Timed tests and "drill-and-kill" approaches to math education can leave students with long-lasting anxiety, writes researcher Jennifer Ruef. There's a better way to teach the subject.

Where businesses are fighting to survive, agility is the name of the game, says Mignon Reynecke.

Strategic partnerships could be used to create win-win outcomes, says Sifiso Skenjana.

Contezolid (MRX-I), a new oxazolidinone, is an antibiotic in development for treating complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. This was a thorough QT study conducted in 52 healthy subjects who were administered oral contezolid at a therapeutic (800 mg) dose, a supratherapeutic (1600 mg) dose, placebo, and oral moxifloxacin 400 mg in 4 separate treatment periods. The pharmacokinetic profile of contezolid was also evaluated. Time-point analysis indicated that the upper bounds of the two-sided 90% confidence interval (CI) for placebo-corrected change-from-baseline QTc (QTc) were <10 ms for the contezolid therapeutic dose at each time point. The upper bound of the 90% CI for QTc were slightly more than 10 ms with the contezolid supratherapeutic dose at 3 and 4 hours postdose, and the prolongation effect on the QT/QTc interval was less than that of the positive control, moxifloxacin 400 mg. At 3 and 4 h after the moxifloxacin dose, the moxifloxacin group met the assay sensitivity criteria outlined in ICH Guidance E14 with having a lower confidence bound ≥5 ms. The results of a linear exposure-response model which were similar to that of a time point analysis demonstrated a slightly positive relationship between contezolid plasma levels and QTcF interval with a slope of 0.227 ms per mg/L (90% CI: 0.188 to 0.266). In summary, contezolid did not prolong the QT interval at a therapeutic dose and may have a slight effect on QT interval prolongation at a supratherapeutic dose.

Durlobactam (DUR, also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii. The safety and pharmacokinetics (PK) of DUR alone and with SUL and/or imipenem/cilastatin (IMI/CIL) were evaluated in healthy subjects. This was a randomized, placebo-controlled study. In Part A, subjects including an elderly cohort (DUR 1 g) received single ascending doses of DUR 0.25-8 g. In Part B, multiple ascending dose of DUR 0.25-2 g were administered every 6 hours (q6h) for 29 doses. In Parts C and D, the drug-drug interaction (DDI) potential, including safety, of DUR (1 g) with SUL (1 g) and/or IMI/CIL (0.5/0.5 g) was investigated after single and multiple doses. Plasma and urine concentrations of DUR, SUL, and IMI/CIL were determined. Among 124 subjects, DUR was generally safe and well tolerated either alone or in combination with SUL and/or IMI/CIL. After single and multiple doses, DUR demonstrated linear dose proportional exposure across the studied dose ranges. Renal excretion was a predominant clearance mechanism. No drug:drug interaction potential was identified between DUR and SUL and/or IMI/CIL. SUL-DUR, 1 g (of each component) administered q6h with a 3 hour IV infusion, is under development for the treatment of serious infections due to A. baumannii.

The off-label use of third generation cephalosporin (3GC) during in ovo vaccination or vaccination of newly hatched chicks, was a common practice worldwide. CMY-2-producing Escherichia coli have been disseminated among broiler production. The objectives of this study were to determine the epidemiological linkage of bla_CMY-2-positive plasmids among broilers both within and outside Japan because grandparent stock and parent stock were imported in Japan. We examined the whole genome sequences of 132 3GC-resistant E. coli isolates collected from healthy broilers during 2002-2014. The predominant 3GC-resistance gene was bla_CMY-2, which was detected in the plasmids of 87 (65.9%) isolates. The main plasmid replicon types were IncI1-I (n=21; 24.1%), IncI (n=12; 13.8%), IncB/O/K/Z (n=28; 32.2%), and IncC (n=22; 25.3%). Those plasmids were subjected to gene clustering and network analyses and plasmid multi-locus sequence typing (pMLST). The chromosomal DNA of isolates was subjected to MLST and single nucleotide variant (SNV)-based phylogenetic analysis.

MLST and SNV-based phylogenetic analysis revealed high diversity of E. coli isolates. ST429 harboring bla_CMY-2-positive IncB/O/K/Z was closely related to isolates from broiler in Germany harboring bla_CMY-2-positive IncB/O/K/Z. pST55-IncI and pST12-IncI1-I and pST3-IncC were prevalent in western Japan. pST12-IncI1-I and pST3-IncC were closely related to those detected in E. coli isolates from chicken in American continent, whereas 26 IncB/O/K/Z were related to those in Europe. These data will be useful to reveal the whole picture of transmission of CMY-2-producing bacteria in and out of Japan.

OBJECTIVES:

Our first aim was to examine baseline differences in body dissatisfaction, depression, and anxiety symptoms by gender, age, and Tanner (ie, pubertal) stage. Our second aim was to test for changes in youth symptoms over the first year of receiving gender-affirming hormone therapy. Our third aim was to examine potential differences in change over time by demographic and treatment characteristics. Youth experiences of suicidal ideation, suicide attempt, and nonsuicidal self-injury (NSSI) are also reported.

BACKGROUND AND OBJECTIVES:

Runaway youth and homeless youth are at risk for adverse mental health outcomes. These 2 populations are frequently pooled together in both research and interventions yet may have unique health needs. We sought to assess differences in mental health outcomes among these populations.

WRS Health is an innovative and clinician-centered solution that improves charting accuracy, individualizes patient-care plans, and enhances reimbursements. This application is definitely a top contender in the electronic medical record (EMR) field.

Penn State Health has appointed Don McKenna as president of Penn State Health Hampden Medical Center.

Penn State Health has enrolled its first COVID-19 patient into an experimental treatment program called convalescent plasma therapy.

Penn State Health today resumed construction of Penn State Health Cocoa Outpatient Center, an expansion of medical services at the former CocoaPlex Center location.

Kristina R. Olson
Mar 1, 2016; 137:e20153223-e20153223
ARTICLES

Katie Marshall, Penn State World Campus mental health case manager, connects students learning online to resources in their own communities.

Want to contribute to Apple's health research studies? You can sign up for programs on women's health, your heart and movement, and hearing using the Research app.

Paul W. Newacheck
Jul 1, 1998; 102:117-123
ARTICLES

Richard A. Ehrenkranz
Dec 1, 2005; 116:1353-1360
ARTICLES

Vinod K. Bhutani
Jan 1, 1999; 103:6-14
ARTICLES

Cynthia L. Ogden
Jan 1, 2002; 109:45-60
ARTICLES

Merle McPherson
Jul 1, 1998; 102:137-139
COMMENTARY

Betty R. Vohr
Jun 1, 2000; 105:1216-1226
ARTICLES

Penn State’s Sexual Assault Forensic Examination Telehealth (SAFE-T) Center is continuing to provide support to sexual-assault nurse examiners in local hospitals across the commonwealth through their innovative telehealth solution, which allows nurse examiners to partner with local-site nurses during live exams.

The Salt Path

Penn State Health has opened two regional clinics to care for patients with confirmed or suspected COVID-19 who have health care needs that are serious enough to warrant a face-to-face appointment.

Eight Penn State Health doctors have been named among the Pennsylvania Medical Society's "Top Physicians Under 40."

When a patient comes through the Penn State Hershey Medical Center drive-through COVID-19 testing site, they're asked if they are worried about running out of food during isolation. If they say yes, they drive away with a box full of 25 meals.

Penn State Health St. Joseph has moved swiftly to tackle the COVID-19 crisis, converting portions of its hospital as COVID-19 clinics, applying tried-and-true methods and learning on the fly.

The Penn State Wilkes-Barre Alumni Society provided lunch for local, hardworking medical professionals as a way to thank them for their efforts during the ongoing coronavirus outbreak and working to keep local residents safe.

Impact of Covid-19 on care homes to be investigated by Health and Sport Committee

Deep-learning algorithms suffer from a fundamental problem: They can adopt unwanted biases from the data on which they're trained. In healthcare, this can lead to bad diagnoses and care recommendations.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

Three ways that the burgeoning healthy afterschool movement can be a leader in incorporating social, emotional, and academic development, as explained by Daniel Hatcher.

Residents of the Liberty Court community in Dover joined Delaware State Housing Authority (DSHA) Director Anas Ben Addi, Sherani Patterson, Population Health Manager at Nemours, and Cassandra Codes-Johnson, Delaware Division of Public Health’s Director of Community Health to celebrate the kick-off of the Healthy Homes Initiative. Dover Mayor Robin Christiansen, Senator Brian Bushweller, and Representative Darryl Scott were also on hand for the festivities. The initiative promotes Safe Cleaning, which is designed to reduce asthma-related hospitalization by educating residents on asthma awareness, safe cleaning techniques, and pest management. The event featured face-painting for the children, refreshments, and the 4-H Club distributed raffle tickets for door prizes.

We conducted a systematic review to demonstrate that tummy time was positively associated with gross motor development; prone, supine, crawling, and rolling development; reduction in BMI-z; and prevention of brachycephaly.

Teacher Adrianne G. Williams cultivates an environment where she focuses on students' interpersonal qualities as well as their academic ones. The students see her effort, she says, and the parents follow.

July 1, 2019  Dover, DE—Highmark Blue Cross Blue Shield of Delaware (Highmark BCBS) has submitted its required annual rate filing to the Delaware Department of Insurance. After years of substantial increases, Delaware’s Marketplace has stabilized and premiums have decreased. Highmark BCBS, the only insurer continuing to offer insurance coverage in Delaware’s individual market, has proposed […]

Delaware’s Department of Insurance is pleased to announce that it is actively recruiting for a qualified independent contractor to staff and run its new Office of Value-Based Health Care Delivery. The Office will assist the Insurance Commissioner and Delaware’s Primary Care Reform Collaborative in evaluating primary care accessibility and affordability statewide. “Reducing health care costs […]

Last year, PepsiCo, too, had reduced the salt content in two of its Lay’s chips variants and introduced Kurkure Multigrain packs with 21% lesser sodium.

Indians make up one in 10 of all foreign-born doctors in the UK's National Health Service (NHS) and therefore face a greater risk from the coronavirus pandemic, according to a new report published on...

The testing capacity for COVID-19 has been scaled up to around 95,000 tests per day and a total of 15,25,631 tests have been conducted so far across 332 government and 121 private laboratories, Union...

Home Minister Amit Shah today tweeted to say he is healthy and not suffering from any disease, dismissing recent speculations on social media about his health.

American sycamore (Platanus occidentalis) is a native tree that can be affected by a fungal disease known as anthracnose. Several factors such as wet weather and lower average temperatures have combined to make this a more severe year for this condition. While many of the trees in the sycamore family are showing signs of stress, experts at the Delaware Forest Service believe that the majority of these will recover and leaf out normally as temperatures warm toward summer.

The Delaware Department of Agriculture has announced the winners of its 2016 Happy and Healthy Chickens Photo Contest, celebrating the best snapshots of Delaware backyard poultry flocks. The winner, chosen from a field of nearly 100 photographs, was Weston Williams, 11, of Felton, for his photo “Proud Stance.”

In late-June, Delaware’s forests get an annual “physical” or “check-up” – just after spring’s “leaf-out" blankets the state in a wave of green color. Just as people should visit the doctor to be screened for potential diseases, trees are examined with a variety of tools to hopefully spot minor issues before they turn into major ones. Armed with a digital camera, GPS technology, and a tablet equipped with specialized software and satellite data, forest health specialist Bill Seybold boards a small plane for a sky-high view of the First State. The annual aerial survey is specifically designed to detect potential threats that can only be seen from the air. Fortunately, early results from the 2018 aerial forest survey indicate no major outbreaks of tree diseases or insect pests.

Agency: HSS Closing Date: 7/15/2020

Agency: CYF Closing Date: 6/30/2020