The guy had to have known how this little social experiment would turn out. At least he used pennies. 

In the latest Candyology 101 podcast, Maria and I tackled a little-celebrated candy bar, the Whatchamacallit. We’re also trying out a new format, which is a little shorter, like a handful of fun size candy bars!

You can see more comics over here.

Researchers at Princeton and Rutgers universities have found that the hepatitis E virus — an emerging liver virus historically found in developing countries but now on the rise in Europe — uses a technique to spread infection that scientists could in fact exploit to treat the disease.

From 2009 but still important I know we all celebrate Mother's Day when we try to make our Moms and Grandmothers feel extra special. My Mom is now 85 so I know the Mother's Day celebrations remaining can be counted on one or two hands. Both of my Gr

“History doesn’t repeat itself but it often rhymes,” Mark Twain was first credited with saying in 1970, 60 years after reports of his death had ceased to be exaggerated.

He's still giving the money back though.

He's still giving the money back though.

He's still giving the money back though.

Edwin Cabrera, a father of two, was unlocking his e-bike after dropping off a pizza on Fort George Hill near Fairview Ave. on May 3 when two suspects jumped out of the shadows and attacked him around 9 p.m.

Dennis Barrett, an east Indianapolis native, died of the coronavirus in March. His wife remembers him as a devoted father and ambitious entrepreneur.

Dr John Wright is intrigued by some singers who became ill long before the UK's first known Covid-19 case.

In 1957 a new strain of flu emerged in East Asia and quickly spread around the world, killing a million people.

Four minutes and 28 seconds. That is how long it took a News24 reporter to find cigarettes – meant to be banned under Level 4 lockdown regulations – which were available for purchase at one of many places in South Africa.

Former captain Paul O'Connell says it will be vital for the British & Irish Lions to pick a leader capable of beating the Springboks at their own game.

The DML News App offers the best in news reporting.

The post REPORT: Here’s What Comey Told Congress About Whether Flynn Lied To FBI: Transcript appeared first on Dennis Michael Lynch.

Flying in Canada during the time of COVID-19 requires a lot extra care, and CTV Senior Political Correspondent Glen McGregor gives a first-hand account on CTVNews.ca.

Many in the region had to dust off their snow shovels for at least one more dig out on Saturday morning after a polar vortex blasted parts of the province, catching many off guard.

7 October 2014

Members Event

Event participants

Professor Kerry Brown, Director, Lau China Institute, King's College London; Associate Fellow, Asia Programme, Chatham House
Chair: Isabel Hilton OBE, Founder and Editor, Chinadialogue

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Migration and development have emerged as a pressing policy priority on the global agenda. This report identifies critical lessons from the past decade of policy experimentation and offers recommendations for migration and development policy.

Mothers are often well-known for their ‘power prayers’ that agree with Heaven to shift circumstances in their families. On this Mother’s Day, we bless them for their love and sacrifice! And now more than ever, we want to make sure that our prayers...

Millie Small, the first Jamaican vocalist in popular music to make the world stop and look at Jamaica as an emerging musical powerhouse, passed away in London on May 5. She was 72 years old. Speaking to Small by telephone from her home in Shepherd’...

This discussion focuses on the MPI report, "Executive Action on Immigration: Six Ways to Make the System Work Better," which outlines administrative actions that can be implemented to improve the immigration system.

The discovery of an inhibitory memory circuit could lead to novel treatments for conditions such as PTSD

In order to remember, we must forget. Recent research shows that when your brain retrieves newly encoded information, it suppresses older related information so that it does not interfere with the process of recall. Now a team of European researchers has identified a neural pathway that induces forgetting by actively erasing memories. The findings could eventually lead to novel treatments for conditions such as post-traumatic stress disorder (PTSD).

We’ve known since the early 1950s that a brain structure called the hippocampus is critical for memory formation and retrieval, and subsequent work using modern techniques has revealed a great deal of information about the underlying cellular mechanisms. The hippocampus contains neural circuits that loop through three of its sub-regions – the dentate gyrus and the CA3 and CA1 areas – and it’s widely believed that memories form by the strengthening and weakening of synaptic connections within these circuits.

Related: Light switches memories on and off | Mo Costandi

Related: The Homer Simpson effect: forgetting to remember

New research shows that we can train our brains to become memory champions

To many of us, having to memorize a long list of items feels like a chore. But for others, it is more like a sport. Every year, hundreds of these ‘memory athletes’ compete with one another in the World Memory Championships, memorising hundreds of words, numbers, or other pieces of information within minutes. The current world champion is Alex Mullen, who beat his competitors by memorizing a string of more than 550 digits in under 5 minutes.

You may think that such prodigious mental feats are linked to having an unusual brain, or to being extraordinarily clever. But they are not. New research published in the journal Neuron shows that you, too, can be a super memorizer with just six weeks of intensive mnemonic training, and also reveals the long-lasting changes to brain structure and function that occur as a result of such training.

Related: The Homer Simpson effect: forgetting to remember

Related: A neural pathway that erases memories

Why did right-winger Yosemite Sam have problem with the leftist Bugs Bunny?

happy, sad, meh, mad, or what?

First, I would love to try Casu marzu and for dessert I am curious about durian. or a drink such as wormwood absinthe.

I am a dog sitter for my sister, she pays me around $100 a week. I also do extra chores around the house such as cleaning as an exchange for not paying rent. The money she pays me is usually transferred through zelle or paid cash. Im not sure if I would be considered an independent contractor or an employee. Also does she have to report to the irs my income and what forms would she have to use? Ive always received w2s from employers, so I’m Clueless to what I should do this tax season.  Thank you in advance!  Sorry I forgot to mention that my income for this last year was approximately $5000

Examples being: XTro (UK), Oldboy (S.Korea), Girl With a Dragon Tattoo (Sweden), Predestination (Australia) ... something like these

....GOING TO DO WHEN THEY BELIEVE THEY APPLY TO THEM BUT THEY HAVEN'T BEEN HOLY SPIRIT BAPTIZED? TODAY'S CHRISTIANS HAVEN'T BEEN "QUICKENED BACK TO LIFE" (EPHESIANS 2:1)  BY HIS "POWER THAT CAME UPON THEM" (ACTS 1:8) WITH HOLY SPIRIT BAPTISM (ACTS 1:5) AS THEY WERE "BORN AGAIN OF THE SPIRIT" (JOHN 3:5-7) FROM THEIR "DEAD SPIRITS" (ROMANS 5:12-14) AND WERE "RESURRECTED" (I COR 15) FROM THEIR GRAVES" (EZEKIEL 37:12-14). WHAT ARE THESE "DEAD SPIRITS" GOING TO DO? 

New Brunswick has entered the next COVID-19 recovery phase, triggering a new round of loosened restrictions and reopening a large swathe of the economy, Premier Blaine Higgs announced Friday.