OBJECTIVE

To determine the incidence of and factors associated with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² in people with diabetes.

Impaired baroreflex sensitivity (BRS) predicts cardiovascular mortality and is prevalent in long-term diabetes. We determined spontaneous BRS in patients with recent-onset diabetes and its temporal sequence over 5 years by recording beat-to-beat blood pressure and R-R intervals over 10 min. Four time domain and four frequency domain BRS indices were computed in participants from the German Diabetes Study baseline cohort with recent-onset type 1/type 2 diabetes (n = 206/381) and age-matched glucose-tolerant control subjects (control 1/control 2: n = 65/83) and subsets of consecutive participants with type 1/type 2 diabetes who reached the 5-year follow-up (n = 84/137). Insulin sensitivity (M-value) was determined using a hyperinsulinemic-euglycemic clamp. After appropriate adjustment, three frequency domain BRS indices were reduced in type 2 diabetes compared with control 2 and were positively associated with the M-value and inversely associated with fasting glucose and HbA_1c (P < 0.05), whereas BRS was preserved in type 1 diabetes. After 5 years, a decrease in one and four BRS indices was observed in patients with type 1 and type 2 diabetes, respectively (P < 0.05), which was explained by the physiologic age-dependent decline. Unlike patients with well-controlled recent-onset type 1 diabetes, those with type 2 diabetes show early baroreflex dysfunction, likely due to insulin resistance and hyperglycemia, albeit without progression over 5 years.

PURPOSE

The prognosis of older patients with dizziness in primary care is unknown. Our objective was to determine the prognosis and survival of patients with different subtypes and causes of dizziness.

Background and objectives

This study aimed to investigate the association between in-hospital trajectories of serum sodium and risk of in-hospital and 1-year mortality in patients in hospital.

Venous thromboembolism (VTE), as a term that encompasses pulmonary embolism (PE) and deep vein thrombosis (DVT), is one of the leading causes of maternal morbidity and mortality [1], especially in developed countries, where PE takes second place after complications of hypertensive disorders [2]. When compared to non-pregnant women of similar age, pregnant women have an approximately four to five times higher risk of VTE [3], with an incidence of 1 in 1000 pregnancies [4]. Approximately 20–25% of VTE cases are caused by PE and 75–80% of cases are caused by DVT [5]. About 60% of DVT occurs antepartum, with the highest risk of antepartum pregnancy-associated VTE being in the third trimester.However, about 60% of PE occurs postpartum [3].

Prime Minister Nguyen Xuan Phuc has just asked the Ministry of Construction (MoC) to promulgate regulations on amendments and supplements to construction standards and rules for condominiums, condotels, resort villas, officetels and rooms for rent.

As any good Guardian knows, Destiny 2 isn’t just a jargon-filled sci-fi loot ’em up. It’s just as much, if not more so, a far-future fashion show. But in a game about constantly trading out new gear, keeping a fresh look has always felt a little contentious. This week, Bungie revealed that Year 4 will […]

City of Windsor payouts on personal injury and property damage claims totaled $2.1 million in 2019, the lowest number in eight years. The total — for settlements as well as court decisions — was well below the $3 million budgeted for the hundreds of claims made each year against the city for everything from trip-and-falls, […]

The millennium bug is back with a vengeance, after programmers in the 1990s simply pushed the problem back by 20 years

Within months researchers will attempt to create a ball of plasma hotter than the sun inside the Joint European Torus, a doughnut-shaped machine in south-east England

GAZIANTEP, Turkey—After five years fighting to preserve Bashar al-Assad’s regime in Syria, Russia now appears inclined to dispose of its infamous client. Assad’s persistent brutality and corruption, and his inability to establish even the semblance of a functioning state, has grown to be a burden Moscow would prefer not to bear.

And then there’s the problem of Iran. Assad, members of his family, and his Alawite clansmen enjoy close, perhaps unbreakable, bonds to the regime in Tehran and to Iranian-backed militias in Syria. All of which undermines Moscow’s primary mission there: to rehabilitate the Assad regime as a symbol of stability capable of attracting hundreds of billions of dollars of foreign investment for reconstruction, which Russian firms would then be poised to receive. 

As long as Assad’s relatives continue to function as a mafia and give free rein to Iranian troops using Syria as base of operations to threaten Israel and plan attacks against U.S. troops in Iraq, those countries likely to foot the bill for Syrian reconstruction—the nations of Europe and the Gulf—are unlikely to come up with the cash. 

Read more at The Daily Beast.

MONEY saving hacks are something which many people will look to adopt in their lives, be it for a financial milestone or for a rainy day fund. And, there may be a way in which some soon see their spare cash add up.

Young Mars may have endured a series of huge collisions that smashed its mantle, throwing off our measurements of when it formed by up to 15 million years

SpaceX is partnering with a US start-up called Axiom Space to launch three space tourists on a 10-day trip to the International Space Station

The Hayabusa-2 spacecraft bombed the asteroid Ryugu in April. Analysing the crater it left behind suggests Ryugu is a relative youngster at 9 million years old

We’ve found a 200-metre cliff in Mars's Hellas basin, the first evidence of a river that flowed on the planet for more than 100,000 years

Whether they feature office bumbling, demon slaying, or parcel delivering, these games couldn’t have come at a better time.

RPGamer’s hosts battle through various ailments to bring you this week’s show. Jon gets ready for National StreetPass day, Anna gets stops Activision Blizzard from...

Some things are better late than never. Adriaan, Glenn, Alex, Sam, and Chris talk Games of the Year. At least, that’s the idea, but I...

It’s time for the latest Game of the Year podcast on the internet. That just means are picks are aged for better taste. Download it...

Adriaan, Glenn and Sam join Chris to talk about the best and worst of 2015. Many battles are fought. Many victories won. But only one...

It’s that time again. Where we get together and discuss the best games of the last year. Then things get weird. Mike is wrong, Sam...

It's time for way too many people to get on a Skype call and debate the following. How much is Wheels is wrong? What decade will the Final Fantasy VII remake will come out? And most importantly, what did we do to deserve Metal Max Xeno and The Witch and the Hundred Knight 2?

Woop woop! Explicit alert! This get a bit unclean as we try to figure out our Game of the Year picks for 2019. We find out just what you can get done with slave labor. We learn the true martial power of haircuts. And we finally realize Anna Marie shouldn't be allowed to keep animals.

ARMED forces veterans are facing a threat from an enemy they cannot see.

Bailey Williams reflects on the final Beatles album.

This heartwarming documentary traces the lives of a baseball star and her partner, now in their 90s, who pretended to be ‘just good friends’ for decades

This documentary from Netflix is a real heart-soother. Directed with tremendous sensitivity and intimacy by Chris Bolan, it’s a love story about two women now in their 90s – Terry Donahue and Pat Henschel, who have been together since the 1940s.

For decades they kept up the pretence of being “just good friends” to their families before finally coming out a few years ago. Talking to outsiders, they still describe each other as “cousins”. The legacy of shame and fear among older people in the gay community is explored in the film, but the overwhelming mood here is love.

Complacency is not a word in Kelsey Wog’s vocabulary. Every season, the fourth-year Bisons swimmer finds a way to take her game to the next level and break records along the ...

A planet’s global magnetic field arises from a so-called dynamo — a flow of molten metal within the planet’s core that produces an electrical current. On Earth, the dynamo is what makes compass needles point north. In a paper published in the journal Science Advances, a team of researchers from Canada, the United States and [...]

A 5-year old boy has died in New York from a rare inflammatory syndrome believed to be linked to the novel coronavirus, highlighting a potential new risk for children in the pandemic, Governor Andrew Cuomo said on Friday.

An analysis of the daily steps taken by about 5000 people in the US has found that a higher step count is linked to a lower yearly risk of death, although the effect tails off above 12,000 steps

India have so far grabbed men's full quota and one individual place in women's category for Tokyo Olympics.

The U.S. Senate on Wednesday approved William Evanina, President Donald Trump's nominee for a top counterintelligence position, after he was blocked for almost two years over a Republican request for documents related to the investigation of Russia and Trump's 2016 election campaign.

Former Chelsea and Arsenal defender Ashley Cole has signed a new one-year contract to remain with the LA Galaxy for a third season in Major League Soccer..

Longships and all

Top officials warned the public against traveling to Florida for the May 27 launch of two NASA astronauts aboard a SpaceX rocket to the International Space Station

Researchers have found the weird exoplanet WASP-79b, nearly 800 light-years from Earth, does not have a blue sky as our planet does. Instead, its skies are yellow.

At one time, a bizarre squid-like creature had arms covered in hooks that enabled it to attack and completely crush the skull of its prey, according to researchers.

GREENSBURG, Pa. (AP) - On a cloudy Friday afternoon 20 years ago Tuesday, an unemployed immigration lawyer went on a killing spree. It started next door to his parents’ Mt. Lebanon home, where he killed his Jewish neighbor. He went on to shoot five more people, all ethnic or racial ...

The 50th annual call for environmental reform falls at a time when the health of people and nature has never been more urgent

Fifty years ago today, the first Earth Day was marked in the United States as a peaceful call for environmental reform, following a massive oil spill off the coast of California. Half a century later, this annual day unites millions across the globe, drawing attention to the huge challenges facing our planet.

Now more than ever, Earth Day offers an opportunity for us all to reflect upon our relationship with the planet, amid the most powerful possible message that nature can surprise us at any moment, with devastating consequences for pretty much every individual. It is a time when the health of the planet and its people has never been so important.

The purpose of such an elaborate structure remains a big open question

Fragments of a comet likely hit Earth 12,800 years ago, and a little Paleolithic village in Syria might have suffered the impact