A GoFundMe page aims to match the nearly $600,000 that Tia Stokes' non-profit dance group Kalamity has raised for people facing real-life calamities.

Want to visit the Northern, Western, Eastern and Southern Capitals? Book flights to Beijing, Xian, Tokyo and Nanjing.

Japonya hükümeti, Uygurlu Türklerin sürgündeki lideri Rabiya Kadir'in Tokyo ziyaretine mesafeli yaklaştı. Çin, Kadir'e vize verilmesinden rahatsızlık duyduğunu ifade etmişti.

Sabonis has two dance videos out, one in Pacers gear, the other shirtless.

It was the match made famous by Ben Stokes' heroics. But just how much can you recall from the epic third Ashes Test last summer?

Tensions on the streets were already high - now the disease has fuelled them, says Jeremy Bowen.

Penalties by Javier Hernandez and Dimitar Berbatov earn Manchester United a comfortable 2-0 victory over Stoke at Old Trafford.

A profile of the three-island territory in the South Pacific

strataconf: The Future Is Graph Databases http://t.co/BVxOZwtoKS A Conversation with @EmilEifrem, founder of @Neo4J #strataconf

Tokyo, Japan

Hear about travel to Tokyo as the Amateur Traveler talks to family travel blogger / podcaster Jason Andrew Jenkins from AnEpicEducation.com about a city he called home for 13 years.

Hear about travel to Tokyo as the Amateur Traveler talks to family travel blogger / podcaster Jason Andrew Jenkins from AnEpicEducation.com about a city he called home for 13 years.

Something’s been bugging me about Tik Tok. I’ve almost downloaded it about a dozen times over the past few months. But I always stop short. I don’t have a ton of time (here’s why) so forgive me as I resort to some short form tricks here. To wit: China employs a breathtaking model of state-driven … Continue reading "Tik Tok, Tick Tock…Boom."

Zoom has become a way of life for some people as of late (despite, uh, some safety concerns), especially when it comes to work meetings. Whether it's a company-wide all hands or a team check-in, it's likely that if you're working from home due to the coronavirus pandemic, you've had to see your coworkers' shining faces in a video call. 

Actor, writer, and Groundlings comedian Caitlin Reilly perfectly encapsulated that one co-worker you just can't stand during these video meetings:

It's so relevant it hurts. Who hasn't heard the phrase "to piggyback off of" during one of these calls?

The inspiration behind the 'tok was experiences Reilly had sitting in Zoom meetings on behalf of her boss. "I had actually never been in a zoom meeting before, so it was funny for me to see all the different 'personality' types in a situation like that," Reilly told Mashable. "And so it popped in my head one day and I just made the video." Read more...

More than 20% of social users will use TikTok this year February 27, 2020 (New York, NY) – Since launching in the US in 2017, social video app TikTok has […]

• Review of Chan Wook Park's Stoker.
• What We Watched: Dredd, The Artist is Present, Side by Side, Silver Lining's Playbook, Arrested Development, All-Star Celebrity Apprentice, Bob's Burgers.

Ricardo G. Durán, Enrique Otárola and Abner J. Salgado
Math. Comp. 89 (2020), 1581-1603.
Abstract, references and article information

Guher Camliyurt, Igor Kukavica and Vlad Vicol
Trans. Amer. Math. Soc. 373 (2020), 3375-3422.
Abstract, references and article information

D. Pauly and S. Repin
St. Petersburg Math. J. 31 (2020), 533-555.
Abstract, references and article information

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22 producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically, we addressed the hypothesis that early in the onset of metabolic diseases there is a decline in serum levels of IL-17/IL-22, with concomitant changes in the gut microbiome. Clustering iHMP study participants on the basis of longitudinal IL-17/IL-22 profiles identified discrete groups. Individuals distinguished by low levels of IL-17/IL-22 were linked to established markers of metabolic disease, including insulin sensitivity. These individuals also displayed gut microbiome dysbiosis, characterized by decreased diversity, and IL-17/IL-22-related declines in the phylum Firmicutes, class Clostridia, and order Clostridiales. This ancillary analysis of the iHMP data therefore supports a link between the gut microbiome, IL-17/IL-22 and the onset of metabolic diseases. This raises the possibility for novel, microbiome-related therapeutic targets that may effectively alleviate metabolic diseases in humans as they do in animal models.

Joachim Spranger
Mar 1, 2003; 52:812-817
Pathophysiology

Treatment of patients with advanced medullary thyroid carcinoma (MTC) is still a challenge. For more than 2 decades, it has been known that the cholecystokinin 2 receptor is a promising target for the treatment of MTC with radiolabeled minigastrin analogs. Unfortunately, kidney toxicity has precluded their therapeutic application so far. In 6 consecutive patients, we evaluated with advanced 3-dimensional dosimetry whether improved minigastrin analog ¹⁷⁷Lu-DOTA-(d-Glu)₆-Ala-Tyr-Gly-Trp-Nle-Asp-PheNH₂ (¹⁷⁷Lu-PP-F11N) is a suitable agent for the treatment of MTC. Methods: Patients received 2 injections of about 1 GBq (~80 μg) of ¹⁷⁷Lu-PP-F11N with and without a solution of succinylated gelatin (SG, a plasma expander used for nephroprotection) in a random crossover sequence to evaluate biodistribution, pharmacokinetics, and tumor and organ dosimetry. An electrocardiogram was obtained and blood count and blood chemistry were measured up to 12 wk after the administration of ¹⁷⁷Lu-PP-F11N to assess safety. Results: In all patients, ¹⁷⁷Lu-PP-F11N accumulation was visible in tumor tissue, stomach, and kidneys. Altogether, 13 tumors were eligible for dosimetry. The median absorbed doses for tumors, stomach, kidneys, and bone marrow were 0.88 (interquartile range [IQR]: 0.85–1.04), 0.42 (IQR: 0.25–1.01), 0.11 (IQR: 0.07–0.13), and 0.028 (IQR: 0.026–0.034) Gy/GBq, respectively. These doses resulted in median tumor-to-kidney dose ratios of 11.6 (IQR: 8.11–14.4) without SG and 13.0 (IQR: 10.2–18.6) with SG; these values were not significantly different (P = 1.0). The median tumor-to-stomach dose ratio was 3.34 (IQR: 1.14–4.70). Adverse reactions (mainly hypotension, flushing, and hypokalemia) were self-limiting and not higher than grade 1. Conclusion: ¹⁷⁷Lu-PP-F11N accumulates specifically in MTC at a dose that is sufficient for a therapeutic approach. With a low kidney and bone marrow radiation dose, ¹⁷⁷Lu-PP-F11N shows a promising biodistribution. The dose-limiting organ is most likely the stomach. Further clinical studies are necessary to evaluate the maximum tolerated dose and the efficacy of ¹⁷⁷Lu-PP-F11N.

Milwaukee Bucks star Giannis Antetokounmpo has apologized after he said someone hacked his Twitter account to send inappropriate tweets about several athletes, including LeBron James, Stephen Curry and Kobe Bryant.

London : printed for J. Callow, 1814.

Press release: CPMI report sets out considerations for developers of wholesale digital tokens, 12 December 2019

The video-sharing platform is a huge hit with teens and some teachers are beginning to integrate it into their lessons. But cyberbullying and data privacy are big concerns, experts say.

In 1951, John A. Stokes joined other black students in a strike over the condition of their school and subsequently became a figure in Brown v. Board of Ed. Hear his story and the message he wants to share with students today.

Stokvels are an important strategy for financial survival, so it's crucial to find a way to make them work during the pandemic, says Dr Norman Chivasa.

Sabric, a financial crime information centre, shares its tips on staying safe over the festive season.

With sports at a complete standstill, David Warner has found a new way of keeping his fans entertained during the coronavirus lockdown.

The statement came as Japanese Prime Minister Shinzo Abe on Thursday requested the closure of schools nationwide in a drive to curb the spread of the coronavirus.

The game will begin at 9 a.m. local time (0000 GMT) at the Fukushima Azuma Baseball Stadium with two further fixtures, Italy v United States and Mexico v Canada, later in the day.

The IOC's executive board will meet via conference call to prepare an "information exchange" ahead of a series of talks with athletes' representatives, National Olympic Committees (NOCs) and International Federations (IFs), planned for Tuesday and Wednesday.

If the Coronavirus goes on to postpone the Tokyo Olympics scheduled in July this year, it will hit yet another prominent sporting event after it delayed the Indian Premier League to April 15 from the scheduled March 29 start.

"Human lives take precedence over everything, including the staging of the Games." -- International Olympic Committee president Thomas Bach, announcing on Sunday that a postponement was under consideration.

IOC officials are studying a postponement, among other options, but they have said a decision would be "premature" four months from the scheduled start.

Japan has asked for a one-year postponement of the Tokyo 2020 Games over the global coronavirus pandemic, and the International Olympic Committee has agreed, the country's prime minister said Tuesday.

The Games were scheduled for July 24-August 9, but after telephone discussions between IOC president Thomas Bach and Japanese Prime Minister Shinzo Abe, a historic joint decision was taken for the first postponement of an Olympics in peacetime.

The deadly COVID-19 pandemic caused an unprecedented postponement as the International Olympic Committee (IOC), the Japanese government and the athletes world over agreed that Olympics in July-August this year could not have gone ahead in the present circumstances.

IOC President Thomas Bach said Wednesday that "all options are on the table" for new dates. He said next year's Olympics don't have to be restricted to summer in the Northern Hemisphere and might occur sooner.

The 2020 Olympics, which were set for July 24-August 9 this year, were postponed until 2021 by the International Olympic Committee (IOC) this week because of the coronavirus.