Archives, Room Use Only - CS71.M885 L67 1896

Archives, Room Use Only - TK5243.M7 O25 1939

Lockdown helps officials put road works across Hyderabad in the fast lane | Hyderabad News - Times of India

Microcrystal electron diffraction (MicroED) combines crystallography and electron cryo-microscopy (cryo-EM) into a method that is applicable to high-resolution structure determination. In MicroED, nanosized crystals, which are often intractable using other techniques, are probed by high-energy electrons in a transmission electron microscope. Diffraction data are recorded by a camera in movie mode: the nanocrystal is continuously rotated in the beam, thus creating a sequence of frames that constitute a movie with respect to the rotation angle. Until now, diffraction-optimized cameras have mostly been used for MicroED. Here, the use of a direct electron detector that was designed for imaging is reported. It is demonstrated that data can be collected more rapidly using the Falcon III for MicroED and with markedly lower exposure than has previously been reported. The Falcon III was operated at 40 frames per second and complete data sets reaching atomic resolution were recorded in minutes. The resulting density maps to 2.1 Å resolution of the serine protease proteinase K showed no visible signs of radiation damage. It is thus demonstrated that dedicated diffraction-optimized detectors are not required for MicroED, as shown by the fact that the very same cameras that are used for imaging applications in electron microscopy, such as single-particle cryo-EM, can also be used effectively for diffraction measurements.

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is a clinically approved anti-IgE monoclonal antibody that binds to free IgE, also with high affinity, preventing its interaction with Fc∊RI. All attempts to crystallize the pre-formed complex between the omalizumab Fab and the Fc region of IgE (IgE-Fc), to understand the structural basis for its mechanism of action, surprisingly failed. Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/Fab interactions that were clearly strong enough to disrupt the Fab/IgE-Fc complexes. Some of these interactions were common to other Fab crystal structures. Mutations were therefore designed to disrupt two recurring packing interactions observed in the omalizumab Fab crystal structures without interfering with the ability of the omalizumab Fab to recognize IgE-Fc; this led to the successful crystallization and subsequent structure determination of the Fab/IgE-Fc complex. The mutagenesis strategy adopted to achieve this result is applicable to other intractable Fab/antigen complexes or systems in which Fabs are used as crystallization chaperones.

Chi Cygni pulses once every 408 days. At its smallest diameter of 300 million miles, it becomes mottled with brilliant spots as massive plumes of hot plasma roil its surface. As it expands, Chi Cygni cools and dims, growing to a diameter of 480 million miles—large enough to engulf and cook our solar system out to the asteroid belt.

The post Distant, dying star gives astronomers preview of the fate of our Sun appeared first on Smithsonian Insider.

This image shows farmer Roy Bardole seated at the controls of his combine in a cornfield on a farm in Iowa. A GPS guidance system […]

The post GPS and the farmer… appeared first on Smithsonian Insider.

One of 4,000 "The Far Side" panels Gary Larson drew over 14 years. The full collection is now out in paperback.; Credit: Gary Larson

Off-Ramp animation expert Charles Solomon reviews "The Complete Far Side: 1980-1994" by Gary Larson.

It’s hard to believe the last panel of Gary Larson’s wildly popular comic strip “The Far Side” ran 20 years ago: January 1, 1995. The comics page of the LA Times (and many other papers) still feels empty without it.

RELATED: Charles Solomon interviews artists responsible for look of "Big Hero 6"

During its 14-year run, "The Far Side" brought a new style of humor to newspaper comics that was weird, outré and hilarious. The strip became an international phenomenon, appearing in over 1,900 newspapers worldwide. Larson won both the National Cartoonists' Society Reuben Award for Outstanding Cartoonist of the Year and the Best Syndicated Panel Award. An exhibit of original artwork from the strip broke attendance records at natural history museums in San Francisco, Denver and here in L.A. Fans bought tens of millions of "Far Side" books and calendars.

Much of the humor in “The Far Side” derived from Larson's seemingly effortless juxtaposition of the mundane and bizarre. When a bug-housewife declares "I'm leaving you, Charles...and I'm taking the grubs with me," it's the utter normalcy of the scene that makes it so funny. Mrs. Bug wears cats eye glasses, while Mr. Bug reads his newspaper in an easy chair with a doily on the back.

Or, a mummy sits an office waiting room reading a magazine while a secretary says into the intercom, “Mr. Bailey? There’s a gentlemen here who claims an ancestor of your once defiled his crypt, and now you’re the last remaining Bailey and … oh, something about a curse. Should I send him in?”

"The Complete Far Side" contains every strip ever syndicated: more than 4,000 panels. It should probably come with a warning label, "Caution: reading this book may result in hyperventilation from uncontrollable laughter." Except for a few references to Leona Helmsley or other now-forgotten figures, Larson’s humor remains as offbeat and funny as it was when the strips were first printed.

Andrews and McMeel initially released this collection in 2003 in two hardbound volumes that weighed close to 10 pounds apiece. You needed a sturdy table to read them. The three volumes in the paperback re-issue weigh in around three pounds and can be held comfortably in the lap for a while.

Because “The Far Side” ended two decades ago, many people under 30 don’t know it. The reprinted collection offers geezers (35 or older) a chance to give a present that should delight to that impossible-to-shop-for son, daughter, niece or nephew. How often does an older adult get a chance to appear cool at Christmas or Hanuka? 

And if that ingrate kid doesn’t appreciate it, "The Complete Far Side" also makes an excellent self-indulgence.

Charles Solomon lends his animatio expertise to Off-Ramp and Filmweek on Airtalk, and has just been awarded the Annie's (The International Animated Film Society) June Foray Award, "for his significant and benevolent or charitable impact on the art and industry of animation." Congratulations, Charles!

This content is from Southern California Public Radio. View the original story at SCPR.org.

Opah fish are hauled onto a dock for sale last week in San Diego. Fishermen coming home to California after weeks at sea are finding strict anti-coronavirus measures, and nowhere to sell their catch.; Credit: Gregory Bull/AP

Commercial fishermen in the U.S. who have already faced challenges in recent years to make it in an increasingly globalized and regulated industry, are now struggling to find customers during the coronavirus crisis.

"This is totally unprecedented. This is the biggest crisis to hit the fishing industry ever, no question about that," Noah Oppenheim, executive director of The Pacific Coast Federation of Fishermen's Associations told NPR in a phone interview. The federation is a trade association representing commercial fishermen along the West Coast.

On Tuesday, seafood industry leaders, processors and fishermen sent a letter to House and Senate leaders requesting $4 billion in aid for the industry.

The closings of restaurants due to the coronavirus pandemic has hit commercial fishermen particularly hard.

An estimated 50% to 60% of wild seafood caught in the U.S. is exported, says Oppenheim. Those international markets have dried up. He says, of the seafood that's not exported, around 80% of that is sold to restaurants.

"Both of those sectors of the seafood economy are largely nonfunctional at the moment, so we're going to have to make up for approximately 90% of our markets ... through either new supply pipelines or new sets of customers."

Jerid Rold, a fishermen in Moss Landing, Calif., tells NPR, he's been out of work for a month, since South Korea stopped taking imports of hagfish. Further damaging profits, Dungeness crab prices on the West Coast have fallen from up to $7 dollars a pound to $2, says Oppenheim.

In Eureka, Calif., "there are no buyers purchasing products at the harbor there. You can't move the Dungeness crab out of the Humboldt bay," Oppenheim said. "It's actually extraordinary how similar these impacts are playing out across the country. They are palpable, they are profound and they are severe."

On the North Atlantic coast, Sam Rosen, a 30-year-old lobsterman based in Vinalhaven, Maine, said he and others are "selling lobster for amounts they shouldn't be sold for."

That's been close to $2.50 a pound, compared to a usual $10 a pound this time of year, Rosen said.

"It's definitely a shock to the system," Rosen said. "This is uncharted territory right now. I don't think anyone thought it was going to be as bad as it's getting."

If aid isn't provided to fishermen soon, "I think we could see hundreds to thousands of fishermen leave the industry nationwide," Oppenheim said.

This content is from Southern California Public Radio. View the original story at SCPR.org.

; Credit: /Hanna Barczyk for NPR

What will happen on college campuses in the fall? It's a big question for families, students and the schools themselves.

A lot of what happens depends on factors outside the control of individual schools: Will there be more testing? Contact tracing? Enough physical space for distancing? Will the coronavirus have a second wave? Will any given state allow campuses to reopen?

For all of these questions, it's really too early to know the answers. But one thing is clear: Life, and learning for the nation's 20 million students in higher education, will be different.

"I don't think there's any scenario under which it's business as usual on American college campuses in the fall," says Nicholas Christakis, a sociologist and physician at Yale University.

So why are so many colleges announcing they will be back on campus in the fall?

In many cases, it's because they're still trying to woo students. A survey of college presidents found their most pressing concern right now is summer and fall enrollment. Even elite schools, typically more stable when it comes to enrollment, have reportedly been tapping their waitlists.

In the midst of all this uncertainty, it's worth looking at some of the ideas out there. With the help of Joshua Kim and Edward J. Maloney, professors and authors of the book Learning Innovation and the Future of Higher Education, here are some potential scenarios for reopening colleges and universities:

All virtual

Perhaps the most obvious option for the fall is to continue doing what they've been doing this spring. Colleges have signaled that they're planning for this option — even if it's a last resort. California State University, Fullerton, was one of the first to announce publicly it was planning for a fall semester online.

"Obviously we want to resume in-person teaching as soon as possible, but we also need to make sure that we're safe," says Ellen Treanor, who helps lead strategic communication at the school. Treanor says it made a lot of sense to assume the school would start online. "What would be the easier way to transition? It would be easier to transition beginning virtually and then transitioning in person," she said. "The faculty [needs] to be prepared."

With virtual classes, students can remain at home, although some colleges are exploring bringing them back to campus, where they could use the school's Wi-Fi to take online classes.

Delayed start

A delay in the semester would allow a school to wait it out until it was safer to reopen. One option is to push back a month or two, starting in October or November. Another idea is to push a normal start to January. In that case, the spring semester would become the fall semester, and potentially students could stay on campus through next summer to make up the spring semester. Boston University floated a version of this January start date when it announced a number of plans it was exploring.

One downside to a late start is what students will do in the meantime, especially those who don't have financial stability and rely on campus or the university to be a safe and stable home.

Some online, some face-to-face

This would be a hybrid model, with a combination of virtual and in-person classes. It may be a good choice for campuses that don't have enough classrooms to allow adjusting face-to-face teaching to the requirements of social distancing.

"You might have some of the larger classes being taught online simply because it's harder to imagine a 150- or 350-person classroom," says Maloney, who leads the Center for New Designs in Learning and Scholarship at Georgetown University. "So you might see that class split up into multiple sections." For large, entry-level classes, colleges may have a lecture component online and then meet in smaller groups in person.

"The hybrid model doesn't have to just be about modality," Maloney says. "It can be, but it could also be about fundamentally rethinking what the core structure has been for those large classes."

Of course, shifting larger classes online may not be enough, by itself, to alleviate the health concerns of having students on campus. Early research from Cornell University found that eliminating such classes didn't lessen student interactions with each other.

Shortened blocks

In block scheduling, students take just one course at a time for a shorter duration, typically three or four weeks. Colorado College, a liberal arts school south of Denver, has been using this model for 50 years. The college adopted this style of classes because "it allows [students] to take a deep dive and really focus in unique ways on the single subject," says Alan Townsend, the provost there. In a typical year, the school offers eight blocks.

In addition to its intensity, block scheduling is attractive right now because it allows flexibility. Colleges that use it have the opportunity to change the way classes look every three weeks — since there are multiple start and stop points. (With a semester, you have only a single start and then, often 16 weeks later, an end.)

"It's easier for us to now think creatively for next year," Townsend says. "Different students can make different choices. That's really hard to do with a semester-based system, but the blocks allow us to do that a little bit more flexibly."

The school is also entertaining the idea of sending faculty abroad to teach a block for international students who might not be able to enter the U.S, or adding summer blocks to give students even more opportunities to take classes.

Only some on campus

Some colleges have suggested bringing only freshmen back to campus and having upperclassmen either delay their start, or be online and remote.

The idea centers on research that shows just how important a student's first year of college is as a predictor of graduation. Adapting to campus can be a challenge, so this would allow first-year students to get comfortable and have extra support on campus.

Since upperclassmen are already familiar with how campus and classes work, the theory goes, they can more easily adapt to an online environment. Other versions of this approach would have students who have housing needs come back to campus first, and then, over time, phase in other groups of students.

All these options seek to keep the population density of the campus lower while still maintaining some face-to-face interactions.

On campus, with some changes

Social distancing, improved testing and contact tracing could help colleges reopen their campuses.

"Every school is trying to figure out a way to have students come back and do whatever we can while also protecting public health," says Learning Innovation co-author Joshua Kim, director of online programs and strategy at Dartmouth College.

"At the same time, we know that, however that works, things will be different. It's probably unlikely that we'll be able to cram students together in large, packed lecture halls or put doubles and triples in residence halls or have big events."

To follow social distancing, professors are measuring their classrooms, calculating how many students could fit in the space if they were 6 feet apart. Deans are planning out how students could enter and exit the classrooms safely.

But it's not just the classrooms that pose a challenge. For residential colleges, it's the dorms.

"Whether or not students are actually learning in the classroom, it's incredibly important for them to have an on-campus experience," Maloney says. So schools are thinking about how they can spread their students out, putting them in places where they normally wouldn't go.

Some ideas include housing students in offices that aren't being used, local hotel rooms or off-campus housing. Institutions are also reimagining campus events, like freshman orientation, since it's unlikely hundreds of students will be in a packed auditorium.

"Rethinking how we do everything we do at a university is part of the process," Maloney says.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Water trading is the buying and selling of access to water and can be an effective tool for water resource management, particularly in relation to the allocation of water among different users. A new tool that evaluates the long-term impacts of climate change on water trading has indicated that such a scheme could be effective in the future but will depend on factors including water demand and availability.

Factors influencing people’s decisions about how they travel to work are highlighted in a new study on commuting in Europe. Key findings include: cycling rates increase with the length of a city’s bicycle network and public transport use rises with a city’s population and GDP per capita. Based on the findings, the researchers propose policy measures for reducing the number of car journeys.

India has tried its hands out in 4.0 technologies to pace up with the rapidly changing retail landscape. The use of AI, ML and data analytics has increased which are being used in functions like BOPIS, Click & Collect and Self-Kiosk.

Biodiversity offset schemes do not always fully compensate for loss of habitat due to development, new research suggests. Of 66 development projects in France with offset schemes, it was found that numbers of species in offset sites was on average five times lower than in the land destined for development. Furthermore, even endangered species were not always protected by these offset sites.

In a new study, scientists have analysed the outcome of millions of barrels of oil and gas discharged into the Gulf of Mexico during the Deepwater Horizon disaster. By measuring changes in the composition of the fluid, scientists now have a better understanding of how pollution behaves in the deep ocean, to improve estimates of environmental impact.

There are some things you can do to ease the adjustment your older kids experience from having a new sibling, including involving them in the baby's arrival.

Once feared because of cholesterol, eggs are now prized for their nutritional value. And there's more to eggs than protein. Here's why eggs are so nutritious.

An honest story from an organic Japanese farm about what to do with an unneeded goat.

Why people are protesting the Dakota Access Pipeline.

Scientists propose dropping poison to kill mice on the Farallon Islands, but there's concern that wildlife and water quality will suffer.

The daughter-in-law and granddaughter of famous explorer Jacques Cousteau continue the mission of water stewardship.

Diners can eat in the same fields where the food is grown and often raise money for a good cause at the same time.

Forthcoming documentary follows movement to link poor growers with roasters and consumers.

Is the person you're calling to unlock your door a real locksmith or a con artist?

Do you really want to green your home? You can't do it alone. Here's how to get the sort of family buy-in you need to make it work.

In this video, the author and real-food advocate talks about why the farm bill should matter to anyone who cares about food.

Congress finally passed the farm bill. Here are 5 facts to start you on your way to knowing what's actually in it.

Oscar-winning actor Daniel Day-Lewis famously went on sabbatical to focus on his family and farming in 2013. Now it's clear he's not coming back.

Famous people understand dogs as well as the rest of us.

The rise and fall of Rev. Billy James Hargis, along with the popularity of Glenn Beck, makes our media columnist long for the days of the Fairness Doctrine.

Noticing the galaxy was a lucky catch by the Hubble telescope.

Small farmers work hard. Should you ask them to charge less for their hard work?

With May comes the opening of seasonal farmers markets in many regions of the country. What's the first thing you'll buy when your local market opens?

Why you should buy food at the farmers market. If you like delicious, nutritious food, then this is the right place for you to shop.

MSNBC offers some useful tips for making a trip to the local farmers market more productive.

For a limited time, this well-reviewed cookbook with 60 recipes divided into the four seasons is free on Amazon for Kindle readers.

Amazon's Farmers Market Direct program brings farmers extra business while delivering produce picked by a personal shopper to your doorstep.

Young entrepreneur wants to bring fresh food to inner city residents through aquaponics.

You'll see all kinds the Rainbow Gathering, a temporary utopian village in the forest of Oregon.

A modern take on comfort foods uses what is fresh and available during the season, but also explores new ingredients and stretches your imagination to look at o

Fanny packs, also known as bum bags, cycle in and out of style, but they just never seem to stick around.

The well-known mountain straddling Switzerland and Italy has its fair share of intrigue.

Strength training for the obese is the first step in taking control of your health. This article provides a positive starting point for strength training for everyone.

A website means a dynamic marketing plan. To court success a website must be promoted well and deliver all that it promises.

Stigma is a harsh reality for people who have mental health problems, because it prevents them from enjoying a normal and productive life. Learn More about the devastating effects of stigma.

The failure is sundered within each of us. Yet innately the affectation begins with our own visceral manumission of guilt, and sadly, empirically lies buried in our own personal failings.

the special custom portable solar panel supply you may interest to know.

As the temperature drops it is time to start thinking about your backyard ice rink plans. Here at Ice Rink Tarps.com, we have been planning the new season since the summer and are now pleased to announce our first phase of stock has arrived.