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Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion

Lab Chip, 2024, 24,5020-5031
DOI: 10.1039/D4LC00664J, Paper
Md Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman, Christopher J. Easley
Droplet-based microfluidic sampling of adipose tissue reveals unique information on lipolytic dynamics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Two youngsters from Kochi determined to smash their disabilities on the badminton court

Atul Krishna and Jyothish Kumar defy physical limitations to excel in badminton, inspiring with their determination and talent.




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Standoff continues in archdiocese over ‘letter’ from Vatican




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Road safety class mandatory for driving licence applicants in Ernakulam from Dec. 2

“The sessions will include new road safety guidelines in keeping with advancements in automobiles and road construction and also amendments made to the Motor Vehicles Act in the recent past”




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HC declines former Chief Secretary’s plea seeking exemption from personal appearance

Court exempts Palakkad Collector from personal appearance on condition that she will appear through virtual mode




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State affected due to lack of support from Centre during disasters: Kerala CM

Union government’s attitude reflects a desire for Kerala to suffer, says Pinarayi Vijayan




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Government formulates ‘work from Kerala’ concept

The idea is to leverage Kerala’s unique advantages from sustainable transport facilities, clean air and water besides open-minded people.




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Bengaluru winter meeting from Nov. 1




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India imposes anti-dumping duty on pentaerythritol imports from China, Saudi Arabia and Taiwan

Kanoria Chemicals had filed the petition seeking anti dumping probe




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Atmanirbhar push: MoD requests 156 LCH Prachand from HAL for Army and IAF

Of the 156 helicopters, 90 are designated for the Army Aviation Corps and 66 for the Indian Air Force 




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UP’s subsidy policy on strong hybrid cars different from FAME scheme: officials

The policy offers no registration cost for strong hybrid vehicles and provides a subsidy of ₹1 lakh or 15% of the ex-factory cost to customers, with a total outlay of ₹250 crore for 25,000 units




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Karnataka temporarily suspends job quota bill after backlash from industry

Influential figures such as Kiran Mazumdar-Shaw and TV Mohandas Pai had voiced strong opposition to the draft bill, citing concerns about its potential impact on business activities and the overall investment climate




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DPIIT may take a relook at FDI restrictions from China in policy review: Sources

No country in the world has been able to decouple with China, says Commerce Secretary




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GoM for freeing health insurance for senior citizens, all policies up to ₹5-lakh cover from GST burden

GoM suggests rate hike on high-end wrist watches, shoes; GST on packaged water to be cut




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Weather Dept issues yellow alert in TN from Nov 13




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Cyclone Dana: Train services in Sealdah division to remain suspended for 14 hours from Thursday night




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Work for revival of Kolkata's iconic Adi Ganga to start from January




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What is saree, petticoat cancer? From causes, symptoms to prevention, all you need to know

Research shows that tight petticoats worn with sarees may increase the risk of skin cancer in women due to constant....




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Focus Tamil Nadu | Is Rajinikanth inseparable from controversies?

In the backdrop of Rajinikanth falling at the feet of Uttar Pradesh Chief Minster Yogi Adityanath during a film promotion recently, the actor was strongly criticised for bowing before a man who is 21 years younger to him.




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Over 20,000 FCRA licences cancelled till date, most from Tamil Nadu | Data

If cancellations are expressed as a share of FCRA licences given, then Uttar Pradesh tops the list




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BRS names candidates for four Lok Sabha seats, fields Koppula Eshwar from Peddapalli

Party president KCR holds meeting with leaders of Mahabubabad, Khammam LS seats




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Uddhav Thackeray’s ‘offer’ to Nitin Gadkari draws jeers from BJP

Devendra Fadnavis says BJP leader’s name will be first when Maharashtra list candidates are announced



  • Lok Sabha Elections

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Mamata dials Odisha CM, urges him to intervene in ‘torture’ of labourers from Bengal

After incidents of Bangladeshi citizens fleeing to India to seek refuge, workers are being labelled as Bangladeshi and are being attacked based on rumours




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From missing big medals to nailing the bigger one — the Swapnil story

The 50-metre rifle 3-position shooter, who lost the plot after being in pole position at major events in the run-up to the Olympic Games, turned it around with a podium performance in Paris as expert guidance, diligent preparation and Himalayan patience do the trick




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Raveendran Sankaran Interview | We will ensure that more athletes from Bihar get into the Indian team in the 2028 Olympics

The Bihar Sports University is the first of its kind; the State Sports Academy, Rajgir, acting as a State Centre for Excellence, will cater to 23 disciplines; Sports academics have to go hand in hand with training and that’s the philosophy behind it




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Australian Olympic breaker Rachael Gunn to retire from competition after backlash

“Raygun”, as she was known, plans to retire after being ridiculed for her unconventional routine at the Paris Olympics




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Bangladesh interim government to seek Interpol support to repatriate Sheikh Hasina from India

Officials said a Red Notice is not an international arrest warrant, but rather a global request for law enforcement agencies to locate and provisionally arrest a person pending extradition, surrender, or similar legal action




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Kremlin says sees 'positive signals' from Trump on Ukraine

Kremlin spokesman Dmitry Pesko said it was hard to predict "to what extent he's going to stick to statements that he made on the campaign trail"




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No invite from India, Nepal PM Oli heads to China on first visit abroad

Visit seen as a symptom of strained ties over issues such as denial of overflight rights and New Delhi’s objection to Chinese investment or components in India-Nepal projects




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Requested ₹130 crore from Centre for the development of Vijayawada GGH: Vijayawada MP Chinni

All Anganwadi centres in NTR district will get a building of their own with clean kitchens, says Chinni




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Two-day 6th National Women’s Conference in Vijayawada from November 22

Objective of the meet is to explain to women their legal right to work in a safe environment; more than 200 delegates working in various public sector organisations to attend




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VVIT Balotsav to be held from November 15 to 17




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Insights from data with R [electronic resource] : an introduction for the life and environmental sciences / Owen L. Petchey, Andrew P. Beckerman, Natalie Cooper, Dylan Z. Childs.

Oxford : Oxford University Press, 2021.




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The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02172F, Paper
Fatemeh Barzegar, Samaneh Nabizadeh, Marzieh Kamankesh, Jahan B. Ghasemi, Abdorreza Mohammadi
Excessive dietary polyamines (PAs), including putrescine (PUT), spermine (SPM), and spermidine (SPD), have become a worldwide concern due to their carcinogenicity and reduced shelf life.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00348A, Paper
Yang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili Xue
A nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Pictures from the dear departed




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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article
Open Access
Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Railways using treated water from its STP for maintaining green spaces

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction




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600: Where Will The Web Be 12 Years from Now?

We've got your feedback as well as our thoughts on where we all think the web will be in 2036 - as we celebrate 12 years of ShopTalk Show history, we're looking forward to what's to come with ideas around cookie banners, undo, no more passwords, React, Deno, Node, and Mozilla's future, ChatGPT's thoughts, accessibility, blockchain, VR / AR, hoverboards, P3 color space, indie web, JS bundle sizes, and more!




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624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch

On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024.




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Power from wind and sun

Human activities are rapidly depleting non-renewable energy sources; therefore hybrid energy has emerged as a viable alternative




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Style and substance, from waste

Many architects with green ideologies have converted waste to usable construction material, some of it in the most innovative manner.




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A sporty knock from India Inc

A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too




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Unlocking renewable energy from industrial waste: Biogas production from spent wash

It is a sustainable solution for industrial waste management and renewable energy generation