پوری دنیا میں کورونا سے امریکہ کے بعد سب سے زیادہ ہلاکتیں اٹلی میں ہی ہوئی ہیں۔

ملک میں کورونا وائرس تیزی سے پھیل رہا ہے اور 50 ہزار سے زائد کیسز والے دنیا بھر کے ممالک میں ہندوستان اب 14 ویں مقام پر ہے او ر کیسز کی مجموعی تعداد 56،342 ہو گئی ہے ۔

ગાંધીનગરઃરાજ્ય પોલીસ દળ-જેલ ખાતામાં ભરતી કરવા માટે અલગ બોર્ડની રચના કરાઇ છે.રાજ્યના ગૃહવિભાગે પરિપત્ર કરી ભરતી બોર્ડની રચના કરી છે.પોલીસ ભરતી બોર્ડ દ્વારા પોલીસ દળ અને જેલ ખાતામાં ખાલી પડેલી 8845 જગ્યાઓ ભરાશે. ગૃહવિભાગે ભરતી બોર્ડની રચના કરી આ આદેશ આપ્યો છે.

Red Hat Security Advisory 2020-1688-01 - The libtiff packages contain a library of functions for manipulating Tagged Image File Format files. Issues addressed include an integer overflow vulnerability.

Digital Whisper Electronic Magazine issue 88. Written in Hebrew.

Red Hat Security Advisory 2020-1288-01 - The haproxy packages provide a reliable, high-performance network load balancer for TCP and HTTP-based applications. Issues addressed include an out of bounds write vulnerability.

Secunia Security Advisory - Niels Heinen has reported a vulnerability in Juniper Networks Secure Access, which can be exploited by malicious people to conduct cross-site scripting attacks.

Red Hat Security Advisory 2019-2885-01 - Dovecot is an IMAP server for Linux and other UNIX-like systems, written primarily with security in mind. It also contains a small POP3 server, and supports e-mail in either the maildir or mbox format. The SQL drivers and authentication plug-ins are provided as subpackages. Issues addressed include an out of bounds write vulnerability.

Red Hat Security Advisory 2020-1880-01 - GLib provides the core application building blocks for libraries and applications written in C. It provides the core object system used in GNOME, the main loop implementation, and a large set of utility functions for strings and common data structures. The Intelligent Input Bus is an input method framework for multilingual input in Unix-like operating systems. Issues addressed include an improper authorization vulnerability.

Red Hat Security Advisory 2020-0588-01 - Red Hat CloudForms Management Engine delivers the insight, control, and automation needed to address the challenges of managing virtual environments. CloudForms Management Engine is built on Ruby on Rails, a model-view-controller framework for web application development. Action Pack implements the controller and the view components. A remote code execution vulnerability has been addressed.

This week global energy and infrastructure group, Eversheds Sutherland, announced that it helped Ball Corporation secure two virtual power purchase agreements (VPPAs) – one wind and one solar – for a total of 388 MW of new renewable energy. According to Ball, these agreements will allow the company to power 100 percent of its corporate, packaging and aerospace operations electricity load in North America with renewable energy by the end of 2021.

This week global energy and infrastructure group, Eversheds Sutherland, announced that it helped Ball Corporation secure two virtual power purchase agreements (VPPAs) – one wind and one solar – for a total of 388 MW of new renewable energy. According to Ball, these agreements will allow the company to power 100 percent of its corporate, packaging and aerospace operations electricity load in North America with renewable energy by the end of 2021.

Health Minister Zweli Mkhize has announced 663 new Covid-19 infections and 17 new deaths - the highest for new cases and deaths - taking SA's Covid-19 cases over 8800 and deaths to 171.

PIC16(L)F18854 Family Silicon Errata and Data Sheet Clarification

PIC16(L)F18857/18877 Family Silicon Errata and Data Sheet Clarification

MIC2788

TC1188

KSZ8873MLLJ - Integrated 3-Port 10/100 Managed Switch with PHYs

ATA6588

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)₃] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conformations. BMS-378806 (here called BMS-806) blocks CD4-induced conformational changes in Env important for entry and is hypothesized to stabilize a state-1-like Env conformation, a key vaccine target. Here, we evaluated the effects of BMS-806 on the conformation of Env on the surface of cells and virus-like particles. BMS-806 strengthened the labile, noncovalent interaction of gp120 with the Env trimer, enhanced or maintained the binding of most broadly neutralizing antibodies, and decreased the binding of poorly neutralizing antibodies. Thus, in the presence of BMS-806, the cleaved Env on the surface of cells and virus-like particles exhibits an antigenic profile consistent with a state-1 conformation. We designed novel BMS-806 analogues that stabilized the Env conformation for several weeks after a single application. These long-acting BMS-806 analogues may facilitate enrichment of the metastable state-1 Env conformation for structural characterization and presentation to the immune system.

IMPORTANCE The envelope glycoprotein (Env) spike on the surface of human immunodeficiency virus type 1 (HIV-1) mediates the entry of the virus into host cells and is also the target for antibodies. During virus entry, Env needs to change shape. Env flexibility also contributes to the ability of HIV-1 to evade the host immune response; many shapes of Env raise antibodies that cannot recognize the functional Env and therefore do not block virus infection. We found that an HIV-1 entry inhibitor, BMS-806, stabilizes the functional shape of Env. We developed new variants of BMS-806 that stabilize Env in its natural state for long periods of time. The availability of such long-acting stabilizers of Env shape will allow the natural Env conformation to be characterized and tested for efficacy as a vaccine.

Dual amylin and calcitonin receptor agonists (DACRAs) are novel candidates for treatment of type 2 diabetes and obesity because of their beneficial effects on body weight, blood glucose, insulin sensitivity, and food preference, at least short-term. DACRAs activate the receptors for a prolonged time period, resulting in metabolic effects superior to those of amylin. Because of the prolonged receptor activation, different dosing intervals and, hence, less frequent receptor activation might change the efficacy of DACRA treatment in terms of weight loss and food preference. In this study, we compared daily dosing to dosing every other day with the aim of understanding the optimal balance between efficacy and tolerability. Obese and lean male Sprague-Dawley rats were treated with the DACRA KBP-088, applying two different dosing intervals (1.5 nmol/kg once daily and 3 nmol/kg every other day) to assess the effect on body weight, food intake, glucose tolerance, and food preference when given the choice between chow (13% fat) and a high-fat diet (60% fat). Treatment with KBP-088 induced significant weight loss, reduction in adiposity, improvement in glucose control, and altered food preference toward food that is less calorie-dense. KBP-088 dosed every other day (3 nmol/kg) was superior to KBP-088 once daily (1.5 nmol/kg) in terms of weight loss and improvement of food preference. The beneficial effects were evident in both lean and obese rats. Hence, dosing KBP-088 every other day positively affects overall efficacy on metabolic parameters regardless of the lean/obese state, suggesting that less-frequent dosing with KBP-088 could be feasible.