Adult On-Road Cyclist Injury in Victoria, 2008/09 to 2017/18: A Report on Ambulance Attendances, Emergency Department Presentations, Hospital Admissions and Deaths , released by Monash University

Фото из архива Сильвии Видаль.

Первопрохождение. Соло. Сильвия Видаль. Не восхищаться этой "Чудо-женщиной" в мире альпинизма и её восхождениями невозможно! На этот раз она отправилась в долину Чилино в Патагонии, чтобы соло проложить новый маршрут по северной стене Сьеро-Чилино-Гранде.

This seems to be something of a thing. Our last "Tales From the Quarantine" post focused on how television celebrities had taken to offering people help on Twitter with their virtual home decor in the latest Animal Crossing game. This post also involves Animal Crossing, but in a much more direct way. Due to the COVID-19 pandemic, there are enormous numbers of people who have suddenly found themselves without jobs or regular income. And, so, they've turned to irregular sources of income instead.

Ars Technica has an interesting interview with one of many people who have taken to the internet to indirectly sell Animal Crossing's "bells", the currency of the game.

In the midst of COVID-19, some New Horizons players are turning to World of Warcraft-style gold farming methods to make ends meet. In early April, Lexy, a 23-year-old recent college grad, created a Twitter account offering up bells (Animal Crossing’s in-game currency) for real-world cash (she requested we refer to her by a nickname to avoid potential reprisal from Nintendo). “I got laid off due to COVID so I'm farming bells in ACNH,” she wrote. “I really need to make rent this month so I'm selling 2 mil bells per $5, please message me if interested, I'll give you a discount the more you buy.”

Before setting up this unorthodox income stream, Lexy had been working at a supermarket while developing her animation portfolio. She began exploring the idea of turning bells into cash after showing friends just how much in-game income she’d been making. “One of them asked to legitimately buy some for me,” she recalled in a Twitter interview. “I did some research and found some people selling bells on sites such as eBay, but for pretty ridiculous prices.” (Current prices on eBay seem more competitive, with some sellers offering rare gold tools and gold nuggets to sweeten the deal).

The threat from Nintendo is probably real. After all, unlike some other games where people do this sort of thing, Nintendo's game doesn't include any method for selling in-game resources for real currency. Nintendo is also notoriously prudish about things like this. And, finally, to make an effective go at this sort of thing, it takes some manipulation of the console in a way that is somewhat controversial with gamers generally.

Understandably, Lexy adjusts the clock on her Nintendo Switch to speed up the game’s slow, “natural” money-making cycle of harvesting daily fruit, digging up bells from the ground, and planting a daily “money tree” that can yield big profits. This kind of in-game “time traveling” is controversial practice among casual Animal Crossing players, but it's a practical necessity to maximize real-world bell-farming profits.

As for how much money people like Lexy are bringing in, it's in the four figures, but she wasn't any more specific than that. Payments are made through digital apps like PayPal, after which she visits the game islands of others and deposits the bells.

That all of this is going on during a global pandemic that has some folks farming bells to make ends meet and others with apparently enough disposable income to be buyers is all, of course, deeply strange. But it's also just yet another way technology is having an impact on our lives during the COVID-19 pandemic.

Automated operators can pay up like anyone – or anything – else

Microsoft has detailed a new form of software licence it offers to non-human users.…

It is time. We need a new Regism and cannot go to the pub to think of one. Can you help?

It is no secret that we like to use the odd bit of shorthand at The Register when biting the hand that feeds IT. Now we need a fresh one for Microsoft.…

A compelling addition to repo house – but is the Redmond flavour too strong?

GitHub had a lot to say about its plans at its virtual Satellite event yesterday, but the most far-reaching was the advent of Codespaces, the ability to edit code online, integrated into the GitHub user interface.…

And now to avoid container sprawl costing you plenty

Microsoft has slipped out licensing details for SQL Server running in containers and it will likely encourage developers to be pretty diligent in their use of Redmond’s database.…

It's over, Amazon, we have the high ground (and all you had was a high price) says Redmond

Updated Amazon.com has filed a second, secret, appeal against the decision to award Microsoft the Pentagon's $10bn Joint Enterprise Defense Infrastructure (JEDI) cloud contract.…

Компания обещает бесплатный ремонт устройств и возмещение расходов, если ноутбук уже отремонтировали.

OED Word of the Day: microfinance, n. The provision of loans and other financial services to low-income individuals and communities for the creation of small businesses…

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. Neuropeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unclear. Here, we observed increased expression of NPY5 receptor (Y5R) in HCC, which correlated with tumor growth and survival. Furthermore, we found that its ligand NPY was secreted by peritumorous hepatocytes. Hepatocyte-derived NPY promoted HCC progression by Y5R activation. TGF-β1 was identified as a regulator of NPY in hepatocytes and induced Y5R in invasive cancer cells. Moreover, NPY conversion by dipeptidylpeptidase 4 (DPP4) augmented Y5R activation and function in liver cancer. The TGF-β/NPY/Y5R axis and DPP4 represent attractive therapeutic targets for controlling liver cancer progression.

IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

Microsoft plans to add trackpad and mouse support to its Word, Excel, and PowerPoint apps for iPad by the fall, according to TechCrunch and The Verge.

iPadOS 13.4 introduced trackpad and mouse support on all iPad models released in the past four to five years. Keyboards with trackpads include Apple's Magic Keyboard and Brydge's Pro+ for the iPad Pro and Logitech's Combo for the 10.2-inch iPad and the 10.5-inch iPad Air.

When using a trackpad, the cursor displays as a circle on the screen, popping up only when you have a finger on the trackpad. The circle then morphs into various other shapes when hovering over app icons, text fields, or other on-screen elements.

Microsoft recently experienced a significant interruption of their Azure cloud service. Since a decent amount of data was available for this incident, I decided to do a partial root cause analysis. All of my source data came from Microsoft's official Azure blog post on 2014-Nov-24. I did this primarily to create a sample analysis that […]

The Weather Company, an IBM Business, and PRISA Noticias, one of the world’s leading Spanish-language media groups and owner of EL PAÍS newspaper, announced today a collaboration to combine the most accurate forecasts with one of the Spanish-speaking world’s largest media groups. The Weather Company will provide in-depth weather data and forecasts, as well as tailored content across PRISA properties. In turn, PRISA Noticias will provide locally relevant articles, photos and video content within the Spanish versions of The Weather Channel app and website (weather.com). The collaboration will also enable local marketers to access advanced data-driven advertising solutions from IBM Watson Advertising (formerly The Weather Company’s ad sales business) across both companies’ properties.

IBM announced today that Acrow, one of Australia’s leading suppliers of scaffolding and formwork for the construction industry, has selected IBM and IT Easy , to implement a total infrastructure refresh built around IBM Cloud, mobile, and network technology.

Millions of consumers depend on The Weather Channel and weather.com for their daily forecasts, breaking weather news, and the latest in health and travel. And, on August 21, they will be able to experience a solar eclipse like never before. The Weather Channel digital properties and Twitter have teamed up for a live stream of this once-in-a lifetime celestial event, which will allow consumers to chase the total solar eclipse in real time as it moves from coast-to-coast.

IBM y Microsoft anunciaron hoy que están trabajando conjuntamente para que el software empresarial de ambas empresas esté disponible en las plataformas cloud (de nube) de las dos organizaciones, denominadas IBM Cloud y Microsoft Azure, respectivamente. Este acuerdo ofrece más opciones en la nube a los clientes, socios tecnológicos y desarrolladores, lo que en definitiva promueve la creación de nuevos negocios, la innovación y la reducción de costos.

IBM y Crown Holdings, Inc., proveedor global líder en productos de empaques metálicos, anunciaron hoy la firma de un contrato de varios años que incluye servicios de TI y servicios administrados corriendo en la robusta plataforma de cómputo en la nube de clase empresarial de IBM.

BNZ, one of the country’s leading banks announces it has selected IBM to deliver cross-channel fraud prevention to its customers. The multi-million dollar deal will support BNZ’s aim to provide its customers the ability to bank securely while delivering a positive customer experience.

Les revendeurs internationaux observent une croissance significative pendant Thanksgiving et le Black Friday. IBM enregistre un engagement record dans son rapport annuel Holiday Readiness Clients

IBM prévoit plusieurs investissements stratégiques pour soutenir le programme finlandais de soins de santé

Southern Cross Computer Systems Pty Ltd has been named winner of the award for “Innovation in Green IT Data Center Solution” in the annual IBM Beacon Awards competition, honoring IBM Business Partners for their ingenuity, innovation, customer satisfaction and outstanding achievements in providing business solutions.

IBM (NYSE: IBM) today announced Melbourne start-up Localz as the winner of IBM SmartCamp Australia 2015, a global competition that brings together entrepreneurs, investors and experienced mentors. Localz provides software that connects the digital and physical worlds for enterprise, using the latest micro-location technology to enhance customer’s in-store experience, improve asset and inventory tracking and provide frictionless mobile payments, at scale. One of the key differentiators of the solution is that it works across different technologies (iBeacons, Bluetoth Low Energy, GPS or even QR Codes).

At a time when the world is piecing itself back together,
There are those who want to rip it apart again.
Teddy Lupin is about to learn how powerful his godfather truly is.

After some discussion with the applied math research groups here at UCLA (in particular the groups led by Andrea Bertozzi and Deanna Needell), one of the members of these groups, Chris Strohmeier, has produced a proposal for a Polymath project to crowdsource in a single repository (a) a collection of public data sets relating to […]