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Madhya Pradesh in the bottom half of all State-level rankings | Data

Madhya Pradesh lags behind most States in all economic and social indicators




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Ram temple sets off realty boom in Ayodhya

As Ayodhya town gears up for the consecration of the temple, land prices soar to an all-time high, especially in areas around the new structure




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HYDRAA clears encroachments on Bam Rukn Ud-Dowlah lake

High tension prevailed in Kings Colony and Shastripuram areas as the houses of some VIPs were allegedly demolished




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Regret standing with BJP during protest by farmers, says Dushyant Chautala

JJP leader says it was a mistake that he did not understand farmers’ sentiments but that he does not regret allying with the BJP in 2019




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Construction of one lakh houses under PMAY 1.0 scheme to be completed by December: Kolusu Parthasarathy

During a review of the Housing Department in Chittoor and Tirupati districts, he says that construction work was not completed in certain places due to lack of sand supply or heavy rains




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P3MOT-decorated metal-porphyrin-based zirconium-MOF for the efficient electrochemical detection of 4-nitrobenzaldehyde

Anal. Methods, 2024, 16,2093-2100
DOI: 10.1039/D4AY00152D, Paper
Wen-yi Chen, Xin-yu Huang, Qian Sun, En-qing Gao
Developed a novel hybrid P3MOT@PCN-222(Fe) via in situ polymerization for 4-NBA detection. Showcased broad detection range, high sensitivity, selectivity and stability, laying groundwork for environmental monitoring.
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Sodium alginate hydrogelation mediated paper-based POCT sensor for visual distance reading and smartphone-assisted colorimetric dual-signal determination of L-lactate

Anal. Methods, 2024, 16,2077-2084
DOI: 10.1039/D4AY00041B, Paper
Wenjuan Wang, Danrong Chen, Yujiao Cai, Zijing Liu, Hongfen Yang, Hongbin Xie, Jinquan Liu, Shengyuan Yang
Here, we show a paper-based POCT sensor based on lactate dehydrogenase-mediated alginate gelation combined with visual distance reading and smartphone-assisted colorimetric dual-signal analysis to determine the concentration of L-lactate in yogurt samples.
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Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
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Rapid and green quantification of phloridzin and trilobatin in Lithocarpus litseifolius (Hance) Chun (sweet tea) using an online pressurized liquid extraction high-performance liquid chromatography at equal absorption wavelength method

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00170B, Paper
Zhengming Qian, Qinggui Lei, Dan Tang, Guoying Tan, Qi Huang, Fucai Zhou, Wenhao Wang
Sweet tea is a functional herbal tea with anti-inflammatory, anti-diabetic, and other effects, in which phloridzin and trilobatin are two functional compounds.
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One-step electrodeposited hybrid nanofilms in amperometric biosensor development

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00290C, Tutorial Review
Yuliya E. Silina
This review summarizes developments in amperometric biosensors with electrodeposited sensing films. It was shown how the analytical merit of one-step designed biosensors can be controlled by the change of chemical factors within the same engineering platform.
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Analysis of O-acetylated sialic acids by 3-nitrophenylhydrazine derivatization combined with LC-MS/MS

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00330F, Paper
Chenhao Zhao, Xingdan Wang, Jing Wu, Yeli Hu, Qiwei Zhang, Qi Zheng
The 3-NPH-labeled sialic acids produce a high abundance of reporter ions, which can improve the accuracy of quantitative analysis of O-acetylated species.
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The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02172F, Paper
Fatemeh Barzegar, Samaneh Nabizadeh, Marzieh Kamankesh, Jahan B. Ghasemi, Abdorreza Mohammadi
Excessive dietary polyamines (PAs), including putrescine (PUT), spermine (SPM), and spermidine (SPD), have become a worldwide concern due to their carcinogenicity and reduced shelf life.
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Discrimination of Diptera order insects based on their saturated cuticular hydrocarbon content using a new microextraction procedure and chromatographic analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper
Open Access
Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper
Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
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Resolving phytosterols in microalgae using offline two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry

Anal. Methods, 2024, 16,2278-2285
DOI: 10.1039/D3AY02261G, Paper
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Development of an off-line LC-SFc-MS method, separation of sterol isomers in algal unsaponifiable fractions, elution pattern helping in the reduction of structural candidates.
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Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+

Anal. Methods, 2024, 16,2386-2399
DOI: 10.1039/D3AY02241B, Paper
Shili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren Liu
L-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg2+ in actual surface water.
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A novel electrophoretic assisted hydrophobic microdevice for enhancing blood cell sorting: design and numerical simulation

Anal. Methods, 2024, 16,2368-2377
DOI: 10.1039/D4AY00196F, Paper
Xinkun Chen, Xueye Chen
Microfluidic technology has great advantages in the precise manipulation of micro–nano particles, and the hybrid microfluidic separation technology has attracted much attention due to the advantages of both active and passive separation technology at the same time.
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Analysis of brominide disinfection by-products in aquaculture water using ultra-high-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper
Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
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A simple and rapid colorimetric detection of Staphylococcus Aureus relied on the distance-dependent optical properties of silver nanoparticles

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02189K, Paper
Ngoc Anh Thu Phan, Hoang Men Nguyen, Cam Duyen Thi Vo, Toi Vo Van, Phuoc Long Truong
The quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The current assays are suffering from limited capacities in...
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Proximity hybridization based “turn-on” DNA tweezer for accurate and enzyme-free small extracellular vesicles analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00487F, Paper
Jinlin Wu, Xi Mei, Xiaoqin Zhan, Fang Liu, Dongfang Liu
Small extracellular vesicles (sEVs) are a type of extracellular vesicles that carry many types of molecular information. The identification of sEVs is essential for the non-invasive detection and treatment of...
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Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00251B, Paper
Ahmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthman
Polymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...
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A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
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​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




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Deep roots: On the 2024 Physics Nobel Prize 

Physics Nobel Prize acknowledges the diverse foundations of AI




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Why Kriti Is So Grateful

Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release.




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Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article
Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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Synthesis and evaluation of tetrahydropyrrolo[1,2-a]quinolin-1(2H)-ones as new tubulin polymerization inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00541D, Research Article
Mikhail N. Anisimov, Maksim A. Boichenko, Vitaly V. Shorokhov, Julia N. Borzunova, Marina Janibekova, Vadim V. Mustyatsa, Ilya A. Lifshits, Andrey Yu. Plodukhin, Ivan A. Andreev, Nina K. Ratmanova, Sergey S. Zhokhov, Elena A. Tarasenko, Daria A. Ipatova, Alexander R. Pisarev, Ivan A. Vorobjev, Igor V. Trushkov, Olga A. Ivanova, Nikita B. Gudimchuk
New 1,5-disubstituted pyrrolidin-2-ones 1, 2 and 5-aryl-3,3a,4,5-tetrahydropyrrolo[1,2-a]quinoline-1(2H)-ones 3 were explored as inhibitors of tubulin polymerization.
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article
Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00663A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin Krátký
Linking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base




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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy




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587: Why Ethan Marcotte Thinks Tech Workers Deserve a Union

Ethan Marcotte is here to talk about his new book, You Deserve a Tech Union, and discusses topics such as why we need unions in tech, who gets to be in the union, how unions can help deal with the AI question, union busting, and some arguments against unions.




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Why we need lane discipline

Stick to the left lane when making a turn, even in smaller lanes




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Why banks are branching furiously

From financial inclusion to wooing back savings deposits, lenders have reasons to reject digital-only mode




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Why peer-to-peer lending has RBI on edge

Forced to drop many of its attractive features, peer-to-peer lending faces an existential crisis in India




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Why power from Sri Lanka is a better option than offshore wind

Wind industry sources estimate island nation has 65 GW onshore potential




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Why more NRIs are buying health insurance in India

The number of NRIs buying health insurance from India has increased steadily over the past three years




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₹200-crore decentralised green hydrogen scheme 

Decentralised use of green hydrogen could include cooking, off-grid electricity generation