Archives, Room Use Only - CS71.M885 L67 1896

Archives, Room Use Only - CS71.V129 1937

Nagaon ASP, family members under home quarantine

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Guj: 5 of family hacked to death over old enmity

She recovered within 42 days of being put in a shelter home

With 22 senior citizens from Madurai, who were on a pilgrimage to north India, stranded in Gaya in Bihar for over 40 days following the lockdown, fami

Five persons of a family were brutally hacked to death in Hamirpur village, 27 km from Rapar town of Kutch, as the simmering animosity between members of two communities came to a boil on Saturday.

The syntheses and crystal structures of three hybrid perovskites, viz. poly[1-methyl­piperizine-1,4-diium [tri-μ-bromido-potassium] hemihydrate], {(C5H14N2)[KBr3]·0.5H2O}n, (I), poly[1-methyl­piperizine-1,4-diium [tri-μ-bromido-rubidium] hemihydrate], {(C5H14N2)[RbBr3]·0.5H2O}n, (II), and poly[1-methyl­piperizine-1,4-diium [tri-μ-bromido-caesium] hemihydrate], {(C5H14N2)[CsBr3]·0.5H2O}n, (III), are described. These isostructural (space group Amm2) phases contain a three-dimensional, corner-sharing network of distorted ABr6 octa­hedra (A = K, Rb, Cs) with the same topology as the classical perovskite structure. The doubly protonated C5H14N22+ cations occupy inter­stices bounded by eight octa­hedra and the water mol­ecules lie in square sites bounded by four octa­hedra. N—H⋯Br, N—H⋯(Br,Br), N—H⋯O and O—H⋯Br hydrogen bonds consolidate the structures.

Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin family, as a zymogen that is proteolytically auto-activated extracellularly at the Ser54–Arg55 bond. Crystal structures of the catalytically impaired promirolysin point mutant E225A at 1.4 and 1.6 Å revealed that latency is exerted by an N-terminal 34-residue pro-segment that shields the front surface of the 274-residue catalytic domain, thus preventing substrate access. The catalytic domain conforms to the metzincin clan of metallopeptidases and contains a double calcium site, which acts as a calcium switch for activity. The pro-segment traverses the active-site cleft in the opposite direction to the substrate, which precludes its cleavage. It is anchored to the mature enzyme through residue Arg21, which intrudes into the specificity pocket in cleft sub-site S1'. Moreover, residue Cys23 within a conserved cysteine–glycine motif blocks the catalytic zinc ion by a cysteine-switch mechanism, first described for mammalian matrix metallopeptidases. In addition, a 1.5 Å structure was obtained for a complex of mature mirolysin and a tetradecapeptide, which filled the cleft from sub-site S1' to S6'. A citrate molecule in S1 completed a product-complex mimic that unveiled the mechanism of substrate binding and cleavage by mirolysin, the catalytic domain of which was already preformed in the zymogen. These results, including a preference for cleavage before basic residues, are likely to be valid for other unicellular pappalysins derived from archaea, bacteria, cyanobacteria, algae and fungi, including archetypal ulilysin from Methanosarcina acetivorans. They may further apply, at least in part, to the multi-domain orthologues of higher organisms.

Aerobic thermoacidophilic archaea belonging to the genus Sulfolobus harbor peroxiredoxins, thiol-dependent peroxidases that assist in protecting the cells from oxidative damage. Here, the crystal structure of the 1-Cys peroxiredoxin from Sulfolobus islandicus, named 1-Cys SiPrx, is presented. A 2.75 Å resolution data set was collected from a crystal belonging to space group P212121, with unit-cell parameters a = 86.8, b = 159.1, c = 189.3 Å, α = β = γ = 90°. The structure was solved by molecular replacement using the homologous Aeropyrum pernix peroxiredoxin (ApPrx) structure as a search model. In the crystal structure, 1-Cys SiPrx assembles into a ring-shaped decamer composed of five homodimers. This quaternary structure corresponds to the oligomeric state of the protein in solution, as observed by size-exclusion chromatography. 1-Cys SiPrx harbors only a single cysteine, which is the peroxidatic cysteine, and lacks both of the cysteines that are highly conserved in the C-terminal arm domain in other archaeal Prx6-subfamily proteins such as ApPrx and that are involved in the association of dimers into higher-molecular-weight decamers and dodecamers. It is thus concluded that the Sulfolobus Prx6-subfamily protein undergoes decamerization independently of arm-domain cysteines.

When songwriter Oscar Hammerstein penned the lyrics “fish gotta swim, birds gotta fly,” he clearly did not have the ratites in mind. Large flightless birds, the ratites include ostriches, emus, rheas and cassowaries, along with kiwis and several extinct species.

The post DNA evidence is rearranging the branches of the avian family tree appeared first on Smithsonian Insider.

A team of scientists led by the Smithsonian Institution has discovered a fossilized dinosaur skull and neck vertebrae that not only reveal a new species, but also an evolutionary link between two groups of dinosaurs.

The post Scientists discover new species of dinosaur bridging a gap in the dinosaur family tree appeared first on Smithsonian Insider.

Collecting trips for Charles Doolittle Walcott (1850-1927), paleontologist and fourth Secretary of the Smithsonian Institution, were often a family affair. This 1910 photograph shows their […]

The post Charles Doolittle Walcott (1850-1927) family campsite in the Canadian Rockies appeared first on Smithsonian Insider.

Christian Renz, Veronique Albanese, Vera Tröster, Thomas K. Albert, Olivier Santt, Susan C. Jacobs, Anton Khmelinskii, Sebastien Leon, and Helle D. Ulrich

Polyubiquitin chains linked via lysine (K) 63 play an important role in endocytosis and membrane trafficking. Their primary source is the ubiquitin protein ligase (E3) Rsp5/NEDD4, which acts as a key regulator of membrane protein sorting. The heterodimeric ubiquitin-conjugating enzyme (E2), Ubc13-Mms2, catalyses K63-specific polyubiquitylation in genome maintenance and inflammatory signalling. In budding yeast, the only ubiquitin protein ligase (E3) known to cooperate with Ubc13-Mms2 so far is a nuclear RING finger protein, Rad5, involved in the replication of damaged DNA. We now report a contribution of Ubc13-Mms2 to the sorting of membrane proteins to the yeast vacuole via the multivesicular body (MVB) pathway. In this context, Ubc13-Mms2 cooperates with Pib1, a FYVE-RING finger protein associated with internal membranes. Moreover, we identified a family of membrane-associated FYVE-(type)-RING finger proteins as cognate E3s for Ubc13-Mms2 in several species, and genetic analysis indicates that the contribution of Ubc13-Mms2 to membrane trafficking in budding yeast goes beyond its cooperation with Pib1. Thus, our results widely implicate Ubc13-Mms2 as an Rsp5-independent source of K63-linked polyubiquitin chains in the regulation of membrane protein sorting.

Fulcaldea stuessyi is a newly discovered member of the Barnadesioideae, a subfamily of the Compositae, or sunflower family of flowering plants. It was found in northeastern […]

The post Fulcaldea stuessyi is newly discovered member of the Barnadesioideae, a subfamily of the Compositae, or sunflower family of flowering plants, appeared first on Smithsonian Insider.

The demand for family caregivers for adults who are 65 or older is increasing significantly, and family caregivers need more recognition, information, and support to fulfill their responsibilities and maintain their own health, financial security, and well-being, says a new report from the National Academies of Sciences, Engineering, and Medicine.

For decades, the Ford Foundation Fellowship programs have contributed to building a more equitable and diverse U.S. higher education system.

So—  We just had our big summer family reunion at a lake in Wisconsin.

You know what they say about family gatherings—  That you should never discuss religion or politics— And we don't plan to—  But because my older daughter Maddy has already started school back in LA and she doesn't want to fall behind in her homework—?  While everyone else is fishing or swimming or prepping the barbeque— Maddy needs to works on her collage. . . for U.S. History.

The theme? What does her generation think is the biggest problem facing the U.S. Right away, we're in crisis mode. We have to find an art store to procure poster paper, a glue stick, highlighters, scissors and three current periodicals.

I remind this L.A. teen that we are deep in the woods of Wisconsin -- Yelp says the nearest "craft supply" store is a "Ben Franklin on Wachookooheesha Lake" an hour away.

So instead we drive 20 minutes to "Trig's" grocery store—  "Oh, and can you pick up tortillas and cilantro?" my partner Charlie calls out.  "Sure!" I say.  "Cilantro!  That's what we came to Wisconsin for!"

Trig's has tortillas, but no cilantro. More importantly, there are no scissors, no highlighters. There are glue sticks, and envelopes we can glue together to make poster paper. There are of course plenty of periodicals. There's Musky Hunter Magazine, Catfish Insider, Log Cabin, Gun Dog Magazine and a glossy publication called Concealed Carry.  Which aside from guns, has a surprising amount of fashion—jeans and cargo shorts with many pockets for—  You know!

For a Blue State metropolitan girl like my 16 year old, this glimpse of the magazine tastes of rural Wisconsin is a fascinating sociological journey.  She reads eagerly from her trove to her boyfriend, safely back in land-locked Northridge—  Until I tell her to get off the phone because my GPS lady is now lost and taking us in circles.  "Harris Creek, Harris Lane, Harris Creek Lane, Harris Bog?" 
"Oh, we'll find it," she says breezily, continuing to chat about Musky Hunters.

 And I'm going, "Hey City Girl, this isn't the Galeria. We are seriously lost. In the back country. And all we've got to defend ourselves is a package of tortillas and Concealed Carry Magazine."  (hum the Deliverance theme)

Next week: Dog Fight.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The $192 billion IT-BPM industry body has informed the Ministry of External Affairs (MEA) about the critical talent from various member companies such as Tata Consultancy Services, Infosys, Wipro, HCL Tech, Startek and many others being stranded and they should be considered for evacuation.

If you want to mix drinks for a living, don't expect to have a typical family life.

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For older adults, having more or closer family members in one's social network decreases his or her likelihood of death, but having a larger or closer group of friends does not, finds a new study that will be presented at the 111th Annual Meeting of the American Sociological Association (ASA).

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The UK’s much-loved best family festival, ​Camp Bestival​, and original family ravers ​Big Fish Little Fish have teamed up once again to host their legendary family rave tour.

A family proves that even the most ramshackle out buildings can be transformed into cozy, habitable spaces with a bit of hard work and creative design.

A horse near the East Fire in California runs back into danger to save its family.

An 18-year-old pizza delivery driver surprises a family in Detroit by playing piano for them.

By keeping things compact, Matt Kirkpatrick and Katherine Bovee were able to splurge and have some fun when designing their boxy, prefab abode.

'Batman v Superman' star says his Thanksgiving tradition is all about respect for animals.

The daughter-in-law and granddaughter of famous explorer Jacques Cousteau continue the mission of water stewardship.

Are you poisoning your family with fish? That is the essence of the question that one San Franciscan man recently took it upon himself to answer.

"Expressing gratitude and feeling gratitude are not the same thing," remind scientists looking at recordings of conversations among families.

A new study suggests Americans actually dread family visits, especially the part that involves spending the night there.

How do they do it? Through lots of glass jars, obliterating clutter, and recycling only as a last resort. Bea Johnson shares her top 10 tips.

The creator of Tabasco sauce is often credited with a proliferation of large rodents called nutria in the swamps of Louisiana.

Green 'Family Weekend'; nature TV premieres.

The idea grew out of disaster message boards that sprung up on Facebook after Japan's most recent natural disaster.

It's rare, but it's real. Here's how to keep it from happening to you.

7 great ways to spend the time and spread the message of Earth Hour with your kids. On Saturday, March 26, 2011, governments, businesses, residential homes, and

An interview with author Alan Durning on his family's year of living car-lessly.