noc Alleviating hypoxia by integrating MnO2 with metal-organic frameworks coated upconversion nanocomposites for enhanced photodynamic therapy in vitro By pubs.rsc.org Published On :: Dalton Trans., 2024, Accepted ManuscriptDOI: 10.1039/D4DT02605E, PaperJunxun Zhou, Mengyue Jiang, Qiangqiang Zhang, Yuan Jiang, Haifang Wang, Lining SunPhotodynamic therapy (PDT) requires the participation of abundant oxygen while the hypoxic tumor microenvironment limits the efficacy of PDT. Here, upconversion luminescent nanocomposites coated with metal-organic frameworks (MOFs) were synthesized...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Post-deposition in situ passivation of AgBiS2 nanocrystal inks for high-efficiency ultra-thin solar cells By pubs.rsc.org Published On :: Energy Environ. Sci., 2024, 17,8885-8892DOI: 10.1039/D4EE03266G, PaperJae Taek Oh, Yongjie Wang, Carmelita Rodà, Debranjan Mandal, Gaurav Kumar, Guy Luke Whitworth, Gerasimos KonstantatosA post-deposition in situ passivation strategy using a multi-functional molecular agent is reported with enhanced colloidal dispersibility of an environmentally-friendly AgBiS2 nanocrystal ink, achieving a PCE over 10% in a solar cell.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Advancing high-temperature electrostatic energy storage via linker engineering of metal–organic frameworks in polymer nanocomposites By pubs.rsc.org Published On :: Energy Environ. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4EE04085F, PaperZongliang Xie, Zhiyuan Huang, He Li, Tianlei Xu, Haoyu Zhao, Yunfei Wang, Pang Xi, Zhiqiang Cao, Virginia Altoe, Liana M Klivansky, Zaiyu Wang, Steven Shelton, Shiqi Lai, Peng Liu, Chenhui Zhu, Michael D. Connolly, Corie Y. Ralston, Xiaodan Gu, Zongren Peng, Jian Zhang, Yi LiuHigh-performance, thermally resilient polymer dielectrics are essential for film capacitors used in advanced electronic devices and renewable energy systems, particularly at elevated temperatures where conventional polymers fail to perform. Compositing...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Photochemical organocatalytic heteroarylation of anilines and secondary alicyclic amines in continuous-flow By pubs.rsc.org Published On :: React. Chem. Eng., 2024, Advance ArticleDOI: 10.1039/D4RE00130C, PaperEgor N. Boronin, Milena M. Svetlakova, Ilya I. Vorobyov, Yulia B. Malysheva, Yuri V. Polushtaytsev, Sergey N. Mensov, Andrey V. Vorotyntsev, Alexey Yu. Fedorov, Timothy Noël, Alexander V. NyuchevPhotoorganocatalytic arylation of amines in continuous-flow enables scaling up including decreasing of both reaction time and catalyst loading.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Bioactive compounds regulate appetite through the melanocortin system: a review By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO04024D, Review ArticleYujia Niu, Wancong Yu, Xiaohong Kou, Shuqi Wu, Mengyi Liu, Chenlong Chen, Jiaxin Ji, Ying Shao, Zhaohui XueThe melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients. Bioactive compounds influence appetite through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1 By pubs.rsc.org Published On :: Food Funct., 2024, 15,11020-11035DOI: 10.1039/D4FO02479F, PaperHuan Zhang, Zhigang Zhu, Wenjing Wei, Zekun Liu, Huiji Zhou, Yueling Gong, Xinlei Yan, Jun Du, Houkai Li, Liang Chen, Lili ShengAronia melanocarpa (AM) was shown to promote the lifespan and health-span of C. elegans via the PMK-1 pathway, highlighting the potential of AM as a dietary supplement for delaying aging.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Dynamic changes in the gel properties, microbial community, and volatile flavor profile of Spanish mackerel (Scomberomorus niphonius) sausages inoculated with Lactiplantibacillus plantarum CY1-2 By pubs.rsc.org Published On :: Food Funct., 2024, 15,11060-11071DOI: 10.1039/D4FO03841J, PaperXinran Lv, Wenyu Wu, Shuilin Liu, Lili Ding, Anqi Ren, Le An, Fengling Bai, Jianrong Li, Xuepeng Li, Shumin YiThis study aimed to examine the dynamic changes in the gel properties, microbial diversity, and volatile flavor compounds (VFCs) of Spanish mackerel sausages inoculated with Lactiplantibacillus plantarum CY1-2 during fermentation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Cycloaddition of CO2 with epoxides into cyclic carbonates catalyzed by a binary organocatalyst under mild conditions By pubs.rsc.org Published On :: Catal. Sci. Technol., 2024, 14,6215-6223DOI: 10.1039/D4CY00639A, PaperWen-Wang Yu, Xiang-Guang Meng, Zi-Yu Gan, Wen Li, Yu-Lian Zhang, Jie ZhouHighly efficient capture and conversion of CO2 into cyclic carbonates from flue gas under atmospheric pressure.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Hydrolysis of ammonia borane for green hydrogen production over a Pd/C3N4 nanocatalyst synthesized by electron beam irradiation By pubs.rsc.org Published On :: Catal. Sci. Technol., 2024, 14,6338-6350DOI: 10.1039/D4CY00761A, PaperManish Shingole, Seemita Banerjee, Priyanka Ruz, Asheesh Kumar, Pratibha Sharma, V. SudarsanRoom temperature hydrolysis of ammonia borane in presence of electron beam irradiated Pd-C3N4 catalyst.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Bis-thiourea and macrocyclic polyamines as binary organocatalysts for the ROP of lactide By pubs.rsc.org Published On :: Catal. Sci. Technol., 2024, Advance ArticleDOI: 10.1039/D4CY00952E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Assunta D'Amato, Maria Voccia, Filippo Bruno, Sara D'Aniello, Lucia Caporaso, Francesco De Riccardis, Irene Izzo, Giorgio Della Sala, Mina MazzeoNew binary catalysts formed by a bis-thiourea and a series of flexible polyaza-macrocycles are revealed to be efficient catalysts for the ring opening polymerization (ROP) of L-lactide.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Innovations in nanocomposite photocatalysts for CO2 to CH3OH conversion By pubs.rsc.org Published On :: Catal. Sci. Technol., 2024, 14,6443-6465DOI: 10.1039/D4CY00822G, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shuang Deng, Nannan Wang, Yanqiu Zhu, Kunyapat ThummavichaiNowadays, the excessive use of fossil fuels has led to a global energy shortage and exacerbated the greenhouse effect.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Morphology–electronic effects in ultra-model nanocatalysts under the CO oxidation reaction: the case of ZnO ultrathin films grown on Pt(111) By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20216-20227DOI: 10.1039/D4NR02935F, PaperHang Liu, Lei Zhang, Sébastien Lebègue, Fabrice Bournel, Jean-Jacques Gallet, Ahmed NaitabdiThickness-dependent morphology and electronic properties of ZnO ultrathin films grown on Pt(111) under the CO oxidation reaction at 1 mbar.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Ni,S co-doped Cu dendrites decorated with core–shell architecture assisted by MOF and Fe0.92Co0.08S nanoflakes on nanocellulose/graphene fibers for fabrication of flexible wire-type micro-supercapacitor By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20260-20279DOI: 10.1039/D4NR02283A, PaperLeila Naderi, Saeed ShahrokhianA flexible 1D micro-SC was fabricated based on a multidimensional nanoarchitecture derived from MOF on foam-like microwires and FeCoS nanoflakes on nanocellulose/graphene fibers and exhibited high energy storage capability.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc High sensing performance flexible nanocomposite sensor with a hybrid nanostructure constructed via nanoscale confined motion of nanofibers and nanoplatelets By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20288-20303DOI: 10.1039/D4NR02541E, PaperZhenghui Xie, Feiran Meng, Junlong Yang, Yuhong Wang, Chul B. Park, Pengjian Gong, Guangxian LiHybrid 1D nanofiber/2D nanoplatelet nanocomposite foam sensor and Monte-Carlo modelling of complex 1D/2D sensing nanostructure.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Effective enrichment of glycated proteome using ultrasmall gold nanoclusters functionalized with boronic acid By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20147-20154DOI: 10.1039/D4NR03283G, PaperHongmae Heo, Seonghyeon Cho, Yuhyeon Kim, Soomin Ahn, Jeong-hun Mok, Hookeun Lee, Dongil LeeA novel approach was developed for the first time by combining ultrasmall Au22 nanoclusters with boronic acid (BA) affinity chemistry, achieving highly efficient enrichment of early-stage glycated peptides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc N-Heterocyclic carbene-stabilized gold–copper nanoclusters: synthesis, bonding and mechanochromism By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20228-20234DOI: 10.1039/D4NR03320E, PaperDongjie Zuo, Huifang Guo, Qinghua Xu, Ayisha He, Zilin Li, Simin Li, Hui ShenThe first gold–copper alloy cluster protected by both NHC and alkyne ligands was reported. The cluster displays interesting mechanochromic properties, highlighting the bright future of NHC-functionalized metal nanoclusters in materials science.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Modulating the photodynamic modality of Au22 nanoclusters through surface conjugation of arginine for promoted healing of bacteria-infected wounds By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20089-20099DOI: 10.1039/D4NR03278K, PaperXinyue Dou, Sariah Saalah, Chel-Ken Chiam, Jianping Xie, Coswald Stephen SipautAn Au nanocluster (NC)-based photodynamic antibacterial is designed by conjugating arginine on the surface of Au22 NCs, achieving healing of bacteria-infected wounds via producing reactive oxygen species (ROS) and reactive nitrogen species (RNS).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Exploring size-dependent optical property alterations in fine-tuning intermetallic PdCd nanocube sizes By pubs.rsc.org Published On :: Nanoscale, 2024, Advance ArticleDOI: 10.1039/D4NR03640A, PaperJia-Lin Li, Ting-Yu Tien, Hung-Chun Liao, Hsin-Lun WuSize-tuned intermetallic PdCd nanocubes, synthesized via a quantum dot-like method, reveal novel size-dependent optical properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Retarding anion exchanges in lead halide perovskite nanocrystals by ligand immobilization By pubs.rsc.org Published On :: Nanoscale, 2024, Advance ArticleDOI: 10.1039/D4NR03241A, PaperGauri Sharma, Radha Rathod, Pralay K. SantraPlasma treatment causes the crosslinking of passivating molecules around CsPbX3 (X = Cl−, Br−, I−) perovskite nanocrystals (PNCs), which retards the anion exchanges.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Carbon-based nanocarriers for plant growth promotion: Fuelling when it needs By pubs.rsc.org Published On :: Nanoscale, 2024, Accepted ManuscriptDOI: 10.1039/D4NR03268C, Review ArticleMohammad Ashfaq, Govind Gupta, Nishith VermaClimate change (i.e., rising temperature and precipitation) due to global warming is affecting soil fertility, thereby significantly causing a decrease in agriculture production worldwide. At the same time, increasing demands...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc DON encapsulated carbon dot–vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5 By pubs.rsc.org Published On :: Nanoscale, 2024, Advance ArticleDOI: 10.1039/D4NR00426D, PaperAfreen Zaman, Aparajita Ghosh, Anup Kumar Ghosh, Prasanta Kumar DasHACD–TMAV, a carbon dot–vesicle conjugate, selectively delivered glutamine inhibitor DON to CD44-enriched cancer cells, inducing ROS triggered apoptosis by dual targeting CD44 and SLC1A5 through downregulation of PI3K/AKT/mTOR signalling cascade.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Preceramic polymer hybridized phenolic aerogels and the derived ZrC/SiC/C ceramic aerogels with ultrafine nanocrystallines By pubs.rsc.org Published On :: Nanoscale, 2024, Accepted ManuscriptDOI: 10.1039/D4NR03470H, PaperDing Nie, Hangyu Zhong, Hongli Hu, Zhenhua Luo, Boxing ZhangPhenolic and carbon aerogels have important applications for thermal insulation and ablative resistance materials in aerospace areas. However, their antioxidant ability in long-term and high-temperature aerobic environments is facing serious...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Hydrodynamic Slip in Nanoconfined Flows: A Review of Experimental, Computational, and Theoretical Progress By pubs.rsc.org Published On :: Nanoscale, 2024, Accepted ManuscriptDOI: 10.1039/D4NR03697B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Abdul Aziz Shuvo, Luis E. Paniagua-Guerra, Juseok Choi, Seong H. Kim, Bladimir Ramos AlvaradoNanofluidics has made significant impacts and advancements in various fields, including ultrafiltration, water desalination, biomedical applications, and energy conversion. These advancements are driven by the distinct behavior of fluids at...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D4BM00357H, PaperBin Zhang, Rui Yang, Hongwei Yu, Yamin Peng, Haoyu Huang, Meera Moydeen Abdul Hameed, Han Wang, Guixiang Zhang, Mohamed EL-Newehy, Mingwu Shen, Xiangyang Shi, Shaojun PengMacrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles can be developed to cross the blood–brain barrier for magnetic resonance imaging and chemo/chemodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Recent advances in shape memory polymeric nanocomposites for biomedical applications and beyond By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,2033-2040DOI: 10.1039/D4BM00004H, Review ArticleYifan Zheng, Yudi Du, Ling Chen, Wei Mao, Yuan Pu, Steven Wang, Dan WangShape memory polymers (SMPs), which initiate shape transformation in response to environmental stimuli, have attracted significant attention in both academic research and technological innovation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Between hope and hubris: Innocence, glumness, despair, gratitude after the World Cup final By www.thehindu.com Published On :: Wed, 22 Nov 2023 00:30:00 +0530 This is sport. Unexpectedness and upsets are what it thrives on. Full Article Columns
noc Nanocrystals give hematite rainbow flair By cen.acs.org Published On :: 01 Jul 2018 13:01:35 +0000 Mineral’s microstructure causes natural iridescence Full Article
noc Sinochem, ChemChina merger appears likely By cen.acs.org Published On :: 08 Jul 2018 13:02:02 +0000 Full Article
noc Bain buys antibiotics maker DSM Sinochem By cen.acs.org Published On :: 08 Jul 2018 13:03:02 +0000 Full Article
noc Membrane knocks out antibiotic-resistant bacteria By cen.acs.org Published On :: 20 Jul 2018 19:57:32 +0000 Combining UV disinfection with a photocatalytic membrane helps to reduce the bacteria and their genes in wastewater Full Article
noc Membrane knocks out antibiotic-resistant bacteria By cen.acs.org Published On :: 29 Jul 2018 12:50:20 +0000 Combining UV disinfection with a photocatalytic membrane helps reduce the bacteria and their genes in wastewater Full Article
noc NSE awaiting NoC from SEBI before filing draft prospectus for IPO By www.thehindubusinessline.com Published On :: Fri, 08 Nov 2024 18:42:00 +0530 Aims to strengthen commodities segment, predicts market cap to double in 10 years Full Article Markets
noc Modular access to multi-substituted allenones via environmentally friendly organocatalytic C–H allenylation of aldehydes By pubs.rsc.org Published On :: Green Chem., 2024, Advance ArticleDOI: 10.1039/D4GC04550E, PaperXinying Hu, Ayisenbati Jialingbieke, Yuzhi Ren, Yifan Yang, Donghui Wei, Jian Gao, Ding DuOrganocatalytic direct C–H allenylation of aldehydes with propargyl bromides has provided a straightforward and step-economical strategy for allenone modular synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Hypervalent iodine chemistry with a mechanochemical twist By pubs.rsc.org Published On :: Green Chem., 2024, Advance ArticleDOI: 10.1039/D4GC04903A, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sayad Doobary, Miguel M. de Vries Ibáñez, Berit OlofssonAn assessment of mechanochemistry's utility with hypervalent iodine reagents highlighted its effectiveness, which showed better selectivity, reaction times and differing reactivity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Production of nanochitins via a shell biorefinery process for self-assembly applications as photonic films and Pickering emulsions By pubs.rsc.org Published On :: Green Chem., 2024, 26,11222-11237DOI: 10.1039/D4GC02680B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xuhai Zhu, Fuyan Peng, Hui Li, Rongjun Lin, Rui Lu, Fang LuA simple, environmentally friendly, and flexible shell biorefinery process for integrated utilization of all NCh products in high-value applications, such as photonic films and Pickering emulsions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Economic and environmental sustainability of bio-based HMF production and recovery from lignocellulosic biomass By pubs.rsc.org Published On :: Green Chem., 2024, 26,11340-11350DOI: 10.1039/D4GC04270K, PaperYuyao Jia, Shraddha Maitra, Lavanya Kudli, Jeremy S. Guest, Vijay SinghTransforming waste stream of biorefinery into high-value bioproducts.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc Mechanoenzymatic Hydrolysis of Cotton to Cellulose Nanocrystals By pubs.rsc.org Published On :: Green Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4GC05113K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sandra Kaabel, Inge Schlapp-Hackl, Eero Kontturi, Mauri A. KostiainenSolid-state mechanoenzymatic approaches for the production of cellulose nanocrystals from cotton were examined using three commercially available cellulase systems from Trichoderma reesei, Aspergillus niger and a Cellic CTec2 cellulase blend....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc DD takes on RCB in potential knockout By www.thehindu.com Published On :: Sun, 22 May 2016 03:06:33 +0530 Full Article Indian Premier League
noc AUS A vs IND A, 2nd Unofficial Test: Dhruv Jurel strengthens his case with another fine knock By indianexpress.com Published On :: Sat, 09 Nov 2024 06:12:33 +0000 Full Article Cricket Sports
noc World Chess Championship: India’s top GMs Pravin Thipsay, Abhijit Kunte predict a Gukesh knockout win inside 12 rounds By indianexpress.com Published On :: Tue, 12 Nov 2024 17:35:08 +0000 Full Article Chess Sports
noc ‘Cummins is tactically good, setting good fields; Bumrah has many more wicket-taking deliveries and can just come and knock your stumps’ – Shaun Tait By indianexpress.com Published On :: Wed, 13 Nov 2024 02:22:11 +0000 Full Article Cricket Sports
noc After Jio deals, RIL valued higher than BP, Sinopec, Shell, ConocoPhillips, Vodafone, Tesco By www.businesstoday.in Published On :: Sun, 10 May 2020 16:48:46 GMT The investor confidence shot up in RIL because of the back-to-back strategic investments in its telecom subsidiary in the last three weeks Full Article
noc Venezuela’s state oil group agrees $2bn Conoco payout By www.ft.com Published On :: Mon, 20 Aug 2018 13:06:57 GMT Deal ends dispute over nationalisation that had disrupted PDVSA’s exports Full Article
noc Materials engineering, processing, and device application of hydrogel nanocomposites By feeds.rsc.org Published On :: Nanoscale, 2020, Advance ArticleDOI: 10.1039/D0NR01456G, MinireviewGi Doo Cha, Wang Hee Lee, Chanhyuk Lim, Moon Kee Choi, Dae-Hyeong KimThe integration of patterning technologies and functional hydrogel nanocomposites enables their advanced device applications such as sensors, actuators, energy devices, and tissue engineering scaffolds.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
noc UP: MSME can start first, take NOC within 3 yrs By timesofindia.indiatimes.com Published On :: Sun, 10 May 2020 05:55:20 IST Generation of employment and attracting foreign investment are the two mainstays of UP government’s decision to suspend a majority of its labour laws for the next three years. Full Article
noc Morrisons recalls Market Street Living Herbs because of possible contamination with Listeria monocytogenes By www.food.gov.uk Published On :: Sat, 09 May 2020 00:00:00 +0100 Morrisons has taken the precautionary step of recalling Market Street Living Herbs because the products might contain Listeria monocytogenes. Full Article
noc Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications [Immunology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms. Full Article
noc A knock at the door By feedproxy.google.com Published On :: Mon, 04 Jul 2011 15:19:56 +0000 A man shares his story of living with HIV at an AIDS workshop aboard Logos Hope, which opened hearts for ministry to others with HIV. Full Article
noc How FIA defrauds innocent citizens and implicates them in bogus case By feedproxy.google.com Published On :: Sun, 10 May 2020 06:00:00 +0500 ISLAMABAD: In a shocking move, Federal Investigation Agency’s own internal inquiry has revealed how an official of the agency converted a business deal between two private parties into a human trafficking case and implicated innocent citizens in a bogus case.Raja Muhammad Ishaq — an... Full Article
noc How FIA defrauds innocent citizens and implicate them in bogus case By feedproxy.google.com Published On :: Sun, 10 May 2020 06:00:00 +0500 ISLAMABAD: In a shocking move, Federal Investigation Agency’s own internal inquiry has revealed how an official of the agency converted a business deal between two private parties into a human trafficking case and implicated innocent citizens in a bogus case.Raja Muhammad Ishaq — an... Full Article