Note left behind blamed the leader

Though he tested negative for COVID-19, staff seek compensation

Total fatalities stand at 3,739, while infections number 137,115. According to figures posted on Twitter by Health Minister Fahrettin Koca, 89,480 patients have recovered.

BMC divides Mumbai into seven zones, appoints IAS officer in each zone to ensure better coordination

District now has 216 cases, 93 active

Three more healthcare workers test positive for COVID-19

Administration denies allegations, says there is an audit panel of doctors that probes and reports every death

Brazil, the hardest-hit Latin American country in the coronavirus pandemic, has surpassed 10,000 deaths, according to figures released Saturday by th

Globally, as of 9 May 2020, there have been 3,862,676 confirmed cases, including 265,961 deaths, reported to WHO.

GATHER CONTENT: Stop content delaying website launches with custom collaborative online templates and workflow. Try it free!

Darrin’s death is not the last word on his life. His love for pastors—and his concern for their mental health and thriving—can be part of our response today.

Darrin Patrick has died.

Darrin is probably best known for planting The Journey Church in St. Louis in 2002, eventually growing to six locations. He was a husband, father, speaker, and author.

Darrin and his spiritual mentor Greg Surratt led the Pastor's Collective podcast and he was serving as a teaching pastor at Seacoast Church.

But, most importantly, Darrin was married to Amie and they have four children.

Darrin’s Journey and Focus

Darrin was very open about his journey—and specifically asked me to help share his story a little over a year ago. His story of leaving the Journey is painful and messy, but he wanted people to know about it.

He wanted people to learn from his pain.

Darrin died from a “self-inflicted gunshot wound.” I know that has caused some people to want more details—to use language that is more precise and to provide added details. And, as you can tell from the statement, the situation is confusing. Seacoast Church shared, ““Darrin was target shooting with a friend at the time of his death. An official cause of death has not been released but it appears to be a self-inflicted gunshot wound. No foul play is suspected.”

Thus, it is important to let families communicate the way they are comfortable. Families grieve in complex ways—and right now, they owe nothing to the rest of us. We just owe them our prayers.

The family is grieving and I am respecting their grief and their communication choices.

And, from there, I am going to take Darrin’s admonition from a year ago and fast forward it until now—hoping that even this moment might be a catalyst for pastors to get help that Darrin always wanted them to get.

Darrin and I talked recently and his last ...

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Maharashtra tops the tally with 779 deaths

Pathan's statement came during an Instagram Live session with Suresh Raina.

Maharashtra has the highest number of cases with around 20,228 positive cases of infection and 779 deaths.

Five persons of a family were brutally hacked to death in Hamirpur village, 27 km from Rapar town of Kutch, as the simmering animosity between members of two communities came to a boil on Saturday.

With the nationwide lockdown in place to fight the spread of COVID-19, the first condolence meeting held on virtual platform. Banerjee had died on March 20 after a prolonged illness while Goswami succumbed to cardiac arrest on April 30.

Of the 2,109 fatalities, Maharashtra tops the tally with 779 deaths. Gujarat comes second with 472 deaths, followed by Madhya Pradesh at 215, West Bengal at 171, Rajasthan at 106, Uttar Pradesh at 74, Delhi at 73, and Andhra Pradesh and Tamil Nadu at 44.

A simple two-spindle based lathe system for the preparation of cylindrical samples intended for X-ray tomography is presented. The setup can operate at room temperature as well as under cryogenic conditions, allowing the preparation of samples down to 20 and 50 µm in diameter, respectively, within minutes. Case studies are presented involving the preparation of a brittle biomineral brachiopod shell and cryogenically fixed soft brain tissue, and their examination by means of ptychographic X-ray computed tomography reveals the preparation method to be mainly free from causing artefacts. Since this lathe system easily yields near-cylindrical samples ideal for tomography, a usage for a wide variety of otherwise challenging specimens is anticipated, in addition to potential use as a time- and cost-saving tool prior to focused ion-beam milling. Fast sample preparation becomes especially important in relation to shorter measurement times expected in next-generation synchrotron sources.

Mum feels the 'earth move' beneath her at Plymouth car park  Plymouth Live

What is a sinkhole and are they caused by bad weather?  expressandstar.com

UK Geothermal: boiling beneath the surface?  Power Technology

The enzyme 4-hydroxy-tetrahydrodipicolinate synthase (DapA) is involved in the production of lysine and precursor molecules for peptidoglycan synthesis. In a multistep reaction, DapA converts pyruvate and l-aspartate-4-semialdehyde to 4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid. In many organisms, lysine binds allosterically to DapA, causing negative feedback, thus making the enzyme an important regulatory component of the pathway. Here, the 2.1 Å resolution crystal structure of DapA from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV is reported. The enzyme crystallized as a contaminant of a protein preparation from native biomass. Genome analysis reveals that M. fumariolicum SolV utilizes the recently discovered aminotransferase pathway for lysine biosynthesis. Phylogenetic analyses of the genes involved in this pathway shed new light on the distribution of this pathway across the three domains of life.

Death-associated protein kinase 1 (DAPK1) was found to form a complex with purpurin and the crystal structure of the complex was determined. Purpurin may be a good lead compound for for the discovery of inhibitors of DAPK1.

Five examples each of 3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-ones and the corresponding 1-(4-azido­phen­yl)-3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones have been synthesized in a highly efficient manner, starting from a common source precursor, and structures have been determined for three examples of each type. In each of 3-[5-(2-chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-one, C28H21ClN2O3, (Ib), the isomeric 3-[5-(2-chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-one, (Ic), and 3-[3-methyl-5-(naphthalen-2-yl­oxy)-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn­yloxy)phen­yl]prop-2-en-1-one, C32H24N2O3, (Ie), the mol­ecules are linked into chains of rings, formed by two independent C—H⋯O hydrogen bonds in (Ib) and by a combination of C—H⋯O and C—H⋯π(arene) hydrogen bonds in each of (Ic) and (Ie). There are no direction-specific inter­molecular inter­actions in the structure of 1-(4-azido­phen­yl)-3-[3-methyl-5-(2-methyl­phen­oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C26H21N5O2, (IIa). In 1-(4-azido­phen­yl)-3-[5-(2,4-di­chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C25H17Cl2N5O2, (IId), the di­chloro­phenyl group is disordered over two sets of atomic sites having occupancies 0.55 (4) and 0.45 (4), and the mol­ecules are linked by a single C—H⋯O hydrogen bond to form cyclic, centrosymmetric R22(20) dimers. Similar dimers are formed in 1-(4-azido­phen­yl)-3-[3-methyl-5-(naphthalen-2-yl­oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C29H21N5O2, (IIe), but here the dimers are linked into a chain of rings by two independent C—H..π(arene) hydrogen bonds. Comparisons are made between the mol­ecular conformations within both series of compounds.

A combined biophysical approach was applied to map gas-docking sites within murine neuroglobin (Ngb), revealing snapshots of events that might govern activity and dynamics in this unique hexacoordinate globin, which is most likely to be involved in gas-sensing in the central nervous system and for which a precise mechanism of action remains to be elucidated. The application of UV–visible microspectroscopy in crystallo, solution X-ray absorption near-edge spectroscopy and X-ray diffraction experiments at 15–40 K provided the structural characterization of an Ngb photolytic intermediate by cryo-trapping and allowed direct observation of the relocation of carbon monoxide within the distal heme pocket after photodissociation. Moreover, X-ray diffraction at 100 K under a high pressure of dioxygen, a physiological ligand of Ngb, unravelled the existence of a storage site for O2 in Ngb which coincides with Xe-III, a previously described docking site for xenon or krypton. Notably, no other secondary sites were observed under our experimental conditions.

Herein the nucleation pathway of conformational polymorphs was revealed by studying the relationships and distinctions among a series of α,ω-alkanedicarboxylic acids [HOOC–(CH2)n−2–COOH, named DAn, where n = 5, 7, 9, 11, 13, 15] in the solid state and in solution. Their polymorphic outcomes, with the exception of DA5, show solvent dependence: form I with conformation I crystallizes from solvents with hydrogen-bond donating (HBD) ability, whereas form II with conformation II crystallizes preferentially from solvents with no HBD ability. In contrast, form II of DA5 does not crystallize in any of the solvents used. Quantum mechanical computation showed that there is no direct conformational link between the solvents and the resultant polymorphic outcomes. Surprisingly, solute aggregates were found in no-HBD solvents by Fourier transform infrared spectroscopy, and only monomers could be detected in HBD solvents, suggesting stronger solvation. Furthermore, it was found that all six compounds including DA5 followed the same pattern in solution. Moreover, crystal-packing efficiency calculations and stability tests stated that dimorphs of DA5 bear a greater stability difference than others. These suggest that the rearrangement from conformation II to I could not be limited by hard desolvation in HBD solvents, where form I was also obtained. In other systems, metastable II was produced in the same solvents, probably as a result of the rearrangement being limited by hard desolvation. In this work, a comparative study uncovers the proposed nucleation pathway: difficulty in desolvation has a remarkable effect on the result of rearrangement and nucleation outcome.

Active cathode particles are fundamental architectural units for the composite electrode of Li-ion batteries. The microstructure of the particles has a profound impact on their behavior and, consequently, on the cell-level electrochemical performance. LiCoO2 (LCO, a dominant cathode material) is often in the form of well-shaped particles, a few micrometres in size, with good crystallinity. In contrast to secondary particles (an agglomeration of many fine primary grains), which are the other common form of battery particles populated with structural and chemical defects, it is often anticipated that good particle crystallinity leads to superior mechanical robustness and suppressed charge heterogeneity. Yet, sub-particle level charge inhomogeneity in LCO particles has been widely reported in the literature, posing a frontier challenge in this field. Herein, this topic is revisited and it is demonstrated that X-ray absorption spectra on single-crystalline particles with highly anisotropic lattice structures are sensitive to the polarization configuration of the incident X-rays, causing some degree of ambiguity in analyzing the local spectroscopic fingerprint. To tackle this issue, a methodology is developed that extracts the white-line peak energy in the X-ray absorption near-edge structure spectra as a key data attribute for representing the local state of charge in the LCO crystal. This method demonstrates significantly improved accuracy and reveals the mesoscale chemical complexity in LCO particles with better fidelity. In addition to the implications on the importance of particle engineering for LCO cathodes, the method developed herein also has significant impact on spectro-microscopic studies of single-crystalline materials at synchrotron facilities, which is broadly applicable to a wide range of scientific disciplines well beyond battery research.

Errors in the article by Opara, Martiel, Arnold, Braun, Stahlberg, Makita, David & Padeste [J. Appl. Cryst. (2017), 50, 909–918] are corrected.

Insights were obtained into the structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway for the biosynthesis of lysine.

It seems the stuff of science fiction, but astronomers have found a real-life “Death Star” that shredded a rocky planet and is swallowing the dusty remains.

The post “Death Star” Shreds, Swallows Dwarf Planet appeared first on Smithsonian Insider.

The expanded and remodeled Mathias Laboratory, named in honor of U.S. Senator Charles "Mac" Mathias Jr. (1922-2010) (R-Md.) will have a low environmental impact on all fronts, from where it gets its power to where it gets its materials.

The post New Mathias Lab at Environmental Research Center will have low environmental impact appeared first on Smithsonian Insider.

"I nearly fell out of my chair at the telescope when I saw one star change its speed by a staggering 750 miles per second in just a few minutes," said Smithsonian astronomer Warren Brown, lead author of the paper reporting the find.

The post Astronomers find two white-dwarf stars locked in death spiral appeared first on Smithsonian Insider.

Ornithologists Carla Dove and Storrs Olson used 700- to 1,100-year-old feathers from a long extinct species of Hawaiian ibis to help determine the bird’s place in the ibis family tree. The feathers are the only known plumage of any of the prehistorically extinct birds that once inhabited the Hawaiian Islands.

The post Fossil feathers from a Hawaiian cave help reveal lineage of extinct, flightless ibis appeared first on Smithsonian Insider.

In a laboratory at the Smithsonian Environmental Research Center in Edgewater, Md., scientist João Canning Clode and colleagues tested the cold-water tolerances of a number of invasive green porcelain crabs.

The post Cold spells spell trouble for warm-weather invasives appeared first on Smithsonian Insider.

Cheeseburgers. Ice cream. French fries. These are a few of the culprits, doctors warn us, responsible for atherosclerosis, a disease commonly known as hardening of […]

The post Ancient mummies reveal atherosclerosis is very likely just a part of aging appeared first on Smithsonian Insider.

Recent spectroscopic analysis of macaroni penguin (Eudyptes chrysolophus) crest feathers and king penguin (Aptenodytes patagonicus) neck feathers have shown they contain a yellow pigment that […]

The post Yellow pigment in penguin feathers is chemically distinct, spectroscopic studies reveal appeared first on Smithsonian Insider.

Out in Montana’s Big Sky Country Dale Greenwalt spends his summers seeking the incredibly tiny and fragile. Armed with a putty knife honed razor-sharp on […]

The post Quality of insect fossils from Montana’s Flathead River astounds scientists appeared first on Smithsonian Insider.

Chip a tooth and expose a nerve and the result can be a searing sensitivity to hot and cold. The hard outer layer of a […]

The post Scientists map pathway from narwhals’ sensitive tusk to brain appeared first on Smithsonian Insider.

Finding a fossil is the first step, recognizing it for what it truly is, is the real challenge. While closely studying three fossil skeletons from […]

The post One Scary Chicken—New species of large, feathered dinosaur discovered appeared first on Smithsonian Insider.

A research team from the Smithsonian and Arizona State University have developed a new, non-destructive method using spectroscopic analysis to help unravel the complex chemistry […]

The post Feathers yield mysteries of pigment chemistry to spectroscopic analysis appeared first on Smithsonian Insider.

Life in the universe might be even rarer than we thought. Recently, astronomers looking for potentially habitable worlds have targeted red dwarf stars because they […]

The post Harsh space weather dooms life on red-dwarf planets appeared first on Smithsonian Insider.

The majestic feathers of the greater bird of paradise (Paradisaea apoda) have inspired people for thousands of years. Like many birds on the isolated island […]

The post Feathers of seduction – the connection between birds and people of New Guinea appeared first on Smithsonian Insider.

The Death Star of the movie Star Wars may be fictional, but planetary destruction is real. Astronomers announced today that they have spotted a large, […]

The post Cosmic “Death Star” is Destroying a Planet appeared first on Smithsonian Insider.