Actually, they weren.t caught together at all their images were put together with software. The shadows cast by the stars. faces give it away: The sun is coming from two different directions on the same beach! More elaborate digital doctoring is detected with mathematics. Calculus, linear algebra, and statistics are especially useful in determining when a portion of one image has been copied to another or when part of an image has been replaced. Tampering with an image leaves statistical traces in the file. For example, if a person is removed from an image and replaced with part of the background, then two different parts of the resulting file will be identical. The difficulty with exposing this type of alteration is that both the location of the replacement and its size are unknown beforehand. One successful algorithm finds these repetitions by first sorting small regions according to their digital color similarity, and then moving to larger regions that contain similar small ones. The algorithm.s designer, a leading digital forensics expert, admits that image alterers generally stay a step ahead of detectors, but observes that forensic advances have made it much harder for them to escape notice. He adds that to catch fakers, At the end of the day you need math.(1) For More Information: Can Digital Photos be Trusted?, Steve Casimiro, Popular Science, October 2005. _______ 1 It May Look Authentic; Here.s How to Tell It Isn't, Nicholas Wade, The New York Times, January 24, 2006.

Facebook has over 700 million users with almost 70 billion connections. The hard part isn.t people making friends; rather it.s Facebook.s computers storing and accessing relevant data, including information about friends of friends. The latter is important for recommendations to users (People You May Know). Much of this work involves computer science, but mathematics also plays a significant role. Subjects such as linear programming and graph theory help cut in half the time needed to determine a person.s friends of friends and reduce network traffic on Facebook.s machines by about two-thirds. What.s not to like? The probability of people being friends tends to decrease as the distance between them increases. This makes sense in the physical world, but it.s true in the digital world as well. Yet, despite this, the enormous network of Facebook users is an example of a small-world network. The average distance between Facebook users the number of friend-links to connect people is less than five. And even though the collection of users and their connections may look chaotic, the network actually has a good deal of structure. For example, it.s searchable. That is, two people who are, say, five friend-links away, could likely navigate from one person to the other by knowing only the friends at each point (but not knowing anyone.s friends of friends). For More Information: Networks, Crowds, and Markets: Reasoning about a Highly Connected World, David Easley and Jon Kleinberg, 2010.

Guest blog by Stephen McKean On my first day of college, I showed up an hour early to my very first class. The class was Math 2210, multivariable calculus. For some reason, I thought this was the highest math class … Continue reading →

Mario Luca Morieri
Apr 1, 2020; 69:771-783
Genetics/Genomes/Proteomics/Metabolomics

When healthy volunteers are scanned as part of a research project, unexpected findings, with uncertain implications, can be thrown up. Joanna Wardlaw, professor of applied neuroimaging and honorary consultant neuroradiologist at the University of Edinburgh, joins us to discuss how her group deals with these incidental findings, and what...

We’ve been banging the drum about transparency of payment to doctors for years - we’ve even put a moratorium on financial conflicts of interest in the authors of any of our education articles. Not because we think that all doctors who receive money from industry are being influenced to push their agenda - but because we have no way of telling when...

The cardiovascular benefits of fibrates have been shown to be heterogeneous and to depend on the presence of atherogenic dyslipidemia. We investigated whether genetic variability in the PPARA gene, coding for the pharmacological target of fibrates (PPAR-α), could be used to improve the selection of patients with type 2 diabetes who may derive cardiovascular benefit from addition of this treatment to statins. We identified a common variant at the PPARA locus (rs6008845, C/T) displaying a study-wide significant influence on the effect of fenofibrate on major cardiovascular events (MACE) among 3,065 self-reported white subjects treated with simvastatin and randomized to fenofibrate or placebo in the ACCORD-Lipid trial. T/T homozygotes (36% of participants) experienced a 51% MACE reduction in response to fenofibrate (hazard ratio 0.49; 95% CI 0.34–0.72), whereas no benefit was observed for other genotypes (P_interaction = 3.7 x 10^–4). The rs6008845-by-fenofibrate interaction on MACE was replicated in African Americans from ACCORD (N = 585, P = 0.02) and in external cohorts (ACCORD-BP, ORIGIN, and TRIUMPH, total N = 3059, P = 0.005). Remarkably, rs6008845 T/T homozygotes experienced a cardiovascular benefit from fibrate even in the absence of atherogenic dyslipidemia. Among these individuals, but not among carriers of other genotypes, fenofibrate treatment was associated with lower circulating levels of CCL11—a proinflammatory and atherogenic chemokine also known as eotaxin (P for rs6008845-by-fenofibrate interaction = 0.003). The GTEx data set revealed regulatory functions of rs6008845 on PPARA expression in many tissues. In summary, we have found a common PPARA regulatory variant that influences the cardiovascular effects of fenofibrate and that could be used to identify patients with type 2 diabetes who would derive benefit from fenofibrate treatment, in addition to those with atherogenic dyslipidemia.

2 July 2014 , Volume 90, Number 4

We aimed to assess the value of ¹¹C-choline PET in patients with primary hyperparathyroidism and negative or discordant results on ^99mTc-sestamibi imaging and neck ultrasound. Methods: Eighty-seven such patients were assessed and subsequently underwent parathyroidectomy. PET/CT image data were analyzed semiquantitatively using SUV_max and SUV ratios (target to contralateral thyroid gland and carotid artery). A positive PET/CT result was defined as focal uptake significantly higher than regular thyroid tissue. Ectopic foci were also considered positive. Inconclusive PET/CT cases were defined as a lesion with uptake equal to normal thyroid tissue. If no prominent or ectopic uptake was detectable, the PET/CT result was considered negative. Results: When dichotomizing the ¹¹C-choline PET/CT imaging results by defining lesions with both positive and inconclusive uptake as positive, we found 84 of 92 lesions (91.3%) to have true-positive uptake whereas 8 lesions (8.7%) had false-positive uptake. One lesion showed false-negative uptake; the sensitivity was 98.8%. The corresponding positive predictive value for lesions was 91.3%. The mean SUV_max was 6.15 ± 4.92 in 72 lesions with positive uptake (70 patients) and 2.96 ± 2.32 in 20 lesions with inconclusive uptake (18 patients). Conclusion: These results in a large group of patients indicate that ¹¹C-choline PET/CT is a promising tool for parathyroid adenoma localization when ultrasound and ^99mTc-sestamibi imaging yield negative or discordant results.

Ian H. de Boer
Jan 1, 2014; 37:24-30
DCCT/EDIC 30th Anniversary Summary Findings

Catherine L. Martin
Jan 1, 2014; 37:31-38
DCCT/EDIC 30th Anniversary Summary Findings

OBJECTIVE

To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes in the T1D Exchange Clinic Registry throughout the U.S.

OBJECTIVE

To determine the risk of cardiovascular disease (CVD), microvascular complications, and mortality in patients with type 2 diabetes who subsequently develop obstructive sleep apnea (OSA) compared with patients with type 2 diabetes without a diagnosis of OSA.

OBJECTIVE

To examine the association between manganese intake and the risk of type 2 diabetes in postmenopausal women and determine whether this association is mediated by circulating markers of inflammation.

I'm trying to make a backup to an external harddrive, but when I go to update & security and then to back up, I don't find the option to 'add a drive'. It's completely empty, even though my computer is detecting the external harddrive.  Where do I find the option to backup files? I'm using windows 10 

Resilience and strength can often be attained through unexpected routes

-- Read more on ScientificAmerican.com

Marking the release of two research reports that highlight promising, effective approaches to teaching and learning for Dual Language Learners in multilingual, multicultural classrooms, report authors present their findings on this webinar and discuss key implications for policy and practice.

Mayor, Thomas -- Travel -- Australia.

A superintendent outlines the importance of various groups coming together to address teacher recruitment and retention challenges in Idaho.

An audit of the early-childhood education offerings in Minnesota finds complexity and fragmentation as well as a lack of data about program effectiveness.

To me, one of the handiest SOLIDWORKS ease-of-use functions hides in plain view: The Command Search. Found at the top of the application, the SOLIDWORKS Search box can be set to several different types of search, but the one I

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The post Finding New Commands in SOLIDWORKS Command Search appeared first on SOLIDWORKS Tech Blog.

CNA Staff, May 7, 2020 / 11:00 am (CNA).- Cardinal George Pell has expressed his “surprise” at newly released findings of an Australian investigation, which concluded that the cardinal was aware of sexual abuse by clerics in the 1970s and 80s, and failed to act.

In 2017, Australia’s Royal Commission released a report on sexual abuse of minors in the country, the result of a five-year enquiry into the behavior and responsibility of institutions including the Church. Sections of the report relating to Cardinal Pell were redacted until the conclusion of criminal legal proceedings against the cardinal. 

The redacted portions were released May 6.

In the newly available material, the commission found that Pell knew about the abusive activities of two priests during his own years as a priest, and that he failed to act to stop them. 

On Thursday, Pell said through a spokesperson that the commission’s conclusions about him were “not supported by evidence.”

Pell gave evidence to the commission in 2016 via video link from Rome. During his testimony, he denied failing to act against known sexual abusers in the clergy. Pell specifically denied that while he was a priest in Ballarat in the 1970s and 80s, he had any awareness of the actions of then-Father Gerald Ridsdale, a serial abuser from the same diocese.

The Royal Commission concluded that, as a member of Bishop Ronald Mulkearns’ college of priest consulters in the diocese, Pell would have been made aware of allegations of abuse against Ridsdale during discussions about the priest’s transfers between assignments in 1977 and 1982.

But Pell told the commission that he and the other consulters had been deceived by Mulkearns and were unaware of Ridsdale’s crimes until years later.

“The Consultors who gave evidence on the meetings in 1977 and 1982 either said they did not learn of Ridsdale’s offending against children until much later or they had no recollection of what was discussed. None said they were made aware of Ridsdale’s offending at these meetings,” Pell said in a statement released through a spokesperson late Wednesday evening.

In a 2017 statement, Pell said “I would never have condoned or participated in a decision to transfer Ridsdale in the knowledge that he had abused children, and I did not do so.” 

The commission rejected Pell’s testimony, and found that it “ought to have been obvious” why Ridsdale was being transferred from one assignment to another.

“We are satisfied Bishop Mulkearns gave reasons for it being necessary to move Ridsdale. We are satisfied that he referred to homosexuality at the meeting, in the context of giving reasons for Ridsdale’s move,” the report found. “However, we are not satisfied that Bishop Mulkearns left the explanation there, as Cardinal Pell said there would have been a discussion."

“We do not accept that Bishop Mulkearns lied to his consultors.”

The commission did not delineate specific proofs for its conclusion.

The commission also said that Pell would have known about allegations of abuse made against Fr. Peter Searson, who was active as a Melbourne priest during Pell’s time as an auxiliary bishop in the Melbourne archdiocese.

In 1989, Pell held a meeting with representatives from the parish and school in Doveton, where Searson was assigned. During that meeting a number of complaints were made against Searson but, according to Pell, sexual misconduct with children was not raised, and Searson’s removal was not requested.

Following Pell’s installation as Archbishop of Melbourne in 1996, Pell placed Searson on administrative leave and removed him from parish ministry in 1997. Searson died in 2009 and was never charged by police.

A spokesman for Victoria Police, which brought charges against Pell leading to his imprisonment for more than a year before the High Court freed him last month, told the Guardian that the newly released sections of the report would be studied and police would “undertake an assessment of those findings.”

“At this time it would not be appropriate to comment further about any possible action,” The spokesman said.

Current Archbishop of Melbourne Peter Comensoli released his own statement in response to the new material from the commission, in which he repeated his previous apologies “for the failure of the Catholic Archdiocese of Melbourne to responsibly care for and protect our young people and vulnerable adults.”

“Child safety and care is not a project with an end date”, Comensoli said, but a project that “requires life-long vigilance.”

In December 2018, Pell was convicted of five counts of sexual abuse, but was acquitted by the Australian High Court last monthl. Following that decision, the redacted portions of the commission’s findings were released.

In a university Discovery Bible Study run by OM Madagascar, a student finds the answers he is looking for in the Bible.

OMers help Hungarian children uncover their gifts through drama camp.

The Harvard political philosopher Michael Sandel offers his take.

IT'S the day after May Day and perhaps you’re feeling you’ve missed out on a good, sweaty Scottish pagan spring ritual of the type done particularly well at Beltane on Edinburgh’s Calton Hill, though not in a year of quarantine. Never fear. There are still ways of channelling the fertility rites of spring, the chief one being, of course, the folk horror classic The Wicker Man. Put on a goat mask, get in touch with your inner Wicker – or even Wicca – and revel in a bit of self-isolation

Sunday, April 19, 2020.

The EdWeek Research Center is conducting twice-monthly surveys of teachers and district leaders across the country to help the K-12 system navigate these unprecedented times.

Chronic wet cough is a common symptom well recognized by pediatricians. Protracted bacterial bronchitis is defined as more than 4 weeks of wet cough that responds to antibiotic treatment. Diagnosis of protracted bacterial bronchitis is not readily accepted by pediatricians

Children with chronic wet cough often have bronchitis, which is evident during bronchoscopy. Purulent bronchial secretions suggest the presence of bacterial infection. Children with chronic wet cough frequently have a bacterial infection of the lower airway. (Read the full article)

Few studies have examined the reliability of clinical findings in pediatric appendicitis. Clinical prediction rules are most useful if the included variables are reliable across practice settings and practitioners.

Among children who present with possible appendicitis, the interrater reliability varied considerably for patient history and physical examination variables. Those variables with the highest degree of reliability may be best suited for inclusion in appendicitis clinical prediction rules. (Read the full article)

Coxsackievirus A6 (CVA6) was identified as an important cause of "severe" hand, foot, and mouth disease (HFMD) during the 2011–2012 outbreak in North America. The atypical cutaneous features in this outbreak have not been well documented.

The cutaneous manifestations of CVA6-associated HFMD may be more extensive and variable than classic HFMD. Four distinct morphologies characterize this exanthem: (1) widespread vesiculobullous and erosive lesions, (2) "eczema coxsackium," (3) an eruption similar to Gianotti-Crosti, and (4) purpuric lesions. (Read the full article)

The evaluation of blunt head trauma in children who undergo cranial computed tomography will occasionally reveal incidental findings. These findings may require further evaluation or intervention. The prevalence of incidental findings has previously been described using small cohorts, limiting generalizability.

This study is the largest pediatric multicenter description of the prevalence of incidental findings on cranial computed tomography. Incidental findings are categorized by urgency to describe the spectrum of abnormalities, providing a context for clinicians faced with these unexpected results. (Read the full article)

The detection of critical congenital heart disease by fetal echocardiography or neonatal physical examination can have limitations. The addition of pulse oximetry screening in the newborn nursery increases the rate of diagnosis of these conditions before hospital discharge.

In a tertiary-care center with comprehensive fetal echocardiography, nearly all newborns with critical congenital heart disease are diagnosed prenatally. Pulse oximetry will identify more infants from settings with lower prenatal detection. Improving access to and training in fetal echocardiography should also improve detection of these conditions. (Read the full article)

A survey of educators around the country found that many reported looking up interventions on their own, when they really wanted more formal training, a survey found.

Members of a Holyrood Committee have visited the shipyard where two overdue and over-budget vessels to serve the Clyde and Hebrides ferries network are being built.

While reaching out to Turks in France, one long-term worker feels like Apostle Paul: preaching in house churches and getting kicked out of a mosque.

Source: www.youtube.com - Friday, May 08, 2020

A man thought he understood how life worked until he had a conversation with OM workers in Bangladesh. Then Jesus changed his life.

For Penn State Scranton students, the first couple of weeks of remote learning have proven to be a big adjustment — academically and socially. Several campus students shared their initial thoughts regarding the virtual learning experience and being away from the physical campus.

An Uzbek woman travels to Russia in search of work and finds God instead.

The DNREC Mosquito Control Section, in conjunction with the Division of Public Health and Department of Agriculture, has announced the first detection this year of West Nile virus in wild birds, indicating the recurrence of this mosquito-borne disease in Delaware.

Clown Me In co-founder Sabine Choucair discusses the group’s new online workshop series, each Friday, ‘Happy Half-Hour’

Geo-microbiologist Yohey Suzuki says clay minerals can be considered 'magic material on Earth' one can always find microbes living in them.

USB4 can simultaneously tunnel USB3, PCIe and DisplayPort native protocol traffic through a hierarchy of USB4 routers. The key to tunneling of these protocols is routing table programmed at each ingress adapter. An entry of a routing table maps an incoming HopID, called Input/Ingress HopID to a corresponding pair of Output/Egress Adapter and Egress/Output HopID.

The responsibility of programming routing tables lies with the Connection Manager. Connection Manager, having the complete view of the hierarchy of the routers, programs the routing tables at all relevant adapter ports. Accordingly, the USB3, PCIe and DisplayPort protocol tunneled packets are routed, and reach their respective intended destinations.

The diagrammatic representation below is an example of tunneling of USB3 protocol traffic from USB4 Host Router to USB4 Peripheral Device Router through a USB4 Hub Router. The path from USB3 Host to USB3 Device is depicted by routing tables indicated at A -> B -> C -> D, and the one from USB3 Device to USB3 Host by routing tables indicated at E -> F -> G -> H . Note that the Input HopID from and Output HopID to all three protocol adapters for USB3, PCIe and DisplayPort Aux traffic, are fixed as 8, and for DisplayPort Main Link traffic are fixed as 9.

Once the native protocol traffic come into the transport layer of a USB4 router, the transport layer of it does not know to which native protocol a tunneled packet belongs to. The only way a transport layer tunneled packet is routed through the hierarchy of the routers is using the HopID values and the information programmed in the routing tables.

The figure below shows an example of tunneling of all the three USB3, PCIe and DisplayPort protocol traffic together. The transport layer tunneled packets of each of these native protocols are transported simultaneously through the routers hierarchy.

 Cadence has a mature Verification IP solution for the verification of USB3, PCIe and DisplayPort tunneling. This solution also employs the industry proven VIPs of each of these native protocols for native USB3, PCIe and DisplayPort traffic.

Hi,

I wanted to find the location of a pin in the design using skill program. pin_dbids = axlDBGetDesign()->pins, this gives me all the dbids of the pins that are present in my design. But when im entering that dbid, pad = axlDBGetPad("000001EA8FD8B9F8" "package geometry/assembly_top" "regular") it is throwing an error stating "This dbid is not user defined. Please enter the user defined". So please provide me a snippet so that I can get the exact pin location in the design using skill script.