Leeds continues their Premier League promotion push with a dominant 4-0 win against Hull on Saturday.

Leeds manager Marcelo Bielsa has admitted that he faces a selection headache for the Whites' Championship game against Huddersfield on Saturday, and he could drop striker Patrick Bamford in favour of youngster Tyler Roberts, with the 21-year-old scoring twice against Hull last weekend.

PIERS MORGAN - a host on Good Morning Britain - issued a warning on Twitter for the public to not be "complacent' as he issued a reminder about his co-star Kate Garraway's husband Derek Draper who he said is "fighting for his life" following his hospital admission with coronavirus.

Episode five of The Last Dance proved to be an emotional watch as a never-before-seen interview with Kobe Bryant was aired.

Some ethics experts say Carmel Mayor Jim Brainard's push for coronavirus testing at Indianapolis lab Aria Diagnostics raises flags.

They've piled up more on-track success than any other drivers over the past three years. But adjusting to sim-racing has been another task entirely.

SONOMA, Calif. – The men and women who pull racing helmets over their heads are a different breed, defying speed and danger mortals cannot imagine.

Love, sadness and jealousy are all common emotions. Find out a lot more from this week's quiz.

How are you feeling? Test your knowledge of negative feelings and emotions in this week's quiz.

How are you feeling? Test your knowledge of emotional phrases and idioms in the English language.

In a tense conversation, Indianapolis Police Chief Randal Taylor speaks with Dreasjon Reed's family near where he was fatally shot by police.

Science instruments sense a big dip in seismic noise as the population stays at home.

A deceased dad in the new "Onward" echoes some of Pixar's most moving moments involving absent relatives.

Invitation Only Research Event

(Institute for Operations Research and the Management Sciences) Job performance has long been understood to be the primary equalizing factor affecting promotions for men and women in the workplace, but research shows, women don't gain as much from the same performance improvements as men do. New research in the INFORMS journal Information Systems Research shows training plays an important part in promotions for women in the field of information technology.

Respiratory motion during the CT and PET parts of a PET/CT scan leads to imperfect alignment of anatomical features seen by the two modalities. In this work, we concentrate on the effects of motion during CT. We propose a novel approach for improving the alignment. Methods: Respiratory waveform data were gathered during the CT and PET parts of 28 PET/CT scans of cancer patients with 40 lesions up to 3 cm size in the lung or upper abdomen. PET list-mode data were reconstructed by three reconstruction methods: PET/static, PET/EX or end of expiration (OncoFreeze), and a novel PET/matched method that used both waveforms. The three methods were compared. The distance between tumor positions in PET and CT were characterized in visual interpretation by physicians as well as quantitatively. Tumor standardized uptake values (SUV_max and SUVpeak) were determined relative to SUV based on the static method. Image noise was evaluated in the liver and compared to PET/static. Results: In visual interpretation, the rate of good alignment was 13/21, 13/23 and 18/21 for PET/static, PET/EX and PET/matched methods, respectively, and the mean PET-CT distances were 3.5, 5.1 and 2.8 mm. In visual comparison with PET/EX, the rate of good alignment was increased in 1/10 and 7/10 cases for PET/static and PET/matched. SUV_max was on average 21% higher than PET/static when either PET/EX or PET/matched was used. SUVpeak was 12% higher. Image noise in the liver was 15% higher than static for the PET/EX method, and 40% higher for PET/matched; that is, noise was much lower than in gated PET. Conclusion: Acquiring respiratory waveforms both in PET (as in the current state of the art) and in CT (an unusual key step in this approach) has the potential to improve the alignment of PET and CT images. A proposed method for using this information was tested. Improved alignment was demonstrated.

Head motion degrades image quality and causes erroneous parameter estimates in tracer kinetic modeling in brain PET studies. Existing motion correction methods include frame-based image-registration (FIR) and correction using real-time hardware-based motion tracking (HMT) information. However, FIR cannot correct for motion within one predefined scan period while HMT is not readily available in the clinic since it typically requires attaching a tracking device to the patient. In this study, we propose a motion correction framework with a data-driven algorithm, i.e., using the PET raw data itself, to address these limitations. Methods: We propose a data-driven algorithm, Centroid of Distribution (COD), to detect head motion. In COD, the central coordinates of the line of response (LOR) of all events are averaged over 1-sec intervals to generate a COD trace. A point-to-point change in the COD trace in one direction that exceeded a user-defined threshold was defined as a time point of head motion, which was followed by manually adding additional motion time points. All the frames defined by such time points were reconstructed without attenuation correction and rigidly registered to a reference frame. The resulting transformation matrices were then used to perform the final motion compensated reconstruction. We applied the new COD framework to 23 human dynamic datasets, all containing large head motions, with ¹⁸F-FDG (N = 13) and ¹¹C-UCB-J (N = 10), and compared its performance with FIR and with HMT using the Vicra, which can be considered as the "gold standard". Results: The COD method yielded 1.0±3.2% (mean ± standard deviation across all subjects and 12 grey matter regions) SUV difference for ¹⁸F-FDG (3.7±5.4% for ¹¹C-UCB-J) compared to HMT while no motion correction (NMC) and FIR yielded -15.7±12.2% (-20.5±15.8%) and -4.7±6.9% (-6.2±11.0%), respectively. For ¹⁸F-FDG dynamic studies, COD yielded differences of 3.6±10.9% in Ki value as compared to HMT, while NMC and FIR yielded -18.0±39.2% and -2.6±19.8%, respectively. For ¹¹C-UCB-J, COD yielded 3.7±5.2% differences in VT compared to HMT, while NMC and FIR yielded -20.0±12.5% and -5.3±9.4%, respectively. Conclusion: The proposed COD-based data-driven motion correction method outperformed FIR and achieved comparable or even better performance as compared to the Vicra HMT method in both static and dynamic studies.

Respiratory gating is the standard to overcome respiration effects degrading image quality in positron emission tomography (PET). Data-driven gating (DDG) using signals derived from PET raw data are promising alternatives to gating approaches requiring additional hardware. However, continuous bed motion (CBM) scans require dedicated DDG approaches for axially-extended PET, compared to DDG for conventional step-and-shoot scans. In this study, a CBM-capable DDG algorithm was investigated in a clinical cohort, comparing it to hardware-based gating using gated and fully motion-corrected reconstructions. Methods: 56 patients with suspected malignancies in thorax or abdomen underwent whole-body ¹⁸F-FDG CBM-PET/CT imaging using DDG and hardware-based respiratory gating (pressure-sensitive belt gating, BG). Correlation analyses were performed on both gating signals. Besides static reconstructions, BG and DDG were used for optimally-gated PET (BG-OG, DDG-OG) and fully motion-corrected PET (elastic motion correction; BG-EMOCO, DDG-EMOCO). Metabolic volumes, SUV_max and SUVmean of lesions were compared amongst the reconstructions. Additionally, the quality of lesion delineation in different PET reconstructions was independently evaluated by three experts. Results: Global correlation coefficients between BG and DDG signals amounted to 0.48±0.11, peaking at 0.89±0.07 when scanning the kidney and liver region. In total, 196 lesions were analyzed. SUV measurements were significantly higher in BG-OG, DDG-OG, BG-EMOCO and DDG-EMOCO compared to static images (P<0.001; median SUV_max: static, 14.3±13.4; BG-EMOCO, 19.8±15.7; DDG-EMOCO, 20.5±15.6; BG-OG, 19.6±17.1; DDG-OG, 18.9±16.6). No significant differences between BG-OG and DDG-OG, and BG-EMOCO and DDG-EMOCO, respectively, were found. Visual lesion delineation was significantly better in BG-EMOCO and DDG-EMOCO than in static reconstructions (P<0.001); no significant difference was found comparing BG and DDG (EMOCO, OG, respectively). Conclusion: DDG-based motion-compensation of CBM-PET acquisitions outperforms static reconstructions, delivering qualities comparable to hardware-based approaches. The new algorithm may be a valuable alternative for CBM-PET systems.

Pharma companies say that money spent on promotion is essential to educate doctors about the best drugs - but when a medical student asked Joseph Ross, associate professor of medicine and public health at Yale, if those companies are promoting the right drugs for that message to be true, the answer wasn't available. Ross and Tyler Greenaway, his...

ADA Practice Transitions, a service offered by the ADA focused on helping dentists make the process of joining or leaving a practice successful, is offering a free three-month trial.

Here’s my Q&A column from the WSJ this week — and if you have any questions for me, you can tweet them to @danariely with the hashtag #askariely, post a comment on my Ask Ariely Facebook page, or email them to AskAriely@wsj.com. ___________________________________________________ Hi, Dan. I offered to purchase a computer...

When COVID-19 emerged as a clear and present public health threat, most people felt the same range of emotions: somewhere along the spectrum of fear and anxiety. People are still...

Why would David Vitter, a U.S. senator with four young children, have gotten involved with a seedy escort service? Why would Michael Vick, a gifted NFL quarterback, get mixed up with the sordid world of dog fighting? Why would Bill Clinton, a Rhodes scholar, six-time governor and president of the...

Too often, teachers are asked to use SEL practices without enough training and ongoing support, tanking the effectiveness.

Students and adults in the school community will all need more support when schools reopen, writes the head of the National Association of School Psychologists.

Students and adults in the school community will all need more support when schools reopen, writes the head of the National Association of School Psychologists.

Wisconsin is one of a handful of states where how much schools will get this fall is still being debated in the state capitol.

Gov. Christie has pushed to flatten the state's funding formula so that the state's impoverished urban districts would get the same amount of money wealthy suburban districts get.

UK, [late 1930s].

UK, [late 1930s].

When Idaho education leaders pitched social-emotional learning training for teachers, some state lawmakers compared the plan to dystopian behavior control. Some walked out of the meeting.

In the Green Mountain State, education leaders discuss their focus on the whole child.

Sophie Achard, Jean-François Coeurjolly

Source: Statist. Surv., Volume 4, 117--147.

Abstract:
This paper gives an overview of the problem of estimating the Hurst parameter of a fractional Brownian motion when the data are observed with outliers and/or with an additive noise by using methods based on discrete variations. We show that the classical estimation procedure based on the log-linearity of the variogram of dilated series is made more robust to outliers and/or an additive noise by considering sample quantiles and trimmed means of the squared series or differences of empirical variances. These different procedures are compared and discussed through a large simulation study and are implemented in the R package dvfBm.

Motion synthesis in a dynamic environment has been a long-standing problem for character animation. Methods using motion capture data tend to scale poorly in complex environments because of their larger capturing and labeling requirement. Physics-based controllers are effective in this regard, albeit less controllable. In this paper, we present CARL, a quadruped agent that can be controlled with high-level directives and react naturally to dynamic environments. Starting with an agent that can imitate individual animation clips, we use Generative Adversarial Networks to adapt high-level controls, such as speed and heading, to action distributions that correspond to the original animations. Further fine-tuning through the deep reinforcement learning enables the agent to recover from unseen external perturbations while producing smooth transitions. It then becomes straightforward to create autonomous agents in dynamic environments by adding navigation modules over the entire process. We evaluate our approach by measuring the agent's ability to follow user control and provide a visual analysis of the generated motion to show its effectiveness.

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 7 November. Speaker: Dr Michael Brown (University of Roehampton), ‘Anxiety and compassion: emotions and the surgical encounter in early 19th-century Britain’ The historical study of the… Continue reading

Surveys provide secure, anonymous feedback from staff at all levels of healthcare organizations

(PRWeb May 06, 2020)

Read the full story at https://www.prweb.com/releases/health_worker_data_alliance_monitoring_emotional_physical_and_occupational_health_of_healthcare_workers_during_covid_19/prweb17101008.htm

Jorge A. León.

Source: Bernoulli, Volume 26, Number 3, 2436--2462.

Abstract:
Let $B^{H}$ be a fractional Brownian motion with Hurst parameter $Hin (0,1/2)$ and $p:mathbb{R} ightarrow mathbb{R}$ a polynomial function. The main purpose of this paper is to introduce a Stratonovich type stochastic integral with respect to $B^{H}$, whose domain includes the process $p(B^{H})$. That is, an integral that allows us to integrate $p(B^{H})$ with respect to $B^{H}$, which does not happen with the symmetric integral given by Russo and Vallois ( Probab. Theory Related Fields 97 (1993) 403–421) in general. Towards this end, we combine the approaches utilized by León and Nualart ( Stochastic Process. Appl. 115 (2005) 481–492), and Russo and Vallois ( Probab. Theory Related Fields 97 (1993) 403–421), whose aims are to extend the domain of the divergence operator for Gaussian processes and to define some stochastic integrals, respectively. Then, we study the relation between this Stratonovich integral and the extension of the divergence operator (see León and Nualart ( Stochastic Process. Appl. 115 (2005) 481–492)), an Itô formula and the existence of a unique solution of some Stratonovich stochastic differential equations. These last results have been analyzed by Alòs, León and Nualart ( Taiwanese J. Math. 5 (2001) 609–632), where the Hurst paramert $H$ belongs to the interval $(1/4,1/2)$.

Ivan Nourdin, Giovanni Peccati, Stéphane Seuret.

Source: Bernoulli, Volume 26, Number 3, 1619--1634.

Abstract:
We describe the size of the sets of sojourn times $E_{gamma }={tgeq 0:|B_{t}|leq t^{gamma }}$ associated with a fractional Brownian motion $B$ in terms of various large scale dimensions.

Stepan Mazur, Dmitry Otryakhin, Mark Podolskij.

Source: Bernoulli, Volume 26, Number 1, 226--252.

Abstract:
In this paper, we investigate the parametric inference for the linear fractional stable motion in high and low frequency setting. The symmetric linear fractional stable motion is a three-parameter family, which constitutes a natural non-Gaussian analogue of the scaled fractional Brownian motion. It is fully characterised by the scaling parameter $sigma>0$, the self-similarity parameter $Hin(0,1)$ and the stability index $alphain(0,2)$ of the driving stable motion. The parametric estimation of the model is inspired by the limit theory for stationary increments Lévy moving average processes that has been recently studied in ( Ann. Probab. 45 (2017) 4477–4528). More specifically, we combine (negative) power variation statistics and empirical characteristic functions to obtain consistent estimates of $(sigma,alpha,H)$. We present the law of large numbers and some fully feasible weak limit theorems.

London (33 Stillness Rd, London, SE23 ING) : Cleanair, Campaign for a Smoke-free Environment, [198-?]

MN Shadlen
Feb 15, 1996; 16:1486-1510
Articles

WT Newsome
Jun 1, 1988; 8:2201-2211
Articles

KH Britten
Dec 1, 1992; 12:4745-4765
Articles

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