Pemigatinib was effective in patients with cholangiocarcinomas with FGFR2 fusions or rearrangements.

The FGFR2b inhibitor bemarituzumab was effective in high-FGFR2b gastroesophageal adenocarcinoma.

Patients with HPV16⁺ cervical cancer and high T-cell responses to an HPV16 vaccine survived longer.

As the COVID-19 pandemic worsens, the clinical cancer community is grappling with how to continue providing access to experimental but potentially lifesaving therapies while keeping immunocompromised patients safe. To that end, cancer centers are making changes to their clinical trial programs, while pharmaceutical companies are deciding how—or whether—trials should continue.

Since 2018, the FDA has required that U.S. clinical trial results be reported to clinicaltrials.gov within a year of trial completion, but this mandate is often ignored. A recent study found that less than half of U.S. trials submitted results to the site by the deadline. Industry-led trials were the most likely to be reported on time.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians, Inc. (ACP), and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of Clinical Diabetes. The following article describes an initiative of the Cleveland Clinic’s internal medicine residents to improve diabetes care and outcomes within an underserved patient population at an East Cleveland, OH, health center.

Structured diabetes education (SDE) is an evidence-based intervention that supports self-management in people with type 2 diabetes. In the United Kingdom, health care providers working in primary care settings are responsible for referring people with type 2 diabetes to SDE programs. However, national audits record a high percentage of nonattenders. We explored the personal experience of living with type 2 diabetes that led to individuals declining invitations to attend SDE programs. The themes suggested that emotional, cognitive, and social issues related to diagnosis and living with diabetes may be responsible for declining to attend SDE and that these factors may be masked by explanations of practical barriers. A person-centered approach to understanding the personal meaning of being diagnosed and living with type 2 diabetes may help to identify individuals’ psychosocial barriers to attending SDE.

BACKGROUND AND PURPOSE:

It is currently not completely clear how well radiologists perform in evaluating large-vessel occlusion on CTA in acute ischemic stroke. The purpose of this study was to investigate potential factors associated with diagnostic error.

We spoke with industry experts to identify what’s preventing developers from fully going green – and it all boils down to lack of finances.

This robot dog can scale ladders that a real dog would struggle with

This uncanny story of preppy drug dealers has a touch of Heathers and a bit of Bret Easton Ellis, and an intriguing take on what high school is really like

Tayarisha Poe, like her partial namesake, has a gift for the uncanny. She is the photographer and film-maker behind this feature debut, which began as an online multimedia project and was developed as a conventional movie through the Sundance screenwriters and directors labs. What has emerged is an intriguing, opaque, tonally elusive story that seems weirdly unfinished. It is set in a privileged high school – a world of ivy-covered stone buildings and shady quadrangles where rich kids are separated into malign and mutually hostile cliques. It has a touch of Donna Tartt and Bret Easton Ellis, a hint of Heathers and a bit of the elegant, disdainful satire of Dear White People.

Somehow, though, it is odder, more stylised and contrived, always holding out the possibility that it is set in the future, or in an alternative present on some other planet, or inside the head of one of its characters who is having a disturbing dream – the kind that ends just as it is about to give up its meaning. Right until the closing credits, I half-expected the face of each person on screen to flip upwards, revealing a Stepford-like set of dials.

In an exclusive interview, climate activist Greta Thunberg has told New Scientist that the coronavirus pandemic shows we can act quickly in an emergency

We can't lose sight of the climate emergency when dealing with the covid-19 pandemic, say Christiana Figueres and Tom Rivett-Carnac

Thousands of cyclists took over streets in the centre of the Slovenian capital Ljubljana on Friday evening to protest against the government of Prime Minister Janez Jansa and the restrictions it has imposed to fight the coronavirus.

GRANT SHAPPS announced the Government is introducing a £2 billion travel scheme to encourage Britons to use alternative transport as the UK slowly relaxes lockdown measures.

Hillary Clinton, the first woman to win a major party’s presidential nomination, teased an expected endorsement of Joe Biden for president Tuesday in a tweet.

Economic reconstruction is a chance to speed up decarbonisation, and the pandemic has shown a different kind of politics is possible

We’re already being swamped with ideas about “reforms” needed to recover from the pandemic crisis. But the word reform is like gift wrap – a handy cover for any offering, thought-through or otherwise.

Perhaps we should ditch the word entirely, and with it the forest of feelpinions about what governments “must” do to advance an author’s previously-held ideological positioning in the post-corona world.

Utah aims to reduce emissions over air quality concerns as other red states are also starting to tackle global heating

In a move to protect its ski slopes and growing economy, Utah – one of the reddest states in the nation – has just created a long-term plan to address the climate crisis.

Related: Washington state takes bold step to restrict companies from bottling local water

Warming springs can cause plants to bloom earlier, alter hibernation times and locations for migrating animals, and increase insect populations

Across the south-eastern US, trees are unfurling their clouds of leaves after winter. Yet this picturesque and usually welcome development is this year cause for consternation.

New data from the USA National Phenology Network (USA-NPN) shows that in parts of North Carolina, South Carolina and northern Florida, spring has arrived more than three weeks earlier than average, and earlier than at any point in the last 39 years it has been tracked.

Bank of England governor warns of financial collapse linked to climate emergency

• Top asset managers oversee $300bn fossil fuel investments
• Why are asset managers investing in fossil fuel companies?

Companies and industries that are not moving towards zero-carbon emissions will be punished by investors and go bankrupt, the governor of the Bank of England has warned.

Mark Carney also told the Guardian it was possible that the global transition needed to tackle the climate crisis could result in an abrupt financial collapse. He said the longer action to reverse emissions was delayed, the more the risk of collapse would grow.

On a ship frozen in the Arctic, scientists have spent all winter to shed light on exactly how the world is changing

Smithsonian's Earth Optimism Summit features CNN's Chief Climate Correspondent Bill Weir

The extent to which Brazilian soy production and trade contribute to climate change depends largely on the location where soybeans are grown, according to a new study. In some municipalities, carbon dioxide emissions resulting from the export of soybean and derivatives are more than 200 times higher than in others.

Over the past quarter-century, changes in Antarctic sea-ice cover have had profound impacts on life on the ocean floor.

A restoration ecologist has a simple message for anyone who thinks planting 1 trillion trees will reverse the damage of climate change: 'We can't plant our way out of climate change.'

Researchers know the secret to geckos' ability to walk on the ceiling: their hairy toes. But how do they use their five toes per foot to adjust to gravity when running horizontally along walls. Biologists have now used high-speed cameras to record how geckos orient their toes with shifting weight, especially when encountering slippery or rough patches, and found a remarkable ability to adjust toe orientation to stick and peel while running full speed.

A cyclist has died after being involved in a collision with a van.

Dozens of climate activists have been referred to the Home Office's anti-terror Prevent programme amid fears they may become radicalised, it has emerged.

Her friend Ahmed Hassan said she was a keen rower who will be remembered as "an amazing person and an amazing analyst" who left an "immense impact" on everyone she met.

Read our coronavirus live updates HERE Coronavirus: The symptoms

A motorcyclist has died after a crash on a busy road in north-east London.

A 35-year-old motorcyclist has died after a crash in east London.

A 90-year-old woman has raised more than £200,000 by attempting to climb the height of a mountain on her stairs to garner funds for the NHS.

Nazanin Zaghari-Ratcliffe and her family must continue their excruciating wait to find out if her temporary release from prison in Iran has been extended.

Donate at virginmoneygiving.com/fund/FoodforLondonNOW

Donations flood in for Margaret Payne's NHS money-raiser as she attempts to mimick a summit of Suilven by making 282 trips upstairs

Nazanin Zaghari-Ratcliffe's temporary release from prison in Iran has been extended during the coronavirus pandemic, her MP has said.

Police in Barnsley have launched an investigation after a three-year-old girl had spit wiped on her face by a teenage cyclist.

A police motorcyclist has died after a collision with a car while responding to an incident in Sheffield, South Yorkshire Police said.

Greta Thunberg has released a video showing a family calmly getting ready for the day while their house burns down around them as a symbol of the threat of climate change.

A man has died after his motorbike crashed into the central reservation of a major London road.

In today's Diary: XR activist says politicians aren't scared enough of the movement / Avgeeks make plane food at home / Sara Britcliffe's slight omission / Ellie Reeves on a positive of remote working