Over a dozen flights cancelled or delayed between Bali and Australia

A UN agency verified victims from a six-month period and said it found international law violations.

Dozens of videos involving a senior civil servant in Equatorial Guinea have flooded social media, shocking people in the country.

A tech recruiting firm left a database unsecured that exposed emails, passport numbers and partial SSNs of job seekers, a security researcher says.

Nintendo has offered an early look at the Donkey Kong expansion to Super Nintendo World in Japan’s Universal Studios. Following… Continue reading Sneak peek at Super Nintendo World expansion

The post Sneak peek at Super Nintendo World expansion appeared first on ReadWrite.

Continuing to set records, Pepe Unchained recently achieved a new milestone after reaching $26 million. The project’s presale has now… Continue reading As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU

The post As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU appeared first on ReadWrite.

The near death and uncertain future of the US National Security Council 27 January 2023 — 9:00AM TO 10:00AM Anonymous (not verified) 9 January 2023 Chatham House

What role should the US National Security Council play in an era of great power competition?

Please plan to arrive at Chatham House from 08:45 GMT as the event will begin promptly at 09:00 GMT

Over the last three years, the US National Security Council (NSC) has gone from being neglected to necessary again, in Washington.

After former US President Donald Trump ignored and then tried to dismantle the NSC, current US President Joe Biden has restored the body but chosen not to reform it.

Born in the days before the Cold War and empowered during the War on Terror, what role should the NSC play in an era of great power competition?

Plus, how must it, and the rest of Washington, evolve to meet the challenges and opportunities that remain in the 21st century?

Expert

Constantin Carle and Marlis Hochbruck
Math. Comp. 93 (), 2611-2641.
Abstract, references and article information

Shoham Letzter
Trans. Amer. Math. Soc. 377 (), 5583-5615.
Abstract, references and article information

Anh Tuan Nguyen, Tómas Caraballo and Nguyen Huy Tuan
Proc. Amer. Math. Soc. 152 (), 5175-5189.
Abstract, references and article information

Rubén Medina and Andrés Quilis
Proc. Amer. Math. Soc. 152 (), 5137-5148.
Abstract, references and article information

Alin Bostan, Xavier Caruso and Julien Roques
Bull. Amer. Math. Soc. 61 (), 609-658.
Abstract, references and article information

An out-of-body experience is the inspiration behind Benzly Hype's latest album Star Its The 7th Year. Released on November 7, the entertainer said the project was done to bring back joy in music and will leave its listeners in an upbeat mood....

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK consists of three subunits: α, β, and γ. AMPKα and β are encoded by two genes, the γ subunit by three genes, all of which are expressed in a tissue-specific manner. It is not fully understood, whether individual isoforms have different functions. Using RNA-Seq technology, we provide evidence that the loss of AMPKβ1 and AMPKβ2 lead to different gene expression profiles in human induced pluripotent stem cells (hiPSCs), indicating isoform-specific function. The knockout of AMPKβ2 was associated with a higher number of differentially regulated genes than the deletion of AMPKβ1, suggesting that AMPKβ2 has a more comprehensive impact on the transcriptome. Bioinformatics analysis identified cell differentiation as one biological function being specifically associated with AMPKβ2. Correspondingly, the two isoforms differentially affected lineage decision toward a cardiac cell fate. Although the lack of PRKAB1 impacted differentiation into cardiomyocytes only at late stages of cardiac maturation, the availability of PRKAB2 was indispensable for mesoderm specification as shown by gene expression analysis and histochemical staining for cardiac lineage markers such as cTnT, GATA4, and NKX2.5. Ultimately, the lack of AMPKβ1 impairs, whereas deficiency of AMPKβ2 abrogates differentiation into cardiomyocytes. Finally, we demonstrate that AMPK affects cellular physiology by engaging in the regulation of hiPSC transcription in an isoform-specific manner, providing the basis for further investigations elucidating the role of dedicated AMPK subunits in the modulation of gene expression.

The cornea is densely innervated, mainly by sensory nerves of the ophthalmic branch of the trigeminal ganglia (TG). These nerves  are important to maintain corneal homeostasis, and nerve damage can lead to a decrease in wound healing, an increase in corneal ulceration and dry eye disease (DED), and neuropathic pain. Pathologies, such as diabetes, aging, viral and bacterial infection, as well as  prolonged use of contact lenses and surgeries to correct vision can produce nerve damage. There are no effective therapies to alleviate DED (a multifunctional disease) and several clinical trials using -3 supplementation show unclear and sometimes negative results. Using animal models of corneal nerve damage, we show that treating corneas with pigment epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA) increases nerve regeneration, wound healing, and tear secretion. The mechanism involves the activation of a calcium-independent phospholipase A2 (iPLA2) that releases the incorporated DHA from phospholipids and enhances the synthesis of docosanoids neuroprotectin D1 (NPD1) and a new resolvin stereoisomer  RvD6i. NPD1 stimulates the synthesis of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and of semaphorin 7A (Sema7A).  RvD6i treatment of injured corneas modulates gene expression in the TG resulting in enhanced neurogenesis; decreased neuropathic pain and increased sensitivity. Taken together, these results represent a promising therapeutic option to re-establish the homeostasis of the cornea.

Amazon Prime Air drone deliveries are underway and delivering small packages within an hour in the West Valley of the Phoenix metro area.

Costco voluntarily recalled 79,200 pounds of two types of its store-brand butter over the past month because their labels may not have said the products contain milk.

Costco voluntarily recalled 79,200 pounds of two types of its store-brand butter over the past month because their labels may not have said the products contain milk.

MILAN, Nov. 6, 2024 — ENEA, Italy’s National Agency for New Technologies, Energy and Sustainable Economic Development, has selected Lenovo for the installation of an HPC system at the Portici […]

The post ENEA Chooses Lenovo for Supercomputer to Accelerate Sustainable Energy Research appeared first on HPCwire.

Montana Superintendent Elsie Arntzen offers practical advice to schools that could open as early as May 7, even as she says "how they open schools and how learning takes place is up to them."

Wayne Sanstead, who has been North Dakota's state schools superintendent for nearly three decades, has decided not to run for an eighth term this fall.

Democrat Gavin Newsom, who takes office Jan. 7, plans to expand full-day kindergarten and child-care offerings in the state, according to media reports.

A new study says that problems surrounding child-care hurt Georgia parents economically in many ways including in turned down promotions and having to cut back on work and school hours.

In the aftermath of last month’s killing of an unarmed Minneapolis man in police custody, school systems are re-examining their own contracts with local police agencies.

The district’s chief of accountability, research, and equity talks about racism, racial equity, and the district’s search for a new student-safety strategy.

In Kodiak, Alaska, a school district with deep ties to the U.S. Coast Guard has been walloped by the government shutdown with hundreds of families going without paychecks. And news of a deal to temporarily reopen the government was doing little to allay the community's anxieties.

In the aftermath of last month’s killing of an unarmed Minneapolis man in police custody, school systems are re-examining their own contracts with local police agencies.

Building on previous efforts, the Kingdom of Morocco will offer technical assistance to the Republic of Guinea through a South-South Cooperation Tripartite Agreement signed today at FAO headquarters by FAO [...]

Rome, 2 December 2014 – The Ministers of Agriculture of the European Union and of other Mediterranean countries welcomed FAO’s transformational changes implemented in the last two years, and underlined [...]

Rome, 02 March 2015 - In a letter addressed to the Director-General, the Chairperson of the Near East Regional Group has announced their endorsement of the candidature [...]

The FMM is a funding mechanism for partners willing to contribute unearmarked funds or slightly earmarked funds. Created in 2010, the FMM is currently supported by the Kingdoms of Belgium, [...]

Archaeologists in Saqqara make a dazzling discovery: a late period Egyptian coffin with a gilded mask. Now, to bring it to the surface, they use a pulley known as a "tambora," a technology that dates back to Ancient Egypt

This unmanned aerial vehicle can be launched from, and land on, a moving ship thanks to new technology Narrated by T.A. Frail Script by Brendan McCabe Video courtesy of Insitu

In this clip from the documentary, see how Cassady embodied the spirit of Jack Kerouac's iconic character from On the Road

A shipwreck discovered off New Zealand dates to a time before Cook's arrival

The discoveries include sharks, shorebirds, mammals and saber-toothed salmon, with the oldest remains dating to almost nine million years ago

New research suggests the sarcophagus' occupant, previously known only as "the horseman," is Joachim du Bellay, a French Renaissance poet who died in 1560

Experts are carefully uncovering traces of the original paint and fragments of gold leaf that once adorned the 2,000-year-old Temple of Edfu

An acoustic survey in 2018 and new analysis with A.I. suggest the sounds are vocalizations from the elusive Bryde’s whale