Lymph node stromal cells (LNSCs) regulate immunity through constructing lymphocyte niches. LNSC-produced laminin α5 (Lama5) regulates CD4+ T cells but the underlying mechanisms of its functions are poorly understood. Here we show that depleting Lama5 in LNSCs resulted in decreased Lama5 protein in the LN cortical ridge (CR) and around high endothelial venules (HEVs). Lama5 depletion affected LN structure with increased HEVs, upregulated chemokines, and cell adhesion molecules, and led to greater numbers of Tregs in the T cell zone. Mouse and human T cell transendothelial migration and T cell entry into LNs were suppressed by Lama5 through the receptors α6 integrin and α-dystroglycan. During immune responses and allograft transplantation, depleting Lama5 promoted antigen-specific CD4+ T cell entry into the CR through HEVs, suppressed T cell activation, and altered T cell differentiation to suppressive regulatory phenotypes. Enhanced allograft acceptance resulted from depleting Lama5 or blockade of T cell Lama5 receptors. Lama5 and Lama4/Lama5 ratios in allografts were associated with the rejection severity. Overall, our results demonstrated that stromal Lama5 regulated immune responses through altering LN structures and T cell behaviors. This study delineated a stromal Lama5–T cell receptor axis that can be targeted for immune tolerance modulation.

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

A new NFC specification announced this week by the NFC Froum will allow future NFC enabled devices to offer wireless charging capabilities, which means a smartphone could be used to charge a small accessory like headphones.


According to the NFC Forum, the Wireless Charging Specification (WLC) will allow smartphones or other NFC charging devices to wirelessly charge small, battery-powered consumer and IoT devices at a power transfer rate of up to one watt.

The 1W rating is much slower than the Qi-based standard used by iPhones and other smartphones. Qi-based wireless charging on the iPhone maxes out at 7.5W, but is even faster on some Android devices.

Charging over NFC would require new hardware, and it's not a feature that can be added to existing devices. The NFC Forum believes the WLC specification could be used to complement Qi-based wireless charging.

It works using a single antenna to manage communications and charging, which is convenient for low-power devices like smart watches, fitness trackers, and earbuds that already use NFC for connectivity because there's no need to build in Qi support.

"The NFC Forum's Wireless Charging Technical Specification allows for wireless charging of small battery-powered devices like those found in many of the estimated 36 billion IoT devices in use today," said Koichi Tagawa, chair, NFC Forum. "NFC wireless charging is truly transformative because it changes the way we design and interact with small, battery-powered devices as the elimination of plugs and cords enables the creation of smaller, hermetically-sealed devices."

Apple in 2015 joined the NFC Forum and participates in the approval of new NFC specifications and developments.

Rumors in 2019 suggested that Apple was working on bilateral wireless charging that would allow its iPhones to charge the AirPods and the Apple Watch, but the feature was ultimately nixed. At the time, Apple analyst Ming-Chi Kuo said that the two-way wireless charging feature Apple was exploring did not meet Apple's requirements.

Samsung has implemented bilateral wireless charging in its smartphones, but the Wireless PowerShare option does not use NFC and is powered by the Qi-based charging coils in the device. Samsung's smartphones can charge other smartphones or accessories like headphones that support Qi wireless chargers.
This article, "New NFC Specification Will Let Smartphones Charge Small Devices" first appeared on MacRumors.com

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Animal Crackers (trailer) is a 94-minute computer-animated children's movie. The brainchild of Scott Sava, it caught the early attention of furry fandom at least as far back as 2015. Concept animation showed a guy haphazardly munching on animal-shaped cookies that turned him into the animals. As time went on, Sava brought in financial backers, a co-director (Tony Bancroft, who'd worked on several Disney movies), and a co-writer (Dean Lorey). The finished product premiered at the Annecy Film Festival in 2017... and then vanished.

It turns out that Sava had made the mistake of not securing a distributor ahead of time. With very little bargaining power, it eventually got shown in China in 2018, and some other countries in 2019.

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“Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading →

Группа ELLEFSON, в состав которой входит басист MEGADETH DAVID ELLEFSON, представили собственное прочтение композиции POST MALONE “Over Now”, а с пятнадцатого мая этот трек появится на всех цифровых площадках. Этот трек будет включен в новый альбом, выход которого предварительно намечен на октябрь. #David_Ellefson #DavidEllefson

IBM today unveiled a number of major additions to its Flex System portfolio. The offerings combine the latest server technology with new virtualization, networking and management tools, allowing clients to consolidate their existing IT infrastructures and reduce operating costs. This will help clients use smaller data center environments to quickly deploy, manage and secure increasingly larger clouds.

Advancements in assistive image analytics and deep learning technology could in the future help doctors in the fight against preventable blindness.

Duncan Trussell on Joe Rogan I’m trying to turn more people on to this Duncan dude! ???? Daily Photo – Male Lion in the Wild On our second day in Botswana, we were lucky enough to see this mature male lion. The previous time I was in Africa, I didn’t see a male lion for […]

UPDATE: Both workshops filled very quickly. I only do these about once a year; apologies for the imbalance. I have set up a system so people who are potentially interested in future small-class lighting workshops can receive advance notice. More info here.

__________
I'll be teaching two, full-day lighting workshops in the suburban Baltimore/DC area on December 6 and 7.

They are two separate one-day events. These are small-group workshops, with a maximum class size of 12 people each day. These are shooting workshops, and you'll be behind (and/or in front of!) a camera for most of the day.

Assuming you arrive at this class with a basic understanding of f/stops and shutter speeds, you will leave with a strong foundation in the fundamentals of off-camera lighting. You will be comfortable using single and multiple lights both alone and/or balanced with a mix of ambient lighting.

All lighting gear will be provided. We will also provide lunch.

You will need to bring a camera that is adjustable in manual mode and has a hot shoe connection for a flash, a lens that covers normal and/or portrait range, one or two fully charged batteries and an empty storage card. Maybe a notebook and pen if you like.

That's it. Just show up ready to learn and to have fun. Leave the rest to me.


Details

Dates:
December 6 and 7, 2019

Time:
9:30am - 5:30pm

Price:
$259

Location:
Sandy Spring Friends Lyceum
17715 Meeting House Road
Sandy Spring, MD 20860


Note; These are the only small-class lighting workshops I'll be teaching in the US this year. In the past, these have tended to fill very quickly. So if this is something you'd like to do, I'd suggest signing up sooner rather than later.


Sign-Up Links

Friday, December 6 [FRIDAY'S CLASS HAS BEEN FILLED]

Saturday, December 7 [SATURDAY'S CLASS HAS BEEN FILLED]

I don't keep my finger on the pulse of all the independent Kickstarter campaigns running at any given time. There's just too much unique content being produced month after month for me to sift through everything. I leave that to those who write previews and reviews for a living (I am an IT Consultant for a living; I write reviews as a hobby because I'm passionate about board gaming). The only way an independent Kickstarter campaign is going to be on my radar is if the designer/publisher reaches out to me to let me know the campaign is running or if it's created a bit of buzz already in the key circles that I frequent. I definitely wasn't closely monitoring Kickstarter campaigns four years ago when the original edition of Middara  was initially funded. It was an adventurous dungeon crawl that promised to be so much more than an ordinary dungeon crawl. With options to run in campaign mode for an ongoing narrative or crawl mode for one off gameplay, it could work as a long term project for committed game groups as well as a fun game for casual players. It was a long road from its 2015 campaign to its 2019 fulfillment with a lot of unhappy backers along the way who voiced frustration at the late fulfillment of the game. In early summer 2019, a few months after delivery of the original Middara  game was completed, Succubus Publishing launched their Middara: Unintentional Malum Triology  Kickstarter campaign. This offered a reprint of the original game (retitled Middara: Unintentional Malum Act 1), expanding it to over 80 hours of content, as well as two new adventure expansions (Acts 2 and 3) and a host of other Kickstarter exclusive add-on and stretch goal content. It also promised a faster turnaround on delivery to backers. Suddenly Middara  and its designers (Clayton Helme, Brooklynn Lundberg, Brenna Moncur, and Ian Tate) were the talk of the town and my husband Chris and I had an intense discussion about backing the second campaign. We were torn - yes the game sounded really cool, but we already own one behemoth campaign dungeon crawl (I’m looking at you Gloomhaven). Did we really need another? We hemmed and hawed and let the decision hang in the air. And then then publisher decided for us, by sending us a review copy of Middara: Unintentional Malum Act 1 (M:UMA1).

As soon as the box arrived at the end of June, I poured over all the components. So much stuff! Such a huge box! The artwork (conceived and illustrated by Stephanie Gustafsson, Alex Hansen, Hector Sevilla Lujan, Rhett Mason, and Jon Troy Nickel) is absolutely beautiful. The illustrations are well drawn, well detailed, and bursting with color.
The game could have an audience in the tween set if the drawings were a little less risqué, but as marketed to older teens and adults, everything is within decency standards.

The minis are of good quality; well sculpted. I do wish that at least the starting adventurer minis came pre-painted (I always wish that because I have no painting skills or supplies) especially when M:UMA1 is priced at $150. The components are sturdy and should hold up to regular usage. We haven’t sleeved our cards yet and because of the sheer quantity of them (hundreds) they’ll likely remain unsleeved. I especially enjoy the custom dice, separated by color to indicate which dice should be used during dice rolls.

After examining all the game contents, my interest was definitely on the upswing and Chris and I  set about assembling a crew to play the game in adventure mode. It’s daunting to find others willing to commit to 80+ hours of gameplay, but soon enough we had a happy foursome. One of the players, Craig, actually owned the original edition of Middara but hadn’t found the time to assemble a group and get it on the table. Our other player was his coworker and friend Matt.
Craig showed up for our first night of gameplay with a sweet surprise – he had ordered the fancy game mats and was happy to share them with us for our adventure.

In M:UMA1  adventure mode, players begin the first game by taking on the roles of young students preparing for their Magical Aptitude and Skill Test (MAST). We spent that first evening getting to know the four starting characters (called adventurers) and deciding who would role play each one. Every adventurer has their own unique backstory, motivations, starting equipment (armor, weapons, relics, consumables, etc.), and vivid personality.  I chose Nightingale because I saw myself in her and thought I would really enjoy playing her. Chris chose Rook, Craig took Remi, and Matt selected Zeke.
M:UMA1  adventure mode breaks down the overall campaign (called the adventure) into many sessions called encounters. We typically play one or two encounters each evening we get together, with each encounter lasting anywhere from one to two hours. To start an encounter, all players gather round the table and lay out their adventurer cards and equipment. The narrative is read from the Adventure book, or alternatively listened to on the Middara app. We all really love the app. It’s available on the Apple App store or Google Play store and allows players to hear the narrative bits of the story without requiring one of them to do the reading aloud. The voice actor Succubus Publishing hired is fantastic; she is an expressive reader who brings the characters alive. While the entire adventure in M:UMA1  is narrative driven and so every encounter advances the plot at least a little bit, there are some encounters that have several pages of story so using the app is really nice. After the narration is finished, the location boards are set up for the encounter, forming the terrain, similar to any other dungeon crawl. Directions for setup are given in the Adventure book with modifications in the Diagram book. Some elements of the terrain may have their details partially hidden, such as loot tokens (which hide the exact reward until a character performs an encounter adjacent to the token) and totem tokens (which hide what they represent until an adventurer comes within line of sight of the token). The starting spaces on the board for each adventurer and the monsters (called combatants) are specified in the Adventure book. Once everything is setup, the game begins; turn order for adventurers and monsters is driven by initiative cards that were shuffled and randomly laid out in a row during setup.
During the encounter, players spend their turns moving their adventurers around the terrain, following movement rules, as they work to complete the encounter goals. Usually this involves reaching the exit token, but other goals are possible. Since players typically get rewards (gold, equipment, experience points, etc.) each time their adventurer slays a monster, most will want to prioritize battling the monsters over making a quick run for the exit token. There isn’t a lot of analysis paralysis during game play as the best options for next steps on a player’s turn are usually fairly obvious. Combatants spend their turns completing actions as specified on their description cards. Those that are designated as adventurer opponents are called intelligent combatants and have intelligent combatant cards, while the ones that players control and that fight on behalf of adventurers are called command combatants. 

Exploring the terrain and battling intelligent combatants are governed by an extensive set of rules (60+ pages!) provided in the rulebook. It took us at least three encounters before we really understood most of the basic rules and even now, we find ourselves frequently checking the summary poster we printed out as a giant player aid. There’s just too much information to memorize it all, especially when the information is subject to change due to errata. Which brings me to one of the few complaints I have about this game -the large volume of errata. You either have to remember to frequently check the long list of corrections and changes (to the 1.0 rulebook and to the text printed on various components such as equipment cards, combatant cards, etc) and update gameplay as you go along,  or dedicate a session to reviewing all the changes and corrections and marking up the components with the correct text in one sitting. We started off trying to do the former but it was so frustrating that we switched to the latter and it took me at least an hour.  For the rulebook errata, you can take a shortcut to getting the updates in place (if you don’t mind the ink and paper expense) by printing out the updated 1.08 rulebook from the Succubus website. Another note on the rules- deciding which rule set to play under has become a complicated issue that players will need to come to agreement on as Succubus has compiled and released an entirely new version of the rules (v1.1) that changes several of the fundamental aspects of the game. This was done in response to the feedback from players who have extensively played through the game using the original 1.0 rulebook with errata corrections. The major overhaul is meant to strengthen aspects of the game that felt too weak and weaken aspects that seemed overpowered, but not all players agree on the changes. Also, the 1.1 changes are still in Beta release and so they are subject to change as they continue to be finalized. Our little group likes to keep things simple, so we opted to stick to the 1.08 rule set, at least for now.
Theme is really important to me, so I was very happy to discover that Middara’s theme is well implemented across all components and the gameplay thus far in M:UMA1 . This is where the game really shines over its competitors. Its narrative is extremely detailed and offers so much depth in the characters. More so than Gloomhaven. More so than any other board game I’ve played. An experienced  screenwriter could easily adapt the storyline into a fantastic adventure film for the big screen and I’d go see it. My two year stint playing through the Pathfinder Skull and Shackles Adventure Card Game is a distant second in plot development, and even then, that game only had such a rich narrative track because we employed a user written storyline that we found on BGG (the publisher offered little in the way of quality narrative for the game). I come back to the table each week to play M:UMA1 , not just for the fun of fighting monsters and gaining rewards, but also to find out what happens next in the story. Bonus: as the plot unfolds, adventurers grow in skill and discipline and new content becomes available.
At the time of this writing, we've played through all of Chapter 1 and are partway through Chapter 2 (about 10 distinct sessions). Once we are finished with M:UMA1  in adventure mode (we estimate it will take us over a year, meeting weekly) there are plenty of scenarios and special content for us to replay M:UMA1  in crawl mode.  In fact, a large portion of the Kickstarter promo box is content exclusively for use with crawl mode and I’m excited about eventually digging into that.
Based on my experience with M:UMA1  so far, I highly recommend the game. Not only is the game worthwhile on its own merits, but the friendship building that comes from playing a year+ long adventure with others is wonderful. You can make a full afternoon or evening out of each session, sharing a meal together before sitting down to play the game. Although I was given a review copy of Act 1, I like Middara so much that I’ll be purchasing Acts 2 and 3 myself (or putting them on my Christmas list). You can pre-order the entire trilogy or any part of it on the Succubus Publishing website once the publisher reopens wave 2 pre-orders.
-------------------------------------------------
Publisher: Succubus Publishing
Players: 2-4 (We played with 4)
Actual Playing Time (vs the guideline on the box): About 1 - 3 hours per encounter
Game type: narrative driven, dungeon crawl, campaign, action points, role playing, cooperative, dice rolling, grid movement
Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.

We'll be at the Small Press Expo in Bethesda Maryland!

This is our first time at SPX! If you're there, feel free to stop by and see us in the Artist Alley – we'll be at table W49!

See you there! <3 -Hamlet

Prostřednictvím amerického Programu ochrany mezd pro malé podniky získal uhelný průmysl v USA více než 31 milionů dolarů. Ozývají se rozhořčené hlasy z řad environmentalistů. Administrativa Donalda Trumpa podle nich využívá finanční pomoc na záchranu odvětví, které mělo potíže již před krizí.

Don't expect a pack of running fanatics swarming to the finish line at road races this year. But that doesn't mean that participants don't have options.

Most stakeholders agree that holding smaller competitions will be the best way forward post-lockdown.

Zájem o nákup rekreačních nemovitostí je letos výrazně vyšší než v posledních letech. Objektů, které se dostávají do prodeje, je naopak tento rok méně. Viníkem je v obou případech epidemie koronaviru a s ní spojená nejistota kolem letních dovolených. To se podepisuje na cenách, často se dostanou výš, než byly inzerované.

Good things: jack and I went to see the Troy exhibition at the British Museum. With a bit of time and energy left after that, we also visited the Aztec room. And then we went out for pancakes at my favourite spot. And it was generally lovely.

Then we had a go at some tabletop roleplaying, with OSOs and their younger two. jack had put together a cut-down system, roughly D&D based but a lot lot lot less complex and fiddly. And a delightful little one-shot story about saving a baby giant turtle from a suspicious sea captain, set in an archipelago of islands on the back of giant turtles. jack really encouraged us to develop fun characters, and we're all excited to play more in this setting.

I have plans for an exciting date with ghoti_mhic_uait next week, and I think after that no more travel for fun. Honestly I'm not sure about this week either. Maybe it isn't morally or safety-wise sensible to visit a huge tourist spot in the capital. I'm expecting several months of somewhere between boring and terrifying, and I'm not really impatient for that to start.

ghoti_mhic_uait bought me and jack an annual membership of the British Museum for our birthdays. And it was a really good time to visit as members; the Troy exhibition, in its last weekend, was completely sold out for non-members, plus it was lovely to be able to go to the museum semi-spontaneously rather than having to plan for a particular time and buy tickets. I probably wouldn't have made a special trip or paid lots of money to see Troy, but when it was low pressure it was worthwhile.

Basically what they've done is presented objects that represent the myth as told in Classical literature, so lots of vases and friezes and so on, arranged to recount the story of the fall of Troy. And then they have a gallery of Renaissance responses to the Trojan myth, and then a gallery of modern (ish) responses. Nice curation, lots of ideas about how the myth was interpreted through the culture of the time. And a marvellous collection of objects, the BM has really a lot of good blackfigure vases and beautiful neo-Classical objects. There is also quite a lot of commentary about how war is actually bad rather than epic, and thoughtful stuff about attitudes to women, and it's 2020 so we're no longer doing the ridiculous 'no homo' thing about Achilles and Patroclus.

My favourites were this gorgeous little bowl with a really sweet picture of Eris:


And a stunning pre-Raphaelite portrait of Clytemnestra immediately post-murder, which I couldn't photograph due to the lighting, and can't find an image of online.

Then we went to have tea in the special members' room. The main advantage is that it's quieter than the main tea-room, as it isn't in a huge echoing hall. We reckoned we had enough time and energy left to look at one more thing, and Jack was excited to see the famous double-headed turquoise snake from the meso-American gallery. I fell slightly in love with this grumpy woman who shares the room with it:


On the way we wandered past a staircase with some cool mosaics, the Wellcome gallery with has a Moai that they're in the process of returning to the Rapa Nui peoples they stole it from, and the gallery of indigenous North American stuff, much of which is again, stolen. Also the Enlightenment room, which I'm interested to go back to with more time, partly because it contains more stuff that the British Museum actually has a right to than a lot of the galleries!

Dinner was pancakes and mango lambic beer at My Old Dutch in Holborn, which has been a tradition since I visited the BM with my friend MK and his then two-year-old.

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