Large and small suppliers vow to help a resource-intensive, cost-sensitive industry change with the times

Technology is a step on the path to on-demand manufacturing of biologics

Online Resource

Hayden Library - TA418.9.N35 F87 2018

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

The enactment of President Clinton’s Limited English Proficiency (LEP) Executive Order, issued in 2000, triggered a proliferation of efforts to provide services to individuals who cannot speak, understand, read, or write English fluently. With increased service provision, state and local government agencies have expressed a strong and growing interest in assuring the quality and cost-effectiveness of language access services. This paper attempts to catalog and describe some of those tools and practices.

Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skull

Since 1997, more than 100,000 Parkinson’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves the implantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as a ‘brain pacemaker’, delivers electrical pulses to a structure called the subthalamic nucleus, located near the centre of the brain, and effectively alleviates many of the physical symptoms of the disease, such as tremor, muscle rigidity, and slowed movements.

DBS is generally safe but, like any surgical procedure, comes with some risks. First and foremost, it is highly invasive, requiring small holes to be drilled in the patient’s skull, through which the electrodes are inserted. Potential complications of this include infection, stroke, and bleeding on the brain. The electrodes, which are implanted for long periods of time, sometimes move out of place; they can also cause swelling at the implantation site; and the wire connecting them to the battery, typically placed under the skin of the chest, can erode, all of which require additional surgical procedures.

Related: Blowing up the brain to reveal its finer details

Related: Traces of memory in a dish | Mo Costandi

Testimony of MPI President Demetrios G. Papademetriou before the House Judiciary’s Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law.

A MDT trainee puts what she has learned into practice as she teaches German to an Egyptian immigrant in Switzerland.

To help ensure the safety of fish passing through the new turbines at 912-MW Priest Rapids, Public Utility District No. 2 of Grant County is employing the BioPA method to analyze the biological performance of proposed designs - and to choose an improved one for this facility.

Many have blamed millennials morals for these short-lived marriages, but I think that's not it. The fault is in how we choose to understand and practice monogamy

With the new advances, fertility doctors will be able to hand-select the healthiest and quality sperm for artificial insemination, in effect increasing a woman's chance of becoming pregnant.

       The office worker is general will see much of a scene, at new of the year split a head, you nearby of person or many or little all someone drive the inner part...

Few things in life are as difficult as acknowledging mistakes, in particular those that we have made out of conviction. Choosing an unsuitable profession or...

While there has been a recent revival of interest in industrial policy around the world, systematic evidence of efficacy is relatively scarce. This report considers recent evidence from the evaluation of industrial policy. It focuses on three specific policy areas: support for R&D, capital market interventions (with a focus on risk capital), and public procurement for innovation.

When economic shocks occur, economic agents are expected to react to reduce the negative impact or amplify the positive effects. The ability of a country to contain economic losses can be defined as the resilience to economic shocks. Using the OECD Inter-Country Input-Output tables, this paper investigates the relationship between changes in final demand and production structures for 61 economies.

The OECD has adopted a new basket methodology for benchmarking wireless broadband prices. It adds to the existing baskets for voice, leased lines and fixed broadband services and reflects the increasing importance of wireless broadband for laptops, tablets and smartphones.

This report takes an initial look at methodologies to measure and estimate the monetary value of personal data, which is creating economic and social value at an increasing pace. But measuring and estimating its value is difficult. This is because not only a huge amount of personal data is being generated, but also as it is used in many different situations and for numerous purposes.

This paper details a methodology for calculating the extent of terrestrial and marine protected areas recorded in the World Database on Protected Areas by country, type and IUCN management categories. The method allows the data on protected areas to be summarised in a harmonised and more detailed way than is currently available, without requiring any additional reporting by countries.

This OECD Regulatory Policy Working Paper presents the methodology, key results and statistical analysis of the 2015 Indicators of Regulatory Policy and Governance (iREG) to complement the OECD Regulatory Policy Outlook 2015.

A detailed explanation of the methodology used to build the OECD PMR indicators

The public consultation took place from 1 August to 31 October 2016.

The OECD has published a guidance for characterising oleochemical substances. The method presented gives guidance on how these complex substances can be characterised in a way that their composition is accurately and consistently reflected to ensure that substances with the same chemical composition, manufactured in different countries, can be characterised with the same description for hazard assessment purposes.

The OECD Advisory Group on Endocrine Disrupters Testing and Assessment met on 16-17 October 2014 in Paris to discuss the development and update of Test Guidelines and related documents for endocrine disrupters testing and assessment.

This guidance is intended to harmonise the way non-guideline in vitro test methods are described. This should in future facilitate an assessment of the relevance of test methods for biological activities and responses of interest, of the quality of data produced, irrespective of whether these tests are based on manual protocols or assay protocols adapted for use on automated platforms or high-throughput screening systems (HTS).

This new document focuses on the evaluation of test methods applied to determine the physico-chemical properties of different types of nanomaterials.

Participants from 15 countries attended the Workshop on Developmental Neurotoxicity: The use of non-animal test methods for regulatory purposes” on 18 October 2016, in Belgium. The event, co-organised by the OECD and the European Food Safety Authority (EFSA), focused on opportunities and challenges related to alternative methods for testing and assessing the DNT potential of chemicals.

GIVIMP aims to reduce the uncertainties in cell and tissue-based in vitro method derived predictions by applying good scientific, technical and quality practices from method development to implementation for regulatory use. Test method developers and test guideline users will find best practices for designing guideline in vitro methods, carrying out safety tests and assuring quality and scientific integrity of the resulting data

On 27 September 2019, Anne Gourmelon of the Environment Directorate presented an overview of the various alternative test methods developed as OECD Test Guidelines and relevant guidance material to address eye irritation and serious eye damage for hazard classification of chemicals.

Since the COVID-19 outbreak, researchers are in full swing to develop effective equipment to deal with the infection. From AI tool that predicts infected COVID-19 cases to virus-scanning tool for vaccine development, from the musical structure of COVID-19 to Bluetooth-based COVID-19

As of April 24, 2020, the total number of confirmed COVID-19 cases in India is 23,077 including 4,749 recovered cases and 718 deaths. Seeing a 19-days incubation period of the virus, medical experts have suggested 14 days quarantine for people who

Archives, Room Use Only - TK5261.F78 1854

Archives, Room Use Only - UG582.H4 F56 1888

Archives, Room Use Only - TK5264.J76 1913

Archives, Room Use Only - TK6162.R33 1917

Archives, Room Use Only - HE7669.P55 1914

Archives, Room Use Only - HE9723.G53 1915

Archives, Room Use Only - TK5262.M23 1914

Archives, Room Use Only - TK5451.S33 1876

Archives, Room Use Only - TK5741.T74 1902

Archives, Room Use Only - HE7669.P55 1945

Archives, Room Use Only - HE7669.B87 1891

Archives, Room Use Only - TK5262.R46 1924

Archives, Room Use Only - HE7669.P55 1925