok star Imsha Rehman’s X-rated video goes viral; here's how she  The Economic Times
5. Imsha Rehman viral video: Why Pakistani TikToker has deactivated her account? What’s there in the ‘explicit’ clip?  Mint

"I realised I could sustain the writing life, whether anyone reads it or not. It’s what separates writers from civilians. It’s probably a mental disorder."

Samantha Harvey's Orbital wins the Booker Prize. The 136-page space novel explores astronauts' reflections on Earth, touching on mourning, desire, and the climate crisis.

In some parts of the capital, protesters negotiated with police. In other parts there was no talking.

A couple weeks ago, my pals at Twitter were kind enough to invite me in to visit with their (rapidly growing) team. The topic was meetings, so I used it as an opportunity to publicly premiere a talk I've been presenting to private clients over the past few months.

I hope you'll enjoy, Broken Meetings (and how you'll fix them).

Slides:

Supplementary links and commentary forthcoming, but I wanted to go ahead and post the talk as quickly as the video was available. Special thanks to Michelle, Jeremy, and the crackerjack Twitter crew for a swell afternoon.

I really like this talk and sincerely hope you will find it useful in helping to un-break your own meetings.

One of the best parts about the first days after a Trump win is how the left has begun to devour themselves.

The post WATCH: Carville Has NO ‘Effs’ Left To Give — Blasts ‘Woke’ In Epic ‘I Told You So’ Rant appeared first on Clash Daily.

Expert

Myosins generate force and motion by precisely coordinating their mechanical and chemical cycles, but the nature and timing of this coordination remains controversial. We utilized a FRET approach to examine the kinetics of structural changes in the force-generating lever arm in myosin V. We directly compared the FRET results with single-molecule mechanical events examined by optical trapping. We introduced a mutation (S217A) in the conserved switch I region of the active site to examine how myosin couples structural changes in the actin- and nucleotide-binding regions with force generation. Specifically, S217A enhanced the maximum rate of lever arm priming (recovery stroke) while slowing ATP hydrolysis, demonstrating that it uncouples these two steps. We determined that the mutation dramatically slows both actin-induced rotation of the lever arm (power stroke) and phosphate release (≥10-fold), whereas our simulations suggest that the maximum rate of both steps is unchanged by the mutation. Time-resolved FRET revealed that the structure of the pre– and post–power stroke conformations and mole fractions of these conformations were not altered by the mutation. Optical trapping results demonstrated that S217A does not dramatically alter unitary displacements or slow the working stroke rate constant, consistent with the mutation disrupting an actin-induced conformational change prior to the power stroke. We propose that communication between the actin- and nucleotide-binding regions of myosin assures a proper actin-binding interface and active site have formed before producing a power stroke. Variability in this coupling is likely crucial for mediating motor-based functions such as muscle contraction and intracellular transport.

Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane-bound glycoproteins and proteoglycans that covers the lumen of endothelial cells, functions as a barrier to circulating cells, the relationship between stroke severity and glycocalyx dysfunction remains unclear. In this study, glycosaminoglycans, a component of the endothelial glycocalyx, were studied in the context of ischemic stroke using a photochemically induced thrombosis mouse model. Decreased levels of heparan sulfate and chondroitin sulfate and increased activity of hyaluronidase 1 and heparanase (HPSE) were observed in ischemic brain tissues. HPSE expression in cerebral vessels increased after stroke onset and infarct volume greatly decreased after co-administration of N-acetylcysteine + glycosaminoglycan oligosaccharides as compared with N-acetylcysteine administration alone. These results suggest that the endothelial glycocalyx was injured after the onset of stroke. Interestingly, scission activity of proHPSE produced by immortalized endothelial cells and HEK293 cells transfected with hHPSE1 cDNA were activated by acrolein (ACR) exposure. We identified the ACR-modified amino acid residues of proHPSE using nano LC–MS/MS, suggesting that ACR modification of Lys139 (6-kDa linker), Lys107, and Lys161, located in the immediate vicinity of the 6-kDa linker, at least in part is attributed to the activation of proHPSE. Because proHPSE, but not HPSE, localizes outside cells by binding with heparan sulfate proteoglycans, ACR-modified proHPSE represents a promising target to protect the endothelial glycocalyx.

14 September 2020

Culture notes: Europe's broken promises to Africa The World Today mhiggins.drupal 1 August 2022

Europe’s ‘gas grab’ in Africa is just the latest abuse of its relationship with the continent, says Catherine Fieschi.

When Emmanuel Macron made one of his first visits to Africa as France’s recently elected young president in 2017, his speech at Ouagadougou University in Burkina Faso was designed to set the tone for a new relationship between his country and African countries. 

‘There no longer is a French policy for Africa,’ he said.

This was a signal away from ‘la Françafrique’, with its post-colonial accents and the propping up of regimes friendly to France, to something that was more strategic, equitable and transparent – more partnership and less tutelage. 

And Europe seemed to be following suit. In March 2020 the European Union and Africa decided that they would redefine their relationship. The European Commission unveiled its vision for a ‘comprehensive strategy with Africa’. The roadmap would give Africa significantly more say over the nature and extent of the relationship, more choice and more political agency.

But what, today, is left of these aspirations? Despite repeated statements, Europe seems to be saying one thing and doing another. 

Earlier this year, after the long-awaited 6th annual EU-African Union summit in Brussels, South African president Cyril Ramaphosa was frank when he summed up the gap between stated ambitions and the current relationship. The pandemic-weary Global South had reason to be wary. Ramaphosa laid out missed opportunities, disappointment and the low expectations that act as self-fulfilling prophecies. 

Europe’s changing focus in Africa 

From the apparent high point of the Ouagadougou speech, Macron has now turned to the Organization Internationale de la Francophonie (OIF) in Africa for geopolitical purposes. His primary aim is to combat the rise of Islamist militants and terrorism in the Sahel as well as to tackle the growing influence of China and Russia in the region. 

Russian inroads – via the security firm Wagner in Mali, for instance – have given France further cause to use the OIF to counter destabilization activities. Both the United Kingdom and France train African military in the Sahel, but now, with the end of France’s anti-insurgent Operation Barkhane in Mali, the subsequent withdrawal of French troops and the increasingly established presence of the Wagner group, the security situation in the region is expected to deteriorate dramatically and become increasingly impermeable to European interests and forces.

As for development aid, Britain’s Integrated Review of Security, Defence, Development and Foreign Policy makes no bones about the fact that Asia is now a priority over Africa.

The relationship between Africa and Britain is being transformed as a result, most obviously through the cuts in development aid, with African aid cut by 66 per cent in 2021. But the nature of the relationship, which has become both more conditional and more transactional, has also changed. 

The UK is emphasizing human rights and ‘free societies’, but also pushing for free market principles rather than the kind of state involvement that some African countries often prefer as a road to accelerated and more autonomous development. 

The future of energy exports and COP27

The issue of energy exports points to what will most likely trigger the greatest disappointment in the next few years – climate and climate finance. 

Green energy deals, like the $8.5 billion COP26 package from the EU, United States and UK to South Africa, look far more problematic now in the light of Europe’s African gas-grab. Indeed, Europe is importing as much African gas as it can after the invasion of Ukraine by Russia reduced supplies. Yet African countries are still being told to curb their own use of ‘dirty’ energy. 

As an illustration, Nigeria holds 3 per cent of the world’s gas reserves, but has barely tapped them, while 40 per cent of its output is exported to Europe. In April, Italy closed deals to buy gas from Angola and the Republic of Congo, while Germany did the same with Senegal.
 

At COP15 in Copenhagen in 2009, developed countries pledged an annual $100 billion in climate finance to developing countries for both adaptation and mitigation. But pledges have never really materialized. The aid agency Oxfam estimates that only about a third of the money has been delivered. Climate finance was again the main focus of COP26 – and dismissed by Greta Thunberg as more ‘blah, blah, blah’.

This series of repeated resets, pledges and disappointments tells a story – indeed, several stories. First and foremost, it is one of arrogance and betrayal. That much is obvious. But it is also a story about stories – about how the narratives elaborated by various European countries and leaders never amount to more than a sum of transactions. 

Climate change places Europe, and other rich nations, at a crossroads in its relationship with Africa: the former holds the wealth, but also some of the keys and threats to the transition. COP27, to be held in Egypt in November, will be the next chapter in the story. 

Africa’s maritime agency cannot be overlooked Expert comment LJefferson 3 November 2022

Increasing maritime awareness has already delivered impact, but consistency and continental leadership are needed to realize the sector’s full potential.

Africa’s 48,000 kilometres of coastline, shared among 38 coastal states, are resource rich and hold some of the world’s most strategic sea lanes, including the approaches to the Suez Canal, which carries 12 per cent of worldwide trade, and the Gulf of Guinea, a critical route for global energy. But despite the vast potential this represents, piracy and maritime insecurity have dominated the narrative of Africa’s coasts, and further propagated the image of African states as beholden to external intervention.

Yet African agency is established and evolving in the sector, with African littoral states enhancing their capacity to face collective security threats and exercising increasing autonomy in responding to the recent rush of external actors looking for port facilities and military bases. Enhanced continental coordination, consistency and leadership can help Africa’s maritime endowment become a resource that can bring sustainable benefit across the continent.  

Agency beyond piracy: the Gulf of Aden and Western Indian Ocean

Piracy became the dominant frame of reference for the East African maritime space as a result of the crisis off the coast of Somalia, which peaked between 2008 and 2012. In 2008, the UN Security Council (UNSC) took the unprecedented step of authorizing international naval operations in Somali territorial waters, contributing to a gradual reduction in attacks. There have been no successful hijackings reported since 2017.

But progress has not just been down to international assistance. Somalia is prioritizing increased domestic enforcement capacity – as demonstrated in the establishment of  a new specialized maritime unit and the wider region enhanced collaboration and information sharing through the Djibouti Code of Conduct of 2009, amended in 2017.

South Africa’s recent admission as a new signatory demonstrates its continued relevance. In March 2022, the UNSC authorization lapsed, following pressure from the Somali government. Although it is not yet clear whether Somali efforts will be sufficient to repress piracy in the long term, this reverse was a clear statement of Somalia’s agency at a level unthinkable during the outset of the crisis.

As the immediate threat of piracy has quietened, broader geopolitical dynamics have come to the fore, notably in a surge by external actors to establish strategic ports and military bases. Here too, African states have demonstrated enhanced agency, for better or worse. Consider Djibouti’s unilateral seizure of a container terminal from an Emirati firm, Sudan’s review of Russian and Turkish deals for maritime facilities, Tanzania’s rejection of a Chinese-led port investment, or the Seychelles withdrawing agreement for an Indian naval base.

Such examples point to a growing awareness of the value of maritime resources within African states, alongside a willingness and ability to push back against external imposition – and indeed to innovate in finding solutions beyond infrastructure and ‘hard’ security. In 2018, the Seychelles launched the world’s first sovereign blue bond to fund sustainable marine projects. That other countries are seeking to replicate this model points to the potentially global impact of African leadership on maritime issues.

Regional cooperation or competition in the Gulf of Guinea?

The Gulf of Guinea is likewise resource rich and geographically strategic, and has faced diverse maritime security threats including piracy, smuggling, illegal fishing, oil theft and pollution. Gulf of Guinea states put in place several initiatives to promote security, including the Yaoundé Code of Conduct (YCoC), signed by 25 states in 2013, that led to information-sharing and cooperation on interdiction, investigation and prosecution. But crime in the Gulf of Guinea nonetheless reached an all-time high in 2020, suffering 130 of the 135 maritime kidnappings recorded worldwide, due to the non-binding nature of the YCoC and gaps in capacity and finance.

Though external actors have become increasingly engaged, including the EU, US, France, Denmark, and the G7++ Group of Friends of the Gulf of Guinea (FOGG), states within the region, especially those most affected by piracy and armed robbery, have nonetheless demonstrated leadership. Nigeria, Ghana, and Cote D’Ivoire have all developed maritime security strategies; Nigeria launched its Deep Blue Project to secure Nigerian waters; Ghana has strengthened its navy; and Togo has changed its laws and judicial system to allow the arrest and prosecution of ships and persons. Maritime security incidents have consequently reduced in 2022.

Alba Simats
Dec 1, 2020; 19:1921-1935
Research

Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures in the hyper-acute phase of ischemic stroke is still a primary interest for translational research on stroke diagnosis, prognosis, and treatment. Data integration from high-throughput -omics techniques has become crucial to unraveling key interactions among different molecular elements in complex biological contexts, such as ischemic stroke. Thus, we used advanced data integration methods for a multi-level joint analysis of transcriptomics and proteomics data sets obtained from mouse brains at 2 h after cerebral ischemia. By modeling net-like correlation structures, we identified an integrated network of genes and proteins that are differentially expressed at a very early stage after stroke. We validated 10 of these deregulated elements in acute stroke, and changes in their expression pattern over time after cerebral ischemia were described. Of these, CLDN20, GADD45G, RGS2, BAG5, and CTNND2 were next evaluated as blood biomarkers of cerebral ischemia in mice and human blood samples, which were obtained from stroke patients and patients presenting stroke-mimicking conditions. Our findings indicate that CTNND2 levels in blood might potentially be useful for distinguishing ischemic strokes from stroke-mimicking conditions in the hyper-acute phase of the disease. Furthermore, circulating GADD45G content within the first 6 h after stroke could also play a key role in predicting poor outcomes in stroke patients. For the first time, we have used an integrative biostatistical approach to elucidate key molecules in the initial stages of stroke pathophysiology and highlight new notable molecules that might be further considered as blood biomarkers of ischemic stroke.

Amid a mounting mental health crisis among farmers, experts are working to make help more accessible

The nation's depleted supply of IV solutions is recovering after a North Carolina facility recently resumed production after Hurricane Helene temporarily put it out of business.

Nov. 8, 2024 — Barcelona Supercomputing Center‘s Innostroke project aims to transform the prevention and monitoring of stroke, one of the leading causes of death and disability worldwide, through artificial […]

The post BSC Develops AI Model to Predict Stroke Risk Using Mobile Devices appeared first on HPCwire.

Peacock anounced four more guest stars for "Poker Face" Season 2 on Tuesday, though no premiere date yet.

We can blame capitalism for worsening the climate crisis, says journalist Akshat Rathi, but we can also use it to create the solutions we need for the mess we're in. He details how “climate capitalism” — the strategic use of market forces and government policies to make polluting the planet cost more than advancing climate solutions — can flip the script and actually make sustainability profitable.

In states like Georgia, the push to empower the youth vote comes to fruition at a time when “every vote counts” is more than just a slogan.

The Christie administration is arguing that the only way to improve education in the state's poorest districts is to ditch teacher job protections.

In states like Georgia, the push to empower the youth vote comes to fruition at a time when “every vote counts” is more than just a slogan.

Caroline Fenton & Jason Fitz react to the second edition of the 2024 College Football Playoff Rankings, discuss Heisman pretenders vs. contenders and preview the biggest matchups of Week 12.

It is well established that holding information in working memory (WM) elicits sustained stimulus-specific patterns of neural activity. Nevertheless, here we provide evidence for a distinct class of neural activity that tracks the number of individuated items in working memory, independent of the type of visual features stored. We present two EEG studies of young adults of both sexes that provide robust evidence for a signal tracking the number of individuated representations in working memory, regardless of the specific feature values stored. In Study 1, subjects maintained either colors or orientations across separate blocks in a single session. We found near-perfect generalization of the load signal between these two conditions, despite being able to simultaneously decode which feature had been voluntarily stored. In Study 2, participants attended to two features with very distinct cortical representations: color and motion coherence. We again found evidence for a neural load signal that robustly generalized across these distinct visual features, even though cortically disparate regions process color and motion coherence. Moreover, representational similarity analysis provided converging evidence for a content-independent load signal, while simultaneously showing that unique variance in EEG activity tracked the specific features that were stored. We posit that this load signal reflects a content-independent "pointer" operation that binds objects to the current context while parallel but distinct neural signals represent the features that are stored for each item in memory.

From the microwave to the food processor, the book author and television personality tried many appliances and devices to figure out the best ways to use them for her audience

In 1918, Lulu Hunt Peters—one of the first women in America to earn a medical doctorate—published the best seller Diet and Health With Key to the Calories, making a name for herself as an apostle for weight reduction in an era when malnutrition was a far greater public health threat than obesity. She pioneered the idea of measuring food intake via the calorie, which at the time was an obscure unit of measurement familiar only to chemists.  A century later, the Centers for Disease Control and Prevention reports (https://www.cdc.gov/nchs/products/databriefs/db360.htm) that 42 percent of American adults are clinically obese and that Type 2 diabetes is on the rise (https://www.cdc.gov/media/releases/2022/p1229-future-diabetes-surge.html) . With those who can afford it now turning to pharmaceuticals to help them lose weight, we’ll examine why and how calorie counting has failed to help Americans maintain a “healthy” weight.  In this episode of “There’s More to That,” we hear from food historian Michelle Stacey about Peters’ legacy—and from Ronald Young Jr., creator and host of the critically acclaimed podcast “Weight For It (https://www.radiotopia.fm/podcasts/weight-for-it) ,” about how American society continues to stigmatize what he calls “fat folks” for reasons that have nothing to do with public, or even individual, health. A transcript is below. To subscribe to “There’s More to That,” and to listen to past episodes on the complex legacy of Sojourner Truth (https://www.smithsonianmag.com/history/how-to-separate-fact-from-myth-in-the-extraordinary-story-of-sojourner-truth-180983820/) , how Joan Baez opened the door for Taylor Swift (https://www.smithsonianmag.com/arts-culture/before-beyonce-taylor-swift-ran-world-joan-baez-180983893/) , how machine learning is helping archeologists to read scrolls (https://www.smithsonianmag.com/history/how-artificial-intelligence-is-making-2000-year-old-scrolls-readable-again-180984264/) buried by the eruption of Mount Vesuvius nearly 2,000 years ago and more, find us on Apple Podcasts (https://podcasts.apple.com/us/podcast/theres-more-to-that/id1694965155?ign-itscg=30200&ign-itsct=podcast_box_player) , Spotify (https://open.spotify.com/show/4NYRCRxkYJTLjW71sqYOFv?si=08fa62c3e59d450f&nd=1) or wherever you get your podcasts. Read Michelle Stacey's story about Dr. Lulu Hunt Peters in the June 2024 issue of Smithsonian here (https://www.smithsonianmag.com/science-nature/doctor-pioneered-counting-calories-century-ago-were-still-dealing-with-consequences-180984282/) . Listen to Ronald Young, Jr.'s podcast "Weight For It" here (https://www.radiotopia.fm/podcasts/weight-for-it) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Rye Dorsey, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

Richard Saul Wurman, the founder of the popular speaker series, shares his ideas for how to make learning more interesting